11 results on '"Goñi-Irigoyen, Fernando"'
Search Results
2. Chemical and in vitro bioanalytical assessment of drinking water quality in Manhiça, Mozambique
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Villanueva, Cristina M., Grau-Pujol, Berta, Evlampidou, Iro, Escola, Valdemiro, Goñi-Irigoyen, Fernando, Kuckelkorn, Jochen, Grummt, Tamara, Arjona, Lourdes, Lazaro, Beatriz, Etxeandia, Arsenio, Ulibarrena, Enrique, Nhacolo, Ariel, and Muñoz, Jose
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- 2021
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3. Prognostic biomarkers of Parkinson’s disease in the Spanish EPIC cohort: a multiplatform metabolomics approach
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Gonzalez-Riano, Carolina, Saiz, Jorge, Barbas, Coral, Bergareche, Alberto, Huerta, José Mª, Ardanaz, Eva, Konjevod, Marcela, Mondragon, Elisabet, Erro, M. E., Chirlaque, M. Dolores, Abilleira, Eunate, Goñi-Irigoyen, Fernando, and Amiano, Pilar
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- 2021
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4. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, Vineis, Paolo, and IRAS OH Epidemiology Chemical Agents
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biomarkers ,environmental health ,Pancreatic cancer ,persistent organic pollutants ,methods - Abstract
Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
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- 2022
5. Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts
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Govarts, Eva, Iszatt, Nina, Trnovec, Tomas, de Cock, Marijke, Eggesbø, Merete, Palkovicova Murinova, Lubica, van de Bor, Margot, Guxens, Mònica, Chevrier, Cécile, Koppen, Gudrun, Lamoree, Marja, Hertz-Picciotto, Irva, Lopez-Espinosa, Maria Jose, Lertxundi, Aitana, Grimalt, Joan O., Torrent, Maties, Goñi-Irigoyen, Fernando, Vermeulen, Roel, Legler, Juliette, Schoeters, Greet, One Health Chemisch, One Health Toxicologie, dIRAS RA-1, dIRAS RA-2, Vlaamse Instelling voor Technologisch Onderzoek [Mol] (VITO), Norwegian Institute of Public Health [Oslo] (NIPH), Slovak Medical University of Bratislava (SMU), VU University Amsterdam, CIBER de Epidemiología y Salud Pública (CIBERESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California [Los Angeles] (UCLA), University of California, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University Medical Center [Utrecht], University of Southern Denmark (SDU), OBELIX no 227391, FP7, Seventh Framework Programme, European Project: 227391,EC:FP7:KBBE,FP7-KBBE-2008-2B,OBELIX(2009), One Health Chemisch, One Health Toxicologie, dIRAS RA-1, dIRAS RA-2, Vrije Universiteit Amsterdam [Amsterdam] (VU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California (UC), Child and Adolescent Psychiatry / Psychology, Chard-Hutchinson, Xavier, OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life - OBELIX - - EC:FP7:KBBE2009-05-01 - 2013-11-30 - 227391 - VALID, E&H: Environmental Health and Toxicology, AIMMS, E&H: Environmental Bioanalytical Chemistry, Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)
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0301 basic medicine ,Male ,medicine.medical_specialty ,Birth weight ,010501 environmental sciences ,Breast milk ,Endocrine Disruptors ,01 natural sciences ,Pooled analysis ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Interquartile range ,Pregnancy ,Medicine ,[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health ,Humans ,Biology ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,2. Zero hunger ,lcsh:GE1-350 ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,Milk, Human ,business.industry ,Obstetrics ,Smoking ,Infant, Newborn ,Gestational age ,Environmental exposure ,Odds ratio ,Endocrine disrupting chemicals (EDCs) ,Infant, Low Birth Weight ,medicine.disease ,Fetal Blood ,3. Good health ,Chemistry ,Small for gestational age (SGA) ,030104 developmental biology ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Maternal Exposure ,Prenatal Exposure Delayed Effects ,Small for gestational age ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background and aims: There is evidence that endocrine disrupting chemicals (EDCs) have developmental effects at environmental concentrations. We investigated whether some EDCs are associated with the adverse birth outcome Small for Gestational Age (SGA). Methods: We used PCB 153, p,p'-DDE, HCB, PFOS and PFOA measured in maternal, cord blood or breast milk samples of 5446 mother-child pairs (subset of 693 for the perfluorinated compounds) from seven European birth cohorts (1997–2012). SGA infants were those with birth weight below the 10th percentile for the norms defined by gestational age, country and infant's sex. We modelled the association between measured or estimated cord serum EDC concentrations and SGA using multiple logistic regression analyses. We explored effect modification by child's sex and maternal smoking during pregnancy. Results: Among the 5446 newborns, 570 (10.5%) were SGA. An interquartile range (IQR) increase in PCB 153 was associated with a modestly increased risk of SGA (odds ratio (OR) of 1.05 [95% CI: 1.04–1.07]) that was stronger in girls (OR of 1.09 [95% CI: 1.04–1.14]) than in boys (OR of 1.03 [95% CI: 1.03–1.04]) (p-interaction = 0.025). For HCB, we found a modestly increased odds of SGA in girls (OR of 1.04 [95% CI: 1.01–1.07] per IQR increase), and an inverse association in boys (OR of 0.90 [95% CI: 0.85–0.95]) (p-interaction = 0.0003). Assessment of the HCB-sex-smoking interaction suggested that the increased odds of SGA associated with HCB exposure was only in girls of smoking mothers (OR of 1.18 [95% CI: 1.11–1.25]) (p-interaction = 0.055). Higher concentrations of PFOA were associated with greater risk of SGA (OR of 1.64 [95% CI: 0.97–2.76]). Elevated PFOS levels were associated with increased odds of SGA in newborns of mothers who smoked during pregnancy (OR of 1.63 [95% CI: 1.02–2.59]), while an inverse association was found in those of non-smoking mothers (OR of 0.66 [95% CI: 0.61–0.72]) (p-interaction = 0.0004). No significant associations were found for p,p'-DDE. Conclusions: Prenatal environmental exposure to organochlorine and perfluorinated compounds with endocrine disrupting properties may contribute to the prevalence of SGA. We found indication of effect modification by child's sex and smoking during pregnancy. The direction of the associations differed by chemical and these effect modifiers, suggesting diverse mechanisms of action and biological pathways. Keywords: Endocrine disrupting chemicals (EDCs), Small for gestational age (SGA), Pooled analysis
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- 2018
6. Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain).
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Fernández-Navarro, Pablo, Villanueva, Cristina, García-Pérez, Javier, Boldo, Elena, Goñi-Irigoyen, Fernando, Ulibarrena, Enrique, Rantakokko, Panu, García-Esquinas, Esther, Pérez-Gómez, Beatriz, Pollán, Marina, and Aragonés, Nuria
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DRINKING water quality ,CANCER prevention ,DISINFECTION by-product ,NITRATE content of water ,WATER pollution ,BROMINE in water - Abstract
Chronic consumption of water, which contains contaminants, may give rise to adverse health effects. The Madrid region, covered by the population-based multicase-control (MCC-Spain) study, includes two drinking water supply areas. The different sources of the water, coupled together with the possible differences in water management, mean that there may be differences in drinking water quality. In the context of the MCC study, our aims were to describe contaminant concentrations in tap water drawn from various sampling points distributed around the region, assess these concentrations by reference to guideline values and study possible differences between the two supply areas. Tap water samples were collected from 34 sampling points in 7 towns in the Madrid region (19-29 April 2010), and 23 contaminants (metals, nitrates, disinfection by-product and Mutagen X levels) were quantified. We undertook a descriptive analysis of the contaminant concentrations in the water and compared them between the two water supply areas (Wilcoxon test). We created maps representing the distribution of the concentrations observed at water sampling points and assessed the correlations (Spearman's coefficient) between the different parameters measured. The concentrations of the contaminants were below guideline values. There were differences between the two supply areas in concentration of nitrates ( p value = 0.0051) and certain disinfection by-products. While there were positive correlations (rho >0.70) among some disinfection by-products, no correlations were found in metals or nitrates. The differences in nitrate levels could be linked to differences in farming/industrial activities in the catchment areas and in disinfection by-products might be related to the existence of different treatment systems or bromine content in source waters. [ABSTRACT FROM AUTHOR]
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- 2017
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7. Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene.
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Llop, Sabrina, Murcia, Mario, Alvarez-Pedrerol, Mar, Grimalt, Joan O., Santa-Marina, Loreto, Julvez, Jordi, Goñi-Irigoyen, Fernando, Espada, Mercedes, Ballester, Ferran, Rebagliato, Marisa, and Lopez-Espinosa, Maria-Jose
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ORGANOCHLORINE compounds , *THYROID hormones , *MATERNAL health , *THYROTROPIN , *QUESTIONNAIRES - Abstract
Introduction: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. Aim: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes. Methods: The study population ( n = 1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003–2006). Hexachlorobenzene (HCB), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4´-DDE), b-hexachlorocyclohexane (b-HCH), polychlorobiphenyl (PCB) congeners 138, 153 and 180, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) were measured in serum samples taken during the first trimester of pregnancy (mean [standard deviation (SD)]: 13.5 [2] weeks of gestation). Polymorphisms in DIO1 (rs2235544) and DIO2 (rs12885300) were genotyped in maternal DNA. Sociodemographic and dietary characteristics were obtained by questionnaire. Results: A 2-fold increase in HCB was associated with lower TT3 (% change = − 1.48; 95%CI: − 2.36, − 0.60). Women in the third tertile for b-HCH had lower TT3 (% change = − 3.19; 95%CI: − 5.64, − 0.67). The interactions between DIO1 rs2235544 and PCB153 and b-HCH were statistically significant. The inverse association between PCB153 and TT3 was the strongest among women with AA genotype. Women with CC genotype presented the strongest inverse association between b-HCH and FT4. Conclusion: Exposure to HCB and b-HCH was associated to a disruption in maternal TT3. The DIO1 rs2235544 SNP modified the association between exposure to some of the OCs (specifically b-HCH and PCB153) and maternal thyroid hormone levels. These results strengthen the hypothesis that DIO enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Changes in serum dioxin and PCB levels in residents around a municipal waste incinerator in Bilbao, Spain.
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Zubero, Miren B., Eguiraun, Elena, Aurrekoetxea, Juan J., Lertxundi, Aitana, Abad, Esteban, Parera, Jordi, Goñi-Irigoyen, Fernando, and Ibarluzea, Jesus
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MUNICIPAL solid waste incinerator residues , *DIOXINS , *ORGANOCHLORINE compounds , *POLYCHLORINATED biphenyls , *FURANS - Abstract
There is a great concern in the Basque Country regarding emissions from waste incineration, in particular that of organochlorines (OCs), including dioxins, furans and polychlorinated biphenyls (PCBs), and their potential effect on human health. In 2005, a municipal solid waste plant (MSWP) started to operate in Bilbao, representing an opportunity to assess the exposure to the aforementioned pollutants among people living at various distances from the plant. In 2006 and 2008, we carried out two cross-sectional studies to quantify and assess changes in levels of these pollutants. The objective of this study was to describe the levels of OCs in the blood serum in 2013 of 127 adults of this prospective cohort, in four centres of population, near to and further away from the MSWP, and to study trends over time since it started to operate. This study shows the levels of OCs have decreased significantly, from 37.2% to 80.1%. Further, levels of OCs in areas near to the MSWP were not found to be higher than those in areas further afield. [ABSTRACT FROM AUTHOR]
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- 2017
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9. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk.
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Porta M, Gasull M, Pumarega J, Kiviranta H, Rantakokko P, Raaschou-Nielsen O, Bergdahl IA, Sandanger TM, Agudo A, Rylander C, Nøst TH, Donat-Vargas C, Aune D, Heath AK, Cirera L, Goñi-Irigoyen F, Alguacil J, Giménez-Robert À, Tjønneland A, Sund M, Overvad K, Mancini FR, Rebours V, Boutron-Ruault MC, Kaaks R, Schulze MB, Trichopoulou A, Palli D, Grioni S, Tumino R, Naccarati A, Panico S, Vermeulen R, Quirós JR, Rodríguez-Barranco M, Colorado-Yohar SM, Chirlaque MD, Ardanaz E, Wareham N, Key T, Johansson M, Murphy N, Ferrari P, Huybrechts I, Chajes V, Gonzalez CA, Bueno-de-Mesquita B, Gunter M, Weiderpass E, Riboli E, Duell EJ, Katzke V, and Vineis P
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- Case-Control Studies, Humans, Persistent Organic Pollutants, Environmental Pollutants, Pancreatic Neoplasms epidemiology, Pesticides, Polychlorinated Biphenyls
- Abstract
Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts., Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline., Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk., Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer., (© The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association.)
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- 2022
- Full Text
- View/download PDF
10. Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts.
- Author
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Govarts E, Iszatt N, Trnovec T, de Cock M, Eggesbø M, Palkovicova Murinova L, van de Bor M, Guxens M, Chevrier C, Koppen G, Lamoree M, Hertz-Picciotto I, Lopez-Espinosa MJ, Lertxundi A, Grimalt JO, Torrent M, Goñi-Irigoyen F, Vermeulen R, Legler J, and Schoeters G
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- Female, Fetal Blood chemistry, Humans, Infant, Newborn, Male, Milk, Human chemistry, Pregnancy, Smoking epidemiology, Endocrine Disruptors adverse effects, Infant, Low Birth Weight, Maternal Exposure, Prenatal Exposure Delayed Effects
- Abstract
Background and Aims: There is evidence that endocrine disrupting chemicals (EDCs) have developmental effects at environmental concentrations. We investigated whether some EDCs are associated with the adverse birth outcome Small for Gestational Age (SGA)., Methods: We used PCB 153, p,p'-DDE, HCB, PFOS and PFOA measured in maternal, cord blood or breast milk samples of 5446 mother-child pairs (subset of 693 for the perfluorinated compounds) from seven European birth cohorts (1997-2012). SGA infants were those with birth weight below the 10th percentile for the norms defined by gestational age, country and infant's sex. We modelled the association between measured or estimated cord serum EDC concentrations and SGA using multiple logistic regression analyses. We explored effect modification by child's sex and maternal smoking during pregnancy., Results: Among the 5446 newborns, 570 (10.5%) were SGA. An interquartile range (IQR) increase in PCB 153 was associated with a modestly increased risk of SGA (odds ratio (OR) of 1.05 [95% CI: 1.04-1.07]) that was stronger in girls (OR of 1.09 [95% CI: 1.04-1.14]) than in boys (OR of 1.03 [95% CI: 1.03-1.04]) (p-interaction = 0.025). For HCB, we found a modestly increased odds of SGA in girls (OR of 1.04 [95% CI: 1.01-1.07] per IQR increase), and an inverse association in boys (OR of 0.90 [95% CI: 0.85-0.95]) (p-interaction = 0.0003). Assessment of the HCB-sex-smoking interaction suggested that the increased odds of SGA associated with HCB exposure was only in girls of smoking mothers (OR of 1.18 [95% CI: 1.11-1.25]) (p-interaction = 0.055). Higher concentrations of PFOA were associated with greater risk of SGA (OR of 1.64 [95% CI: 0.97-2.76]). Elevated PFOS levels were associated with increased odds of SGA in newborns of mothers who smoked during pregnancy (OR of 1.63 [95% CI: 1.02-2.59]), while an inverse association was found in those of non-smoking mothers (OR of 0.66 [95% CI: 0.61-0.72]) (p-interaction = 0.0004). No significant associations were found for p,p'-DDE., Conclusions: Prenatal environmental exposure to organochlorine and perfluorinated compounds with endocrine disrupting properties may contribute to the prevalence of SGA. We found indication of effect modification by child's sex and smoking during pregnancy. The direction of the associations differed by chemical and these effect modifiers, suggesting diverse mechanisms of action and biological pathways., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
11. Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain).
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Lopez-Espinosa MJ, Murcia M, Iñiguez C, Vizcaino E, Costa O, Fernández-Somoano A, Basterrechea M, Lertxundi A, Guxens M, Gascon M, Goñi-Irigoyen F, Grimalt JO, Tardón A, and Ballester F
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- Adult, Female, Humans, Pregnancy, Spain, Ultrasonography, Prenatal, Fetal Development drug effects, Hydrocarbons, Chlorinated toxicity, Maternal Exposure adverse effects
- Abstract
Background: Several studies have reported decreases in birth size associated with exposure to organochlorine compounds (OCs), but uncertainties remain regarding the critical windows of prenatal exposure and the effects on fetal body segments., Objective: We examined the relationship between prenatal OC concentrations and fetal anthropometry., Methods: We measured 4,4´-dichlorodiphenyldichloroethylene (4,4´-DDE), hexachlorobenzene (HCB), and polychlorinated biphenyl (PCB) congeners (138, 153, and 180) in 2,369 maternal and 1,140 cord serum samples in four Spanish cohorts (2003-2008). We used linear mixed models to obtain longitudinal growth curves for estimated fetal weight (EFW), abdominal circumference (AC), biparietal diameter (BPD), and femur length (FL) adjusted by parental and fetal characteristics. We calculated standard deviation (SD) scores of growth at 0-12, 12-20, and 20-34 weeks of gestation as well as size at gestational week 34 for the four parameters. We studied the association between OCs and the fetal outcomes by cohort-specific linear models and subsequent meta-analyses., Results: PCBs were associated with a reduction in AC up to mid-pregnancy, and BPD and FL from gestational week 20 onward. An inverse association was also found between HCB and AC growth in early pregnancy. The reduction of these parameters ranged from -4% to -2% for a doubling in the OC concentrations. No association between 4,4´-DDE and fetal growth was observed., Conclusions: To our knowledge, this is the first study to report an association between prenatal exposure to some PCBs and HCB and fetal growth: AC during the first two trimesters of pregnancy, and BPD and FL later in pregnancy., Citation: Lopez-Espinosa MJ, Murcia M, Iñiguez C, Vizcaino E, Costa O, Fernández-Somoano A, Basterrechea M, Lertxundi A, Guxens M, Gascon M, Goñi-Irigoyen F, Grimalt JO, Tardón A, Ballester F. 2016. Organochlorine compounds and ultrasound measurements of fetal growth in the INMA cohort (Spain). Environ Health Perspect 124:157-163; http://dx.doi.org/10.1289/ehp.1408907.
- Published
- 2016
- Full Text
- View/download PDF
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