23 results on '"Gonzalo, Montserrat"'
Search Results
2. A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity
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Ho-Plagaro, Ailec, Santiago-Fernandez, Concepción, García-Serrano, Sara, Rodriguez, Cristina, Garrido-Sanchez, Lourdes, Escamilla, Alejandro, Gonzalo, Montserrat, Montiel-Casado, Custodia, Alcaín-Martínez, Guillermo, Garcia-Muñoz, Beatriz, Ruiz-Santana, Natalia, Vázquez-Pedreño, Luis, and Garcia-Fuentes, Eduardo
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- 2020
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3. The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance
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Gutierrez-Repiso, Carolina, Rodriguez-Pacheco, Francisca, Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J, Rodriguez-Cañete, Alberto, Gallego-Perales, Jose L, Alcain-Martinez, Guillermo, Vazquez-Pedreño, Luis, Lopez-Enriquez, Soledad, Garcia-Serrano, Sara, Garrido-Sanchez, Lourdes, and Garcia-Fuentes, Eduardo
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- 2015
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4. The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120
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Rodriguez-Pacheco, Francisca, Gutierrez-Repiso, Carolina, Garcia-Serrano, Sara, Alaminos-Castillo, Miguel A., Ho-Plagaro, Ailec, Valdes, Sergio, Garcia-Arnes, Juan, Gonzalo, Montserrat, Andrade, Raul J., Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Martinez-Ferriz, Abelardo, and Garcia-Fuentes, Eduardo
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- 2017
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5. The Metagenomic Composition and Effects of Fecal-Microbe-Derived Extracellular Vesicles on Intestinal Permeability Depend on the Patient's Disease.
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Rodríguez-Díaz, Cristina, Martín-Reyes, Flores, Taminiau, Bernard, Ho-Plágaro, Ailec, Camargo, Raquel, Fernandez-Garcia, Felix, Pinazo-Bandera, José, Toro-Ortiz, Juan Pedro, Gonzalo, Montserrat, López-Gómez, Carlos, Rodríguez-Pacheco, Francisca, Rodríguez de los Ríos, Dámaris, Daube, Georges, Alcain-Martinez, Guillermo, and García-Fuentes, Eduardo
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EXTRACELLULAR vesicles ,CROHN'S disease ,METAGENOMICS ,MORBID obesity ,CELL permeability ,CLOSTRIDIA ,GUT microbiome - Abstract
The composition and impact of fecal-microbe-derived extracellular vesicles (EVs) present in different diseases has not been analyzed. We determined the metagenomic profiling of feces and fecal-microbe-derived EVs from healthy subjects and patients with different diseases (diarrhea, morbid obesity and Crohn's disease (CD)) and the effect of these fecal EVs on the cellular permeability of Caco-2 cells. The control group presented higher proportions of Pseudomonas and Rikenellaceae_RC9_gut_group and lower proportions of Phascolarctobacterium, Veillonella and Veillonellaceae_ge in EVs when compared with the feces from which these EVs were isolated. In contrast, there were significant differences in 20 genera between the feces and EV compositions in the disease groups. Bacteroidales and Pseudomonas were increased, and Faecalibacterium, Ruminococcus, Clostridium and Subdoligranum were decreased in EVs from control patients compared with the other three groups of patients. Tyzzerella, Verrucomicrobiaceae, Candidatus_Paracaedibacter and Akkermansia were increased in EVs from the CD group compared with the morbid obesity and diarrhea groups. Fecal EVs from the morbid obesity, CD and, mainly, diarrhea induced a significant increase in the permeability of Caco-2 cells. In conclusion, the metagenomic composition of fecal-microbe-derived EVs changes depending on the disease of the patients. The modification of the permeability of Caco-2 cells produced by fecal EVs depends on the disease of the patients. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Fatty Acid Supplementation Improves Respiratory, Inflammatory and Nutritional Parameters in Adults with Cystic Fibrosis
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Olveira, Gabriel, Olveira, Casilda, Acosta, Eva, Espíldora, Francisco, Garrido-Sánchez, Lourdes, García-Escobar, Eva, Rojo-Martínez, Gemma, Gonzalo, Montserrat, and Soriguer, Federico
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- 2010
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7. Usefulness of the daily defined dose method to estimate trends in the consumption, costs and prevalence of the use of home enteral nutrition
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Olveira, Gabriel, Tapia, María José, Colomo, Natalia, Muñoz, Antonio, Gonzalo, Montserrat, and C-Soriguer, Federico
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- 2009
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8. FNDC5 could be regulated by leptin in adipose tissue
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Gutierrez-Repiso, Carolina, Garcia-Serrano, Sara, Rodriguez-Pacheco, Francisca, Garcia-Escobar, Eva, Haro-Mora, Juan J., Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Martinez-Ferriz, Abelardo, Santoyo, Julio S., Perez-Valero, Vidal, and Garcia-Fuentes, Eduardo
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- 2014
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9. Effects of obesity/fatty acids on the expression of GPR120
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Rodriguez-Pacheco, Francisca, Garcia-Serrano, Sara, Garcia-Escobar, Eva, Gutierrez-Repiso, Carolina, Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Gallego-Perales, Jose L., Martinez-Ferriz, Abelardo, Rojo-Martínez, Gemma, and Garcia-Fuentes, Eduardo
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- 2014
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10. Morbidly Obese Individuals with Impaired Fasting Glucose have a Specific Pattern of Insulin Secretion and Sensitivity: Effect of Weight Loss after Bariatric Surgery
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García-Fuentes, Eduardo, García-Almeida, Jose Manuel, García-Arnés, Juan, Rivas-Marín, Jose, Gallego-Perales, Jose Luis, González-Jiménez, Belén, Cardona, Isabel, García-Serrano, Sara, José Garriga, M, Gonzalo, Montserrat, Sol Ruiz de Adana, M, and Soriguer, Federico
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- 2006
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11. Serum phospholipid fatty acid profile and dietary intake in an adult Mediterranean population with cystic fibrosis
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Olveira, Gabriel, Dorado, Antonio, Olveira, Casilda, Padilla, Alicia, Rojo-Martínez, Gemma, García-Escobar, Eva, Gaspar, Inmaculada, Gonzalo, Montserrat, and Soriguer, Federico
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- 2006
12. Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity.
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Lago-Sampedro, Ana, Ho-Plagaro, Ailec, Garcia-Serrano, Sara, Santiago-Fernandez, Concepción, Rodríguez-Díaz, Cristina, Lopez-Gómez, Carlos, Martín-Reyes, Flores, Ruiz-Aldea, Gonzalo, Alcaín-Martínez, Guillermo, Gonzalo, Montserrat, Montiel-Casado, Custodia, Fernández, José R., García-Fuentes, Eduardo, and Rodríguez-Pacheco, Francisca
- Abstract
We investigated whether oleic acid (OA), one of the main components of the Mediterranean diet, participates in the regulation of the intestinal circadian rhythm in patients with morbid obesity. Stomach and jejunum explants from patients with morbid obesity were incubated with oleic acid to analyze the regulation of clock genes. Stomach explants showed an altered circadian rhythm in CLOCK, BMAL1, REVERBα, CRY1, and CRY2, and an absence in PER1, PER2, PER3 and ghrelin (p > 0.05). OA led to the emergence of rhythmicity in PER1, PER2, PER3 and ghrelin (p < 0.05). Jejunum explants showed an altered circadian rhythm in CLOCK, BMAL1, PER1 and PER3, and an absence in PER2, REVERBα, CRY1, CRY2 and GLP1 (p > 0.05). OA led to the emergence of rhythmicity in PER2, REVERBα, CRY1 and GLP1 (p < 0.05), but not in CRY2 (p > 0.05). OA restored the rhythmicity of acrophase and increased the amplitude for most of the genes studied in stomach and jejunum explants. OA placed PER1, PER2, PER3, REVERBα, CRY1 and CRY2 in antiphase with regard to CLOCK and BMAL1. There is an alteration in circadian rhythm in stomach and jejunum explants in morbid obesity. OA restored the rhythmicity of the genes related with circadian rhythm, ghrelin and GLP1, although with slight differences between tissues, which could determine a different behaviour of the explants from jejunum and stomach in obesity. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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13. Normative reference values for hand grip dynamometry in Spain. Association with lean mass
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Sánchez-Torralvo, Francisco-José, Porras, Nuria, Abuín-Fernández, José, García-Torres, Francisca, Tapia, María-José, Lima, Fuensanta, Soriguer, Federico, Gonzalo, Montserrat, Rojo-Martínez, Gemma, and Olveira, Gabriel
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Hand grip ,Nutritional status ,Dynamometry ,Hand strength ,Valores de normalidad. Prensión de la mano ,Fuerza muscular ,Dinamometría. Estado nutricional ,Reference values - Abstract
Background and objectives: The objective of this study was to establish reference values for hand grip strength, compare the results obtained with Collin and Jamar type dynamometers and determine their association with anthropometric and lean mass measurements. Material and methods: This cross-sectional population-based study was undertaken in Pizarra (Málaga, Spain). The grip strength of the dominant hand was measured using Collin and Jamar dynamometers. Skinfolds (triceps, abdominal, biceps of dominant arm and subscapular) were measured, and body composition was estimated. Eight hundred seventeen adults randomly selected from the census were recruited. Dynamometry reference values are presented for the dominant hand, by gender and age groups. Results: No determinations could be made with the Collin dynamometer in 69 women due to the difficulty in grasping the dynamometer. We found significant positive correlations between the measurements with Jamar and Collin dynamometers (r = 0.782; p < 0.001) and between grip strength and lean mass index (LMI), determined by both dynamometers (r = 0.538, p < 0.001 and r = 0.462, p < 0.001, respectively). Malnourished patients according to LMI had significantly lower grip strength than normally nourished patients (p < 0.001 for Jamar; p < 0.02 for Collin). Conclusions: Dynamometry reference values in the Spanish population are presented. We recommend the use of the Jamar type dynamometer versus the Collin type dynamometer. Hand grip dynamometry is associated with lean mass, which confirms its usefulness in nutritional assessment. Resumen Antecedentes y objetivos: no existen valores de normalidad en España con el dinamómetro Jamar. El objetivo fue determinar valores de normalidad de fuerza muscular, comparar los resultados obtenidos con los dinamómetros tipo Collin y tipo Jamar entre sí, y determinar su asociación con medidas antropométricas y de masa magra. Material y métodos: estudio transversal de base poblacional en Pizarra (Málaga). Se determinó la fuerza de prensión de la mano dominante mediante dinamómetros Collin y Jamar. Se midieron los pliegues cutáneos (tricipital, abdominal, bicipital del brazo dominante y subescapular) y se estimó la composición corporal. Se reclutaron 817 adultos seleccionados aleatoriamente del censo. Se presentan valores de referencia de dinamometría para la mano dominante, por género y grupos de edad. Resultados: no se pudieron realizar determinaciones con el dinamómetro Collin en 69 mujeres debido a la dificultad para agarrar el dinamómetro. Encontramos correlaciones positivas significativas entre las medidas de los dinamómetros Jamar y Collin (r = 0,782; p < 0,001) y entre la fuerza muscular determinada mediante ambos dinamómetros y el índice de masa magra (IMM) (r = 0,538, p < 0,001 y r = 0,462, p < 0,001, respectivamente). Los pacientes desnutridos según IMM presentaron una fuerza muscular significativamente menor a la de los pacientes normonutridos (p < 0,001 para Jamar y p < 0,02 para Collin). Conclusiones: se presentan valores de referencia de dinamometría en población española. Recomendamos el uso del dinamómetro tipo Jamar frente al dinamómetro tipo Collin. La dinamometría de mano se asocia con la masa magra, lo que avala su utilidad en la valoración nutricional.
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- 2018
14. Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis
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Garcia-Fuentes, Eduardo, Gutierrez-Repiso, Carolina, García-Serrano, Sara, Ho-Plagaro, Ailec, Valdes, Sergio, Gonzalo, Montserrat, Cobos-Bravo, Francisco J., Montiel-Casado, Custodia, Rojo-Martinez, Gemma, Garcia-Escobar, Eva, and Rodríguez-Pacheco, Francisca
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- 2017
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15. Lactonase activity of HDL is increased in morbidly obese subjects and is associated to atherogenic index of plasma
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Garcia-Fuentes, Eduardo, Garcia-Serrano, Sara, Gutierrez-Repiso, Carolina, Rodríguez-Pacheco, Francisca, Ho-Plagaro, Ailec, Valdes, Sergio, Gonzalo, Montserrat, Montiel-Casado, Custodia, Rodriguez-Cañete, Alberto, Moreno-Ruiz, Francisco J., and Alaminos-Castillo, Miguel A.
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- 2017
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16. SCD1 expression is associated to free fatty acid levels, but not to SCD1 gene promoter methylation levels in morbid obese patients
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Garcia-Fuentes, Eduardo, Garcia-Serrano, Sara, Martín-Nuñez, Gracia, Gutierrez-Repiso, Carolina, Rodriguez-Pacheco, Francisca, Ho-Plagaro, Ailec, Valdes, Sergio, Gonzalo, Montserrat, Moreno-Ruiz, Francisco J., Montiel-Casado, Custodia, Rodriguez-Cañete, Alberto, and Morcillo, Sonsoles
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- 2017
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17. C-peptide modifies leptin and visfatin secretion in human adipose tissue.
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Garcia‐Serrano, Sara, Gutiérrez‐Repiso, Carolina, Gonzalo, Montserrat, Garcia‐Arnes, Juan, Valdes, Sergio, Soriguer, Federico, Perez‐Valero, Vidal, Alaminos‐Castillo, Miguel A., Francisco Cobos‐Bravo, Juan, Moreno‐Ruiz, Francisco J., Rodriguez‐Cañete, Alberto, Rodríguez‐Pacheco, Francisca, Garcia‐Escobar, Eva, and García‐Fuentes, Eduardo
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C-peptide ,OBESITY risk factors ,ADIPOSE tissues ,INSULIN resistance ,ADIPOKINES ,HOMEOSTASIS - Abstract
Objective The effects of C-peptide on adipose tissue, an organ involved in the development of obesity and insulin resistance, are not yet well known. The aim of this study was to determine whether C-peptide could be involved in the regulation of the adipocytokine synthesis in human visceral adipose tissue. Methods The association between C-peptide and different serum adipocytokines, with an intravenous glucose tolerance test (IVGTT), and in an in vitro study in subjects without obesity and in subjects with morbid obesity were analyzed. Results In different multiple regression analysis models, C-peptide and C-peptide increase above basal levels during total IVGTT and between 0 and 10 min were associated positively with leptin and negatively with visfatin. Rhodamine-labeled C-peptide binds to human adipocytes, and this binding was blocked with excess of unlabeled C-peptide. Exposure of human visceral explants and adipocytes from subjects with morbid obesity to C-peptide at 1 and 10 nM induced a significant increase in leptin and a decrease in visfatin secretion. In subjects without obesity, these C-peptide effects were found mainly at 10 nM. These effects can be inhibited by phosphatidylinositol 3-kinase (PI3K) or protein kinase B (PKB) inhibitors. Conclusions C-peptide may be involved in the regulation of leptin and visfatin secretion, molecules intimately involved in energy homeostasis processes, through PI3K or PKB pathways. [ABSTRACT FROM AUTHOR]
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- 2015
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18. Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile.
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Alaminos‐Castillo, Miguel Á., Ho‐Plagaro, Ailec, García‐Serrano, Sara, Santiago‐Fernandez, Concepción, Rodríguez‐Pacheco, Francisca, Garrido‐Sanchez, Lourdes, Rodriguez, Cristina, Valdes, Sergio, Gonzalo, Montserrat, Moreno‐Ruiz, Francisco J., Rodríguez‐Cañete, Alberto, Montiel‐Casado, Custodia, Garcia‐Fuentes, Eduardo, Alaminos-Castillo, Miguel Á, Ho-Plagaro, Ailec, García-Serrano, Sara, Santiago-Fernandez, Concepción, Rodríguez-Pacheco, Francisca, Garrido-Sanchez, Lourdes, and Moreno-Ruiz, Francisco J
- Abstract
Aims: The paraoxonase-1 (PON1) enzyme could play an important role in the anti-oxidant capacity of high-density lipoprotein. However, there are no studies which analyse the evolution of the three activities of PON1 (PON arylesterase, PON paraoxonase and PON lactonase) after Roux-en-Y Gastric Bypass (RYGB) in morbidly obese subjects. We analysed the association of PON concentration and activities with the evolution of morbidly obese subjects who underwent RYGB, and its relationship with biochemical variables and different atherogenic indices.Methods: Twenty-seven non-obese and 82 morbidly obese subjects were studied before and 6 months after RYGB.Results: Before RYGB, morbidly obese subjects had a lower PON1 concentration (P < 0.05) and higher PON lactonase activity (P < 0.001) than non-obese subjects, with no differences in PON arylesterase and PON paraoxonase activities. After RYGB, PON1 concentration (P < 0.05) and PON lactonase activity (P < 0.001) decreased with regard to the presurgery state. PON lactonase activity correlated with the atherogenic index of plasma before (r = 0.19, P = 0.047) and after RYGB (r = 0.27, P = 0.035). In different multiple lineal regression analysis models, presurgery PON lactonase activity was associated with total cholesterol (β = 0.909, P < 0.001), LDL (β = 0.632, P = 0.006) and DBP (β = 0.230, P = 0.030) (R2 = 0.295), postsurgery PON lactonase activity was associated with esterified cholesterol (β = 0.362, P = 0.011) (R2 = 0.131), and the change (Δ) in PON lactonase activity after RYGB was associated with Δesterified cholesterol (β = 0.304, P = 0.030) (R2 = 0.093).Conclusions: PON lactonase activity is associated with the presence of morbid obesity and with an impaired lipid profile. All associations found could indicate the relationship between PON lactonase activity and the development of atherosclerosis. [ABSTRACT FROM AUTHOR]- Published
- 2019
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19. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids.
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Morcillo, Sonsoles, Martín-Núñez, Gracia Mª, García-Serrano, Sara, Gutierrez-Repiso, Carolina, Rodriguez-Pacheco, Francisca, Valdes, Sergio, Gonzalo, Montserrat, Rojo-Martinez, Gemma, Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Tinahones, Francisco, and García-Fuentes, Eduardo
- Abstract
Stearoyl CoA Desaturase-1 (SCD) is considered as playing an important role in the explanation of obesity. The aim of this study was to evaluate whether the DNA methylation SCD gene promoter is associated with the metabolic improvement in morbidly obese patients after bariatric surgery. The study included 120 subjects with morbid obesity who underwent a laparoscopic Roux-en Y gastric by-pass (RYGB) and a control group of 30 obese subjects with a similar body mass index (BMI) to that found in morbidly obese subjects six months after RYGB. Fasting blood samples were obtained before and at six months after RYGB. DNA methylation was measured by pyrosequencing technology. DNA methylation levels of the SCD gene promoter were lower in morbidly obese subjects before bariatric surgery but increased after RYGB to levels similar to those found in the control group. Changes of DNA methylation SCD gene were associated with the changes of free fatty acids levels (r = −0.442, p = 0.006) and HOMA-IR (r = −0.249, p = 0.035) after surgery. RYGB produces an increase in the low SCD methylation promoter levels found in morbidly obese subjects. This change of SCD methylation levels is associated with changes in FFA and HOMA-IR. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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20. La influencia del trasplante de hígado en el perfil nutricional de pacientes cirróticos graves
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Torralvo, Francisco José Sánchez, Porras, Nuria, Fernández, José Abuín, Torres, Francisca García, Tapia, María José, Lima, Fuensanta, Soriguer, Federico, Gonzalo, Montserrat, Martínez, Gemma Rojo, Olveira, Gabriel, Sánchez Torralvo, Francisco José, Abuín Fernández, José, García Torres, Francisca, Rojo Martínez, Gemma, Andrade, Caroline Pinho R, Portugal, Mileda L T, Paz, Ellén De Sousa, Freitas, Paula A, Daltro, Ana Filomena C S, and Almondes, Kaluce G S
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GRIP strength , *REFERENCE values , *ANTHROPOMETRY , *DYNAMOMETER , *LEAN body mass , *SKINFOLD thickness , *LIVER transplantation , *INGESTION , *CIRRHOSIS of the liver , *NUTRITIONAL assessment , *NUTRITIONAL status , *PSYCHOLOGY - Abstract
Objective: The aim of this study was to analyze the influence of liver transplantation in food intake and nutritional status of severe cirrhotic patients.Methods: The sample consisted of 23 patients who underwent liver transplantation. Three 24-hour dietary recall were applied and anthropometric measurements were collected before and three months after transplantation. The consumption of macronutrients and fat soluble vitamins were also evaluated. The anthropometric data evaluated were body mass index, abdominal circumference, percentage of adequacy of arm circumference, triceps skinfold thickness and arm muscle circumference. Related mean comparison tests, comparison of changes in the proportions of categorical variables and correlation of quantitative variables were used in the statistical analysis. Data were considered to be significant when p < 0.05.Results: Most patients were female and aged between 40 and 65 years. The average consumption of calories, proteins, lipids, cholesterol and monounsaturated fatty acids was significantly higher after liver transplantation (p < 0.05). The average of anthropometric parameters did not differ significantly between the evaluated times. There was no significant change in nutrient intake or anthropometric classification after transplantation. Most patients were classified as malnourished or overweight after transplantation, according to some anthropometric parameters.Conclusion: Food consumption changed after transplantation. There was no change in the nutritional status from pre- to post-transplant but, in general, most patients had altered nutritional status in both evaluation moments. [ABSTRACT FROM AUTHOR]- Published
- 2018
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21. Oleic acid regulates the circadian rhythm of adipose tissue in obesity.
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Martín-Reyes, Flores, Ho-Plagaro, Ailec, Rodríguez-Díaz, Cristina, Lopez-Gómez, Carlos, Garcia-Serrano, Sara, de los Reyes, Dámaris Rodriguez, Gonzalo, Montserrat, Fernández-Garcia, Jose C., Montiel-Casado, Custodia, Fernández-Aguilar, Jose L., Fernández, José R., García-Fuentes, Eduardo, and Rodríguez-Pacheco, Francisca
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CIRCADIAN rhythms , *ADIPOSE tissues , *OLEIC acid , *MORBID obesity , *CLOCK genes , *MOLECULAR clock , *BODY weight - Abstract
The effect of oleic acid (OA) on the regulation of the circadian rhythm present in human visceral (VAT) and subcutaneous (SAT) adipose tissue from patients with morbid obesity has not been analyzed yet. VAT and SAT explants from patients with morbid obesity were incubated with OA to analyze the circadian regulation of clock and other genes related to lipid metabolism (SREBP-1c, FAS, LPL and CPT1), and their association with baseline variables and the improvement of these patients after bariatric surgery. There were significant differences in amplitude and acrophase in VAT with respect to SAT. In VAT, body weight negatively correlated with BMAL1 and CRY1 amplitude, and REVERBα acrophase; body mass index (BMI) negatively correlated with REVERBα acrophase; and waist circumference negatively correlated with PER3 acrophase. In SAT, BMI negatively correlated with CLOCK amplitude, and CLOCK, REVERBα and CRY2 MESOR; and waist circumference negatively correlated with PER3 amplitude and acrophase. A greater short-term improvement of body weight, BMI and waist circumference in patients with morbid obesity after bariatric surgery was associated with a lower CRY1 and CRY2 amplitude and an earlier PER1 and PER3 acrophase in SAT. OA produced a more relevant circadian rhythm and increased the amplitude of most clock genes and lipid metabolism-related genes. OA regulated the acrophase of most clock genes in VAT and SAT, placing CLOCK/BMAL1 in antiphase with regard to the other genes. OA increased the circadian rhythmicity, although with slight differences between adipose tissues. These differences could determine its different behavior in obesity. [Display omitted] • An altered circadian rhythmicity of adipose tissue is associated with the grade of obesity in patients with morbid obesity. • Oleic acid, one of the main components of the Mediterranean diet, is a regulator of the adipose tissue circadian rhythm. • Oleic acid could be used as a dietary intervention strategy for the prevention of obesity and its comorbidities. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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22. Compliance with a high-protein and energy-dense oral nutritional supplement in patients with disease-related malnutrition: a randomized open-label crossover trial.
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Leon-Sanz M, Linares F, Gonzalo M, Tapia MJ, Maiz-Jimenez M, Ruiz Aguado M, Lizán L, and Olveira G
- Abstract
Introduction: Patient compliance with oral nutritional supplements (ONS) is not optimal for meeting energy and nutritional requirements in a high proportion of patients with disease-related malnutrition (DRM). Energy density or prescribed volume of ONS may impact compliance., Methods: A randomized, open-label crossover trial was conducted in outpatients with DRM to compare compliance with a high energy-dense ONS (edONS, 2.4 kcal/mL) and a reference ONS (heONS, 2.0 kcal/mL; NCT05609006). Patients were randomly assigned to two 8-week treatment sequences of four-weeks periods: edONS + heONS (sequence A) or heONS + edONS (sequence B). Patients daily reported the amount of product left over gastrointestinal tolerance and satisfaction with ONS. A non-inferiority analysis was performed to compare the compliance rate (percentage of consumed energy over the prescribed) for each period and sequence., Results: Fifty-three patients were assigned to sequence A and 50 to sequence B (55.7 ± 13.9 years, 37.0% female, 67.1% oncology patients). In sequence A, the compliance rates were 88.6% ± 14.3% vs. 84.1 ± 21.8% ( p = 0.183), while in sequence B, they were 78.9% ± 23.8% vs. 84.4% ± 21.4% ( p < 0.01). In both sequences, the lower range of the confidence interval for compliance with edONS was greater than the non-inferiority threshold (for sequence A Δ
Comp A was 4.5% [95% CI, -2.0% to 10.0%], and for sequence, B ΔComp B was 5.6% [95% CI, -3.0% to 14.0%]). The total discarded cost for each ONS was higher for heONS than edONS, being the difference statistically significant in sequence B. BMI increased slightly and not significantly in both sequences, and the percentage of patients with severe malnutrition was reduced. The frequency of gastrointestinal symptoms was low for both sequences, and satisfaction with ONS was slightly higher for edONS., Conclusion: Our findings highlight that edONS was non-inferior to heONS in terms of consumed energy over the prescribed, with a lower amount of edONS discarded, which suggests a higher efficiency of edONS., Competing Interests: LL works for an independent research entity, Outcomes’10, that received funding from Danone Specialized Nutrition to conduct the project and for medical writing. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest, (Copyright © 2023 Leon-Sanz, Linares, Gonzalo, Tapia, Maiz-Jimenez, Ruiz Aguado, Lizán and Olveira.)- Published
- 2023
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23. Normative reference values for hand grip dynamometry in Spain. Association with lean mass.
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Sánchez Torralvo FJ, Porras N, Abuín Fernández J, García Torres F, Tapia MJ, Lima F, Soriguer F, Gonzalo M, Rojo Martínez G, and Olveira G
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- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Reference Values, Skinfold Thickness, Spain, Young Adult, Body Composition physiology, Hand Strength physiology, Muscle Strength Dynamometer
- Abstract
Background and Objectives: The objective of this study was to establish reference values for hand grip strength, compare the results obtained with Collin and Jamar type dynamometers and determine their association with anthropometric and lean mass measurements., Material and Methods: This cross-sectional population-based study was undertaken in Pizarra (Málaga, Spain). The grip strength of the dominant hand was measured using Collin and Jamar dynamometers. Skinfolds (triceps, abdominal, biceps of dominant arm and subscapular) were measured, and body composition was estimated. Eight hundred seventeen adults randomly selected from the census were recruited. Dynamometry reference values are presented for the dominant hand, by gender and age groups., Results: No determinations could be made with the Collin dynamometer in 69 women due to the difficulty in grasping the dynamometer. We found significant positive correlations between the measurements with Jamar and Collin dynamometers (r = 0.782; p < 0.001) and between grip strength and lean mass index (LMI), determined by both dynamometers (r = 0.538, p < 0.001 and r = 0.462, p < 0.001, respectively). Malnourished patients according to LMI had significantly lower grip strength than normally nourished patients (p < 0.001 for Jamar; p < 0.02 for Collin)., Conclusions: Dynamometry reference values in the Spanish population are presented. We recommend the use of the Jamar type dynamometer versus the Collin type dynamometer. Hand grip dynamometry is associated with lean mass, which confirms its usefulness in nutritional assessment.
- Published
- 2018
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