119 results on '"Grande, Enrico"'
Search Results
2. Suicide After Partner's Death in the Elderly Population: Results From a Nationwide Cohort Study in Italy
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Grande, Enrico, Alicandro, Gianfranco, Vichi, Monica, Pompili, Maurizio, and Frova, Luisa
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- 2024
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3. Global trends in youth suicide from 1990 to 2020: an analysis of data from the WHO mortality database
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Bertuccio, Paola, Amerio, Andrea, Grande, Enrico, La Vecchia, Carlo, Costanza, Alessandra, Aguglia, Andrea, Berardelli, Isabella, Serafini, Gianluca, Amore, Mario, Pompili, Maurizio, and Odone, Anna
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- 2024
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4. Nationwide longitudinal population-based study on mortality in Italy by immigrant status
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Di Napoli, Anteo, Ventura, Martina, Grande, Enrico, Frova, Luisa, Mirisola, Concetta, and Petrelli, Alessio
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- 2022
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5. A long-term nationwide study on chronic kidney disease-related mortality in Italy: trends and associated comorbidity
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Navarra, Simone, Solini, Anna, Baroni, Marco Giorgio, Frova, Luisa, and Grande, Enrico
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- 2022
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6. Suicide among adolescents in Italy: a nationwide cohort study of the role of family characteristics
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Grande, Enrico, Vichi, Monica, Alicandro, Gianfranco, Simeoni, Silvia, Murianni, Laura, Marchetti, Stefano, Zengarini, Nicolas, Frova, Luisa, and Pompili, Maurizio
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- 2021
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7. The 2011 Italian census cohort for the study of socioeconomic inequality in mortality
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Alicandro, Gianfranco, Grande, Enrico, Sebastiani, Gabriella, and Frova, Luisa
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- 2020
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8. The increase of sepsis-related mortality in Italy: a nationwide study, 2003–2015
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Grande, Enrico, Grippo, Francesco, Frova, Luisa, Pantosti, Annalisa, Pezzotti, Patrizio, and Fedeli, Ugo
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- 2019
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9. Mortality rates from asbestos-related diseases in Italy during the first year of the COVID-19 pandemic.
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Fazzo, Lucia, Grande, Enrico, Zona, Amerigo, Minelli, Giada, Crialesi, Roberta, Iavarone, Ivano, and Grippo, Francesco
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- 2024
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10. Mortality associated to hematological malignancies across pandemic waves in 2020: A nationwide analysis of multiple causes of death in Italy.
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Grande, Enrico, Grippo, Francesco, Barbiellini Amidei, Claudio, Fedeli, Ugo, and Tosetto, Alberto
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HEMATOLOGIC malignancies ,COVID-19 pandemic ,CAUSES of death ,INTERNATIONAL Statistical Classification of Diseases & Related Health Problems - Abstract
This article examines the impact of the COVID-19 pandemic on mortality rates associated with hematological malignancies in Italy. The study found that deaths with any mention of hematological malignancies increased in 2020 compared to the previous year, while deaths classified as the underlying cause of death declined. The increase in mortality was most pronounced for chronic lymphocytic leukemia (CLL) and less prominent for non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). The study highlights the importance of considering multiple causes of death in assessing the mortality burden in hematological patients during the pandemic. [Extracted from the article]
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- 2024
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11. Suicide mortality in Italy during the first year of the COVID-19 pandemic.
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Grande, Enrico, Grippo, Francesco, Crialesi, Roberta, Marchetti, Stefano, and Frova, Luisa
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PROOF & certification of death , *COVID-19 pandemic , *SUICIDE , *SUICIDE statistics , *AGE groups - Abstract
Italy was severely hit by COVID-19 during 2020 and great concern about the possible increase of suicide rates in the population has arisen since early pandemic phases. Analyses limited to March–April have shown a drop in suicides in both sexes. This study aims to analyze suicide mortality in Italy during the whole 2020 making comparisons with the pre-pandemic period 2015–19, by sex, age and geographic area. Official cause-of-death data with national coverage were used to analyze suicide mortality by sex, month, age class and geographic area in the population aged ≥10 years (54,595,179). The monthly number of suicide deaths in 2020 was compared to the average number in 2015–19. Age-specific and age-adjusted suicide rates in 2020 and in 2015–19 were compared using rate-ratios with 95 % confidence intervals. Compared to 2015–19 a non-significant reduction of the overall suicide rate was observed during 2020, both in males (−3 %) and females (−7 %). Suicide rates non-significantly decreased in most age groups; an increase, although not statistically significant, was found among males aged ≥75 years and females aged ≥85 years. Suicide deaths reduced mainly in Central-Southern areas and the Islands, while they slightly increased in the North especially among males. Study limitations include accuracy of death certification and the relatively brief observation period. The study contributes to the analysis of early effects of the COVID-19 pandemic on suicide mortality in the whole population highlighting sex, age and territorial differences and suggesting to monitor possible increases in a longer observation period. • In Italy, compared to 2015-19 a non-significant reduction of the overall suicide rate was observed in 2020, in both sexes • An increase in suicide rates, although non-significant, was found among males aged ≥75 years and females aged ≥85 years • The variation in the number of suicide deaths during 2020 is not uniform across the country [ABSTRACT FROM AUTHOR]
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- 2023
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12. Mortality from chronic liver disease: Recent trends and impact of the COVID-19 pandemic
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Fedeli, Ugo, Barbiellini Amidei, Claudio, Casotto, Veronica, Grande, Enrico, Saia, Mario, Zanetto, Alberto, and Russo, Francesco Paolo
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Multiple causes of death ,Chronic liver disease ,Liver cirrhosis ,COVID-19 ,Liver cancer ,Mortality - Published
- 2023
13. Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach
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Suligoi, Barbara, Virdone, Saverio, Taborelli, Martina, Frova, Luisa, Grande, Enrico, Grippo, Francesco, Pappagallo, Marilena, Regine, Vincenza, Pugliese, Lucia, Serraino, Diego, and Zucchetto, Antonella
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- 2018
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14. Projected Perspective Reformulations with Applications in Design Problems
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Frangioni, Antonio, Gentile, Claudio, Grande, Enrico, and Pacifici, Andrea
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- 2011
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15. Mortality Related to Chronic Obstructive Pulmonary Disease during the COVID-19 Pandemic: An Analysis of Multiple Causes of Death through Different Epidemic Waves in Veneto, Italy.
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Fedeli, Ugo, Barbiellini Amidei, Claudio, Marcon, Alessandro, Casotto, Veronica, Grippo, Francesco, Grande, Enrico, Gaisl, Thomas, and Barco, Stefano
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- 2022
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16. Covering a line segment with variable radius discs
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Agnetis, Alessandro, Grande, Enrico, Mirchandani, Pitu B., and Pacifici, Andrea
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- 2009
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17. Suicide mortality among the elderly population in Italy: A nationwide cohort study on gender differences in sociodemographic risk factors, method of suicide, and associated comorbidity.
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Grande, Enrico, Vichi, Monica, Alicandro, Gianfranco, Marchetti, Stefano, Frova, Luisa, and Pompili, Maurizio
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SUICIDE , *SEX distribution , *QUALITY of life , *COMORBIDITY , *LONGITUDINAL method - Abstract
Objectives: This study aimed at investigating gender differences in the relationship between sociodemographic factors and suicide mortality, as well as in the method used for suicide and the presence of comorbidities in an older population in Italy.Methods/design: We conducted a historical cohort study based on individual record linkage across the 15th Italian Population Census, the Italian Population Register, and the National Register of Causes of Death. Suicides among people aged 75 years or older from 2012 to 2017 were analyzed. Crude mortality rates were computed, and cause-specific mortality rate ratios were estimated using negative binomial regression models. Chi-square tests were used to evaluate significant gender differences in suicide methods and comorbidities associated with suicide.Results: The study included 9,686,698 individuals (41% men, 59% women). Compared to living alone, living with children or partners reduced suicide mortality, especially among men. Having high or medium educational levels was associated with lower mortality than low educational levels among men. Foreign citizens had lower mortality among men, but not among women. Living in urban areas was associated with lower suicide rates in men and higher rates in women. Methods of suicide significantly differed by gender: leading methods were hanging, strangulation, and suffocation in men, and falling from height in women. Mental comorbidity was significantly more frequent among women, especially at ages 75-84 years.Conclusions: We believe that our findings might help to promote public health strategies taking gender differences in old age into account to improve social support and quality of life of older men and women. [ABSTRACT FROM AUTHOR]- Published
- 2022
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18. Demand allocation with latency cost functions
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Agnetis, Alessandro, Grande, Enrico, and Pacifici, Andrea
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- 2012
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19. Mortality of people with AIDS in Italy: comparison of AIDS surveillance and multiple cause-of-death registries.
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Grippo, Francesco, Grande, Enrico, Zucchetto, Antonella, Frova, Luisa, Pappagallo, Marilena, Pugliese, Lucia, Regine, Vincenza, Serraino, Diego, Taborelli, Martina, and Suligoi, Barbara
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- 2022
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20. The role of COVID-19 in the death of sars-COV-2–positive patients: A study based on death certificates
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Grippo, Francesco, Navarra, Simone, Orsi, Chiara, Manno, Valerio, Grande, Enrico, Crialesi, Roberta, Frova, Luisa, Marchetti, Stefano, Pappagallo, Marilena, Simeoni, Silvia, Di Pasquale, Lucilla, Carinci, Annamaria, Donfrancesco, Chiara, Lo Noce, Cinzia, Palmieri, Luigi, Onder, Graziano, Minelli, Giada, Italian National Institute of Health Covid-Mortality Group, and Raparelli, Valeria
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,lcsh:Medicine ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Article ,NO ,Comorbidities ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,030212 general & internal medicine ,Coronavirus ,Respiratory distress ,business.industry ,Death certificates ,lcsh:R ,virus diseases ,COVID-19 ,General Medicine ,medicine.disease ,Obesity ,Hypertensive heart disease ,Pneumonia ,Respiratory failure ,comorbidities ,death certificates ,Emergency medicine ,business - Abstract
Background: Death certificates are considered the most reliable source of information to compare cause-specific mortality across countries. The aim of the present study was to examine death certificates of persons who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to (a) quantify the number of deaths directly caused by coronavirus 2019 (COVID-19), (b) estimate the most common complications leading to death, and (c) identify the most common comorbidities. Methods: Death certificates of persons who tested positive for SARS-CoV-2 provided to the National Surveillance system were coded according to the 10th edition of the International Classification of Diseases. Deaths due to COVID-19 were defined as those in which COVID-19 was the underlying cause of death. Complications were defined as those conditions reported as originating from COVID-19, and comorbidities were conditions independent of COVID-19. Results: A total of 5311 death certificates of persons dying in March through May 2020 were analysed (16.7% of total deaths). COVID-19 was the underlying cause of death in 88% of cases. Pneumonia and respiratory failure were the most common complications, being identified in 78% and 54% of certificates, respectively. Other complications, including shock, respiratory distress and pulmonary oedema, and heart complications demonstrated a low prevalence, but they were more commonly observed in the 30–59 years age group. Comorbidities were reported in 72% of certificates, with little variation by age and gender. The most common comorbidities were hypertensive heart disease, diabetes, ischaemic heart disease, and neoplasms. Neoplasms and obesity were the main comorbidities among younger people. Discussion: In most persons dying after testing positive for SARS-CoV-2, COVID-19 was the cause directly leading to death. In a large proportion of death certificates, no comorbidities were reported, suggesting that this condition can be fatal in healthy persons. Respiratory complications were common, but non-respiratory complications were also observed.
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- 2020
21. Projected perspective reformulations with applications in design problems
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Franqioni, Antonio, Gentile, Claudio, Grande, Enrico, and Pacifici, Andrea
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Investment analysis -- Technology application -- Methods ,Nonlinear programming -- Analysis -- Methods ,Mathematical optimization -- Research ,Business ,Mathematics - Abstract
The perspective relaxation (PR) is a general approach for constructing tight approximations to mixed-integer nonlinear programs (MINLP) with semicontinuous variables. The PR of a MINLP can be formulated either as a mixed-integer second-order cone program (MI-SOCP), provided that the original objective function is SOCP-representable, or as a semi-infinite MINLP. In this paper, we show that under some further assumptions (rather restrictive, but satisfied in several practical applications), the PR of a mixed-integer quadratic program (MIQP) can also be reformulated as a piecewise-quadratic program (QP), ultimately yielding a QP relaxation of roughly the same size of the standard continuous relaxation. Furthermore, if the original problem has some exploitable structure, then this structure is typically preserved in the reformulation, thus allowing the construction of specialized approaches for solving the PR. We report on implementing these ideas on two MIQPs with appropriate structure: a sensor placement problem and a quadratic-cost (single-commodity) network design problem. Subject classifications: mixed-integer nonlinear programming problems; semicontinuous variables; perspective relaxation; sensor placement problem; network design problem. Area of review.Optimization. History: Received December 2009; revision received May 2010; accepted August 2010., 1. Introduction Semicontinuous variables are very often found in models of real-world problems, such as distribution and production planning problems (see Zamora and Grossmann 1998, Frangioni and Gentile 2006, Frangioni [...]
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- 2011
22. REGIONAL ESTIMATES OF COLORECTAL CANCER BURDEN IN ITALY
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Grande, Enrico, Inghelmann, Riccardo, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Capocaccia, Riccardo, and De Angelis, Roberta
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- 2007
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23. ESTIMATED AND OBSERVED CANCER INCIDENCE IN ITALY: A VALIDATION STUDY
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Capocaccia, Riccardo, Buzzoni, Carlotta, Grande, Enrico, Inghelmann, Riccardo, Bellù, Francesco, Cassetti, Tiziana, de Dottori, Margherita, Donato, Andrea, De Lisi, Vincenzo, Falcini, Fabio, Federico, Massimo, Ferretti, Stefano, Fusco, Mario, Giacomin, Adriano, Guzzinati, Stefano, Mangone, Lucia, Piffer, Silvano, Rosso, Stefano, Sechi, Ornella, Tagliabue, Giovanna, Tumino, Rosario, Vercelli, Marina, and Vitarelli, Susanna
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- 2007
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24. CANCER PREVALENCE ESTIMATES IN ITALY FROM 1970 TO 2010
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De Angelis, Roberta, Grande, Enrico, Inghelmann, Riccardo, Francisci, Silvia, Micheli, Andrea, Baili, Paolo, Meneghini, Elisabetta, Capocaccia, Riccardo, and Verdecchia, Arduino
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- 2007
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25. REGIONAL ESTIMATES OF ALL CANCER MALIGNANCIES IN ITALY
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Grande, Enrico, Inghelmann, Riccardo, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Capocaccia, Riccardo, and De Angelis, Roberta
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- 2007
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26. ITALIAN CANCER BURDEN BY BROAD GEOGRAPHICAL AREA
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Baili, Paolo, De Angelis, Roberta, Casella, Ilaria, Grande, Enrico, Inghelmann, Riccardo, Francisci, Silvia, Verdecchia, Arduino, Capocaccia, Riccardo, Meneghini, Elisabetta, and Micheli, Andrea
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- 2007
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27. REGIONAL ESTIMATES OF BREAST CANCER BURDEN IN ITALY
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Grande, Enrico, Inghelmann, Riccardo, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Capocaccia, Riccardo, and De Angelis, Roberta
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- 2007
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28. REGIONAL ESTIMATES OF PROSTATE CANCER BURDEN IN ITALY
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Inghelmann, Riccardo, Grande, Enrico, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Gatta, Gemma, Capocaccia, Riccardo, Valdagni, Riccardo, and De Angelis, Roberta
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- 2007
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29. METHODOLOGY FOR ESTIMATION OF CANCER INCIDENCE, SURVIVAL AND PREVALENCE IN ITALIAN REGIONS
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Verdecchia, Arduino, De Angelis, Roberta, Francisci, Silvia, and Grande, Enrico
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- 2007
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30. REGIONAL ESTIMATES OF STOMACH CANCER BURDEN IN ITALY
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Inghelmann, Riccardo, Grande, Enrico, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Capocaccia, Riccardo, and De Angelis, Roberta
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- 2007
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31. REGIONAL ESTIMATES OF LUNG CANCER BURDEN IN ITALY
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Inghelmann, Riccardo, Grande, Enrico, Francisci, Silvia, Verdecchia, Arduino, Micheli, Andrea, Baili, Paolo, Capocaccia, Riccardo, and De Angelis, Roberta
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- 2007
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32. An exact algorithm for a multicommodity min-cost flow over time problem
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Grande, Enrico, Nicosia, Gaia, Pacifici, Andrea, and Roselli, Vincenzo
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- 2018
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33. Mortality from suicide among agricultural, fishery, forestry and hunting workers in Italy and the contribution of work-related factors.
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Alicandro, Gianfranco, Grande, Enrico, Sebastiani, Gabriella, Violante, Francesco Saverio, Vecchia, Carlo La, Frova, Luisa, and La Vecchia, Carlo
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Objectives: Excess risk of suicide has been reported among workers in agriculture, fishery, forestry and hunting (AFFH). However, there is still uncertainty in the quantification of the risk and in the contribution of work-related factors. We aimed to quantify the suicide mortality risk among these workers in Italy.Methods: We carried out a historical cohort study based on record linkage between the 2011 Italian census and the mortality archives for years 2012-2017. The mortality rate ratio (MRR) was used as a measure of risk. MRR was estimated through quasi-Poisson regression models using workers in other sectors as reference category. Models were adjusted for age, citizenship, marital status, area of residence, education, employment status and hours worked per week.Results: The cohort included 1 004 655 workers employed in the AFFH sector and 15 269 181 workers in other sectors. During the 6-year follow-up, 559 deaths from suicide (500 men and 59 women) occurred among AFFH workers and 5917 (4935 men and 982 women) among workers in other sectors. The MRR for suicide was 1.36 (95% CI 1.19 to 1.55) among men and 1.18 (95% CI 0.87 to 1.60) among women. The excess risk was remarkably high for casual and fixed-term contract workers (3.01, 95% CI 1.50 to 6.04).Conclusions: Male workers in AFFH are at high risk of suicide mortality, and casual and fixed-term contract workers are at exceedingly high risk. Our study also suggests a higher risk among single, highly educated and long-hours workers. Female workers in AFFH do not have an appreciably increased risk. [ABSTRACT FROM AUTHOR]- Published
- 2021
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34. Minimum cost paths over dynamic networks
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Grande, Enrico, Nicosia, Gaia, and Pacifici, Andrea
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- 2016
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35. The cure of cancer: a european perspective
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Francisci, Silvia, Capocaccia, Riccardo, Grande, Enrico, Santaquilani, Mariano, Simonetti, Arianna, Allemani, Claudia, Gatta, Gemma, Sant, Milena, Zigon, Giulia, Bray, Freddie, Janssen-Heijnen, Maryska, Steward, J. A., Oberaigner, W., Hackl, M., Van Eycken, E., Verstreken, Martine, Holub, J., Jurickova, L., Storm, H. H., Engholm, G., Hakulinen, T., Belot, A., Hã©delin, G., Velten, M., Tron, I., Le Gall, E., Launoy, G., Guizard, A. V., Faivre, J., Bouvier, A. M., Carli, P. M., Maynadiã©, M., Danzon, A., Buemi, A., Tretarre, B., Lacour, B., Desandes, E., Colonna, M., Moliniã©, F., Bara, S., Schvartz, C., Ganry, O., Grosclaude, P., Brenner, H., Kaatsch, P., Ziegler, H., Tryggvadottir, L., Comber, H., Berrino, F., Allemani, C., Baili, P., Ciampichini, R., Ciccolallo, L., Gatta, G., Micheli, A., Sant, M., Sowe, S., Zigon, G., Tagliabue, G., Contiero, P., Bellã¹, F., Giacomin, A., Ferretti, S., Dal Maso, D. Serraino L., De Dottori, M., De Paoli, A., Zanier, L., Vercelli, M., Orengo, M. A., Casella, C., Quaglia, A., Pannelli, F., Federico, M., Rashid, I., Cirilli, C., Fusco, M., Traina, A., De Lisi, V., Bozzani, F., Magnani, C., Pastore, G., Tumino, R., La Rosa, M. G., Spata, E., Sigona, A., Mangone, L., Falcini, F., Foca, F., Giorgetti, S., Senatore, G., Iannelli, A., Budroni, M., Zanetti, R., Patriarca, S., Rosso, S., Piffer, S., Franchini, S., Paci, E., Crocetti, E., La Rosa, F., Stracci, F., Cassetti, T., Zambon, P., Guzzinati, S., Caldora, M., Capocaccia, R., Carrani, E., De Angelis, R., Francisci, S., Grande, E., Inghelmann, R., Lenz, H., Martina, L., Roazzi, P., Santaquilani, M., Simonetti, A., Tavilla, A., Verdecchia, A., Dalmas, M., Langmark, F., Bray, F., Johannesen, T. B., Rachtan, J., Gã³åºdåº, S., Siudowska, U., Mè©zyk, R., Bielska-Lasota, M., Zwierko, M., Pinheiro, P. S., Primic-Žakelj, M. P. -. Z., Mateos, A., Izarzugaza, I., Torrella-Ramos, A., Zurriaga, Oscar, Marcos-Gragera, R., Vilardell, M. L., Izquierdo, A., Martinez-Garcia, C., Sã¡nchez, M. J., Navarro, C., Chirlaque, M. D., Peris-Bonet, R., Ardanaz, E., Moreno, C., Galceran, J., Klint, Ã. ., Talbã¤ck, M., Jundt, G., Usel, M., Frick, H., Ess, S. M., Bordoni, A., Luthi, J. C., Konzelmann, I., Probst, N., Lutz, J. M., Pury, P., Visser, O., Otter, R., Schaapveld, M., Coebergh, J. W. W., Janssen-Heijnen, M. L., Van Der Heijden, Louis, Greenberg, D. C., Coleman, M. P., Woods, Laura, Moran, T., Forman, D., Cooper, N., Roche, M., Verne, J., Mã¸ller, H., Meechan, D., Poole, J., Lawrence, G., Stiller, C., Gavin, A., Black, R. J., Brewster, D. H., National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita [Rome], Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Evaluative Epidemiology Unit, Fondazione IRCCS, Department of Preventive and Predictive Medicine, Unit of Etiological Epidemiology and Prevention, Istituto Nazionale per lo Studio e la Cura dei Tumori, Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )
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Male ,Cancer Research ,Colorectal cancer ,MESH : Age Distribution ,MESH : Aged ,Gastroenterology ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer ,Prostate cancer ,0302 clinical medicine ,Breast cancer ,MESH: Aged, 80 and over ,Colon and rectum cancer ,Cure ,Lung cancer ,Relative survival ,Statistical models ,Stomach cancer ,Oncology ,Neoplasms ,MESH : Female ,MESH: Neoplasms ,030212 general & internal medicine ,cancer survival ,Aged, 80 and over ,MESH: Aged ,MESH : Prognosis ,MESH: Middle Aged ,Middle Aged ,MESH : Adult ,Prognosis ,3. Good health ,Europe ,MESH: Young Adult ,030220 oncology & carcinogenesis ,MESH: Survival Analysis ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,MESH : Male ,MESH : Europe ,MESH : Young Adult ,Socio-culturale ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,MESH: Prognosis ,03 medical and health sciences ,Young Adult ,Age Distribution ,Internal medicine ,MESH : Adolescent ,medicine ,Humans ,MESH : Middle Aged ,MESH : Aged, 80 and over ,MESH: Age Distribution ,Aged ,MESH: Adolescent ,MESH: Humans ,business.industry ,MESH : Humans ,Cancer ,MESH: Adult ,medicine.disease ,Survival Analysis ,MESH : Neoplasms ,MESH: Male ,Cancer registry ,MESH: Europe ,MESH : Survival Analysis ,business ,MESH: Female - Abstract
International audience; Cancer survival analyses based on cancer registry data do not provide direct information on the main aim of cancer treatment, the cure of the patient. In fact, classic survival indicators do not distinguish between patients who are cured, and patients who will die of their disease and in whom prolongation of survival is the main objective of treatment. In this study, we applied parametric cure models to the cancer incidence and follow-up data provided by 49 EUROCARE-4 (European Cancer Registry-based study, fourth edition) cancer registries, with the aims of providing additional insights into the survival of European cancer patients diagnosed from 1988 to 1999, and of investigating between-population differences. Between-country estimates the proportion of cured patients varied from about 4-13% for lung cancer, from 9% to 30% for stomach cancer, from 25% to 49% for colon and rectum cancer, and from 55% to 73% for breast cancer. For all cancers combined, estimates varied between 21% and 47% in men, and 38% and 59% in women and were influenced by the distribution of cases by cancer site. Countries with high proportions of cured and long fatal case survival times for all cancers combined were characterised by generally favourable case mix. For the European pool of cases both the proportion of cured and the survival time of fatal cases were associated with age, and increased from the early to the latest diagnosis period. The increases over time in the proportions of Europeans estimated cured of lung, stomach and colon and rectum cancers are noteworthy and suggest genuine progress in cancer control. The proportion of cured of all cancers combined is a useful general indicator of cancer control as it reflects progress in diagnosis and treatment, as well as success in the prevention of rapidly fatal cancers.
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- 2009
36. Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study.
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Grande, Enrico, Zucchetto, Antonella, Suligoi, Barbara, Grippo, Francesco, Pappagallo, Marilena, Virdone, Saverio, Camoni, Laura, Taborelli, Martina, Regine, Vincenza, Serraino, Diego, and Frova, Luisa
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MORTALITY of AIDS patients , *AIDS , *CONFIDENCE intervals , *CAUSES of death , *NOSOLOGY , *RESEARCH funding , *DEATH certificates , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Background: Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS. Methods: We conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS. Results: The most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin's disease (ASPR = 3.1). Conclusions: Study findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population. [ABSTRACT FROM AUTHOR]
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- 2017
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37. Cheapest paths in dynamic networks.
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Di Bartolomeo, Marco, Grande, Enrico, Nicosia, Gaia, and Pacifici, Andrea
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TELECOMMUNICATION systems ,COMPUTATIONAL complexity ,COMPUTER algorithms - Abstract
Flows over time problems relate to finding optimal flows over a capacitated network where transit times on network arcs are explicitly considered. In this article, we study the problem of determining a minimum cost origin-destination path where the cost and the travel time of each arc depend on the time taken to travel from the origin to that particular arc along the path. We provide computational complexity results for this problem and an exact solution algorithm based on an enumeration scheme on the corresponding time expanded network. Finally, we show the efficiency of our approach through a number of experimental tests. © 2016 Wiley Periodicals, Inc. NETWORKS, Vol. 69(1), 23-32 2017 [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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38. Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
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Zucchetto, Antonella, Virdone, Saverio, Taborelli, Martina, Grande, Enrico, Camoni, Laura, Pappagallo, Marilena, Regine, Vincenza, Grippo, Francesco, Polesel, Jerry, Dal Maso, Luigino, Suligoi, Barbara, Frova, Luisa, and Serraino, Diego
- Published
- 2016
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39. Mortality in Italian veterans deployed in Bosnia-Herzegovina and Kosovo.
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Capocaccia, Riccardo, Biselli, Roberto, Ruggeri, Raffaella, Tesei, Cristiano, Grande, Enrico, Martina, Lucia, Rocchetti, Anna, Salmaso, Stefania, Caldora, Massimiliano, and Francisci, Silvia
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MORTALITY ,WAR ,COMPARATIVE studies ,CONFIDENCE intervals ,CAUSES of death ,LONGITUDINAL method ,VETERANS ,RESEARCH methodology ,RESEARCH funding ,STATISTICAL sampling ,TUMORS ,DEATH certificates ,DESCRIPTIVE statistics - Abstract
Background and Aims: The possible increase of cancer risk in military personnel deployed in Balkans during and after the 1992-1999 wars, mainly related to the depleted uranium, was addressed by several studies on European veterans of those war theatres. This article reports on the results of the mortality study on the Italian cohort of Bosnia and Kosovo veterans (Balkan cohort). Methods: Mortality rates for the Balkan cohort (71 144 persons) were compared with those of the Italian general population as well as to those of a comparable and unselected control cohort of not deployed military personnel (114 269 persons). Ascertainment of vital status during the period 1995-2008 of all the persons in the two cohorts has been carried out through deterministic record linkage with the national death records database, from information provided by the respective Armed Force General Staff, and through the civil registry offices of the veterans' residence or birth municipalities. Results: The Balkan cohort experienced a mortality rates lower than both the general population (SMR = 0.56; 95% CI 0.51-0.62) and the control group (SMR = 0.88; 95% CI 0.79-0.97). Cancer mortality in the deployed cohort group was half of that from the general population mortality rates (SMR = 0.50; 95% CI 0.40-0.62) and slightly lower if compared with the control group cancer mortality rates (SMR = 0.95; 95% CI 0.77-1.18). Conclusion: Balkan veteran cohort did not show any increase in general mortality or in cancer mortality. [ABSTRACT FROM AUTHOR]
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- 2016
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40. Risk factors for early mortality after AIDS in the cART era: A population-based cohort study in Italy.
- Author
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Suligoi, Barbara, Zucchetto, Antonella, Grande, Enrico, Camoni, Laura, Maso, Luigino Dal, Frova, Luisa, Virdone, Saverio, Boros, Stefano, Pappagallo, Marilena, Taborelli, Martina, Regine, Vincenza, De Paoli, Paolo, and Serraino, Diego
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AIDS patients ,MORTALITY of AIDS patients ,HIV infection prognosis ,KAPLAN-Meier estimator ,CONFIDENCE intervals ,LOGISTIC regression analysis - Abstract
Background: Despite the dramatically improved survival due to combination antiretroviral therapies (cART), life expectancy of people with HIV/AIDS remains lower than that of the general population. This study aimed to estimate, at a population level, the survival experience of Italian people with AIDS (PWA) and to quantify the prognostic role of selected factors at diagnosis in the risk of early mortality (i.e., within six months from AIDS diagnosis). Methods: A population-based, retrospective-cohort study was conducted among Italian PWA diagnosed between 1999 and 2009 and recorded in the national AIDS registry. The vital status, up to December 2010, of 14,552 PWA was ascertained through a record linkage procedure with the Italian mortality database. Survival probabilities were estimated through Kaplan-Meier method. To identify risk factors for early mortality from any cause, odds ratios (ORs) and corresponding 95 % confidence intervals (CIs), adjusted for major confounders, were computed using multivariate logistic regression models. Results: Of the 5,706 deaths registered among the 14,552 PWA included in the study, 2,757 (18.9 %) occurred within six months from AIDS diagnosis. The probability of surviving six months increased from 81.2 % in PWA diagnosed in 1999-2000 to 82.9 % in 2009, while the 5-year survival augmented from 60.7 % in PWA diagnosed in 1999-2000 to 65.4 % for PWA diagnosed in 2005-2006. Elevated risks of early mortality were associated to older age (OR = 5.28; 95 % CI: 4.41-6.32 for age ≥60 vs. <35 years), injecting drug use (OR = 1.71; 95 % CI: 1.53-1.91 vs. heterosexual intercourse), and CD4 count <50 cells/mm³ at AIDS diagnosis (OR = 1.87, 95 % CI: 1.55-2.27 vs. ≥350). Elevated ORs for early mortality also emerged for PWA diagnosed with primary brain lymphoma (OR= 11.66, 95 % CI: 7.32-18.57), or progressive multifocal leukoencephalopathy (OR = 4.21, 95 % CI: 3.37-5.27). Conclusions: Our study documented, among Italian PWA, the high -- though slightly decreasing - frequency of early mortality in the full cART era. These findings indicate the need for enduring and ameliorating preventive actions aimed at timely HIV testing among all individuals at risk for HIV infection and/or those who present diseases known to be related with HIV infection. [ABSTRACT FROM AUTHOR]
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- 2015
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41. Variation in Cause-Specific Mortality Rates in Italy during the First Wave of the COVID-19 Pandemic: A Study Based on Nationwide Data.
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Grande, Enrico, Fedeli, Ugo, Pappagallo, Marilena, Crialesi, Roberta, Marchetti, Stefano, Minelli, Giada, Iavarone, Ivano, Frova, Luisa, Onder, Graziano, and Grippo, Francesco
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- 2022
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42. Variation in relative survival of thyroid cancers in Europe: Results from the analysis on 21 countries over the period 1983–1994 (EUROCARE-3 study)
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Colonna, Marc, Grande, Enrico, Jónasson, Jón G., and EUROCARE Working Group
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- *
THYROID cancer , *CANCER patients , *CANCER in women , *HISTOPATHOLOGY - Abstract
Abstract: We described the relative survival of thyroid cancer cases diagnosed in Europe during the period 1990–1994 and analysed time trends in relative survival during the period 1983–1994 using the EUROCARE-3 database. Relative survival of thyroid cancers is one of the highest amongst cancer sites, with age-standardised relative survival rates of 74% in men and 82% in women over the period 1990–1994, with marked differences between countries. The higher relative survival rates are observed in Scandinavian countries and the lower rates are observed in the UK and the countries of Eastern Europe. Relative survival is higher in women than in men, and decreases with age whatever the histological group. There are significant differences in relative survival according to histological type. Relative survival has slightly increased over the period 1983–1994 only when all histological types have been considered together. Time trend was, however, non-existent when the different histological groups were taken into account except during the most recent period of observation. One possible explanation for the differences in relative survival between countries and sex may probably be found in the changes in thyroid classification and diagnosis techniques. When these changes are not homogeneous, the distribution of thyroid cancers by histology and by stage at diagnosis may be very different. The only way to understand these differences is to conduct specific studies including a description of stage at diagnosis, diagnosis procedures used for staging and details of treatment. [Copyright &y& Elsevier]
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- 2006
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43. Sepsis as a Cause of Infectious Disease Mortality.
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Fedeli, Ugo and Grande, Enrico
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SEPSIS , *COMMUNICABLE diseases , *MORTALITY - Published
- 2018
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44. Multiple tumours in survival estimates
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Rosso, Stefano, De Angelis, Roberta, Ciccolallo, Laura, Carrani, Eugenio, Soerjomataram, Isabelle, Grande, Enrico, Zigon, Giulia, and Brenner, Hermann
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- *
MULTIPLE tumors , *CANCER reporting , *MEDICAL practice , *CANCER patients , *EUROPEANS , *CANCER research , *DISEASES - Abstract
Abstract: In international comparisons of cancer registry based survival it is common practice to restrict the analysis to first primary tumours and exclude multiple cancers. The probability of correctly detecting subsequent cancers depends on the registry’s running time, which results in different proportions of excluded patients and may lead to biased comparisons. We evaluated the impact on the age-standardised relative survival estimates of also including multiple primary tumours. Data from 2,919,023 malignant cancers from 69 European cancer registries participating in the EUROCARE-4 collaborative study were used. A total of 183,683 multiple primary tumours were found, with an overall proportion of 6.3% over all the considered cancers, ranging from 0.4% (Naples, Italy) to 12.9% (Iceland). The proportion of multiple tumours varied greatly by type of tumour, being higher for those with high incidence and long survival (breast, prostate and colon-rectum). Five-year relative survival was lower when including patients with multiple cancers. For all cancers combined the average difference was –0.4 percentage points in women and –0.7 percentage points in men, and was greater for older registries. Inclusion of multiple tumours led to lower survival in 44 out of 45 cancer sites analysed, with the greatest differences found for larynx (–1.9%), oropharynx (–1.5%), and penis (–1.3%). Including multiple primary tumours in survival estimates for international comparison is advisable because it reduces the bias due to different observation periods, age, registration quality and completeness of registration. The general effect of inclusion is to reduce survival estimates by a variable amount depending on the proportion of multiple primaries and cancer site. [Copyright &y& Elsevier]
- Published
- 2009
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45. The cancer survival gap between elderly and middle-aged patients in Europe is widening
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Quaglia, Alberto, Tavilla, Andrea, Shack, Lorraine, Brenner, Hermann, Janssen-Heijnen, Maryska, Allemani, Claudia, Colonna, Marc, Grande, Enrico, Grosclaude, Pascale, and Vercelli, Marina
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- *
CANCER patients , *CANCER prognosis , *COHORT analysis , *CANCER reporting , *CANCER diagnosis ,AGE factors in cancer - Abstract
Abstract: The present study is aimed to compare survival and prognostic changes over time between elderly (70–84 years) and middle-aged cancer patients (55–69 years). We considered seven cancer sites (stomach, colon, breast, cervix and corpus uteri, ovary and prostate) and all cancers combined (but excluding prostate and non-melanoma skin cancers). Five-year relative survival was estimated for cohorts of patients diagnosed in 1988–1999 in a pool of 51 European populations covered by cancer registries. Furthermore, we applied the period-analysis method to more recent incidence data from 32 cancer registries to provide 1- and 5-year relative survival estimates for the period of follow-up 2000–2002. A significant survival improvement was observed from 1988 to 1999 for all cancers combined and for every cancer site, except cervical cancer. However, survival increased at a slower rate in the elderly, so that the gap between younger and older patients widened, particularly for prostate cancer in men and for all considered cancers except cervical cancer in women. For breast and prostate cancers, the increasing gap was likely attributable to a larger use of, respectively, mammographic screening and PSA test in middle-aged with respect to the elderly. In the period analysis of the most recent data, relative survival was much higher in middle-aged patients than in the elderly. The differences were higher for breast and gynaecological cancers, and for prostate cancer. Most of this age gap was due to a very large difference in survival after the 1st year following the diagnosis. Differences were much smaller for conditional 5-year relative survival among patients who had already survived the first year. The increase of survival in elderly men is encouraging but the lesser improvement in women and, in particular, the widening gap for breast cancer suggest that many barriers still delay access to care and that enhanced prevention and clinical management remain major issues. [Copyright &y& Elsevier]
- Published
- 2009
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46. Cheapest paths in dynamic networks
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Gaia Nicosia, Marco Di Bartolomeo, Enrico Grande, Andrea Pacifici, DI BARTOLOMEO, Marco, Grande, Enrico, Nicosia, Gaia, and Pacifici, Andrea
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Scheme (programming language) ,shortest path ,Mathematical optimization ,network flow ,Computational complexity theory ,Computer science ,Computer Networks and Communications ,0211 other engineering and technologies ,0102 computer and information sciences ,02 engineering and technology ,Information System ,time-dependent network ,01 natural sciences ,Arc (geometry) ,branch and bound ,time-expanded network ,computer.programming_language ,021103 operations research ,computational complexity ,Branch and bound ,Flow network ,Exact solutions in general relativity ,010201 computation theory & mathematics ,Hardware and Architecture ,Path (graph theory) ,Shortest path problem ,Settore MAT/09 - Ricerca Operativa ,computer ,Software ,Information Systems - Abstract
Flows over time problems relate to finding optimal flows over a capacitated network where transit times on network arcs are explicitly considered. In this article, we study the problem of determining a minimum cost origin-destination path where the cost and the travel time of each arc depend on the time taken to travel from the origin to that particular arc along the path. We provide computational complexity results for this problem and an exact solution algorithm based on an enumeration scheme on the corresponding time expanded network. Finally, we show the efficiency of our approach through a number of experimental tests. © 2016 Wiley Periodicals, Inc. NETWORKS, Vol. 69(1), 23–32 2017.
- Published
- 2017
47. Mortality from chronic liver disease: Recent trends and impact of the COVID-19 pandemic.
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Fedeli U, Barbiellini Amidei C, Casotto V, Grande E, Saia M, Zanetto A, and Russo FP
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- Humans, Adolescent, Pandemics, Liver Cirrhosis epidemiology, COVID-19 complications, Liver Diseases, Alcoholic epidemiology, Non-alcoholic Fatty Liver Disease epidemiology, Non-alcoholic Fatty Liver Disease complications, Liver Neoplasms epidemiology, Liver Neoplasms complications
- Abstract
Prepandemic time trends in mortality from chronic liver disease (CLD) differed according to specific cause of death (decreasing for liver cirrhosis, stable or increasing for liver cancer), etiology (increasing for nonalcoholic fatty liver disease, generally decreasing for other etiologies), and world region (decreasing in areas with the highest burden of hepatitis B virus, increasing in Eastern Europe and other countries). The coronavirus disease 2019 (COVID-19) pandemic affected mortality of patients with CLD both directly, with a higher risk for severe illness and death depending on age, stage and etiology of the disease, and indirectly, through social isolation and loss of support, harmful drinking, and difficulties in access to care. Nevertheless, only sparse data are available on variations in CLD as a cause of death during the pandemic. In the USA, in 2020-2021 a growth in mortality was registered for all liver diseases, more marked for alcoholic liver disease, especially among young people aged 25-44 years and in selected ethnic groups. COVID-19 related deaths accounted only for a minor part of the excess. Further data from mortality registers of other countries are warranted, preferably adopting the so-called multiple cause-of-death approach, and extended to deaths attributed to viral hepatitis and liver cancer., Competing Interests: Conflict-of-interest statement: The authors declare they have no conflict of interest., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2023
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48. Increased kidney disease mortality among people with AIDS versus the general population: a population-based cohort study in Italy, 2006-2018.
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Taborelli M, Suligoi B, Serraino D, Frova L, Grande E, Toffolutti F, Regine V, Pappagallo M, Pugliese L, Grippo F, and Zucchetto A
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- Humans, Cohort Studies, Retrospective Studies, Kidney, Italy epidemiology, Acquired Immunodeficiency Syndrome, Kidney Diseases, Renal Insufficiency
- Abstract
Objectives: This study aimed to assess whether an excess mortality related to kidney and other urinary tract diseases exists among Italian people with AIDS (PWA), as compared with the general population without AIDS (non-PWA)., Design: Population-based, retrospective cohort study., Setting and Participants: We conducted a nationwide study including 9481 Italian PWA, aged 15-74 years, reported to the National AIDS Registry between 2006 and 2018., Methods: Vital status and causes of death were retrieved by record linkage with the National Register of Causes of Death up to 2018. Excess mortality for PWA versus non-PWA was estimated through sex-standardised and age-standardised mortality ratios (SMRs) with corresponding 95% CIs., Results: Among 2613 deceased PWA, 262 (10.0%) reported at least one urinary tract disease at death, including 254 (9.7%) non-cancer diseases-mostly renal failures (225 cases, 8.6%)-and 9 cancers (0.3%). The overall SMR for non-cancer urinary tract diseases was 15.3 (95% CI 13.4 to 17.3) with statistically significant SMRs for acute (SMR=22.3, 95% CI 18.0 to 27.4), chronic (SMR=8.4, 95% CI 6.0 to 11.3), and unspecified renal failure (SMR=13.8, 95% CI 11.2 to 16.8). No statistically significant excess mortality was detected for urinary tract cancers (SMR=1.7, 95% CI 0.8 to 3.3). The SMRs were particularly elevated among PWA aged <50 years, injecting drug users, or those with the first HIV-positive test >6 months before AIDS diagnosis., Conclusions: The excess mortality related to non-cancer kidney and other urinary tract diseases reported among PWA highlights the importance of implementing the recommendation for screening, diagnosis and management of such conditions among this population., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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49. Evolution of Pathology Patterns in Persons Who Died From COVID-19 in Italy: A National Study Based on Death Certificates.
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Grippo F, Grande E, Maraschini A, Navarra S, Pappagallo M, Marchetti S, Crialesi R, Frova L, Orsi C, Simeoni S, Carinci A, Loreto G, Donfrancesco C, Lo Noce C, Palmieri L, Andrianou X, Urdiales AM, Onder G, and Minelli G
- Abstract
Background: In Italy, during the first epidemic wave of 2020, the peak of coronavirus disease 2019 (COVID-19) mortality was reached at the end of March. Afterward, a progressive reduction was observed until much lower figures were reached during the summer, resulting from the contained circulation of SARS-CoV-2. This study aimed to determine if and how the pathological patterns of the individuals deceased from COVID-19 changed during the phases of epidemic waves in terms of: (i) main cause of death, (ii) comorbidities, and (iii) complications related to death. Methods: Death certificates of persons who died and tested positive for SARS-CoV-2, provided by the National Surveillance system, were coded according to ICD rev10. Deaths due to COVID-19 were defined as those in which COVID-19 was the underlying cause of death. Results: The percentage of COVID-19 deaths varied over time. It decreased in the downward phase of the epidemic curve (76.6 vs. 88.7%). In February-April 2020, hypertensive heart disease was mentioned as a comorbidity in 18.5% of death certificates, followed by diabetes (15.9% of cases), ischemic heart disease (13.1%), and neoplasms (12.1%). In May-September, the most frequent comorbidity was neoplasms (17.3% of cases), followed by hypertensive heart disease (14.9%), diabetes (14.8%), and dementia/Alzheimer's disease (11.9%). The most mentioned complications in both periods were pneumonia and respiratory failure with a frequency far higher than any other condition (78.4% in February-April 2020 and 63.7% in May-September 2020). Discussion: The age of patients dying from COVID-19 and their disease burden increased in the May-September 2020 period. A more serious disease burden was observed in this period, with a significantly higher frequency of chronic pathologies. Our study suggests better control of the virus' lethality in the second phase of the epidemic, when the health system was less burdened. Moreover, COVID-19 care protocols had been created in hospitals, and knowledge about the diagnosis and treatment of COVID-19 had improved, potentially leading to more accurate diagnosis and better treatment. All these factors may have improved survival in patients with COVID-19 and led to a shift in mortality to older, more vulnerable, and complex patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Grippo, Grande, Maraschini, Navarra, Pappagallo, Marchetti, Crialesi, Frova, Orsi, Simeoni, Carinci, Loreto, Donfrancesco, Lo Noce, Palmieri, Andrianou, Urdiales, Onder, Minelli and Italian National Institute of Health COVID-19 Mortality Group.)
- Published
- 2021
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50. A long-term nationwide study on mortality associated to rheumatoid arthritis in Italy.
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Ometto F, Fedeli U, Botsios C, Punzi L, and Grande E
- Subjects
- Aged, Comorbidity, Female, Humans, Italy epidemiology, Longitudinal Studies, Male, Mortality, Arthritis, Rheumatoid mortality, Cause of Death
- Abstract
Objectives: We aimed to evaluate trends of rheumatoid arthritis (RA) mortality reported as the underlying cause of death (UCD) and as multiple causes of death (MCD) in Italy between 2003 and 2015., Methods: Analyses were carried out on the Italian National Cause of Death Register, managed by the Italian National Institute of Statistics (ISTAT). Deaths from January 1, 2003 to December 31, 2015 with any mention of RA were included. Diseases are coded according to the International Classification of Diseases, 10th Edition (ICD- 10, 2009 version). Time trends of age-standardised rates were analysed for RA both as UCD and MCD, and the annual percent change (APC) was estimated., Results: Overall, 26,564 deaths with a mention of RA were retrieved out of 7,595,214 deaths (0.35% of all certificates). The mention of RA as MCD increased throughout the study period, meanwhile the selection as the UCD decreased. RA mortality rates based on the UCD declined (males APC -3.1%, CI -3.9, -2.3; females APC -3.3%, CI -4.1, -2.4); while rates based on the MCD were stable. Specifically, rates were stable or declined among younger subjects and increased in subjects aged ≥80 years., Conclusions: RA was found to be increasingly reported in death certificates in the last two decades in Italy, although it is less frequently reported as the UCD. Due to the increased survival of patients, we observed a shift of RA-related mortality towards the elderly, making RA a comorbidity contributing to death in these patients.
- Published
- 2020
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