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15 results on '"Greer, William E."'

7. Vibriocidal Activity, Immune Globulin Producing Cells and Immune Globulin Levels in Theropithecus gelada After Administration of a Vibrio cholerae Antigen.

Author

Felsenfeld, Oscar and Greer, William E.

Subjects
*GELADA baboon, *ANTIGENS, *AGGLUTININS, *SERUM, *LYMPH nodes, *LYMPHOID tissue, *IMMUNOGLOBULIN G
Abstract

Geladas were fed or injected with an antigen that contained Burrows' type 2 cholera toxin. Rising agglutinin and vibriocidal titres were observed in the serum, peripheral and mesenteric lymph nodes, spleen and lymphatic tissue of the upper intestine. Oral administration stimulated a more intensive vibriocidal activity in the mesenteric lymphatic nodes and intestinal lymphatic tissue, and within a shorter time than parenteral injection of the same antigen. Immune globulin synthesis paralleled largely the number of immunologically active cells. The agglutinin titres reflected the level of immune globulins and the numbers of globulin producing cells, whereas vibriocidal titres appeared independent of both. In terms of antibody site serum IgG was weight for weight more vibriocidal than serum IgM. [ABSTRACT FROM AUTHOR]

Published
1968

11. Oral Immunization with Polyvalent Streptomycin-Dependent Escherichia coli Vaccine1

Author

Felsenfeld, Oscar, Wolf, Robert H., Greer, William E., and Brannon, Richard B.

Subjects
Diarrhea, Genetics, Microbial, Antigens, Bacterial, Time Factors, Vaccination, Radioimmunoassay, Administration, Oral, Haplorhini, Feces, Antibody Formation, Bacterial Vaccines, Chromium Isotopes, Escherichia coli, Streptomycin, Animals, Immunization, Clinical Microbiology, Virology, and Immunology, Serotyping, Escherichia coli Infections, Densitometry
Abstract

Streptomycin-dependent Escherichia coli serotypes O 111, O 55 and O 26 were used to vaccinate young patas monkeys against these organisms by the oral route. Five administrations of 10(10) cells in 3-day intervals gave almost full protection to the animals against challenge with 9 to 11 minimal infective doses of homologous virulent organisms for at least 1 month, whether the three serotypes were administered singly or simultaneously.

Published
1972

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