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2. The Immunomodulatory Effects of Dexamethasone on Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer

Author

Johnson, Kai Conrad Cecil, Goldstein, Daniel, Tharakan, Jasmin, Quiroga, Dionisia, Kassem, Mahmoud, Grimm, Michael, Miah, Abdul, Vargo, Craig, Berger, Michael, Sudheendra, Preeti, Pariser, Ashley, Gatti-Mays, Margaret E., Williams, Nicole, Stover, Daniel, Sardesai, Sagar, Wesolowski, Robert, Ramaswamy, Bhuvaneswari, Tozbikian, Gary, Schnell, Patrick M., and Cherian, Mathew A.

Published
2023
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7. Survival outcomes seen with neoadjuvant chemotherapy in the management of locally advanced inflammatory breast cancer (IBC) versus matched controls

Author

Johnson, Kai CC, Grimm, Michael, Sukumar, Jasmine, Schnell, Patrick M., Park, Ko Un, Stover, Daniel G., Jhawar, Sachin R., Gatti-Mays, Margaret, Wesolowski, Robert, Williams, Nicole, Sardesai, Sagar, Pariser, Ashley, Sudheendra, Preeti, Tozbikian, Gary, Ramaswamy, Bhuvaneswari, Doto, Dureti, and Cherian, Mathew A.

Published
2023
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9. Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery

Author

Pölzl, Leo, Engler, Clemens, Sterzinger, Philipp, Lohmann, Ronja, Nägele, Felix, Hirsch, Jakob, Graber, Michael, Eder, Jonas, Reinstadler, Sebastian, Sappler, Nikolay, Kilo, Juliane, Tancevski, Ivan, Bachmann, Sebastian, Abfalterer, Hannes, Ruttmann-Ulmer, Elfriede, Ulmer, Hanno, Griesmacher, Andrea, Heuts, Samuel, Thielmann, Matthias, Bauer, Axel, Grimm, Michael, Bonaros, Nikolaos, Holfeld, Johannes, and Gollmann-Tepeköylü, Can

Published
2023
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13. Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification

Author

Gollmann-Tepeköylü, Can, Graber, Michael, Hirsch, Jakob, Mair, Sophia, Naschberger, Andreas, Pölzl, Leo, Nägele, Felix, Kirchmair, Elke, Degenhart, Gerald, Demetz, Egon, Hilbe, Richard, Chen, Hao-Yu, Engert, James C., Böhm, Anna, Franz, Nadja, Lobenwein, Daniela, Lener, Daniela, Fuchs, Christiane, Weihs, Anna, Töchterle, Sonja, Vogel, Georg F., Schweiger, Victor, Eder, Jonas, Pietschmann, Peter, Seifert, Markus, Kronenberg, Florian, Coassin, Stefan, Blumer, Michael, Hackl, Hubert, Meyer, Dirk, Feuchtner, Gudrun, Kirchmair, Rudolf, Troppmair, Jakob, Krane, Markus, Weiss, Günther, Tsimikas, Sotirios, Thanassoulis, George, Grimm, Michael, Rupp, Bernhard, Huber, Lukas A., Zhang, Shen-Ying, Casanova, Jean-Laurent, Tancevski, Ivan, and Holfeld, Johannes

Published
2023
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15. Safety and efficacy of direct cardiac shockwave therapy in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (the CAST-HF trial): study protocol for a randomized controlled trial—an update

Author

Nägele, Felix, Pölzl, Leo, Graber, Michael, Hirsch, Jakob, Mayr, Agnes, Pamminger, Mathias, Troger, Felix, Theurl, Markus, Schreinlechner, Michael, Sappler, Nikolay, Dorfmüller, Christian, Mitrovic, Martina, Ulmer, Hanno, Grimm, Michael, Gollmann-Tepeköylü, Can, and Holfeld, Johannes

Published
2022
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18. Patient preferences and adherence to adjuvant GnRH analogs among premenopausal women with hormone receptor positive breast cancer

Author

Sukumar, Jasmine S., Quiroga, Dionisia, Kassem, Mahmoud, Grimm, Michael, Shinde, Namrata Vilas, Appiah, Leslie, Palettas, Marilly, Stephens, Julie, Gatti-Mays, Margaret E., Pariser, Ashley, Cherian, Mathew, Stover, Daniel G., Williams, Nicole, Van Deusen, Jeffrey, Wesolowski, Robert, Lustberg, Maryam, Ramaswamy, Bhuvaneswari, and Sardesai, Sagar

Published
2021
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22. Five-year outcomes of different techniques for minimally invasive mitral valve repair in Barlow's disease.

Author

Pölzl, Leo, Gollmann-Tepeköylü, Can, Nägele, Felix, Cetin, Kardelen, Spilka, Johannes, Holfeld, Johannes, Oezpeker, Ulvi C, Stastny, Luka, Graber, Michael, Hirsch, Jakob, Engler, Clemens, Dumfarth, Julia, Ruttmann-Ulmer, Elfriede, Hangler, Herbert, Grimm, Michael, Müller, Ludwig, Höfer, Daniel, and Bonaros, Nikolaos

Subjects
MITRAL valve, MINIMALLY invasive procedures, MITRAL valve insufficiency, OPERATIVE surgery, CONSORTIA, THORACOTOMY
Abstract

OBJECTIVES Barlow's disease is a specific sub-form of mitral valve (MV) disease, characterized by diffuse excessive tissue and multi segment prolapse. The anterolateral mini-thoracotomy represents the standard access for MV regurgitation in many centres. It still remains unclear which surgical technique provides the best results. Therefore, the aim of this study was to compare operative safety and mid-term outcomes after (i) isolated annuloplasty, (ii) use of additional artificial chordae or (iii) leaflet resection in patients suffering from Barlow's disease undergoing minimally invasive MV repair. METHODS A consecutive series of patients suffering from Barlow′s disease undergoing minimally invasive MV surgery between 2001 and 2020 were analysed (n  = 246). Patients were grouped and analysed according to the used surgical technique. The primary outcome was a modified Mitral Valve Academic Research Consortium combined end-point of mortality, reoperation due to repair failure or reoccurrence of severe mitral regurgitation within 5 years. The secondary outcome included operative success and safety up to 30 days. RESULTS No significant difference was found between the 3 surgical techniques with regard to operative safety (P  = 0.774). The primary outcome did not differ between groups (P  = 0.244). Operative success was achieved in 93.5% and was lowest in the isolated annuloplasty group (77.1%). Conversion to MV replacement was increased in patients undergoing isolated annuloplasty (P  < 0.001). CONCLUSIONS Isolated annuloplasty, use of additional artificial chordae and leaflet resection represent feasible techniques in Barlow patients undergoing minimally invasive MV surgery with comparable 5-year results. In view of the increased conversion rate in the annuloplasty group, the pathology should not be oversimplified. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Measuring youth empowerment: An application to Tunisia.

Author

Goedhuys, Micheline, Grimm, Michael, Meysonnat, Aline, Nillesen, Eleonora, and Reitmann, Ann‐Kristin

Subjects
SELF-efficacy, SUSTAINABLE development, HOUSEHOLD surveys, WELL-being
Abstract

Youth empowerment has become a growing concern for achieving sustainable development worldwide. Yet, there is limited evidence on which domains of empowerment are important for youth and how they can be operationalized with indicators for measurement. We propose four domains of youth empowerment with corresponding indicators and use a well‐established methodology for constructing a composite index. Using data from a household survey in Tunisia, we assess youth empowerment in the proposed domains and explore their relation to youth well‐being. The proposed approach can help monitor youth empowerment in various contexts and evaluate the effectiveness of youth interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Long-Term Prognostic Value of High-Sensitivity Troponin T Added to N-Terminal Pro Brain Natriuretic Peptide Plasma Levels Before Valve Replacement for Severe Aortic Stenosis

Author

Barbieri, Fabian, Senoner, Thomas, Adukauskaite, Agne, Dobner, Stephan, Holfeld, Johannes, Semsroth, Severin, Lambert, Thomas, Zweiker, David, Theurl, Thomas, Rainer, Peter Paul, Schmidt, Albrecht, Feuchtner, Gudrun Maria, Steinwender, Clemens, Hoppe, Uta Charlotte, Hintringer, Florian, Bauer, Axel, Müller, Silvana, Grimm, Michael, Pfeifer, Bernhard Erich, and Dichtl, Wolfgang

Published
2019
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35. RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis

Author

Hirano, Ikuo, Collins, Margaret H., Assouline-Dayan, Yehudith, Evans, Larry, Gupta, Sandeep, Schoepfer, Alain M., Straumann, Alex, Safroneeva, Ekaterina, Grimm, Michael, Smith, Heather, Tompkins, Cindy-ann, Woo, Amy, Peach, Robert, Frohna, Paul, Gujrathi, Sheila, Penenberg, Darryl N., Li, Caiyan, Opiteck, Gregory J., Olson, Allan, Aranda, Richard, Rothenberg, Marc E., and Dellon, Evan S.

Published
2019
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37. Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death

Author

Danzl, Katarina, Messner, Barbara, Doppler, Christian, Nebert, Clemens, Abfalterer, Anna, Sakic, Adel, Temml, Veronika, Heinz, Katharina, Streitwieser, Robert, Edelmann, Thomas, Mairhofer, Mario, Grimm, Michael, Laufer, Günther, Zierer, Andreas, Stuppner, Hermann, Schuster, Daniela, Ploner, Christian, Müller, Thomas, and Bernhard, David

Published
2019
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40. Analysis of factors affecting outcome in acute type A aortic dissection complicated by preoperative cardiopulmonary resuscitation.

Author

Montagner, Matteo, Kofler, Markus, Pitts, Leonard, Gasser, Simone, Stastny, Lukas, Kurz, Stephan D, Grimm, Michael, Falk, Volkmar, Kempfert, Jörg, and Dumfarth, Julia

Subjects
AORTIC dissection, CARDIOPULMONARY resuscitation, FACTOR analysis, AORTIC rupture, SURVIVAL rate, DISSECTION
Abstract

Open in new tab Download slide OBJECTIVES Cardiopulmonary resuscitation (CPR) aggravates the pre-existing dismal prognosis of patients suffering from acute type A aortic dissection (ATAAD). We aimed to identify factors affecting survival and outcome in ATAAD patients requiring CPR at presentation at 2 European aortic centres. METHODS Data on 112 surgical candidates and undergoing preoperative CPR were retrospectively evaluated. Patients were divided into 2 groups according to 30-day mortality. A multivariable model identified predictors for 30-day mortality. RESULTS Preoperative death occurred in 23 patients (20.5%). In the remaining 89 surgical patients (79.5%) circulatory arrest time (41 ± 20 min in 30-day non-survivors vs 30 ± 13 min in 30-day survivor, P  = 0.003) as well as cardiopulmonary bypass time (320 ± 132 min in 30-day non-survivors vs 252 ± 140 min in 30-day survivor, P  = 0.020) time was significantly longer in patients with worse outcome. Thirty-day mortality of the total cohort was 61.6% (n  = 69) with cardiac failure in 48% and aortic rupture or haemorrhagic shock (28%) as predominant reasons of death. Age [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.01–1.09, P  = 0.034], preoperative coronary (OR 3.42, 95% CI 1.34–9.26, p = 0.012) and spinal malperfusion (OR 12.49, 95% CI 1.83–225.02, P  = 0.028) emerged as independent predictors for 30-day mortality while CPR due to tamponade was associated with improved early survival (OR 0.29, 95% CI 0.091–0.81, P  = 0.023). CONCLUSIONS Assessment of underlying cause for CPR is mandatory. Pericardial tamponade, rapidly resolved with pericardial drainage, is a predictor for improved survival, while age and presence of coronary and spinal malperfusion are associated with dismal outcome in this high-risk patient group. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Open transcatheter double valve-in-valve replacement for degenerated bioprostheses on the arrested heart.

Author

Gollmann-Tepeköylü, Can, Holfeld, Johannes, Naegele, Felix, Grimm, Michael, and Bonaros, Nikolaos

Subjects
HEART valve prosthesis implantation, VENTRICULAR outflow obstruction, BIOPROSTHESIS, BIOPROSTHETIC heart valves, MITRAL valve, AORTIC valve
Abstract

Background Failing bioprosthesis is an emerging issue due to (i) a shift towards liberal bioprosthesis implantation instead of mechanical prosthesis and (ii) an ageing population. Management of high-risk patients with bioprosthesis degeneration remains challenging. Case summary An 82-year-old patient with history of aortic and mitral valve replacement six years before presents with severe dyspnoea. Echocardiograpic assessment reveals (i) structural valve degeneration of the mitral prosthesis (severe stenosis and regurgitation) with concomitant major annular calcifications and (ii) structural valve degeneration of the aortic prosthesis with low-flow, low-gradient restenosis. Due to mitral annular calcifications, the risk of double valve re-replacement and the age of the patient conventional reoperation was deemed very high. The patient is evaluated for transapical double valve implantation. This option is rejected due to the high risk of left ventricular outflow obstruction. The patient is treated with an open transcatheter double valve-in-valve procedure at the following sequence: leaflet resection of the mitral bioprosthesis, mitral valve implantation and fixation under direct view, leaflet resection of the aortic bioprosthesis, and valve frame cracking and aortic valve implantation under direct view. Post-bypass echocardiography shows neither left ventricular outflow tract obstruction nor paravalvular leak or prosthesis dysfunction. The patient is extubated on the first post-operative day and transferred to normal care unit. Discussion Open transcatheter double valve-in-valve replacement for degenerated bioprostheses on the arrested heart might be a valuable alternative to treat selected high-risk patients with bioprosthetic valve degeneration. [ABSTRACT FROM AUTHOR]

Published
2023
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42. In Vivo Evaluation of a Gastro-Resistant Enprotect ® Capsule under Postprandial Conditions.

Author

Grimm, Michael, Rump, Adrian, Kromrey, Marie-Luise, Morof, Felix, Dumont, Camille, Jannin, Vincent, Tzvetkov, Mladen Vassilev, and Weitschies, Werner

Subjects
*GASTRIC emptying, *MAGNETIC resonance imaging, *FERRIC oxide, *SMALL intestine, *METHYLCELLULOSE
Abstract

Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In this study, the capsules were administered to 16 healthy young subjects after intake of a light meal. The Enprotect® capsules were labelled with 5 mg black iron oxide and 25 mg 13C3-caffeine. Magnetic Resonance Imaging was used to identify the localization and visual dispersion of the capsule filling. The salivary appearance of caffeine was considered a second independent and sensitive marker for the initial release. Whereas the fasted gastric residence time of the capsules amounted to 43 ± 32 min, it was increased to 158 ± 36 min after postprandial intake. Therefore, the mean dispersion time according to MRI and the mean caffeine appearance time were increased to 196 ± 37 min and 189 ± 37 min, respectively. But, similar to fasted administration, no capsule disintegration or leakage was observed in the stomach and 38% of the capsules disintegrated in the jejunum and 62% in the ileum. The mean dispersion time after gastric emptying and the mean caffeine appearance time after gastric emptying amounted to 38 ± 21 min and 31 ± 17 min, respectively. Both did not relevantly change compared to the fasted intake. Only the absolute dispersion time and caffeine appearance were prolonged due to the increased gastric residence and no relevant influence of the light meal was observed on the disintegration or release behavior of Enprotect® capsules after gastric emptying. The capsules also showed robust enteric properties after postprandial administration. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics.

Author

Tzakri, Theodora, Rehenbrock, Lara, Senekowitsch, Stefan, Rump, Adrian, Schick, Philipp, Krause, Julius, Kromrey, Marie-Luise, Grimm, Michael, and Weitschies, Werner

Subjects
GASTRIC emptying, CAFFEINE, CROSSOVER trials, OLDER people, CLINICAL trials
Abstract

Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule's advantage in labeling ingested fluids with caffeine for subsequent salivary detection, its risk of premature melting before swallowing, and its complicated storage and preparation, limit its application, particularly in special populations (e.g., older people). For this reason, here, a compression-coated tablet was developed and validated against the ice capsule in a cross-over clinical trial. The two dosage forms were administered simultaneously to 12 volunteers in an upright position under fasted and fed state conditions. To distinguish the caffeine concentrations in saliva from each dosage form, regular type of caffeine (12C) was added to the tablet, while for the ice capsule 13C3 labelled caffeine was used. The salivary caffeine concentrations showed no statistically significant differences for the pharmacokinetic parameters tmax and AUC0→60 (p > 0.05). Thus, the new formulation is a useful tool for determining gastric emptying that can also be used in special populations. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Safety and efficacy of direct Cardiac Shockwave Therapy in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (the CAST-HF trial): study protocol for a randomized controlled trial

Author

Pölzl, Leo, Nägele, Felix, Graber, Michael, Hirsch, Jakob, Lobenwein, Daniela, Mitrovic, Martina, Mayr, Agnes, Theurl, Markus, Schreinlechner, Michael, Pamminger, Matthias, Dorfmüller, Christian, Grimm, Michael, Gollmann-Tepeköylü, Can, and Holfeld, Johannes

Published
2020
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49. Effect of surface machining on the environmentally-assisted cracking of Alloy 182 and 316L stainless steel in light water reactor environments

Author

Zimina, Mariia, Ritter, Stefan, Zajec, Bojan, Vankeerberghen, Marc, Volpe, Liberato, Hojna, Anna, Bosch, Rik-Wouter, Scenini, Fabio, Que, Zaiqing, Sáez-Maderuelo, Alberto, Meadows, P. Jill, Grimm, Michael, Herbst, Matthias, Legat, Andraž, Maurotto, Agostino, Novotny, Radek, and Seifert, Karl-Heinz

Subjects
open access, environmentally-assisted cracking, crack initiation, avstenitno nerjavno jeklo AISI 304L, lahkovodni reaktor, crack initiation, environmentally-assisted cracking, Alloy 182, AISI 304 stainless steel, surface treatment, light water reactor, open access, odprti dostop, surface treatment, light water reactor, iniciacija razpoke, AISI 304 stainless steel, iniciacija razpoke, pokanje zaradi vplivov okolja, zlitina Alloy 182, avstenitno nerjavno jeklo AISI 304L, površina obdelave, lahkovodni reaktor, odprti dostop, udc:544.5/.6, Alloy 182, površina obdelave, zlitina Alloy 182, pokanje zaradi vplivov okolja
Abstract

The main objective of the EU-funded project mitigating environmentally-assisted cracking through optimisation of surface condition (MEACTOS) was to gain knowledge on the ability of different surface machining procedures to mitigate environmentally-assisted cracking (EAC) in typical light water reactor structural materials and environments. Surfaces of cold-worked (CW) type 316L austenitic stainless steel and nickel-based weld metal Alloy 182 flat tapered tensile specimens were machined using different processes. EAC initiation susceptibility of these specimens was evaluated using constant extension rate tensile (CERT) tests under simulated boiling water reactor (BWR) and pressurized water reactor (PWR) conditions and assessed using constant load experiments. More than a hundred tests were performed covering about 10 years of autoclave testing time. Only minor or no measurable improvements in EAC initiation susceptibility as a function of surface treatments (grinding or advanced machining) compared to the standard industrial face milling were demonstrated. In most cases, the stress thresholds for EAC initiation determined in constant load tests confirmed the trend obtained from CERT tests. This paper summarises the most important results and conclusions concerning the EAC initiation behaviour for the CW 316L and Alloy 182 under reducing PWR and oxidizing BWR conditions. Nasl. z nasl. zaslona. Opis vira z dne: 23. 5. 2023. Abstract. Bibliografija: str. 19-20.

Published
2023

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