1. ANTI-VE-CADHERIN AUTOANTIBODIESAS A BOMARKER O FVASCULAR ALTERATIONS ASSOCATED WITH DISORDERS
- Author
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Vilgrain, Isabelle, GULINO, Danielle, Bouillet, Laurence, Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), VILGRAIN, ISABELLE, Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,Auto-antibodies ,[SDV]Life Sciences [q-bio] ,Vascular Disorders ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,antiVE-cadherin antibodies ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
The present invention relates to a method for predicting and/or diagnosing vascular alterations associated with a disorder in a patient, comprising a step of detecting or quantifying the presence of anti-VE-cadherin autoantibodies in a biological sample obtained from said patient.The present invention also relates to a kit suitable for carrying out the method of the invention, comprising a solid support coated with at least one VE-cadherin antigen and at least a labelled antibody specifically recognizing antibodies.The inventors have now identified that anti-VE-cadherin autoantibodies is a biomarker for predicting and/or diagnosing, in particular in serum, vascular alterations associated with diverse disorders or diseases. Indeed, they have detected and quantified anti-VE-cadherin autoantibodies in sera of patients affected with various diseases and disorders. They have also characterized these autoantibodies by demonstrating after their purification they may be pathogenic and contribute to vascular injury in several diseases.
- Published
- 2014