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All‐solid‐state rechargeable batteries are regarded as one of the most promising next‐generation energy storage devices, while their cycling stability is still a great challenge due to the nonuniform lithium ion transportation and the loss of active lithium during cycling. Herein, a LiF embedded prelithiated graphite interface layer is designed and inserted between Li6PS5Cl solid electrolyte layer and graphite anode layer. The presence of LiF, C−F bonds and prelithiated graphite in this unique interface layer can facilitate uniform lithium ion migration and compensate the loss of active lithium, thus significantly improving the cyclic performances of both monopolar and bipolar all‐solid‐state lithium ion batteries. After 100 cycles at 0.1 C, the capacity retention increases from 58 % to 78.5 % for the monopolar LiNi0.5Co0.2Mn0.3O2|Li6PS5Cl|LiF@2.5 %Li@G|graphite all‐solid‐state lithium ion battery. Besides, the bipolar all‐solid‐state lithium ion batteries show a high discharge plateau of ~7.6 V with a capacity retention of 60.2 % after 190 cycles at 0.1 C. This work demonstrates the effectiveness of LiF embedded prelithiated graphite interface layer for improving the electrochemical performances of all‐solid‐state lithium ion batteries. [ABSTRACT FROM AUTHOR]

Lithium‐oxygen batteries have received great research interest owing to their ultrahigh theoretical energy density and are considered as one of the promising secondary batteries. However, there are still some challenges in their practical application, like liquid organic electrolyte evaporation in the semi‐open system and instability in the high‐voltage oxidizing environment. In this work, a cellulose acetate‐based gel polymer electrolyte (CA@GPE) is proposed, whose cross‐linked microporous structure ensures the ultrahigh liquid electrolyte uptake of 2391%. The prepared CA@GPE exhibits a high lithium‐ion transference number of 0.595, a satisfying ionic conductivity of 0.47 mS cm−1 and a wide electrochemical stability window up to 5.0 V. The Li//Li symmetric cell employing CA@GPE could cycle stably over 1200 h. The lithium‐oxygen battery with CA@GPE presents a superb cycling lifetime of 370 cycles at 0.1 mA cm−2 under 0.25 mAh cm−2. This work offers a possible strategy to realize long‐cycling stability lithium‐oxygen batteries. [ABSTRACT FROM AUTHOR]

Objective: The integration of curriculum is an important approach for enhancing medical education and facilitating interdisciplinary connections among students. This study aimed to develop a new morphological integrated teaching mode for undergraduate stomatology education by combining stomatological pathology and radiology courses with instructional media., Methods: In total, 63 undergraduates were included in this study and divided into three groups: traditional (Group T; the control group) and two experimental groups: KoPa WiFi EDU (Group K), and KoPa WiFi EDU-cone beam computed tomography (CBCT) (Group K-C). All participants attended a 2-h lecture on periapical cysts and completed the first theoretical test. Subsequently, they underwent a 4-h experimental training session on the pathology and radiology of periapical cysts using different teaching methods. Following the training, participants completed the second theoretical test and underwent the first image-reading skill evaluation. After a 3-month period, participants completed the third theoretical test and underwent the second image-reading skill evaluation. The effectiveness of the teaching methods was assessed by analyzing the differences in theoretical test and experimental skill evaluation scores., Results: There were no significant differences in the first theoretical outcomes among three groups (p > 0.05). However, the second theoretical scores, the first objective evaluation scores, and the first subjective evaluation scores were significantly higher in the integrated teaching mode (3D teaching mode with the KoPa WiFi EDU and CBCT: 89.29 ± 4.55, 81.00 ± 8.15, and 61.57 ± 5.52, respectively; 2D teaching mode with the KoPa WiFi EDU system: 80.43 ± 3.41, 73.00 ± 8.01, and 55.67 ± 5.66, respectively) than in the traditional teaching mode (72.57 ± 3.84, 69.38 ± 4.91, and 48.67 ± 5.54, respectively) (p < 0.05). Moreover, the long-term teaching effect of the integrated mode was better than that of the traditional mode (p < 0.05)., Conclusions: The morphology-based integrated teaching mode combining pathology and radiology aroused student enthusiasm for learning, and resulted in enhanced learning outcomes in dental experimental education., (© 2024 American Dental Education Association.)

The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is associated with human papillomavirus (HPV) infection. However, the molecular mechanisms underlying the interactions between HNSCC and HPV remain unclear. Bioinformatics was used to analyze the gene expression dataset of HPV-associated HNSCC based on the Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) in HPV-positive and HPV-negative HNSCC were screened. Gene function enrichment, protein-protein interactions (PPI), survival analysis, and immune cell infiltration of DEGs were performed. Furthermore, the clinical data of HNSCC tissue samples were analyzed using immunohistochemistry. In total, 194 DEGs were identified. A PPI network was constructed and 10 hub genes (EREG, PLCG1, ERBB4, HBEGF, ZFP42, CBX6, NFKBIA, SOCS1, ATP2B2, and CEND1) were identified. Survival analysis indicated that low expression of SOCS1 was associated with worse overall survival. Immunohistochemistry demonstrated that SOCS1 expression was higher in HPV-negative HNSCC than in HPV-positive HNSCC, and there was a positive correlation between SOCS1 expression and patient survival. This study provides new information on biological targets that may be relevant to the molecular mechanisms underpinning the occurrence and development of HNSCC. SOCS1 may play an important role in the interaction between HPV and HNSCC and serve as a potential biomarker for future therapeutic targets.

Background: PEST-containing nuclear protein (PCNP), a novel zinc finger protein, participates in cell cycle regulation. Previous studies have confirmed that PCNP plays a role in mediating cellular development and invasion in a variety of cancer types. However, the relationship between PCNP expression and the occurrence and development of oral squamous cell carcinoma (OSCC) requires further exploration. In this study, we used biological atomic force microscopy to examine the histomorphological and mechanical properties of OSCC to explore the relationship between PCNP expression and differentiation of OSCC., Methods: Seventy-seven OSCC samples with varying degrees of differentiation were selected for hematoxylin and eosin staining, immunohistochemistry, and cellular mechanical measurement. The expression of PCNP and the mechanical properties such as stiffness and roughness of the tissue interface in OSCC samples were investigated. The Kaplan-Meier survival curve was utilized to assess the relationship of PCNP expression with patient survival., Results: The level of PCNP was significantly higher in well-differentiated OSCC than in moderately and poorly differentiated OSCC (P < 0.001). High expression of PCNP was specifically associated with higher tumor differentiation, lack of lymph node metastasis, and lower tumor node metastasis stage (all P < 0.05). Patients with high PCNP expression had a higher survival rate than those with low PCNP expression. The average variation of stiffness within a single tissue ranged from 347 kPa to 539 kPa. The mean surface roughness of highly, moderately, and poorly differentiated OSCC and paraneoplastic tissues were 795.53 ± 47.2 nm, 598.37 ± 45.76 nm, 410.16 ± 38.44 nm, and 1010.94 ± 119.07 nm, respectively. Pearson correlation coefficient demonstrated a positive correlation between PCNP expression and tissue stiffness of OSCC (R = 0.86, P < 0.001)., Conclusion: The expression of PCNP was positively correlated with patient survival, tumor differentiation, and mechanical properties of tissue interfaces. PCNP is a potential biomarker for the early diagnosis and staging of OSCC. Furthermore, determination of the mechanical properties of the tissue interface could provide further useful information required for the detection and differentiation of OSCC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Zhang, Guo, Shen, Zheng, Zhai, Li, He and Zhang.)