49 results on '"Gynecological disease"'
Search Results
2. Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis
- Author
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Ziwei Zhou, Yifei Feng, Lishan Xie, Song Ma, Zhaoxia Cai, and Ying Ma
- Subjects
16S rRNA sequencing ,Diversity ,Dysbiosis ,Genital tract ,Gut microbiome ,Gynecological disease ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis. Methods We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean difference (SMD) was conducted using the inverse-variance method for alpha diversity indices. Results Of 3327 unique articles, 87 eligible studies were included. Significant decreases were found in gut microbiome of patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 to -0.09; Shannon index SMD=-0.23; 95%CI, -0.40 to -0.06), whereas significant increases were observed in vaginal microbiome (Chao1 SMD = 1.15; 95%CI, 0.74 to 1.56; Shannon index SMD = 0.51; 95%CI, 0.16 to 0.86). Most studies of different diagnostic categories showed no significant differences in beta diversity. Disease specificity was observed, but almost all the changes were only replicated in three studies, except for the increased Aerococcus in bacterial vaginosis (BV). Patients with major gynecological diseases shared the enrichment of Prevotella and depletion of Lactobacillus, and an overlap in microbes was implied between BV, cervical intraepithelial neoplasia, and cervical cancer. Conclusions These findings demonstrated an association between alterations in gut and genital microbiota and gynecological diseases. The most observed results were shared alterations across diseases rather than disease-specific alterations. Therefore, further investigation is required to identify specific biomarkers for diagnosis and treatment in the future.
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- 2024
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- View/download PDF
3. Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis.
- Author
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Zhou, Ziwei, Feng, Yifei, Xie, Lishan, Ma, Song, Cai, Zhaoxia, and Ma, Ying
- Subjects
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FEMALE reproductive organ diseases , *CERVICAL intraepithelial neoplasia , *GUT microbiome , *BACTERIAL vaginitis , *GENITALIA , *NUCLEOTIDE sequencing , *CERVICAL cancer - Abstract
Background: Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis. Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean difference (SMD) was conducted using the inverse-variance method for alpha diversity indices. Results: Of 3327 unique articles, 87 eligible studies were included. Significant decreases were found in gut microbiome of patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 to -0.09; Shannon index SMD=-0.23; 95%CI, -0.40 to -0.06), whereas significant increases were observed in vaginal microbiome (Chao1 SMD = 1.15; 95%CI, 0.74 to 1.56; Shannon index SMD = 0.51; 95%CI, 0.16 to 0.86). Most studies of different diagnostic categories showed no significant differences in beta diversity. Disease specificity was observed, but almost all the changes were only replicated in three studies, except for the increased Aerococcus in bacterial vaginosis (BV). Patients with major gynecological diseases shared the enrichment of Prevotella and depletion of Lactobacillus, and an overlap in microbes was implied between BV, cervical intraepithelial neoplasia, and cervical cancer. Conclusions: These findings demonstrated an association between alterations in gut and genital microbiota and gynecological diseases. The most observed results were shared alterations across diseases rather than disease-specific alterations. Therefore, further investigation is required to identify specific biomarkers for diagnosis and treatment in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery
- Published
- 2023
5. Online Education and Counseling Regarding Gynecological Examination
- Author
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Belma Toptas Acar, Principal Investigator
- Published
- 2023
6. Epidemiology of endometriosis in women of Arab ancestry
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Mousa, Mira, Zondervan, Krina, Rahmioglu, Nilufer, and Becker, Christian
- Subjects
Genetic epidemiology ,Epidemiology ,Women's and Reproductive Health ,Endometriosis ,Gynecological Disease - Abstract
Introduction: Investigating the epidemiology of endometriosis in women of Arab ancestry, in the context of regionally important environmental and genetic effects, will provide us with a better understanding on the endometriosis phenome across different populations. Under the following initiative, the Middle Eastern Women Research Association: the MAR'A project, the study aimed to investigate for the first time in women of Arab ancestry: (1) Associations of symptomatology, risk factors, phenotypic profile, and comorbidities with endometriosis (2) Assess the impact of endometriosis on health-related quality of life (HRQoL), work productivity, activity impairment, physical activity, and diagnostic delay (3) Conduct a candidate gene association study (CGAS) on variants in wingless-type MMTV integration site family member 4 (WNT4) and the Vezatin (VEZT) in women with endometriosis. Method: The MAR'A Project is a case-control study with multiple hospital and population-based sites across the United Arab Emirates, between August 2018 and August 2019. In total, 2,610 (518 endometriosis cases; 2092 controls) premenopausal women, aged 18-50 years, without a previous surgical diagnosis of endometriosis and self-reported ethnically Arab, were recruited. The study design of a case-control study compared incident endometriosis cases (n=518) with the following two comparison groups to evaluate potential risk factors: (1) ascertainment criteria (hospital controls (n=1251) vs. population controls (n=841)); and (2) symptomatic criteria (symptomatic controls (n=1331) vs. asymptomatic controls (n=761)). A subset of the samples (100 endometriosis cases and 100 hospital controls) was selected for the CGAS. Standardized, validated questionnaires, basic anthropometric measurements and saliva samples were collected from consenting participants. Results: (1) Women with endometriosis had a lower BMI and WHRadjBMI, reported a higher frequency of pain phenotypes (dysmenorrhea, chronic pelvic pain, dysuria, and dyschezia) with greater severity, earlier age of symptom onset, and higher pain catastrophizing score, in comparison to controls. Similar to the Western population studies, women with endometriosis had earlier age at menarche, shorter menstrual cycle, heavier menstrual flow, and longer duration of menstrual phase. Women with endometriosis had a higher frequency of miscarriages, ectopic pregnancy, preterm birth, and emergency caesarean section. (2) The average diagnostic delay was 11.61 years, with single women experiencing 15.81 years of diagnosis delay. HRQoL scores were significantly impaired in women with endometriosis, for both the Physical and Mental Composite Scores, affecting work productivity and activity impairment. (3) A significant association was observed for SNP rs12320196 (OR=1.60 (95% CI: 1.05, 2.45), p=0.027) intronic to the VEZT gene, and SNPs rs12037376 (OR=1.89 (95% CI: 1.06, 3.37), p=0.029) and rs3820282 (OR=1.90 (95% CI: 1.05, 3.46), p=0.033) intronic to the WNT4 gene. Conclusion: This study provided novel findings of the clinical presentation and risk factors of endometriosis among Arab women from a combined hospital and population-based sites. Along with the presence, duration and severity of the pain phenotypes, adverse reproductive outcomes, and comorbidities, Arab women experience among the highest diagnostic delay of endometriosis. Social exacerbation and cultural factors may influence management of endometriosis-associated pain, leading to psychological distress and significant impacts on HRQoL. Further research must be conducted among Arab women to improve early diagnosis and provide culturally sensitive clinical care.
- Published
- 2021
7. Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge
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Oszajca, Katarzyna and Adamus, Adrianna
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- 2024
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8. Association between red blood cell folate and Trichomonas vaginalis infection among women
- Author
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Wan-Zhe Liao, Zhi-Yi Zhou, Jun-Hao Mao, Zi-Xun Wang, Yi-Ming Hu, Yong-Fu Lou, Qiao-Rui Zheng, and Xu-Guang Guo
- Subjects
Trichomonas vaginalis ,RBC folate ,NHANES ,Multivariate regression models ,Gynecological disease ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan. Methods We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women. Results In the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups. Conclusions The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found.
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- 2023
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9. Arterial Hypertension in Women: State of the Art and Knowledge Gaps.
- Author
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Chapman, Niamh, Ching, Siew M., Konradi, Aleksandra O., Nuyt, Anne Monique, Khan, Taskeen, Twumasi-Ankrah, Betty, Cho, Eun J., Schutte, Aletta E., Touyz, Rhian M., Steckelings, U. Muscha, and Brewster, Lizzy M.
- Abstract
Hypertension is the leading risk factor for cardiovascular disease and premature death among women globally. However, there is a fundamental lack of knowledge regarding the sex-specific pathophysiology of the condition. In addition, risk factors for hypertension and cardiovascular disease unique to women or female sex are insufficiently acknowledged in clinical guidelines. This review summarizes the existing evidence on women and female-specific risk factors and clinical management of hypertension, to identify critical knowledge gaps relevant to research, clinical practice, and women's heart health awareness. Female-specific risk factors relate not only to reproduction, such as the association of gynecological conditions, adverse pregnancy outcomes or menopause with hypertension, but also to the specific roles of women in society and science, such as gender differences in received medical care and the underrepresentation of women in both the science workforce and as participants in research, which contribute to the limited evidence-based, gender- or sex-specific recommendations. A key point is that the development of hypertension starts in young, premenopausal women, often in association with disorders of reproductive organs, and therefore needs to be managed early in life to prevent future cardiovascular disease. Considering the lower blood pressure levels at which cardiovascular disease occurs, thresholds for diagnosis and treatment of hypertension may need to be lower for women. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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10. Association between red blood cell folate and Trichomonas vaginalis infection among women.
- Author
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Liao, Wan-Zhe, Zhou, Zhi-Yi, Mao, Jun-Hao, Wang, Zi-Xun, Hu, Yi-Ming, Lou, Yong-Fu, Zheng, Qiao-Rui, and Guo, Xu-Guang
- Subjects
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TRICHOMONAS vaginalis , *TRICHOMONIASIS , *ERYTHROCYTES , *FOLIC acid , *HEALTH & Nutrition Examination Survey - Abstract
Background: Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan. Methods: We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women. Results: In the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups. Conclusions: The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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11. Optimal Haloperidol Dose for Postoperative Nausea and Vomiting Prevention in High-risk Patients
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Young Eun Moon, clinical associate professor
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- 2020
12. Effects of subcutaneous drain on wound dehiscence and infection in gynecological midline laparotomy: Secondary analysis of a Korean Gynecologic Oncology Group study (KGOG 4001).
- Author
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Choi, Chel Hun, Kim, Nam Kyeong, Kim, Kidong, Lee, Yong Jae, Lee, Keun Ho, Lee, Jong-Min, Lee, Kwang Beom, Suh, Dong Hoon, Kim, Sunghoon, Kim, Min Kyu, Seong, Seok Ju, and Lim, Myong Cheol
- Subjects
SURGICAL wound dehiscence ,FEMALE reproductive organ diseases ,WOUND infections ,GYNECOLOGIC oncology ,ONCOLOGIC surgery - Abstract
To identify the effects of subcutaneous drain insertion on wound dehiscence and infection in patients who underwent gynecological midline laparotomy. This analysis identified the secondary endpoints of the KGOG 4001 study, a prospective, multicenter, non-blind, randomized controlled trial. Patients scheduled to undergo midline laparotomy for gynecological diseases and, with body mass index<35 kg/m
2 , were randomized (1:1) to treatment (with subcutaneous drain) and control (without subcutaneous drain) groups from February 2021 to December 2021. We compared the incidence rate of wound dehiscence 4 weeks post-surgery and the cumulative incidence rate of wound dehiscence and infection up to 4 weeks post-surgery between the two groups. Of 174 patients randomized to the treatment (n = 84) and control (n = 90) groups, 12 were excluded owing to loss to follow-up; finally, 162 patients (treatment, n = 79; control, n = 83) were included in intention-to-treat analysis. The frequency of cancer surgery (79.7 % vs. 77.1 %, p = 0.683), mean surgery time (227.7 vs. 226.7 min, p = 0.960), and mean wound length (24.2 vs. 24.3 cm, p = 0.933) were comparable between two groups. No significant differences were observed in the incidence rate of wound dehiscence 4 weeks post-surgery (1.3 % vs. 2.4 %, p > 0.999), cumulative incidence rate of wound dehiscence (8.9 % vs. 6.0 %, p = 0.491), and cumulative incidence rate of wound infection (1.3 % vs. 0.0 %, p = 0.488) up to 4 weeks post-surgery between the two groups. Subcutaneous drain insertion is not associated with a significant improvement in the incidence of wound dehiscence and infection in patients who undergo gynecological midline laparotomy. ClinicalTrials.gov, NCT04643197. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Endometriosis: A Disease with Few Direct Treatment Options.
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França, Patricia Ribeiro de Carvalho, Lontra, Anna Carolina Pereira, and Fernandes, Patricia Dias
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- *
ENDOMETRIOSIS , *PELVIS , *THERAPEUTICS - Abstract
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Notch signaling in reproduction.
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Moldovan, Genna E., Miele, Lucio, and Fazleabas, Asgerally T.
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FEMALE reproductive organs , *NOTCH signaling pathway , *MALE reproductive organs , *GENITALIA , *RECURRENT miscarriage - Abstract
The Notch signaling pathway is conserved among mammalian species and controls proliferation, differentiation, and cell death in many organs throughout the body including the reproductive tract. Notch signaling plays critical roles in the development and function of both the male and female reproductive systems. Specifically, within the female reproductive tract, Notch signaling is hormone regulated and mediates key reproductive events important for ovarian and uterine function. In this review, we highlight the tissues that express Notch receptors, ligands, and downstream effectors and distinguish how these molecules regulate reproductive function in male and female mice, non-human primates, and humans. Finally, we describe some of the aberrations in Notch signaling in female reproductive pathologies and identify opportunities for future investigation. The Notch signaling pathway is an important mediator of cell fate controlling cell proliferation, differentiation, and cell death. Notch signaling contributes to the reproductive function of the male and female reproductive organs. Notch signaling is hormonally regulated. The Notch signaling pathway is implicated in gynecological pathologies such as polycystic ovary syndrome, adenomyosis, endometriosis, pre-eclampsia, recurrent pregnancy loss and infertility, and endometrial cancer. [ABSTRACT FROM AUTHOR]
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- 2021
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15. Prevalence of Common Gynecological Conditions in the Middle East: Systematic Review and Meta-Analysis
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Mira Mousa, Moamar Al-Jefout, Habiba Alsafar, Shona Kirtley, Cecilia M. Lindgren, Stacey A. Missmer, Christian M. Becker, Krina T. Zondervan, and Nilufer Rahmioglu
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gynecological disease ,epidemiology ,global health ,Middle East ,polycystic ovary syndrome ,endometriosis ,Reproduction ,QH471-489 ,Medicine (General) ,R5-920 - Abstract
Introduction: High prevalence of gynecological conditions in women of Middle Eastern origin is reported, likely due to regional risk factors and mediators. The objective of this systematic review and meta-analysis is to investigate the prevalence of polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin.Methods: MEDLINE, EMBASE, PsycINFO, Global Health, and Google Scholar databases were searched from database inception until 14 February 2021 to identify relevant studies. Peer-reviewed research articles that reported the prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern population were written in English or Arabic. The primary outcome was the estimated pooled prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern populations. The secondary outcome was to assess the evidence in the data for the presence of heterogeneity, by conducting subtype-pooled analysis of prevalence estimates of the conditions. Total weighted prevalence was calculated via Freeman–Tukey arcsine transformation and heterogeneity through the I2 statistic. Quality control was performed using GRADE criteria.Results: A total of 47 studies, 26 on PCOS, 12 on endometriosis, eight on uterine fibroids, and seven on adenomyosis, were included. The pooled prevalence of PCOS diagnosed according to the NIH criteria was 8.9% (95% CI: 6.5–11.7; prevalence range: 4.0–27.6%), with a higher prevalence from the Gulf Arab states (18.8%, 95% CI: 9.5–30.3; range: 12.1–27.6%). According to the Rotterdam criteria, the pooled prevalence of PCOS was 11.9% (95% CI: 7.1–17.7; range: 3.4–19.9%) with studies limited to the Persian and Levant regions. Endometriosis was diagnosed in 12.9% (95% CI: 4.2–25.4; range: 4.2–21.0%) of women undergoing laparoscopy, for any indication. Uterine fibroid and adenomyosis prevalence of women was 30.6% (95% CI: 24.9–36.7; range: 18.5–42.6%) and 30.8% (95% CI: 27.1–34.6, range: 25.6–37.7%), respectively. Heterogeneity was present between studies due to statistical and methodological inconsistencies between studies, and quality of evidence was low due to sample size and unrepresentative participant selection.Conclusion: This is the first review that has reported the prevalence of gynecological diseases in the Middle Eastern population, suggesting that gynecological morbidity is a public health concern. Due to the health disparities in women, further research is required to understand the relative roles of environmental and genetic factors in the region to serve as a benchmark for evaluation and comparative purposes with other populations.
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- 2021
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16. Endometriosis: A Disease with Few Direct Treatment Options
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Patricia Ribeiro de Carvalho França, Anna Carolina Pereira Lontra, and Patricia Dias Fernandes
- Subjects
endometriosis ,gynecological disease ,inflammation ,drug therapy ,Organic chemistry ,QD241-441 - Abstract
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.
- Published
- 2022
- Full Text
- View/download PDF
17. Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats.
- Author
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Takiyama, Mikina, Matsumoto, Takashi, Sanechika, Sho, and Watanabe, Junko
- Abstract
Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecological diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of the pharmacological actions of shimotsuto is traditionally considered to be exerted by an improvement effect of the blood and the circulatory system. Multiple ingredients (e.g., catalpol and paeoniflorin) contained in shimotsuto have been reported to have pharmacological activities on the blood and circulatory system, and thus been considered to contribute to the pharmacological actions of shimotsuto. However, it remains unclear whether the ingredients can be absorbed into the body following oral administration of shimotsuto. The aim in the present study was to specify shimotsuto ingredient absorbed into the systemic circulation in rats. Seven candidate active ingredients (catalpol, paeoniflorin, albiflorin, ligustilide, senkyunolide A, butylphthalide, and ferulic acid) in plasma after oral administration of shimotsuto were quantified by targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis. This study also performed nontargeted LC–MS/MS analysis of plasma following administration of constituent crude drugs of shimotsuto to find extensively blood-absorbed ingredients of shimotsuto. Among detected peaks in the nontargeted analysis, two peaks could be identified as bergapten and 8-debenzoylpaeoniflorin, subsequently their concentrations in shimotsuto-treated rat plasma were quantified. These pharmacokinetic studies indicated that catalpol showed the highest plasma concentration following administration of shimotsuto, followed by 8-debenzoylpaeoniflorin. This study suggests that all nine ingredients are absorbed into the blood following oral administration of shimotsuto and possibly contribute to its pharmacological action. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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18. Development of the Blood Stasis Questionnaire for Gynecological Diseases: An Analytical Cross-Sectional Study.
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Kang BK, Jang S, Ko MM, and Jung J
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- Humans, Female, Cross-Sectional Studies, Middle Aged, Adult, Surveys and Questionnaires, Aged, Reproducibility of Results, Sensitivity and Specificity, Genital Diseases, Female diagnosis
- Abstract
Objectives: Blood stasis is the slowing or stagnation of blood and can cause metabolic, musculoskeletal, and gynecological diseases. This study developed the Blood Stasis Questionnaire for gynecological disease (BSQ-GD) by extracting clinical indicators related to gynecological diseases using the Blood Stasis Questionnaires I and II (BSQ-I and II, respectively) and analyzed the clinical data of a cross-sectional study., Patients and Methods: In total, 103 women aged between 25 and 65 years who met gynecological disease criteria were enrolled in this study. Blood stasis scores (BSS) were evaluated using the BSQ-II and categorized into BSS and non-BSS groups. To assess the reliability of BSQ-GD, the internal consistency coefficient was employed using Cronbach's α. Furthermore, correlation analyses were conducted for the clinical symptoms related to gynecological diseases, and the discriminant validity was confirmed by comparing the two groups. The prediction accuracy was determined using logistic regression and the cut-off value of the BSQ-GD was established via the sensitivity and specificity calculations., Results: The BSQ-GD showed satisfactory internal consistency (Cronbach's α coefficient = 0.71) and validity, with significant differences in mean scores between blood stasis (22.30 ± 3.34) and non-blood stasis (14.93 ± 3.49) groups. The cut-off value of the BSQ-GD score was 19 points when the Youden index (73.45) and the concordance probability (0.75) were at their maximum. The area under the receiver operating characteristic curve was approximately 96%, and the sensitivity and specificity of the diagnostic accuracy according to the cut-off value are 80.95% and 92.50%, respectively., Conclusion: The BSQ-GD can be an appropriate instrument to estimate blood stasis in patients with gynecological diseases; its diagnostic sensitivity according to the cut-off value is high., (© 2024 S. Karger AG, Basel.)
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- 2024
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19. The Molecular Basis of Adenomyosis Development
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Woo Sub Yang, Jeong Mook Lim, and Ji Yeon Ahn
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adenomyosis ,pathogenesis ,molecular mechanisms ,gynecological disease ,adenomyoma ,Biotechnology ,TP248.13-248.65 ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Adenomyosis is a benign gynecological disease frequently affecting women of reproductive age. It has a negative impact on the quality of life, causing bleeding disorders, dysmenorrhea, chronic pelvic pain, and infertility. However, the molecular mechanisms involved in adenomyosis development remain unclear. This paper summarizes the reports found in the MEDLINE database on the molecular mechanisms involved in the development and progression of uterine adenomyosis. The literature search included the following terms: “adenomyosis,” “adenomyoma,” “pathogenesis,” “molecular mechanisms,” and “gynecological disorders.” Only peer-reviewed, English-language journal articles were included. This review focuses on the molecular genetics, epigenetic modifications, and pivotal signaling pathways associated with adenomyosis development and progression, which will provide insights into and a better understanding of its underlying pathophysiology.
- Published
- 2018
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20. Chinese expert consensus on clinical application of female contraceptive methods
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Li-Nan Cheng, Wen Di, Yan Ding, Guang-Sheng Fan, Xiang-Ying Gu, Min Hao, Jing He, Li-Na Hu, Ke-Qin Hua, Wei Huang, Li Jin, Bei-Hua Kong, Jing-He Lang, Jin-Hua Leng, Jian Li, Cai-Xia Liu, Guan-Yuan Liu, Lei Song, Xiao-Ye Wang, Shang-Chun Wu, Min Xue, Hui-Xia Yang, Qing Yang, Shu-Zhong Yao, Zhen-Yu Zhang, Ying-Fang Zhou, and Lan Zhu
- Subjects
Contraceptive Methods ,Gynecological Disease ,Postabortion Contraception ,Postpartum Family Planning ,Unintended Pregnancy ,Immunologic diseases. Allergy ,RC581-607 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Unintended pregnancy is a global issue, with approximately 85,000,000 women around the world having unintended pregnancy annually. The contents of clinical application of women's contraceptive methods are very wide, involving multiple areas. This consensus deeply discusses the specific contraceptive needs at different statuses, combined with gynecological diseases, postabortion contraception, and postpartum family planning, ensuring the correct use of contraceptive methods under the corresponding status. The top priority of the consensus is the specific contraception consensus section for women combined with gynecological diseases because medical treatment effect as well as side effects should be weighed carefully. The consensus is to make high-efficiency and individual contraceptive strategy for different groups based on multidisciplinary (gynecology, obstetrics, and family planning) and multidimensional aspects, which can provide uniform guidance for medical and health organizations under the condition as relevant global guidance or consensus is still lacking.
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- 2018
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21. Sevoflurane, Propofol, Postoperative Pain
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Arvi Yli-Hankala, Professor
- Published
- 2013
22. Clinical application of serum anti‐Müllerian hormone as an ovarian reserve marker: A review of recent studies.
- Author
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Iwase, Akira, Osuka, Satoko, Goto, Maki, Murase, Tomohiko, Nakamura, Tomoko, Takikawa, Sachiko, and Kikkawa, Fumitaka
- Subjects
- *
INFERTILITY treatment , *OVARIAN diseases , *OVARIAN surgery , *AGING , *BIOMARKERS , *SEX hormones , *HUMAN reproductive technology , *MENOPAUSE , *POLYCYSTIC ovary syndrome , *STATISTICAL models , *OVARIAN reserve , *DIAGNOSIS - Abstract
Abstract: It has been more than 15 years since the measurement of serum anti‐Müllerian hormone (AMH) first allowed the quantitative assessment of ovarian reserve. Meanwhile, the clinical implication of serum AMH has been expanding. The measurement of serum AMH has been applied in various clinical fields, including assisted reproduction, menopause, reproductive disorders and assessment of ovarian damage/toxicity. Well‐known findings about the usefulness of serum AMH revealed by numerous studies executed in the early era include decline with aging, a good correlation with oocyte yield in assisted reproduction, upregulation in polycystic ovarian syndrome and a decrease on ovarian surgery and toxic treatment. More intensive research, including a meta‐analysis, cutting‐edge clinical trial and advances in AMH assays, has yielded newer findings and firmer clinical interpretations in serum AMH in the past few years. Variations in the AMH decline trajectory in the general population do not support the accurate prediction of menopause. The ability to predict pregnancy in infertility treatment and natural conception is poor, while a nomogram integrating serum AMH as a stimulation protocol is useful for avoiding poor and/or hyper‐responses. On the other hand, improvements in measuring very low concentrations of serum AMH may be capable of distinguishing women with poor ovarian function. Age‐independent standardization of AMH values may be helpful for comparing ovarian reserves among women at different ages. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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23. Epidemiology of endometriosis in women of Arab ancestry
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Mousa, M, Zondervan, K, Rahmioglu, N, and Becker, C
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Gynecological Disease ,Epidemiology ,Women's and Reproductive Health ,Endometriosis ,Genetic epidemiology - Abstract
Introduction Investigating the epidemiology of endometriosis in women of Arab ancestry, in the context of regionally important environmental and genetic effects, will provide us with a better understanding on the endometriosis phenome across different populations. Under the following initiative, the Middle Eastern Women Research Association: the MAR’A project, the study aimed to investigate for the first time in women of Arab ancestry: (1) Associations of symptomatology, risk factors, phenotypic profile, and comorbidities with endometriosis (2) Assess the impact of endometriosis on health-related quality of life (HRQoL), work productivity, activity impairment, physical activity, and diagnostic delay (3) Conduct a candidate gene association study (CGAS) on variants in wingless-type MMTV integration site family member 4 (WNT4) and the Vezatin (VEZT) in women with endometriosis. Method The MAR’A Project is a case-control study with multiple hospital and population-based sites across the United Arab Emirates, between August 2018 and August 2019. In total, 2,610 (518 endometriosis cases; 2092 controls) premenopausal women, aged 18-50 years, without a previous surgical diagnosis of endometriosis and self-reported ethnically Arab, were recruited. The study design of a case-control study compared incident endometriosis cases (n=518) with the following two comparison groups to evaluate potential risk factors: (1) ascertainment criteria (hospital controls (n=1251) vs. population controls (n=841)); and (2) symptomatic criteria (symptomatic controls (n=1331) vs. asymptomatic controls (n=761)). A subset of the samples (100 endometriosis cases and 100 hospital controls) was selected for the CGAS. Standardized, validated questionnaires, basic anthropometric measurements and saliva samples were collected from consenting participants. Results (1) Women with endometriosis had a lower BMI and WHRadjBMI, reported a higher frequency of pain phenotypes (dysmenorrhea, chronic pelvic pain, dysuria, and dyschezia) with greater severity, earlier age of symptom onset, and higher pain catastrophizing score, in comparison to controls. Similar to the Western population studies, women with endometriosis had earlier age at menarche, shorter menstrual cycle, heavier menstrual flow, and longer duration of menstrual phase. Women with endometriosis had a higher frequency of miscarriages, ectopic pregnancy, preterm birth, and emergency caesarean section. (2) The average diagnostic delay was 11.61 years, with single women experiencing 15.81 years of diagnosis delay. HRQoL scores were significantly impaired in women with endometriosis, for both the Physical and Mental Composite Scores, affecting work productivity and activity impairment. (3) A significant association was observed for SNP rs12320196 (OR=1.60 (95% CI: 1.05, 2.45), p=0.027) intronic to the VEZT gene, and SNPs rs12037376 (OR=1.89 (95% CI: 1.06, 3.37), p=0.029) and rs3820282 (OR=1.90 (95% CI: 1.05, 3.46), p=0.033) intronic to the WNT4 gene. Conclusion This study provided novel findings of the clinical presentation and risk factors of endometriosis among Arab women from a combined hospital and population-based sites. Along with the presence, duration and severity of the pain phenotypes, adverse reproductive outcomes, and comorbidities, Arab women experience among the highest diagnostic delay of endometriosis. Social exacerbation and cultural factors may influence management of endometriosis-associated pain, leading to psychological distress and significant impacts on HRQoL. Further research must be conducted among Arab women to improve early diagnosis and provide culturally sensitive clinical care.
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- 2022
24. Psychological Morbidity in Endometriosis: A Couple’s Study
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Maria da Graça Pereira, Filipa Osório, Cristina Nogueira-Silva, Ana C. Almeida, Inês Ribeiro, Helder Ferreira, and Universidade do Minho
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Infertility ,endometriosis ,Gynecological disease ,Patients ,Health, Toxicology and Mutagenesis ,Sexual Behavior ,Population ,Endometriosis ,Disease ,Personal Satisfaction ,Marital relationship ,Hospital Anxiety and Depression Scale ,patients ,Article ,03 medical and health sciences ,0302 clinical medicine ,5. Gender equality ,Intervention (counseling) ,Surveys and Questionnaires ,Adaptation, Psychological ,medicine ,Humans ,education ,psychological morbidity ,education.field_of_study ,Science & Technology ,030219 obstetrics & reproductive medicine ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,3. Good health ,Psychological morbidity ,Sexual Partners ,030220 oncology & carcinogenesis ,Medicine ,Female ,Morbidity ,partners ,business ,Partners ,Clinical psychology - Abstract
Endometriosis is a chronic gynecological disease that impacts more than 176 million women worldwide, having a strong impact on psychological morbidity. This study aimed to evaluate the contribution of psychological morbidity, in women with endometriosis, taking into consideration the duration of the couple’s relationship and the duration of the disease and also examine whether women’s sexual satisfaction had an impact on their psychological morbidity (actor effect) and on their sexual partners’ psychological morbidity (partner effect) and vice versa. Participants were 105 women and their partners, who answered the Hospital Anxiety and Depression Scale (HADS), Couple Satisfaction Index (CSI-4) and the Global Measure of Sexual Satisfaction (GMSEX). The results revealed a direct effect between the perception of symptom severity, marital satisfaction, and women’s psychological morbidity. Sexual activity and the presence of infertility had an indirect effect on the relationship between sexual satisfaction, diagnosis duration, and psychological morbidity, respectively. Finally, women’s sexual satisfaction had a direct effect on their own and partner’s marital satisfaction that predicted less psychological morbidity, in each. Thus, multidisciplinary interventions focused on the couple’s sexual and marital relationship, as well as illness representations, are needed to promote psychological well-being in this population.
- Published
- 2021
25. Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay
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Irene O Aninye, Stacey A. Missmer, Omar T Sims, and Jhumka Gupta
- Subjects
endometriosis ,Delayed Diagnosis ,Health, Toxicology and Mutagenesis ,Social Stigma ,Endometriosis ,Psychological intervention ,Stigma (botany) ,Review ,chronic pelvic pain ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,women’s health ,Health care ,Medicine ,Humans ,030212 general & internal medicine ,gynecological disease ,030219 obstetrics & reproductive medicine ,psychosocial well-being ,business.industry ,Pelvic pain ,Public Health, Environmental and Occupational Health ,medicine.disease ,diagnostic delay ,Mental health ,Mental Health ,stigma ,Quality of Life ,Female ,medicine.symptom ,business ,Psychosocial ,Clinical psychology - Abstract
Endometriosis is a chronic gynecological disease that affects approximately 1 in 10 women of reproductive age. Symptoms of severe pelvic pain, infertility, fatigue, and abnormal menstruation can cause significant negative effects on an individual’s physical and mental health, including interactions with their family, friends, and health care providers. Stigma associated with endometriosis has been under-studied and is rarely discussed in current literature. Herein, this paper aims to provide a brief overview of published literature to explore and establish the plausibility of stigma as a driver of suboptimal psychosocial well-being and diagnostic delay among individuals living with endometriosis. We present the clinical characteristics and physical and mental health consequences associated with endometriosis, highlight several theoretical constructs of stigma, and review the limited studies documenting women’s lived experiences of endometriosis-related stigma. To mitigate harmful effects of this phenomenon, we recommend increasing efforts to assess the prevalence of and to characterize endometriosis-related stigma, implementing awareness campaigns, and developing interventions that combat the multidimensional negative effects of stigma on timely care, treatment, and quality of life for individuals living with endometriosis.
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- 2021
26. Indoleamine 2,3-dioxygenase in endometriosis
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Ming-Qing Li and Hui-Li Yang
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lcsh:Immunologic diseases. Allergy ,lcsh:RC648-665 ,Gynecological disease ,business.industry ,Endometriosis ,Obstetrics and Gynecology ,3-Dioxygenase ,medicine.disease ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Reproductive Medicine ,Apoptosis ,medicine ,Cancer research ,Endocrine system ,Indoleamine 2,3-dioxygenase ,business ,lcsh:RC581-607 ,Pathological ,Intracellular ,Endometrial Stromal Cell ,Endometrial Stromal Cells ,Immunocytes ,Indoleamine 2 - Abstract
Endometriosis (EMS) is a chronic inflammatory and estrogen-dependent gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. Although it is a benign disease, EMS is tumor-like in several aspects, which include unrestrained growth, decreased apoptosis, and aggressive invasion. EMS involves endocrine disorders and immunological factors. Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that catalyzes the initial and rate-limiting step of the metabolism of tryptophan. IDO is a potential candidate facilitating EMS development. Increased IDO expression in both eutopic and ectopic endometria of women with EMS is biologically important in aspects, which include regulation of endometrial stromal cell function and modulation of adjacent local immunocytes to generate a supportive microenvironment. In turn, the expression of IDO can be regulated by the complex endocrine-immune microenvironment networks in endometrial lesions. Here, we systematically review the roles of IDO in EMS to explore its pathological implications and treatment potential.
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- 2019
27. Nanomedicines for Endometriosis: Lessons Learned from Cancer Research
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Ananiya A. Demessie, Abraham S. Moses, Olena Taratula, Ov D. Slayden, Oleh Taratula, and Tetiana Korzun
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Infertility ,medicine.medical_specialty ,Gynecological disease ,Endometriosis ,02 engineering and technology ,010402 general chemistry ,Pelvic Pain ,01 natural sciences ,Article ,Biomaterials ,Endometrium ,Neoplasms ,medicine ,Humans ,General Materials Science ,Intensive care medicine ,business.industry ,Pelvic pain ,Cancer ,General Chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,medicine.anatomical_structure ,Nanomedicine ,Female ,Uterine cavity ,medicine.symptom ,0210 nano-technology ,business ,Biotechnology - Abstract
Endometriosis is an incurable gynecological disease characterized by the abnormal growth of endometrium-like tissue, characteristic of the uterine lining, outside of the uterine cavity. Millions of people with endometriosis suffer from pelvic pain and infertility. This review aims to discuss whether nanomedicines that are promising therapeutic approaches for various diseases have the potential to create a paradigm shift in endometriosis management. For the first time, the available reports and achievements in the field of endometriosis nanomedicine are critically evaluated, and a summary of how nanoparticle-based systems can improve endometriosis treatment and diagnosis is provided. Parallels between cancer and endometriosis are also drawn to understand whether some fundamental principles of the well-established cancer nanomedicine field can be adopted for the development of novel nanoparticle-based strategies for endometriosis. This review provides the state of the art of endometriosis nanomedicine and perspective for researchers aiming to realize and exploit the full potential of nanoparticles for treatment and imaging of the disorder.
- Published
- 2021
28. Current assessment of the (dys)function of macrophages in endometriosis and its associated pain
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Nalini Santanam and Sarah Brunty
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Infertility ,medicine.medical_specialty ,Gynecological disease ,business.industry ,Peritoneal fluid ,Endometriosis ,Uterus ,Inflammation ,General Medicine ,Disease ,medicine.disease ,Gastroenterology ,Editorial Commentary ,medicine.anatomical_structure ,Internal medicine ,Etiology ,Medicine ,medicine.symptom ,business - Abstract
Endometriosis is a gynecological disease that affects 1 in 10 women worldwide and is characterized by the presence of lesions made up of endometrial cells (ECs) outside of the uterus. Symptoms associated with endometriosis include pain and infertility. It was realized in early last century that endometriosis is an inflammatory disease. Search for the mediators of this inflammation had been one of the key areas of research in understanding the etiology of this disease. Pioneering work by Halme, Olive, and Arici’s groups provided evidences for an inflammatory peritoneal milieu and the role for macrophages in endometriosis (1-3). Publications as early as in the 1980s showed that the peritoneal macrophages are present at higher levels in women with endometriosis-associated infertility when compared to infertile women due to causes other than endometriosis or normal women (4). Just a few years later, Badawy et al . also examined the peritoneal fluid (PF) of women with endometriosis and those who were infertile and showed that macrophages and lymphocytes were the dominant cells in their fluid. They also noted that prostaglandins, PGF2α, and PGE2 were also increased in the fluid (5).
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- 2019
29. The Molecular Basis of Adenomyosis Development
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Ji Yeon Ahn, Woo Sub Yang, and Jeong Mook Lim
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lcsh:R5-920 ,lcsh:Internal medicine ,Basis (linear algebra) ,pathogenesis ,lcsh:Biotechnology ,molecular mechanisms ,General Medicine ,Biology ,Bioinformatics ,medicine.disease ,adenomyoma ,adenomyosis ,lcsh:TP248.13-248.65 ,medicine ,Adenomyosis ,gynecological disease ,lcsh:Medicine (General) ,lcsh:RC31-1245 - Abstract
Adenomyosis is a benign gynecological disease frequently affecting women of reproductive age. It has a negative impact on the quality of life, causing bleeding disorders, dysmenorrhea, chronic pelvic pain, and infertility. However, the molecular mechanisms involved in adenomyosis development remain unclear. This paper summarizes the reports found in the MEDLINE database on the molecular mechanisms involved in the development and progression of uterine adenomyosis. The literature search included the following terms: “adenomyosis,” “adenomyoma,” “pathogenesis,” “molecular mechanisms,” and “gynecological disorders.” Only peer-reviewed, English-language journal articles were included. This review focuses on the molecular genetics, epigenetic modifications, and pivotal signaling pathways associated with adenomyosis development and progression, which will provide insights into and a better understanding of its underlying pathophysiology.
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- 2018
30. Serum Vascular Endothelial Growth Factor and Adiponectin Levels in Patients With Benign and Malignant Gynecological Diseases.
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Lasalandra, Carla, Coviello, Maria, Falco, Gaetano, Divella, Rosa, Trojano, Giuseppe, Laterza, Anna Maria, Quero, Carmela, Pepe, Vito, Zito, Francesco Alfredo, and Quaranta, Michele
- Abstract
One of the most specific and critical regulators of angiogenesis is vascular endothelial growth factor (VEGF), which regulates endothelial proliferation, permeability, and survival. Vascular endothelial growth factor is an angiogenic mediator in tumors and has been implicated in the pathogenesis and progression of cancer. Adipose tissue is a major endocrine and it secretes hormones termed adipokines. These factors are derived from adipocytes and include proteins and metabolites such as adiponectin. Recently, adiponectin was also shown to modulate angiogenesis. This study was designed to determine the serum VEGF and adiponectin levels in patients with benign and malignant gynecological diseases and if there was a correlation between serum VEGF and adiponectin.Serum samples, collected fasting before surgery or intervention, were available for total of 114 female patients recorded between October 2006 and December 2008. Diagnosis of benign and malignant gynaecological diseases was established by biopsy. Serum levels VEGF and adiponectin were using commercially available enzyme linked immunosorbent assay (R&D Systems Inc, Minneapolis, MN), respectively. Statistical analysis was performed by using the SPSS 9.0 software package (SPSS, Inc, Chicago, IL). The correlation between serum VEGF and serum Adiponectin was calculated using the Pearson correlation coefficient. P values of < 0.05 were considered statistically significant.Our results were analyzed on the basis of 2 different parameters: age and benign and malignant gynecological diseases of the patient. Only for serum VEGF levels was a significant difference observed (P = 0.004) between patients with benign and malignant gynecological diseases. A significantly inverse correlation between serum VEGF and adiponectin levels among patients with benign and malignant gynecological diseases was found. Adiponectin level is not correlated with body mass index.This is one of the first report on adiponectin in benign and malignant gynecological diseases. Future studies are needed to address the clinical potential role of adiponectin in cancer. [ABSTRACT FROM AUTHOR]
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- 2010
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31. PD/PDT for gynecological disease: A clinical review.
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Allison, R.R., Cuenca, R., Downie, G.H., Randall, M.E., Bagnato, V.S., and Sibata, C.H.
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PHOTOCHEMOTHERAPY ,DIGESTIVE system diseases ,PATIENTS ,DISEASES - Abstract
Summary: The evolution of diagnostic and interventional procedures for gynecologic disease has led to organ, sexual and reproductive sparing treatments. Photodiagnosis (PD) and photodynamic therapy (PDT) may play a great role for gynecological patients as both offer the potential to achieve these goals. PD/PDT for a wide variety of diagnostic and therapeutic interventions have shown potential for excellent clinical outcomes. However, significant limitations remains, both clinically and dosimetrically, that prevent consistent results. When those limitations are resolved PD/PDT could move to the forefront of gynecological therapy. This clinical review highlights the outcomes and shortcomings of PD/PDT through the peer reviewed literature for gynecological sites. [Copyright &y& Elsevier]
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- 2005
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32. Circular RNAs in gynecological disease: promising biomarkers and diagnostic targets
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Yunyun Li, Qin Zhou, and Jie Huang
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0301 basic medicine ,Genetic Markers ,Gynecological disease ,cervical cancer ,Biophysics ,Computational biology ,Review Article ,Biology ,Biochemistry ,Conserved sequence ,03 medical and health sciences ,0302 clinical medicine ,Transcription (biology) ,microRNA ,Animals ,Humans ,gynecological disease ,Molecular Biology ,Review Articles ,RNA ,Cell Biology ,RNA, Circular ,ovarian disease ,Tissue specificity ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,RNA, Long Noncoding ,Genital Diseases, Female ,Biogenesis ,Circular RNAs - Abstract
Circular RNAs (circRNAs) are a category of RNA molecules with covalently closed circles lacking both a 5′ cap and a 3′ tail. In recent years, circRNAs have attracted much attention and become a research hotspot of the RNA field following miRNAs and lncRNAs. CircRNAs exhibit tissue specificity, structural stability, and evolutionary conservation. Although the biological effects of circRNAs are still underestimated, many studies have shown that circRNAs have functions including regulation of transcription, translation into proteins and miRNA sponges. In this review, we briefly described the biogenesis and function of circRNAs and present circular transcripts in gynecological disease.
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- 2019
33. Phytotherapy in endometriosis An up-to-date review
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Ursula Catena, Maria Magliarditi, Michał Ciebiera, Zaki Sleiman, Giovanni Falzone, Luigi Della Corte, Simone Garzon, Calogero Salvaggio, Erbil Karaman, Marco Noventa, DELLA CORTE, Luigi, Noventa, Marco, Ciebiera, Michal, Magliarditi, Maria, Sleiman, Zaki, Karaman, Erbil, Catena, Ursula, Salvaggio, Calogero, Falzone, Giovanni, and Garzon, Simone
- Subjects
endometriosis ,Gynecological disease ,medicine.drug_class ,Endometriosis ,Disease ,flavonoids ,pharmacological treatments ,phytochemicals ,phytotherapy ,Bioinformatics ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Animals ,Humans ,endometriosis, flavonoids, pharmacological treatments, phytochemicals, phytotherapy ,Medicinal plants ,Plants, Medicinal ,030219 obstetrics & reproductive medicine ,business.industry ,medicine.disease ,Clinical trial ,Treatment Outcome ,Complementary and alternative medicine ,Estrogen ,030220 oncology & carcinogenesis ,Female ,Plant Preparations ,business ,Phytotherapy - Abstract
Endometriosis is a benign gynecological disease which symptoms can provide a severe impact on patient’s quality of life with subsequent impact on psychological well-being. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Nevertheless, the efficacy of conventional medical treatments is limited or intermittent in most of the patients due to the associated side effects. Therefore, a woman with endometriosis often search for additional and alternative options, and phytotherapy might be a promising alternative and complementary strategy. Different medicinal plants, multicomponent herbal preparations, and phytochemicals were investigated for pharmacological proprieties in endometriosis therapy. In most of the cases, the effect on endometriosis was related to phenolic compounds, such as flavonoids and phenolic acids reporting anti-inflammatory, proapoptotic, antioxidant, and immunomodulatory functions. Moreover, some phytochemicals have been related to a strong phytoestrogenic effect modulating the estrogen activity. Although promising, available evidence is based on in vitro and animal models of endometriosis with a limited number of well-performed clinical studies. There are almost none randomized control trials in this area. Therefore, properly constructed clinical trials are mandatory to achieve more conclusive results about the promising role of phytotherapy in the management of endometriosis.
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- 2019
34. Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China
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Xinlin Li, Zhong Lin, Danxia Wang, Xiaomin Yang, Xiongzhi Tang, Xiaoqing Ren, Fuyan Jiang, Ying Lan, Yanming Jiang, Zhi-jun Yang, Jinghua Gan, Meiying Li, Hua Bai, Lian Li, Junsong Jiang, Zhiying Lei, Xiaoyan Wu, Mei Liu, Yuan Ye, Qinmei Wang, Li Li, Xiaoxia Hu, Dingyuan Zeng, Hongying He, and Jiangtao Fan
- Subjects
Cancer Research ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Gynecological disease ,Traditional medicine ,Benign gynecological disease ,business.industry ,laparoscopic hysterectomy (LH) ,General surgery ,Laparoscopic hysterectomy ,Term (time) ,03 medical and health sciences ,0302 clinical medicine ,quality of life (QoL) ,Oncology ,Long term outcomes ,Medicine ,Original Article ,030212 general & internal medicine ,abdominal hysterectomy (AH) ,business ,Abdominal hysterectomy - Abstract
Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy (LH) compared with abdominal hysterectomy (AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies (3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time (OT), estimated blood loss (EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed. Results: The EBL (174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus (38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter (1.5±0.6 vs. 2.2±0.8 days), use of analgesics (6.5% vs. 73.1%), intra-operative complication rate (2.4% vs. 4.1%), post-operative complication rate (2.3% vs. 5.7%), post-operative constipation (12.1% vs. 24.6%), mild and serious stress urinary incontinence (SUI) post-operative (P
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- 2016
35. Peri- and postoperative changes in serum levels of four tumor markers and three acute phase reactants in benign and malignant gynecological diseases.
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Åvall-Lundqvist, E., Sjövall, K., Hansson, L., and Eneroth, P.
- Abstract
Serum levels of squamous cell carcinoma antigen, carcinoembryonic antigen, CA 125, tissue polypeptide antigen, CRP, α-antitrypsin and haptoglobin were determined peri- and postoperatively in patients undergoing surgery for benign gynecological disease ( n=18) and postoperatively in women operated for cervical carcinoma ( n=23). The only significant changes seen after premedication, during anesthesia and during surgery were a decrease in serum concentrations of α-antitrypsin and haptoglobin. We found no post-operative changes in the serum levels of squamous cell carcinoma antigen nor in carcinoembryonic antigen values. However, the latter analyte was influenced by smoking habits. Elevated levels of CA 125 and tissue polypeptide antigen were found in the cancer patients, predominantly within the first 1-3 weeks after surgery. These levels decreased to normal values within 4-6 weeks postoperatively. The median intraindividual coefficients of variation for the tumor markers ranged between 15% and 28% in 30 control women not having surgery. In general, it would seem advisable to wait 6 weeks after surgery before monitoring with CA 125 and TPA is started. [ABSTRACT FROM AUTHOR]
- Published
- 1992
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36. The Effect of Anterior Uterocervical Angle on Primary Dysmenorrhea and Disease Severity
- Author
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Gökhan Açmaz, Erdem Sahin, Yusuf Madendag, Ahter Tanay Tayyar, Ilknur Col Madendag, Mefkure Eraslan Sahin, Iptisam Ipek Muderris, and Fatma Ozdemir
- Subjects
Adult ,medicine.medical_specialty ,Gynecological disease ,Adolescent ,Article Subject ,Pain ,Body Mass Index ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Disease severity ,Quality of life ,Dysmenorrhea ,Internal medicine ,Secondary dysmenorrhea ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Family history ,lcsh:R5-920 ,030219 obstetrics & reproductive medicine ,business.industry ,Uterus ,Anesthesiology and Pain Medicine ,Neurology ,Menstrual cramps ,Quality of Life ,Female ,medicine.symptom ,business ,lcsh:Medicine (General) ,Body mass index ,Research Article - Abstract
Background. Primary dysmenorrhea, defined as painful menstrual cramps originating in the uterus without underlying pathology, is a gynecological disease that affects quality of life and school success. Our goal was to determine the effect of anterior uterocervical angle on primary dysmenorrhea and disease severity. Methods. A total of 200 virgin adolescents, 16 to 20 years of age, were included in the study. The Andersch and Milsom scale was used to determine dysmenorrhea severity. Those with pathologies causing secondary dysmenorrhea were excluded from the study. Study subjects were grouped based on severity of pain. Demographic characteristics and uterocervical ultrasonographic measurements were compared among groups. Results. Of the 200 participants enrolled in the study, 50 were healthy controls and 150 had primary dysmenorrhea. Those with primary dysmenorrhea had a significant family history of primary dysmenorrhea compared with controls (P<0.001). Age (P=0.668), body mass index (P=0.898), menarche age (P=0.915), and length of menstrual cycles (P=0.740) were similar in all groups. The uterine corpus longitudinal axis, uterine corpus transverse axis, and uterine cervix longitudinal axis were also similar (P=0.359, P=0.279, and P=0.369, resp.). The mean uterocervical angle was 146.8 ± 6.0 in controls and 143.3 ± 7.3 in those with mild pain with no significant difference between the groups. In those with moderate pain, the mean uterocervical angle was 121.2 ± 7.3 compared with 101 ± 9.2 in those with severe pain, which was a significant difference. Additionally, there was also a significant difference in the uterocervical angle among those with mild, moderate, and severe pain (P<0.001). Conclusion. Our results indicate that a narrower anterior uterocervical angle is associated with primary dysmenorrhea and disease severity.
- Published
- 2018
37. Treatment options and reproductive outcome for adenomyosis-associated infertility
- Author
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Roberto Marci, Nicola Pluchino, Jean-Marie Wenger, and Ilaria Soave
- Subjects
Infertility ,medicine.medical_specialty ,Gynecological disease ,uterus-sparing surgery ,Socio-culturale ,adenomyoma ,adenomyosis ,assisted reproduction ,infertility ,ivf ,medicine (all) ,Diagnostic tools ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Adenomyosis ,Adenomyoma ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Medicine (all) ,Treatment options ,General Medicine ,medicine.disease ,humanities ,Treatment Outcome ,IVF ,030220 oncology & carcinogenesis ,Female ,business ,Infertility, Female - Abstract
Adenomyosis is a benign gynecological disease mostly diagnosed in the forth and fifth decades. The recent improvement of the diagnostic tools and a better understanding of the pathology allowed clinicians to postulate a possible relationship between adenomyosis and infertility and to diagnose it in younger asymptomatic women during infertility work-up. Purpose of this article is to review the different theories regarding the possible correlation between adenomyosis and infertility and to discuss the treatment options and the final reproductive outcome after the treatment.We search Pubmed for articles published in the English language with the use of the following MeSH search terms: "adenomyosis" combined with "treatment" and "fertility outcome" with the restriction to the human species. A manual search of review articles and cross-references completed the search. All selected articles were assessed for study design, patients characteristic, diagnosis of adenomyosis, type of treatment, post-treatment rates of conception, full-term pregnancy and completeness of information of the data sets.Limited data are available concerning the efficacy of the different treatment options of adenomyosis on fertility outcome and the only ones published are retrospective evaluations or small case series.Adenomyosis represents a common gynecological disorder with a negative impact on fertility. However, it remains challenging to establish if adenomyosis is the only cause of the infertility or not, because patients, in both case and control groups, may be affected by concomitant endometriosis. Further studies are required to determine the reason of implantation failure in women with adenomyosis and the impact of adenomyosis on infertile women with or without endometriosis.
- Published
- 2018
38. A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil
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Paes Marcela F, Daltoé Renata D, Madeira Klesia P, Rezende Lucas CD, Sirtoli Gabriela M, Herlinger Alice L, Souza Leticia S, Coitinho Luciana B, Silva Débora, Cerri Murilo F, Chiaradia Ana Cristina N, Carvalho Alex A, Silva Ian V, and Rangel Leticia BA
- Subjects
ovarian neoplasias ,Espírito Santo ,retrospective study ,clinical outcome ,gynecological disease ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Ovarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impact in public economy, Brazil still lacks valuable information concerning epidemiological aspects of this disease Methods We've compiled clinical data of all ovarian tumors registered at the two public hospitals of reference (1997 - 2007), such as: patients' age at diagnosis, tumor histological type, tumor stage, chemotherapy regimens, chemotherapy responsiveness, disease-free survival, and overall survival. Results Women's mean age at diagnosis was 54.67 ± 13.84 for ovarian cancer, 46.15 ± 11.15 for borderline tumors, and 42.01 ± 15.06 for adenomas. Among epithelial ovarian cancer cases, 30.1% were of serous, 13.7% were of mucinous, and 13.7% were of endometrioid type; exceptionally serous carcinoma was diagnosed in women younger than 30 years old. Endometrioid cancer had lower disease-free survival than others (p < 0.05). Cases were predominantly diagnosed as poor prognosis disease (FIGO III and IV, 56.2%). Regarding responsiveness to platinum-based therapy, 17.1% of patients were resistant, whereas 24.6%, susceptible. From these, we found equally responsiveness to platinum alone or its association with paclitaxel or cyclophosphamide. Discussion Our data agreed with other studies regarding mean patients' age at diagnosis, histological type frequency, FIGO stages distribution, and chemotherapy regimens. However, the histological type distribution, with equal contribution of mucinous and endometrioid types seems to be a unique characteristic of the studied highly miscegenated population. Conclusion We have enlighten the profile of the studied ovarian cancer population, which might enable the development of more efficient political strategies to control this malignancy that is the fifth leading cause of cancer-related deaths among women.
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- 2011
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39. Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay.
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Sims OT, Gupta J, Missmer SA, and Aninye IO
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- Female, Humans, Mental Health, Quality of Life, Social Stigma, Delayed Diagnosis, Endometriosis diagnosis, Endometriosis epidemiology
- Abstract
Endometriosis is a chronic gynecological disease that affects approximately 1 in 10 women of reproductive age. Symptoms of severe pelvic pain, infertility, fatigue, and abnormal menstruation can cause significant negative effects on an individual's physical and mental health, including interactions with their family, friends, and health care providers. Stigma associated with endometriosis has been under-studied and is rarely discussed in current literature. Herein, this paper aims to provide a brief overview of published literature to explore and establish the plausibility of stigma as a driver of suboptimal psychosocial well-being and diagnostic delay among individuals living with endometriosis. We present the clinical characteristics and physical and mental health consequences associated with endometriosis, highlight several theoretical constructs of stigma, and review the limited studies documenting women's lived experiences of endometriosis-related stigma. To mitigate harmful effects of this phenomenon, we recommend increasing efforts to assess the prevalence of and to characterize endometriosis-related stigma, implementing awareness campaigns, and developing interventions that combat the multidimensional negative effects of stigma on timely care, treatment, and quality of life for individuals living with endometriosis.
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- 2021
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40. Sparganii Rhizoma: A review of traditional clinical application, processing, phytochemistry, pharmacology, and toxicity.
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Jia, Jia, Li, Xiang, Ren, Xueyang, Liu, Xiaoyun, Wang, Yu, Dong, Ying, Wang, Xiaoping, Sun, Siqi, Xu, Xiao, Li, Xiao, Song, Ruolan, Ma, Jiamu, Yu, Axiang, Fan, Qiqi, Wei, Jing, Yan, Xin, Wang, Xiuhuan, and She, Gaimei
- Subjects
- *
DRUG toxicity , *FEMALE reproductive organ diseases , *HEALTH , *MEDICINAL plants , *MEDICAL research , *CHINESE medicine , *PHARMACOLOGY , *PHARMACY information services , *REFERENCE books , *PLANT roots , *INFORMATION resources , *DRUG development , *PHYTOCHEMICALS , *PLANT extracts ,THERAPEUTIC use of plant extracts - Abstract
Sparganii Rhizoma (SR), a traditional Chinese medicine (TCM), is the rhizome of Sparganium stoloniferum Buch.-Ham. mainly distributed in East Asia. It has been used for eliminating blood stasis, promoting the flow of Qi, removing the retention of undigested food and relieving pain in China for hundreds of years. This review summarizes comprehensive information in traditional clinical application, processing, phytochemistry, pharmacology, quality control and toxicity of SR, in exploring future scientific and therapeutic potentials. Pertinent information was systematically collected from several electronic scientific databases (e.g., Web of Science, PubMed, China Knowledge Resource Integrated, Springer, Elsevier, ScienceDirect, and Google Scholar), PhD and MS dissertations, and classic Chinese medical books. SR is a gynecological drug which is often used to treat dysmenorrhea, mass in the abdomen, amenorrhea due to blood stasis, and abdominal distension in TCM. Two kinds of processed products of SR are included in Chinese Pharmacopoeia, which have better pharmacological effects than the crude herb. Approximately 180 compounds have been identified from SR, including phenylpropanoids, flavonoids, anthraquinones, organic acids, alkaloids, steroids, volatile oils, diarylheptanes, etc. The crude extracts and isolated components of SR have been reported to have anti-tumor, antithrombotic, estrogen antagonistic , anti-inflammatory, analgesic, antioxidant, anti organ fibrosis and other pharmacological activities. SR also has reproductive toxicity. As an important TCM, SR has been demonstrated by modern pharmacological researches to have significant bioactivities, especially on anti-tumor, antithrombotic, and estrogen antagonistic activities. These activities provide prospects for the development of new drugs and therapeutics for future applications. Nevertheless, quality control and evaluation, in-depth pharmacological mechanism, and toxicological effect of SR require further detailed research. Image 1 [ABSTRACT FROM AUTHOR]
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- 2021
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41. Prevalence of Common Gynecological Conditions in the Middle East: Systematic Review and Meta-Analysis.
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Mousa M, Al-Jefout M, Alsafar H, Kirtley S, Lindgren CM, Missmer SA, Becker CM, Zondervan KT, and Rahmioglu N
- Abstract
Introduction: High prevalence of gynecological conditions in women of Middle Eastern origin is reported, likely due to regional risk factors and mediators. The objective of this systematic review and meta-analysis is to investigate the prevalence of polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin. Methods: MEDLINE, EMBASE, PsycINFO, Global Health, and Google Scholar databases were searched from database inception until 14 February 2021 to identify relevant studies. Peer-reviewed research articles that reported the prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern population were written in English or Arabic. The primary outcome was the estimated pooled prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern populations. The secondary outcome was to assess the evidence in the data for the presence of heterogeneity, by conducting subtype-pooled analysis of prevalence estimates of the conditions. Total weighted prevalence was calculated via Freeman-Tukey arcsine transformation and heterogeneity through the I
2 statistic. Quality control was performed using GRADE criteria. Results: A total of 47 studies, 26 on PCOS, 12 on endometriosis, eight on uterine fibroids, and seven on adenomyosis, were included. The pooled prevalence of PCOS diagnosed according to the NIH criteria was 8.9% (95% CI: 6.5-11.7; prevalence range: 4.0-27.6%), with a higher prevalence from the Gulf Arab states (18.8%, 95% CI: 9.5-30.3; range: 12.1-27.6%). According to the Rotterdam criteria, the pooled prevalence of PCOS was 11.9% (95% CI: 7.1-17.7; range: 3.4-19.9%) with studies limited to the Persian and Levant regions. Endometriosis was diagnosed in 12.9% (95% CI: 4.2-25.4; range: 4.2-21.0%) of women undergoing laparoscopy, for any indication. Uterine fibroid and adenomyosis prevalence of women was 30.6% (95% CI: 24.9-36.7; range: 18.5-42.6%) and 30.8% (95% CI: 27.1-34.6, range: 25.6-37.7%), respectively. Heterogeneity was present between studies due to statistical and methodological inconsistencies between studies, and quality of evidence was low due to sample size and unrepresentative participant selection. Conclusion: This is the first review that has reported the prevalence of gynecological diseases in the Middle Eastern population, suggesting that gynecological morbidity is a public health concern. Due to the health disparities in women, further research is required to understand the relative roles of environmental and genetic factors in the region to serve as a benchmark for evaluation and comparative purposes with other populations., Competing Interests: SM has been a member of advisory/scientific boards for AbbVie. CB reports grant from Bayer AG, others from AbbVie Inc., grants from Volition Rx, grants from MDNA Life Sciences, grants from Roche Diagnostics Inc., nonfinancial support from Population Diagnostics Ltd, others from ObsEva, and others from Flo Health, outside the submitted work. KZ reports grants from Bayer Healthcare, MDNA Life Sciences, Roche Diagnostics Inc., Volition Rx, and Evotec (Lab282 - Partnership program with Oxford University), nonfinancial support from AbbVie Ltd, all outside the submitted work, and is a Board member (Secretary) of the World Endometriosis Society and World Endometriosis Research Foundation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Mousa, Al-Jefout, Alsafar, Kirtley, Lindgren, Missmer, Becker, Zondervan and Rahmioglu.)- Published
- 2021
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42. Cervical cancer screening in young and elderly women of the Xingu Indigenous Park: evaluation of the recommended screening age group in Brazil
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Juliana da Silva Pinheiro, Gustavo Rubino de Azevedo Focchi, Douglas Rodrigues, Erica Ribeiro Pereira, Neila Maria de Góis Speck, and Julisa Chamorro Lascasas Ribalta
- Subjects
Gerontology ,Gynecological disease ,lcsh:Medicine ,Uterine Cervical Neoplasms ,Cervical cancer screening ,Rastreamento ,Risk Factors ,Neoplasms ,Atypia ,Mass Screening ,Child ,Early Detection of Cancer ,Female population ,Cervical cancer ,education.field_of_study ,Artigo Original ,Age Factors ,General Medicine ,Indigenous population ,Neoplasias ,Colposcopy ,Screening ,Female ,Original Article ,Christian ministry ,Brazil ,Adult ,medicine.medical_specialty ,Vaginal Neoplasms ,Adolescent ,Population ,Indigenous ,Young Adult ,Age Distribution ,Population Groups ,medicine ,Humans ,education ,Aged ,Retrospective Studies ,Vaginal Smears ,População indígena ,Colo do útero/patologia ,business.industry ,lcsh:R ,Carcinoma ,Grupos etários ,medicine.disease ,Family medicine ,Age groups ,business ,Cervix uteri/pathology - Abstract
Objective To analyze the occurrence of atypia in the cytology/histology examinations of young women under the age of 25 years and of elderly women aged over 64 years, in the Xingu Indigenous Park and to evaluate, in a subjective manner, if the age range for screening established by the Ministry of Health and the Instituto Nacional de Câncer is appropriate for this population. Methods The Xingu/UNIFESP Project, in partnership with the Center for Gynecological Disease Prevention, develops programs to prevent cervical cancer. The exploratory, retrospective and descriptive study of cytological and histopathological examinations of young (12-24 years) and elderly (aged 64 and over) women of the Xingu Indigenous Park, between 2005 and 2011. Results There was low occurrence of cytological atypia in the elderly female population, but there were occasional high-grade lesions in the indigenous youth. Conclusion Interrupting screening at the limit age of 64 years, as established by the Ministry of Health and the Instituto Nacional de Câncer is justified. However, screening of young women should begin at an earlier age. Objetivo Analisar a ocorrência de atipias nos exames citológicos e histológicos de jovens e idosas indígenas, e também avaliar se a faixa etária preconizada pelo Ministério da Saúde e pelo Instituto Nacional de Câncer em rastreamento do câncer de colo uterino é adequada para essa população. Métodos O Projeto Xingu/UNIFESP, em parceria com o Núcleo de Prevenção de Doenças Ginecológicas, desenvolve programas de prevenção do câncer do colo de útero. Foi realizado estudo exploratório, retrospectivo e descritivo de exames cito/histopatológicos em jovens do Parque Indígena do Xingu de 12 a 24 anos e em idosas a partir dos 64 anos, no período de 2005 a 2011. Resultados Em idosas, houve baixa ocorrência de atipias citológicas, mas nas jovens indígenas, ocorreram casos eventuais de lesão de alto grau. Conclusão Justifica respeitar o limite de 64 anos para a interrupção do rastreamento, como o estabelecido pelo Ministério da Saúde/Instituto Nacional de Câncer, mas, nas jovens, seria importante iniciar o rastreamento mais precocemente.
- Published
- 2015
43. Somatic Stem Cells and Their Dysfunction in Endometriosis
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Djokovic, Dusan, Calhaz-Jorge, Carlos, and Repositório da Universidade de Lisboa
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endometriosis ,endocrine system ,Gynecological disease ,business.industry ,pathogenesis ,lcsh:Surgery ,Endometriosis ,Diagnostic test ,lcsh:RD1-811 ,English language ,Disease ,Bioinformatics ,medicine.disease ,endometriosis markers ,somatic stem cells ,drug target ,Pathogenesis ,Medicine ,Hormonal therapy ,Surgery ,business ,Adult stem cell - Abstract
Copyright: © 2015 Djokovic and Calhaz-Jorge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms., Emerging evidence indicates that somatic stem cells (SSCs) of different types prominently contribute to endometrium-associated disorders such as endometriosis. We reviewed the pertinent studies available on PubMed, published in English language until December 2014 and focused on the involvement of SSCs in the pathogenesis of this common gynecological disease. A concise summary of the data obtained from in vitro experiments, animal models, and human tissue analyses provides insights into the SSC dysregulation in endometriotic lesions. In addition, a set of research results is presented supporting that SSC-targeting, in combination with hormonal therapy, may result in improved control of the disease, while a more in-depth characterization of endometriosis SSCs may contribute to the development of early-disease diagnostic tests with increased sensitivity and specificity. Key message: Seemingly essential for the establishment and progression of endometriotic lesions, dysregulated SSCs, and associated molecular alterations hold a promise as potential endometriosis markers and therapeutic targets.
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- 2015
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44. Effect of Jingqian Zhitong Fang on Serum Sex Hormone Levels in Women with Primary Dysmenorrhea
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Na Dai, Ju Yin, Ling Fang, Yu-bo Li, Yuming Wang, and Bao-chan Pu
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medicine.medical_specialty ,biology ,Gynecological disease ,Article Subject ,business.industry ,media_common.quotation_subject ,Therapeutic effect ,lcsh:Other systems of medicine ,lcsh:RZ201-999 ,Sex hormone-binding globulin ,Endocrinology ,Complementary and alternative medicine ,Internal medicine ,biology.protein ,Medicine ,business ,Luteinizing hormone ,Testosterone ,Menstrual cycle ,Hormone ,media_common ,Western medicine ,Research Article - Abstract
Primary dysmenorrhea is a common gynecological disease garnering increasing attention and research. To investigate the clinical therapeutic effects of Jingqian Zhitong Fang (JQF) and the differences in serum sex hormone levels during the treatment of primary dysmenorrhea, we selected 30 healthy volunteers and 60 individuals with primary dysmenorrhea. On the third day of the menstrual cycle, we used ELISA to determine the levels of serum prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TEST), progesterone (PROG), and estradiol (E2) compared with normal levels and levels in the JQF group, the Western medicine group receiving continuous treatment during the first and third menstrual cycles, and the group followed up after the drug was stopped. We observed that after JQF treatment, the levels of the following hormones changed significantly: PRL, LH, TEST, and E2levels decreased significantly and the PROG level increased significantly after treatment. After treatment with Western medicine, the serum levels of FSH, LH, PROG, and E2showed no significant change. We conclude that the long-term effect of JQF treatment was better than that of Western medicine. JQF treatment of primary dysmenorrhea is related to adjustment of PRL, LH, TEST, and E2 hormone levels in the human body.
- Published
- 2014
45. Circular RNAs in gynecological disease: promising biomarkers and diagnostic targets.
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Huang J, Zhou Q, and Li Y
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- Animals, Female, Humans, MicroRNAs genetics, RNA, Long Noncoding genetics, Genetic Markers genetics, Genital Diseases, Female genetics, RNA, Circular genetics
- Abstract
Circular RNAs (circRNAs) are a category of RNA molecules with covalently closed circles lacking both a 5' cap and a 3' tail. In recent years, circRNAs have attracted much attention and become a research hotspot of the RNA field following miRNAs and lncRNAs. CircRNAs exhibit tissue specificity, structural stability, and evolutionary conservation. Although the biological effects of circRNAs are still underestimated, many studies have shown that circRNAs have functions including regulation of transcription, translation into proteins and miRNA sponges. In this review, we briefly described the biogenesis and function of circRNAs and present circular transcripts in gynecological disease., (© 2019 The Author(s).)
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- 2019
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46. Robotically Assisted Hysterectomy versus Vaginal Hysterectomy for Benign Disease: A Prospective Study
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G. Hamdi, A. Jnifen, H. Abbou, J. M. Ayoubi, M. Carbonnel, H. T. N’Guyen, and S. Roy
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medicine.medical_specialty ,Hysterectomy ,Gynecological disease ,Benign disease ,Article Subject ,business.industry ,medicine.medical_treatment ,lcsh:Surgery ,lcsh:RD1-811 ,Surgery ,Blood loss ,Laparotomy ,Hysterectomy vaginal ,medicine ,Clinical Study ,Operative time ,Prospective cohort study ,business - Abstract
Objectives. A prospective study was carried out to compare vaginal hysterectomy (VH) and robotically assisted hysterectomy (RH) for benign gynecological disease.Materials and Methods. All patients who underwent hysterectomy from March 2010 to March 2012 for a benign disease were included. Patients’ demographics per and post surgery results were collected from medical files. A questionnaire was also conducted 2 months after surgery.Results. Sixty patients were included in the RH group and thirty four in the VH one. Operative time was significantly longer in the RH group ( versus min; ). Blood loss and length of hospital stay were significantly reduced: versus ml; , and versus days; , respectively. Less pain was reported at D1 and D2 by RH patients, and levels of analgesia were lower compared to those observed in the VH group. No differences were found regarding the rate of conversion to laparotomy, intra- or postoperative complications.Conclusion. Robotically assisted hysterectomy appears to reduce blood loss, postoperative pain, and length of hospital stay, but it is associated with longer operative time and higher cost. Specific indications for RH remain to be defined.
- Published
- 2013
47. Imaging of gynecological disease (4): clinical and ultrasound characteristics of struma ovarii
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Luca Savelli, Lil Valentin, Dirk Timmerman, Antonia Carla Testa, Dario Paladini, Otto Ljungberg, Savelli, L, Testa, Ac, Timmerman, D, Paladini, Dario, Ljungberg, O, and Valentin, L.
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Adult ,medicine.medical_specialty ,Gynecological disease ,White ball ,Pattern Recognition, Automated ,Ovarian tumor ,Young Adult ,Histological diagnosis ,medicine ,Biomarkers, Tumor ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Doppler, Color ,ovaries ,Aged ,Dermoid Cyst ,Gynecology ,Aged, 80 and over ,Ovarian Neoplasms ,Radiological and Ultrasound Technology ,Struma ovarii ,business.industry ,ultrasound ,Ultrasound ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Struma Ovarii ,Settore MED/40 - GINECOLOGIA E OSTETRICIA ,Reproductive Medicine ,Dermoid cyst ,Female ,Teratoma ,business - Abstract
Objectives To describe the clinical history and ultrasound findings in women with struma ovarii. Methods Women with a histological diagnosis of struma ovarii who bad undergone preoperative ultrasound examination were identified front the databases of five ultrasound centers. The tumors were characterized on the basis of ultrasound images,, ultrasound reports and research protocols (when applicable) using the terms and definitions of the International Ovarian Tumor Analysis (IOTA) group. In addition, four authors reviewed all ultrasound images and described them using pattern recognition. Results Of 31 patients identified, 16 bad pure struma ovarii (one malignant), whereas in 15 patients the struma ovarii were 'impure', constituting the major part of a dermoid cyst (all benign, bilateral in one case). Median age was 40 (range, 18-80) years and 22 (71%) patients were of fertile age. Thirteen patients (42%) were asymptomatic, nine (29%) presented with pain, six (19%) with bloating, two (6%) with irregular bleeding and one (3%) with thyreotoxicosis. Most pure struma ovarii (11/16 cases, 69%) contained solid components, but cystic components were always present. The color content at Doppler examination varied front none to abundant. Four patients had ascites. Using pattern recognition the most specific feature of pure struma ovarii was the 'struma pearl', i.e. a smooth roundish solid area, similar, but not identical, to the 'round white ball' seen in dermoid cysts. 'Struma pearls' were present in six cases of Pure struma ovarii. Most (10116, 63%) cases of impure struma ovarii manifested ultrasound features compatible with a dermoid cyst, but six manifested ultrasound features similar to those of pure struma ovarii, 'struma pearls' being seen in three of these. Conclusions The sonographic features of struma ovarii vary. Struma ovarii may be suspected when a 'struma pearl' is seen. Whether 'struma pearls' are indeed a specific ultrasonographic feature of struma ovarii needs to be determined in a prospective study. Copyright (C) 2008 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
- Published
- 2008
48. The promise and reality of the intrauterine route for hormone delivery for prevention and therapy of gynecological disease
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Fraser, Ian S.
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- *
PROGESTATIONAL hormones , *INTRAUTERINE contraceptives , *FEMALE reproductive organ diseases , *MYOMETRIUM , *DISEASES - Abstract
Abstract: Context: Progestins delivered by a variety of routes have been demonstrated, in addition to their high contraceptive effect, to have substantial benefits in the treatment of various gynecological disorders, and the intrauterine route has particular efficacy in treating endometrial and myometrial disorders. It should be possible to extend this to prevention of disease. Therapy of Gynecological Disease: Those conditions for which there is most evidence of therapeutic benefit from intrauterine release of progestins include heavy menstrual bleeding (due to most causes), endometrial hyperplasia, endometriosis and adenomyosis. Prevention of Gynecological Disease: Reasonable evidence exists to support the findings that intrauterine levonorgestrel helps to prevent the development of uterine fibroids, endometriosis, endometrial hyperplasia, acute episodes of pelvic infection and a wide range of menstrual symptoms. There is also promise of prevention of endometrial carcinoma, endometrial polyps, infertility and perhaps adenomyosis. Conclusions: There is a need for specific studies to further explore the prevention of these gynecological conditions which can cause major health disturbances and community distress. [Copyright &y& Elsevier]
- Published
- 2007
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49. A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil
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Leticia Ba Rangel, Luciana B Coitinho, Alex Assis de Carvalho, Letícia Soncini Souza, Murilo F. Cerri, Alice Laschuk Herlinger, Klesia Pirola Madeira, Gabriela Modenesi Sirtoli, Renata Dalmaschio Daltoé, Débora Silva, Marcela F. Paes, Ian Victor Silva, Lucas Cd Rezende, and Ana Cristina Nascimento Chiaradia
- Subjects
Oncology ,medicine.medical_specialty ,Espírito Santo ,endocrine system diseases ,Serous carcinoma ,retrospective study ,Population ,clinical outcome ,Malignancy ,lcsh:Gynecology and obstetrics ,ovarian neoplasias ,Internal medicine ,Obstetrics and Gynaecology ,medicine ,gynecological disease ,education ,lcsh:RG1-991 ,Cause of death ,Gynecology ,education.field_of_study ,business.industry ,Research ,Mortality rate ,Obstetrics and Gynecology ,Cancer ,medicine.disease ,female genital diseases and pregnancy complications ,Serous fluid ,Ovarian cancer ,business - Abstract
Background Ovarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impact in public economy, Brazil still lacks valuable information concerning epidemiological aspects of this disease Methods We've compiled clinical data of all ovarian tumors registered at the two public hospitals of reference (1997 - 2007), such as: patients' age at diagnosis, tumor histological type, tumor stage, chemotherapy regimens, chemotherapy responsiveness, disease-free survival, and overall survival. Results Women's mean age at diagnosis was 54.67 ± 13.84 for ovarian cancer, 46.15 ± 11.15 for borderline tumors, and 42.01 ± 15.06 for adenomas. Among epithelial ovarian cancer cases, 30.1% were of serous, 13.7% were of mucinous, and 13.7% were of endometrioid type; exceptionally serous carcinoma was diagnosed in women younger than 30 years old. Endometrioid cancer had lower disease-free survival than others (p < 0.05). Cases were predominantly diagnosed as poor prognosis disease (FIGO III and IV, 56.2%). Regarding responsiveness to platinum-based therapy, 17.1% of patients were resistant, whereas 24.6%, susceptible. From these, we found equally responsiveness to platinum alone or its association with paclitaxel or cyclophosphamide. Discussion Our data agreed with other studies regarding mean patients' age at diagnosis, histological type frequency, FIGO stages distribution, and chemotherapy regimens. However, the histological type distribution, with equal contribution of mucinous and endometrioid types seems to be a unique characteristic of the studied highly miscegenated population. Conclusion We have enlighten the profile of the studied ovarian cancer population, which might enable the development of more efficient political strategies to control this malignancy that is the fifth leading cause of cancer-related deaths among women.
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