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Conventional cardiac MRI acquisition involves a multi-step approach, requiring a few double-oblique localizers in order to locate the heart and prescribe long- and short-axis views of the heart. This approach is operator-dependent and time-consuming. We propose a new approach to automating and accelerating the acquisition process to improve the clinical workflow. We capture a highly accelerated static 3D full-chest volume through parallel imaging within one breath-hold. The left ventricle is localized and segmented, including left ventricle outflow tract. A number of cardiac landmarks are then detected to anchor the cardiac chambers and calculate standard 2-, 3-, and 4-chamber long-axis views along with a short-axis stack. Learning-based algorithms are applied to anatomy segmentation and anchor detection. The proposed algorithm is evaluated on 173 localizer acquisitions. The entire view planning is fully automatic and takes less than 10 seconds in our experiments.

Purpose: We report a retrospective series of 850 patients treated by external irradiation for carcinoma of the eyelid at Institut Curie and we compare our results with other techniques: brachytherapy and surgery., Methods and Materials: Eight hundred fifty patients were treated by external radiotherapy for carcinoma of the eyelid. None of these patients have been previously treated. All the patients were classified according to the TNM classification of (UICC). We distinguished five histological types and five clinical groups according to the site of the skin tumor. Three modalities of external radiotherapy were used: contact therapy, conventional radiotherapy, and electrontherapy. We reviewed the clinical files of the 850 patients who went regularly at follow-up visits., Results: We report the 5-year survival results--alive with no evidence of disease: 72%; alive with progression: 2%; died from tumor progression: 0.5%; died from intercurrent disease: 19.5%; and lost to follow-up: 5%. The 5-year local control rate was 97.5%. We observed 45 failures--lymph node, metastatic, and local--and emphasize this last group by presenting the results of treatment of these local failures. We studied the complications of treatment: 2.3% of corneal complications, 2% of cataracts, and 1.4% of serious ocular complications., Conclusions: Our results concerning local failures and loss of the eye are comparable to those reported for other techniques involving brachytherapy or surgery. Overall, external radiotherapy is a safe and effective treatment, as it ensures a high local control rate and provides perfectly satisfactory functional and esthetic results. It seemed particularly useful to report this series in that few publications are available on this subject that, nevertheless, constitutes a topical issue.

Acute pancreatitis was induced in 139 Wistar rats by injection of trypsin in the common bilio-pancreatic duct. Peritoneal dialysis was performed in 93 rats. In some of these rats, aprotinin (250,000 UI/L) was added to the lavage fluid. Macroscopically, we noted the amount of steatonecrosis, pulmonary congestion and pleural effusion produced. The pancreatic and pulmonary lesions were studied microscopically. The effect of peritoneal dialysis with and without aprotinin on the survival rate was evaluated. Survival curves were established for the different groups of rats i.e. the non-treated group and the two groups of dialysed rats (with and without aprotinin). Peritoneal dialysis reduces the amount of steatonecrosis and the incidence of pulmonary complications of trypsin-induced pancreatitis in rats, but does not influence the pancreatic lesions. Peritoneal dialysis significantly improves the early survival rate. Addition of aprotinin to the dialysis fluid reduces the total mortality rate.

Fine-needle cytology (FNC) of 292 palpable orbital and eyelid tumors was performed with a 25-gauge (0.5-mm), 3-cm needle and compared with the histopathologic findings in 286 cases. Among these 286 cases, a concordant diagnosis of malignancy and type was achieved in 249 cases (87%). False positive diagnoses were made in four cases (1.6%) and false negative diagnoses in five cases (1.8%). No complications were encountered. These results led to the conclusion that FNC is an accurate tool in the diagnosis of orbital and eyelid tumors, especially when sampling and interpretation are performed by an experienced pathologist.

Sixty-six retinoblastoma patients were investigated using high resolution banding techniques, sister chromatid exchange (SCE) studies, and esterase-D phenotype determination and dosage. Seven patients (in six families) were found to be carriers of a rearrangement of band 13q14 due to de novo deletions, apparently balanced de novo translocations, or parental insertions. The possible role of submicroscopic parental insertions is suggested to explain transmission of nonchromosomal forms through unaffected carriers.

The authors have studied 600 cases of spinal metastasis causing a neurological syndrome. The most significant statistical data are reviewed. The cases are examined according to clinical characteristics, type of primary tumor, site of lesion, and survival. Each of these factors influenced the choice and results of treatment. As a general rule, combined treatment (surgery and radiotherapy) was used. Preliminary surgery was performed as an emergency, designed to halt progression of the neurological syndrome and to prevent its more serious manifestations. The technique and usefulness of surgery are discussed for different situations and the short-term results of treatment are related to the various factors involved.