106 results on '"Hegazy, S."'
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2. Effect of silica ions and nano silica on rice plants under salinity stress
- Author
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Abdel-Haliem, Mahmoud E.F., Hegazy, Hegazy S., Hassan, Noaman S., and Naguib, Deyala M.
- Published
- 2017
- Full Text
- View/download PDF
3. Vestibular evoked myogenic potentials (VEMPs) in young children: Test parameters and normative data
- Author
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El-Danasoury, I., El Sirafy, G., Taha, H., and Hegazy, S.
- Published
- 2015
- Full Text
- View/download PDF
4. Physiological response of 'Vicia faba' L. to inoculation with 'Rhizobium' and arbuscular mycorrhizal fungi: Comparative study for irrigation with Nile water and wastewater
- Author
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Ismaiel, Ahmed A, Hegazy, Hegazy S, and Azb, Maha A
- Published
- 2014
5. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
- Author
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. J., Chacon-Alves, S., Renes-Carreño, E., Montejo-González, J. C., Parlevliet, K. L., Touw, H. R. W., Beerepoot, M., Boer, C., Elbers, P. W. G., Tuinman, P. R., Abdelmonem, S. A., Helmy, T. A., El Sayed, I., Ghazal, S., Akhlagh, S. H., Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, A. M., Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, P. L., Chang, W. Y., Lin, W. C., Chen, C. W., Facchin, F., Zarantonello, F., Panciera, G., De Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Tonetti, T., Guanziroli, M., Colombo, A., Tomic, I., Colombo, A., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, A. Serpa, Schmidt, M., Pham, T., Combes, A., de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Katira, B. H., Engelberts, D., Giesinger, R. E., Ackerley, C., Yoshida, T., Zabini, D., Otulakowski, G., Post, M., Kuebler, W. M., McNamara, P. J., Kavanagh, B. P., Pirracchio, R., Rigon, M. Resche, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., De Pascale, G., Vallecoccia, M. S., Cutuli, S. L., Di Gravio, V., Pennisi, M. A., Conti, G., Antonelli, M., Andreis, D. T., Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, S. Alcantara, Almudevar, P. Matia, Abellán, A. Naharro, Ramos, J. Veganzones, Pérez, L. Pérez, Valbuena, B. Lobo, Sanz, N. Martínez, Simón, I. Fernández, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, A. Vieillard, Legrand, M., Gayat, E., Mebazaa, A., Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, J. L., Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, K. T., Hoppu, S., Lin, K. C., Hung, W. T., Chiang, C. C., Huang, W. C., Juan, W. C., Lin, S. C., Cheng, C. C., Lin, P. H., Fong, K. Y., Hou, D. S., Kang, P. L., Wann, S. R., Chen, Y. S., Mar, G. Y., Liu, C. P., Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, J. P., Sandroni, C., Cariou, A., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., McHugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, R. A., Brandon, R. B., Zwaag, J., Beunders, R., Pickkers, P., Kox, M., Gul, F., Arslantas, M. K., Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, M. P., Andreis, D. T., Singer, M., Garcia, I. Palacios, Cordero, M., Martin, A. Diaz, Pallás, T. Aldabó, Montero, J. Garnacho, Rey, J. Revuelto, Malo, L. Roman, Montoya, A. A. Tanaka, Martinez, A. D. C. Amador, Ayala, L. Y. Delgado, Zepeda, E. Monares, Granillo, J. Franco, Sanchez, J. Aguirre, Alejo, G. Camarena, Cabrera, A. Rugerio, Montenegro, A. Pedraza, Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Soilemezi, E., Koco, E., Savvidou, S., Nouris, C., Matamis, D., Di Mussi, R., Spadaro, S., Volta, C. A., Mariani, M., Colaprico, A., Antonio, C., Bruno, F., Grasso, S., Rodriguez, A., Martín-Loeches, I., Díaz, E., Masclans, J. R., Gordo, F., Solé-Violán, J., Bodí, M., Avilés-Jurado, F. X., Trefler, S., Magret, M., Reyes, L. F., Marín-Corral, J., Yebenes, J. C., Esteban, A., Anzueto, A., Aliberti, S., Restrepo, M. I., Larsson, J. Skytte, Redfors, B., Ricksten, S. E., Haines, R., Powell-Tuck, J., Leonard, H., Ostermann, M., Berthelsen, R. E., Itenov, T. S., Perner, A., Jensen, J. U., Ibsen, M., Jensen, A. E. K., Bestle, M. H., Bucknall, T., Dixon, J., Boa, F., MacPhee, I., Philips, B. J., Doyle, J., Saadat, F., Samuels, T., Huddart, S., McCormick, B., DeBrunnar, R., Preece, J., Swart, M., Peden, C., Richardson, S., Forni, L., Kalfon, P., Baumstarck, K., Estagnasie, P., Geantot, M. A., Berric, A., Simon, G., Floccard, B., Signouret, T., Boucekine, M., Fromentin, M., Nyunga, M., Sossou, A., Venot, M., Robert, R., Follin, A., Renault, A., Garrouste, M., Collange, O., Levrat, Q., Villard, I., Thévenin, D., Pottecher, J., Patrigeon, R. G., Revel, N., Vigne, C., Mimoz, O., Auquier, P., Pawar, S., Jacques, T., Deshpande, K., Pusapati, R., Wood, B., Pulham, R. A., Wray, J., Brown, K., Pierce, C., Nadel, S., Ramnarayan, P., Azevedo, J. R., Montenegro, W. S., Rodrigues, D. P., Sousa, S. C., Araujo, V. F., Leitao, A. L., Prazeres, P. H., Mendonca, A. V., Paula, M. P., Das Neves, A., Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Lischinsky, A., Veronesi, M., Emmerich, M., Descotte, E., Juliarena, A., Bisso, M. Carboni, Grando, M., Tapia, A., Camargo, M., Ulla, D. Villani, Corzo, L., dos Santos, H. Placido, Ramos, A., Doglia, J. A., Estenssoro, E., Carbonara, M., Magnoni, S., Donald, C. L. Mac, Shimony, J. S., Conte, V., Triulzi, F., Stretti, F., Macrì, M., Snyder, A. Z., Stocchetti, N., Brody, D. L., Podlepich, V., Shimanskiy, V., Savin, I., Lapteva, K., Chumaev, A., Tjepkema-Cloostermans, M. C., Hofmeijer, J., Beishuizen, A., Hom, H., Blans, M. J., van Putten, M. J. A. M., Longhi, L., Frigeni, B., Curinga, M., Mingone, D., Beretta, S., Patruno, A., Gandini, L., Vargiolu, A., Ferri, F., Ceriani, R., Rottoli, M. R., Lorini, L., Citerio, G., Pifferi, S., Battistini, M., Cordolcini, V., Agarossi, A., Di Rosso, R., Ortolano, F., Stocchetti, N., Lourido, C. Mora, Cabrera, J. L. Santana, Santana, J. D. Martín, Alzola, L. Melián, del Rosario, C. García, Pérez, H. Rodríguez, Torrent, R. Lorenzo, Eslami, S., Dalhuisen, A., Fiks, T., Schultz, M. J., Hanna, A. Abu, Spronk, P. E., Wood, M., Maslove, D., Muscedere, J., Scott, S. H., Saha, T., Hamilton, A., Petsikas, D., Payne, D., Boyd, J. G., Puthucheary, Z. A., McNelly, A. S., Rawal, J., Connolly, B., McPhail, M. J., Sidhu, P., Rowlerson, A., Moxham, J., Harridge, S. D., Hart, N., Montgomery, H. E., Jovaisa, T., Thomas, B., Gupta, D., Wijayatilake, D. S., Shum, H. P., King, H. S., Chan, K. C., Tang, K. B., Yan, W. W., Arias, C. Castro, Latorre, J., De La Rica, A. Suárez, Garrido, E. Maseda, Feijoo, A. Montero, Gancedo, C. Hernández, Tofiño, A. López, Rodríguez, F. Gilsanz, Gemmell, L. K., Campbell, R., Doherty, P., MacKay, A., Singh, N., Vitaller, S., Nagib, H., Prieto, J., Del Arco, A., Zayas, B., Gomez, C., Tirumala, S., Pasha, S. A., Kumari, B. K., Martinez-Lopez, P., Puerto-Morlán, A., Nuevo-Ortega, P., Pujol, L. Martinez, Dolset, R. Algarte, González, B. Sánchez, Riera, S. Quintana, Álvarez, J. Trenado, Quintana, S., Martínez, L., Algarte, R., Sánchez, B., Trenado, J., Tomas, E., Brock, N., Viegas, E., Filipe, E., Cottle, D., Traynor, T., Martínez, M. V. Trasmonte, Márquez, M. Pérez, Gómez, L. Colino, Martínez, N. Arias, Muñoz, J. M. Milicua, Bellver, B. Quesada, Varea, M. Muñoz, Llorente, M. Á. Alcalá, Calvo, C. Pérez, Hillier, S. D., Faulds, M. C., Hendra, H., Lawrence, N., Maekawa, K., Hayakawa, M., Ono, Y., Kodate, A., Sadamoto, Y., Tominaga, N., Mizugaki, A., Murakami, H., Yoshida, T., Katabami, K., Wada, T., Sawamura, A., Gando, S., Silva, S., Kerhuel, L., Malagurski, B., Citerio, G., Chabanne, R., Laureys, S., Puybasset, L., Nobile, L., Pognuz, E. R., Rossetti, A. O., Verginella, F., Gaspard, N., Creteur, J., Ben-Hamouda, N., Oddo, M., Taccone, F. S., Ono, Y., Hayakawa, M., Iijima, H., Maekawa, K., Kodate, A., Sadamoto, Y., Mizugaki, A., Murakami, H., Katabami, K., Wada, T., Sawamura, A., Gando, S., Kodate, A., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Andersen, L. W., Raymond, T., Berg, R., Nadkarni, V., Grossestreuer, A., Kurth, T., Donnino, M., Krüger, A., Ostadal, P., Janotka, M., Vondrakova, D., Kongpolprom, N., Cholkraisuwat, J., Pekkarinen, P. T., Ristagno, G., Masson, S., Latini, R., Bendel, S., Ala-Kokko, T., Varpula, T., Vaahersalo, J., Hoppu, S., Tiainen, M., Mion, M. M., Plebani, M., Pettilä, V., Skrifvars, M.B., Son, Y., Kim, K. S., Suh, G. J., Kwon, W. Y., Ko, J. I., Park, M. J., Cavicchi, F. Zama, Iesu, E., Nobile, L., Vincent, J. L., Creteur, J., Taccone, F. 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S., Fumagalli, F., Scala, S., Affatato, R., De Maglie, M., Zani, D., Novelli, D., Marra, C., Luciani, A., De Zani, D., Luini, M., Letizia, T., Pravettoni, D., Staszewsky, L., Masson, S., Belloli, A., Di Giancamillo, M., Scanziani, E., Latini, R., Ristagno, G., Kye, Y. C., Suh, G. J., Kwon, W. Y., Kim, K. S., Yu, K. M., Babini, G., Ristagno, G., Grassi, L., Fumagalli, F., Bendel, S., De Maglie, M., Affatato, R., Masson, S., Latini, R., Scanziani, E., Reinikainen, M., Skrifvars, M., Kappler, F., Blobner, M., Schaller, S. J., Roasio, A., Costanzo, E., Cardellino, S., Iesu, E., Cavicchi, F. Zama, Fontana, V., Nobile, L., Vincent, J. L., Creteur, J., Taccone, F. S., Park, M., You, K. M., Suh, G. J., Kwon, W. Y., Ko, S. B., Kim, K. S., Xini, A., Marca, L., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Beane, A., Thilakasiri, M. C. K. T., De Silva, A. P., Stephens, T., Sigera, C. S., Athapattu, P., Jayasinghe, S., Padeniya, A., Haniffa, R., Santiago, A. Iglesias, Sáez, V. Chica, Ruiz-Ruano, R. de la Chica, González, A. Sánchez, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, D. J., Rutherford, W. B., Scales, D. C., Adhikari, N. K., Cuthbertson, B. H., Suzuki, T., Takei, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M. W., Romero, D. González, Cabrera, J. L. Santana, Santana, J. D. Martín, Padilla, Y. Santana, Pérez, H. Rodríguez, Torrent, R. Lorenzo, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, R. D. T., Day, A., Arora, N., Henderson, M. A., Hickey, S., Costa, M. I. Almeida, Carvalho, J. P., Gomes, A. A., Mergulhão, P. J., Chan, K. K. C., Shum, H. P., Yan, W. W., Maghsoudi, B., Tabei, S. H., Masjedi, M., Sabetian, G., Tabatabaei, H. R., Akbarzadeh, A., Saigal, S., Pakhare, A., Joshi, R., Pattnaik, S. K., Ray, B., Rousseau, A. F., Michel, L., Bawin, M., Cavalier, E., Reginster, J. Y., Damas, P., Bruyere, O., Zhou, J. C., Cauwenberghs, H., De Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, J. A., Portillo, I. Prieto, Fernández, M. Valiente, Gigorro, R. Garcia, Vela, J. L. Perez, Mateos, H. Marín, Alves, S. Chacón, Varas, G. Morales, Rodriguez-Biendicho, A., Carreño, E. Renes, González, J. C. Montejo, Yang, J. S., Chiang, C. H., Hung, W. T., Huang, W. C., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Lin, K. L., Kang, P. L., Mar, G. Y., Liu, C. P., Zhou, J. C., Choi, Y. J., Yoon, S. Z., Gordillo-Brenes, A., Fernandez-Zamora, M. D., Perez-Borrero, L., Arias-Verdu, M. D., Aguilar-Alonso, E., Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., Curiel-Balsera, E., Rivera-Fernandez, R., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Herrera, A. N. García, Sanz, E. Regidor, Sánchez, M. J. Gómez, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Irazabal, J. M. Guergue, Pérez, A. González, Fernández, P. Alvarez, Amor, L. Lopéz, Albaiceta, G. Muñiz, Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Sanz, E. Regidor, Sánchez, M. J. Gómez, Calvo, S. Aldunate, Herrera, A. N. García, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Corona, A., Ruffini, C., Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Catena, E., Ke, M. W., Cheng, C. C., Huang, W. C., Chiang, C. H., Hung, W. T., Lin, K. C., Lin, S. C., Wann, S. R., Chiou, K. R., Tseng, C. J., Kang, P. L., Mar, G. Y., Liu, C. P., Bertini, P., De Sanctis, F., Guarracino, F., Bertini, P., Baldassarri, R., Guarracino, F., Buitinck, S. H., van der Voort, P. H. J., Oto, J., Nakataki, E., Tsunano, Y., Izawa, M., Tane, N., Onodera, M., Nishimura, M., Ghosh, S., Gupta, A., De Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, N. D., Mukherjee, D. N., Agarwal, L. K., Mandal, K., Palomar, M., Balsera, B., Vallverdu, M., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, G. E., Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., De la Torre, M. A., Torres, E., Bogossian, E., Nouer, S. Aranha, Salgado, D. Ribeiro, Brugger, S. Carvalho, Jiménez, G. Jiménez, Torner, M. Miralbés, Vidal, M. Vallverdú, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Cabello, J. Trujillano, Martínez, M. Palomar, Doganci, M., Izdes, S., Besevli, S. Guzeldag, Alkan, A., Kayaaslan, B., Ramírez, C. Sánchez, Balcázar, L. Caipe, Santana, M. Cabrera, Viera, M. A. Hernández, Escalada, S. Hípola, Vázquez, C. F. Lübbe, Penichet, S. M. Marrero, Campelo, F. Artiles, López, M. A. De La Cal, Santana, P. Saavedra, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Marmanidou, K., Oikonomou, M., Nouris, C., Dimitroulakis, K., Soilemezi, E., Matamis, D., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Prīdāne, S., Sabeļņikovs, O., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Beduneau, G., Pham, T., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Spadaro, S., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Volta, C. A., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Yonis, H., Tapponnier, R., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Richard, J. C., Guérin, C., Shinotsuka, C. Righy, Creteur, J., Taccone, F. S., Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pettilä, V., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Forni, L., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
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- 2016
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6. Systemic treatment of severe adult Atopic dermatitis in clinical practice: analysis of prescribing pattern in a cohort of 241 patients
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Hegazy, S., Tauber, M., Bulai‐Livideanu, C., Uthuriague, C., Giordano‐Labadie, F., Marguery, M. C., Regnault, M. M., Konstantinou, M. P., and Paul, C.
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- 2017
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7. Effect of active infection on cytochrome P450-mediated metabolism of cyclosporine in renal transplant patients
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Hegazy, S. K., Adam, A. G., Hamdy, N. A., and Khalafallah, N. M.
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- 2015
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8. Possible immuno-modulatory effects of tocilizumab in patients with refractory status epilepticus.
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EL-HAGGAR, S. M., HEGAZY, S. K., MUSTAFA, W., and KHRIEBA, M. O.
- Abstract
OBJECTIVE: Refractory Status Epilepticus (RSE) is a neurologic emergency that carries a high risk of mortality and morbidity. Every year, there are about 200,000 cases in the United States, affecting people of all ages. This study aimed to investigate the possible immuno-modulatory effect of tocilizumab in RSE patients receiving conventional anti-epileptic drugs. PATIENTS AND METHODS: 50 outpatients who fulfilled the inclusion requirements for RSE were recruited in this randomized, controlled, and prospective study. The patients were divided into two groups randomly (n=25); the control group received standard RSE treatment, consisting of propofol, pentobarbital, and midazolam, and the tocilizumab group received standard RSE treatment plus tocilizumab. A neurologist evaluated each patient at the beginning of the therapy and after 3 months. Before and after treatment, serum nuclear factor kappa B (NF-B), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-a), interleukin-1ß (IL-1ß) and serum electrolytes were assessed. RESULTS: The tocilizumab group showed a statistically significant reduction in the level of assessed parameters in comparison with the control group. CONCLUSIONS: Tocilizumab might be a novel adjuvant anti-inflammatory medication in managing RSE. [ABSTRACT FROM AUTHOR]
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- 2023
9. Atorvastatin improves erectile dysfunction in patients initially irresponsive to Sildenafil by the activation of endothelial nitric oxide synthase
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El-Sisi, A A, Hegazy, S K, Salem, K A, and AbdElkawy, K S
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- 2013
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10. Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort.
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Assan, F., Husson, B., Hegazy, S., Seneschal, J., Aubin, F., Mahé, E., Jullien, D., Sbidian, E., D'Incan, M., Conrad, C., Brenaut, E., Girard, C., Richard, M.A., Bachelez, H., and Viguier, M.
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AGE of onset ,BODY mass index ,RHEUMATISM ,COMPARATIVE studies ,INDIVIDUALIZED medicine - Abstract
Background: Acral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP. Objectives: We aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort. Methods: In this multicentre national retrospective cohort study, we compared the epidemiological characteristics, comorbidities and psoriasis characteristics of patients with PPP and ACH. Results: A total of 234 patients were included: 203 (87%) with PPP, 18 (8%) with ACH and 13 (6%) with both, according to 2017 ERASPEN criteria. As compared with ACH, PPP was associated with female sex, smoking activity and higher median BMI (P = 0.01, P = 0.02 and P = 0.05 respectively). A family background of psoriasis was more frequent in PPP than ACH. Age of onset of palmoplantar disease was similar between PPP and ACH patients, median age 44 and 48 years respectively. Peripheral joint inflammatory involvement was the only rheumatic disease associated with ACH. The association with another psoriasis type was similar in PPP and ACH (57.6% and 61.1% respectively). Conclusion: Our study confirms in a large PPP cohort the predominance of females and a high prevalence of smoking and elevated body mass index but also shows an association of these features in PPP as compared with ACH. In addition, it highlights peripheral arthritis as the only arthritis endotype associated with ACH. Increased knowledge of the immunogenetic backgrounds underlying these two entities is warranted to better stratify pustular psoriasis or psoriasis‐like entities for precision medicine. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Assessment of Morphological Traits and Yield Potentiality of some Egyptian Lentil (Lens culinaris Medik) Cultivars under normal and Water Deficit Conditions.
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Abo-Hegazy, S. R. E., Farag, Hend M., and Yacoub, I. H.
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LENTILS ,CULTIVARS ,WATER levels ,SEED yield ,DROUGHT tolerance ,YIELD stress - Abstract
Copyright of Journal of Plant Production is the property of Egyptian National Agricultural Library (ENAL) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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12. Impact of Locator Attachments with Different Retentive Insert Materials on Bite Force in Mandibular Implant Overdenture.
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Abdelaziz, S. M., Altonbary, G. Y., El Mekawy, N., and Hegazy, S.
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- 2021
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13. Sunscreen photoprotection: An observational study of cosmetic suitability and skin colour inclusivity.
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Hegazy, S., Leahy, M., and Laing, M.
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SUNSCREENS (Cosmetics) , *SCIENTIFIC observation , *HUMAN skin color - Abstract
This article discusses the cosmetic suitability and inclusivity of tinted sunscreens for different skin types. The study examined the subjective and objective opinions of participants with Fitzpatrick skin types I-VI regarding the acceptability of various sunscreens. The results showed that there were limited options for tinted sunscreens that were cosmetically acceptable for individuals with darker skin types (FST V-VI). Additionally, the study found that non-tinted sunscreens often left a white cast on the skin, which can be particularly pronounced on darker skin tones. The authors emphasize the need for increased awareness and availability of sunscreens that meet the photoprotective needs of diverse skin colors. [Extracted from the article]
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- 2023
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14. Biochemical responses of wheat to silicon application under salinity.
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Zia, Ahmad, Hegazy, Hegazy S., Hassan, Noaman S., Naguib, Deyala M., and Abdel-Haliem, Mahmoud E. F.
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- *
SALINITY , *JASMONATE , *WHEAT , *FOOD crops , *PHOTOSYNTHETIC pigments , *GENES - Abstract
Background: Salinity is one of the main threats that can cause crop yield losses by limiting plant growth. Several important cultivated crops including wheat exhibit sensitivity to salt stress by severe yield reductions. Approaches to improve salt resistance are critical for improved food production in the future. Aims: Silicon (Si) is well known for its role as quasi‐essential element to enhance growth and development of monocot food crops, especially under a variety of abiotic and biotic stress conditions. However, the mechanism of Si‐induced stress resistance is still not fully understood. Here, we investigate the biochemical basis of Si‐induced salt resistance of wheat. Methods: Effect of Si treatment on wheat plants under salt stress was measured by biochemical studies of photosynthetic pigments, ions, oxidative stress indicators, enzymatic and non‐enzymatic antioxidant systems, phytohormones along with expression of two Si‐transport genes. Results: Our results suggest that Si‐induced salt resistance of wheat involves a signaling cascade that triggers the biochemical defense responses. Salinity induces production of the stress hormone abscisic acid that upregulates the expression of Si‐influx transporter gene TaLsi1 and Si‐efflux transporter gene TaLsi2, in the presence of soluble Si in cytosol, and this triggers jasmonate‐mediated activation of both enzymatic and non‐enzymatic antioxidant systems along with osmolyte production. Moreover, peculiar stoichiometric changes in photosynthetic pigments after Si application, as signatures of shaded condition, also lead us to the hypothesis that insoluble Si phytoliths in plants may aid a physical defense response by creating a "mechanically shielded leaf microenvironment" against a variety of abiotic and biotic stress conditions. Conclusion: This study demonstrates that Si activates biochemical defense responses against salt stress in wheat plants. [ABSTRACT FROM AUTHOR]
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- 2021
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15. Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau.
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Husson, B., Barbe, C., Hegazy, S., Seneschal, J., Aubin, F., Mahé, E., Jullien, D., Sbidian, E., D'Incan, M., Conrad, C., Brenaut, E., Girard, C., Richard, M.A., Bachelez, H., and Viguier, M.
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MULTIVARIATE analysis ,BIOLOGICALS ,ETANERCEPT ,ADALIMUMAB - Abstract
Background: Palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH) are rare variants of psoriasis. Knowledge of the efficacy of biologics is scarce. Objectives: To evaluate the real‐life efficacy of tumour necrosis factor blockers and ustekinumab in PPP and in ACH. Methods: A multicentre retrospective descriptive study was conducted in 19 dermatology departments, including all patients with PPP or ACH seen from 2014 to 2016 who received one of the studied biologics. The data were collected by a standardized document. Factors associated with complete clearance (CC) were analysed by multivariate analysis, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Results: Among 92 patients included, 50 received adalimumab, 44 ustekinumab, 36 etanercept and 31 infliximab. Improvement and CC were observed in 83.9% and 20.0% patients receiving infliximab, 75.0% and 38.6% ustekinumab, 57.1% and 20.0% etanercept and 60.4% and 29.2% adalimumab. We found no significant difference in CC rates or duration of treatment among the biological treatments (P = 0.18 and P = 0.10, respectively). On multivariate analysis, CC with etanercept was associated with the ACH form and not smoking [OR = 9.5 (95% CI 1.1–82.7), P = 0.04 and 0.1 (0.01–0.9), P = 0.04]; with ustekinumab, male sex and absence of obesity [6.0 (1.3–28.6), P = 0.02 and 4.7 (1.0–22.7), P = 0.05]; with adalimumab, the ACH form [11.9 (2.7–52.3), P = 0.001]; and with infliximab, obesity [5.6 (1.1–29.4), P = 0.04]. Conclusions: We found no difference in efficacy between TNF blockers and ustekinumab and among the three different TNF blockers in real life for PPP or ACH, which reveals the heterogeneity of clinical response to biologics in pustular psoriasis as compared with plaque psoriasis. [ABSTRACT FROM AUTHOR]
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- 2020
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16. Optimal Ultra-wide Spatial-Spectral Windows for Hyperentangled Two-photon Emission
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Hegazy, S. F., El-Azab, J., Badr, Y. A., and Obayya, S. S. A.
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Quantum Physics ,FOS: Physical sciences ,Quantum Physics (quant-ph) - Abstract
While being optimally compensated for spatial phase variations, the two-photon state produced by the two-crystal emission exhibits spatial and spectral decoherence off the central emission modes. In this paper, we present an experimentally convenient method to optimize the ultra-wide spatial and spectral windows; allowing the minimum spatial-spectral decoherence for a required two-photon flux., META 2016
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- 2016
17. Long‐term continuation with secukinumab in psoriasis: association with patient profile and initial psoriasis clearance.
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Ferrières, L., Konstantinou, M. P., Bulai Livideanu, C., Hegazy, S., Tauber, M., Amelot, F., and Paul, C.
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PSORIASIS ,BIOTHERAPY ,DISEASE duration ,UNIVERSITY hospitals ,ADVERSE health care events - Abstract
Summary: Background: There are limited data regarding the long‐term continuation with biological therapy for patients with psoriasis. In particular, the reasons for secukinumab discontinuation have not been thoroughly investigated. Aim: To better ascertain the real‐life continuation of secukinumab in psoriasis, we conducted a retrospective study to evaluate the incidence, causes and factors of secukinumab discontinuation in patients with psoriasis. Methods: All patients treated with secukinumab for psoriasis in the Department of Dermatology (Toulouse University and Larrey Hospital, Toulouse, France), between September 2011 and June 2017, were enrolled in the study. Results: Of the 91 patients in the study, 22 (24.2%) discontinued secukinumab. In 14 (15%) patients, the discontinuation was due to loss of efficacy. Two patients stopped treatment because they planned a pregnancy and five patients stopped because of adverse events. A longer disease duration (P = 0.01) and presence of palmoplantar psoriasis (P = 0.01) seem to be predictive factors for treatment failure. Patients reaching 90 or 100% improvement in Psoriasis Area and Severity Index (PASI90 and PASI100, respectively) at weeks 12–16 had a lower risk of long‐term treatment discontinuation compared with patients who had less complete clearance (P = 0.04). Conclusion: Long‐term persistence of secukinumab appears to be good, as only 24.2% (n = 22) of the patients in this study discontinued secukinumab over the follow‐up period. Loss of efficacy prompted discontinuation in about 14% of patients by the 2‐year follow‐up. Persistence appears to be lower in patients with palmoplantar psoriasis and in patients previously exposed to many systemic treatments. Optimal therapeutic response at 12–16 weeks as defined by reaching PASI90–100 seems to be predictive of long‐term treatment persistence. [ABSTRACT FROM AUTHOR]
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- 2019
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18. Efficacy of ixekizumab in patients with resistance or incomplete response to secukinumab.
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Hegazy, S., Konstantinou, M.P., Bulai Livideanu, C., Tauber, M., and Paul, C.
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- *
PSORIATIC arthritis - Abstract
Twelve patients had exposure to prior systemic therapy and eight patients were naive to biological agents. Before discontinuation of secukinumab and initiation of ixekizumab treatment, the mean PASI was 10.5 and the PGA was two in four patients, three in nine patients, and four in one patient. A favourable response to ixekizumab was observed in all patients with a mean PASI of 0.6 and a PGA of 0 in six patients, one in seven patients, and two in one patient at week 16 (Figs 1-2). [Extracted from the article]
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- 2019
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19. Automatic Adaptation of Tire Pressure According to Operating Conditions.
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Hendy, A., Hegazy, S., Emam, M. A. A., and Hossamel-din, Yehia H.
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INFLATION pressure of automobile tires , *AUTOMOBILE tire safety measures , *ROLLING friction , *OFF-road vehicles , *TRACTION (Engineering) - Abstract
The off-road vehicles have much higher rolling resistance due to tire sinkage. This paper presents a proposed system for automatic adaptation for tire inflation/deflation, according to operating conditions. The tire inflation pressure is manually changed by the driver to some prefixed pressure values. The proposed control system is based on calculating the instantaneous wheel slip ratio. As the slip ratio increases, the tire pressure decreases automatically to increase the contact area and to decrease the dynamic sinkage and vice versa. An algorithm for the control strategy is developed. The proposed system provides a continuous monitoring of tire pressures inside the tire and then to inflate/deflate according to terrain types. The results show that a low inflation pressure has a considerable effect on the net traction ratio where it improves the performance by 20% and the buffed tire has a better traction than lugged tire on sand. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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20. Tunable spatial-spectral phase compensation of type-I (ooe) hyperentangled photons.
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Hegazy, S. F. and Obayya, S. S. A.
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- 2015
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21. A comparative investigation of a rule based energy management algorithm for hybrid electric vehicles.
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Ali, A. M., Kamel, H. M., Sharaf, A. M., and Hegazy, S. A.
- Published
- 2014
- Full Text
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22. Transient vehicle handling analysis with aerodynamic interactions.
- Author
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Hussain, K., Rahnejat, H., and Hegazy, S.
- Subjects
AERODYNAMICS ,NONLINEAR mechanics ,TIRES ,AIR suspension for automobiles ,AUTOMOBILE steering gear ,AUTOMOBILE handling ,COMPUTER simulation ,MULTIBODY systems - Abstract
This article presents transient handling analysis with a full-vehicle non-linear multi-body dynamic model, having 102 degrees of freedom. A transient cornering manoeuvre, with a constant steer angle and velocity has been undertaken. The effects of aerodynamic lift and drag forces have been included in the simulation tests. The vehicle handling characteristics with and without aerodynamic forces have been compared and various observations made. The aerodynamic forces have been predicted by a k-ε model solution of the Navier-Stokes equations for turbulent flow. The numerical predictions for the evaluation of aerodynamic lift coefficient agrees well with the scaled-down air tunnel experimental work, using hot-wire anemometry. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
23. E. coil transport in soil columns: implications for reuse of treated wastewater in irrigation.
- Author
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Smith, E. and Hegazy, S.
- Subjects
- *
WASTEWATER treatment , *INDUSTRIAL wastes , *WASTE management , *IRRIGATION , *SEPARATION (Technology) , *FILTERS & filtration , *ESCHERICHIA coli - Abstract
Reuse of treated wastewater in irrigation is gaining recognition as a vital element in the water resources management plan of developing countries, especially those situated in arid and semi-arid regions. An understanding of the transport of residual pollutants from treated wastewater, such as bacteria, in soil as a result of irrigation is critical to assessing health risks and the possible contamination of limited groundwater resources. In this work, retention of E. coli is evaluated for a soil that is irrigated by treated wastewater for growth of non-food crops near Egypt's Red Sea coast. In particular, the effects of soil organic fraction (SOF) and hydraulic loading rate (HLR) were investigated in laboratory soil columns. The matrix of experiments included three HLRs and three SOFs. The retention of bacteria by adsorption was observed at HLRs of 5 and 13 cm/h, with the magnitude of the adsorption increasing proportionally to the SOF. The impact of SOF was greater for the lower HLR. At the lowest HLR investigated (5 cm/h), filtration was also observed for the two higher SOFs (0.674 and 2.04 per cent). At a high HLR (66 cm/h) simulating flood irrigation, retention of bacteria was minimal regardless of the SOF. Since the bacterial solution is applied to a dry soil column to simulate field conditions, E. coli breakthrough after two pore volumes of throughput (vs. one) provided a meaningful comparison of bacterial retention as a function of HLR and SOF. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
24. Pond treatment and effluent reuse of sewage from an oil production site in an arid coastal environment.
- Author
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Smith, E., Hegazy, S., and El-Aassar, N.
- Subjects
- *
SEWAGE lagoons , *SURFACE impoundments , *WATER reuse , *GROUNDWATER tracers , *FECAL contamination , *AQUATIC microbiology , *BACTERIAL pollution of water , *ARID regions - Abstract
A pond system consisting of two lines each of an anaerobic followed by facultative and maturation ponds is used to treat site sewage from oil and gas production operations in an arid coastal environment. The performance of the pond system was evaluated together with the suitability of treated effluent for reuse in local irrigation. Effluent from the pond system by-and-large satisfies criteria for irrigation of non-food crop plants with respect to chemical parameters. The primary problem is coliform bacteria levels which are an order of magnitude higher than preferred values. First-order decay rate constants for each pond were calculated from a mass balance model that assumes complete mixing and incorporates the considerable evaporation that occurs in this setting. While the anaerobic ponds of both lines exhibit suitable performance, rate calculations indicate that the facultative and maturation ponds of the East Line are performing better than the West. A tracer study of the facultative and maturation ponds indicates that some short-circuiting is occurring in the West Line. A field experiment of coliform transport in irrigated soil gives indications of shortand long-term risks associated with reuse of the effluent. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
25. Multi-Body Dynamics in Full-Vehicle Handling Analysis under TransientManoeuvre.
- Author
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HEGAZY, S., RAHNEJAT, H., and HUSSAIN, K.
- Subjects
- *
MOTOR vehicle dynamics , *NONLINEAR systems - Abstract
This paper presents a 94 degrees of freedom non-linear multi-body dynamics model of a vehicle comprising front and rear suspensions, steering system, road wheels, tyres and vehicle inertia. The model incorporates all sources of compliance: stiffness and damping, all with non-linear characteristics. The model is used for the purpose of vehicle handling analysis. A simulation run, pertaining to a double lane change is undertaken in-line with the ISO 3888 standard. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
- View/download PDF
26. Multi-Body Dynamics in Full-Vehicle Handling Analysis.
- Author
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Hegazy, S, Rahnejat, H, and Hussain, K
- Subjects
VEHICLES ,DEGREES of freedom - Abstract
This paper presents a multidegrees-of-freedom non-linear multibody dynamic model of a vehicle, comprising front and rear suspensions, steering system, road wheels, tyres and vehicle inertia. The model incorporates all sources of compliance, stiffness and damping, all with non-linear characteristics. The vehicle model is created in ADAMS (automatic dynamic analysis of mechanical systems) formulation. The model is used for the purpose of vehicle handling analysis. Simulation runs, in-line with vehicle manoeuvres specified under ISO and British Standards, have been undertaken and reported in the paper. [ABSTRACT FROM AUTHOR]
- Published
- 1999
- Full Text
- View/download PDF
27. Effect of dupilumab on atopic manifestations in patients treated for atopic dermatitis in real‐life practice.
- Author
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Tauber, M., Apoil, P.A., Richet, C., Laurent, J., De Bonnecaze, G., Mouchon, E., Cassagne, M., Marguery, M.C., Hegazy, S., Konstantinou, M.P., Severino, M., Uthurriague, C., Giordano‐Labadie, F., Didier, A., and Paul, C.
- Subjects
ATOPIC dermatitis ,ALLERGIC conjunctivitis - Abstract
The article offers information on the effect of dupilumab on atopic manifestations in patients treated for atopic dermatitis in real-life practice. It mentions the ophthalmological examination was abnormal for 10 patients at inclusion with one case of acute allergic conjunctivitis; and also mentions treatment for conjunctivitis requires collaboration with an experienced ophthalmologist.
- Published
- 2019
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- View/download PDF
28. Efficacy of ustekinumab in palmoplantar pustulosis.
- Author
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Hegazy, S., Konstantinou, M. P., Bulai Livideanu, C., Tauber, M., Uthurriague, C., and Paul, C.
- Subjects
- *
ACRODERMATITIS , *DRUG efficacy , *T helper cells , *GENETICS , *THERAPEUTICS ,HEALTH of patients - Abstract
The author discusses the efficacy of ustekinumab refractory palmoplantar pustulosis (PPP). Topics include health conditions of patients treated with ustekinumab such as plaque psoriasis, development of T-helper (Th)17 cells, and patients' quality of life. It also presents table representing patients' demographic and clinical data including comorbidities, weight, and history of diabetes mellitus.
- Published
- 2018
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29. Diffuse PRAME Expression in Transdifferentiated Melanomas.
- Author
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Hegazy S, Karunamurthy A, and John I
- Published
- 2024
- Full Text
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30. Low-Level MDM2 Amplification by FISH: An Institutional Experience With a Diagnostic Dilemma.
- Author
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Naous R and Hegazy S
- Abstract
Background: MD M2 ( murine double minute-2 ) amplification via fluorescence in-situ hybridization (FISH) is the gold standard test used for confirming the diagnosis of atypical lipomatous tumor/well differentiated liposarcoma and dedifferentiated liposarcoma. It is also used as a screening test in high grade spindle cell or pleomorphic neoplasms. MDM2 FISH is considered positive for amplification when the MDM2 /CEP12 ratio is greater than 2; however, a ratio between 2 and 3 is considered a "low-level" amplification and raises the possibility of a false positive result; thus, posing a diagnostic dilemma. Another molecular modality, next generation sequencing (NGS) assay, can help in such situations in confirming or excluding the M D M 2 amplification status. Confronted by a number of neoplastic specimens at our institution with "low-level" MDM2 amplification via FISH, we aimed to assess the specificity of fluorescence in situ hybridization (FISH) in such tumors by comparing their NGS assay results and determine an accurate MDM2 amplification status that further aids in diagnosis. Methods: Tumors with "low-level" MDM2 amplification via FISH, defined as MDM2 /CEP12 ratio between 2 and 3, and harboring a high grade and/or pleomorphic morphology were retrospectively retrieved from our institutional archives from the last five years. The retrieved specimens were evaluated for concordant retrospective Oncomine v3 analysis. Oncomine v3 is an institutional NGS assay that covers 161 genes and assesses for DNA mutations, RNA fusions, and copy number alterations including MDM2 gene gain or amplification. The tumors with Oncomine v3 results were compared and the FISH specificity was calculated. Results: Twenty-seven high grade and/or pleomorphic tumors with "low-level" MDM2 amplification were retrieved. Eight out of twenty-seven tumors had Oncomine v3 performed on them. The tumors correlated to neoplasms from different lineage types including undifferentiated melanoma, sarcomatoid squamous cell carcinoma, leiomyosarcoma, myxofibrosarcoma, undifferentiated pleomorphic sarcoma, and high-grade poorly differentiated pleomorphic neoplasm. All 8 tumors had a low-level MD M2 amplification ratio ranging between 2.09 and 2.84. Seven out of eight had no MD M2 copy number alteration. One only (leiomyosarcoma) demonstrated MD M2 copy number gain (∼5 copies) that did not qualify as amplification due to the "6 copy number" gain cutoff. TP53, CDKN2A/B, PIKC3 , and PTEN alterations were the most common genetic aberrations detected by Oncomine v3. Conclusion: We demonstrated the absence of MDM2 amplification via Oncomine in all our 8 "low-level" MDM2 FISH amplification specimens confirming the FISH results as "false positive" with a corresponding FISH specificity rate of 0%. Laboratory measures and utilizing NGS assay when needed, could be implemented when encountering such problematic "low-level" MDM2 amplification specimens to avoid misdiagnosis and misuse of targeted therapy. Future studies are needed to better characterize and investigate such findings., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
31. Green Synthesis of Hexagonal-like ZnO Nanoparticles Modified with Phytochemicals of Clove ( Syzygium aromaticum ) and Thymus capitatus Extracts: Enhanced Antibacterial, Antifungal, and Antioxidant Activities.
- Author
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Haiouani K, Hegazy S, Alsaeedi H, Bechelany M, and Barhoum A
- Abstract
The green synthesis of ZnO NPs is becoming increasingly valued for its cost-effectiveness and environmental benefits. This study successfully synthesized hexagonal ZnO NPs using a combination of clove ( Syzygium aromaticum ) and Thymus capitatus extracts. The use of both extracts significantly improved the antibacterial and antioxidant properties of the ZnO NPs. By optimizing synthesis conditions, including ZnCl
2 and extract concentrations, hexagonal wurtzite ZnO NPs were produced at room temperature with only drying at 80 °C without high-temperature annealing. The synthesized ZnO NPs exhibited a hexagonal morphology with an average particle size of 160 nm and a crystallite size of 30 nm. Energy-dispersive X-ray spectroscopy (SEM-EDX) confirmed the elemental composition of the ZnO NPs, showing a high carbon content (63.9 wt.%), reflecting the presence of phytochemicals from the extracts coated the ZnO NPs surface. The UV-Vis spectrum revealed an absorption peak at 370 nm and a bandgap energy of 2.8 eV due to lattice defects caused by organic impurities. The ZnO NPs demonstrated exceptional antioxidant activity, with a DPPH radical scavenging rate of 95.2%. They also exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, with inhibition zones of 25 mm against Bacillus subtilis , 26 mm against Escherichia coli , 24 mm against Salmonella typhimurium , 22 mm against Klebsiella pneumoniae , 21 mm against Staphylococcus aureus , 20 mm against Staphylococcus hominis , and 18 mm against Bacillus subtilis at 200 ppm. Furthermore, significant antifungal activity was observed against Candida albicans , with an inhibition zone of 35 mm at the same concentration. These findings underscore the effectiveness of using combined plant extracts for producing ZnO NPs with controlled morphology and enhanced biological properties, highlighting their potential for various biomedical applications.- Published
- 2024
- Full Text
- View/download PDF
32. EMA-Positive Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm Masquerading as Perineurioma/Hybrid Nerve Sheath Tumor.
- Author
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Hegazy S and Naous R
- Subjects
- Humans, Female, Adult, Diagnosis, Differential, Mucin-1 analysis, Soft Tissue Neoplasms genetics, Soft Tissue Neoplasms pathology, Soft Tissue Neoplasms diagnosis, Immunohistochemistry, Anaplastic Lymphoma Kinase genetics, Nerve Sheath Neoplasms genetics, Nerve Sheath Neoplasms pathology, Nerve Sheath Neoplasms diagnosis, Gene Rearrangement, Biomarkers, Tumor genetics, Biomarkers, Tumor analysis
- Abstract
Abstract: Superficial anaplastic lymphoma kinase (ALK)-rearranged myxoid spindle cell neoplasm (SAMS) is a recently described entity which coexpresses ALK, CD34, and commonly S100. These neoplasms are characterized morphologically by concentric spindle cell whorls and cords and are commonly set in an abundant myxoid to myxocollagenous stroma, thus mimicking perineurioma or hybrid nerve sheath tumor. EMA immunostain has been reported to be negative in SAMS which helps in excluding the latter entities. Herein, we report the first EMA-positive SAMS of the right leg in a 37-year-old female patient masquerading as perineurioma/hybrid nerve sheath tumor. The tumor morphologically was comprised of spindle cells arranged in loose whorls and short fascicles set in myxoid to collagenous stroma and coexpressed CD34 and EMA, reminiscent of perineurioma. S100 showed focal staining. ALK immunostain was subsequently performed and was positive. ALK gene rearrangement was identified by fluorescence in situ hybridization break-apart assay and was further confirmed by next-generation sequencing-based RNA sequencing demonstrating FLNA::ALK fusion, thus supporting the diagnosis of SAMS. In conclusion, EMA can be expressed in SAMS, thus posing as a diagnostic pitfall. ALK immunostain and molecular studies are essential for confirming the diagnosis of SAMS and excluding potential mimickers, particularly perineurioma or hybrid nerve sheath tumor., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
33. Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor.
- Author
-
Schoedel K, Hegazy S, Zilla ML, Chang J, and Nacev BA
- Abstract
The list of potential gene fusions involving sarcomas, and particularly infantile fibrosarcoma-like tumors, continues to expand. The receptor tyrosine kinases are dysregulated in several tumor types, underscoring their roles in neoplasia. In this case presentation, we describe a pulmonary metastasis with two novel gene fusions (FKBP5::PRKCA and in-frame SEPT7::RAF1) occurring at least two decades after the primary tumor developed., Competing Interests: Declarations. Consent to participate: Informed consent will be submitted on request. Conflict of interest: The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
34. Cytomorphology of metastatic dedifferentiated/undifferentiated melanoma to the gallbladder: A case report and review of literature.
- Author
-
Hegazy S, Kamaluddin Z, and Naous R
- Subjects
- Female, Humans, Middle Aged, Gallbladder pathology, Melanoma pathology, Skin Neoplasms pathology, Sarcoma diagnosis, Soft Tissue Neoplasms, Neoplasms, Second Primary
- Abstract
Dedifferentiated/undifferentiated melanoma (DM/UM) is a distinct subtype of malignant melanoma that tends to lose all melanocytic markers of differentiation. DM/UM pose major diagnostic challenges as they could be easily confused with UM sarcoma or carcinoma, thus necessitating the use of molecular studies such as Next Generation Sequencing (NGS) for detecting melanoma-compatible mutations to confirm such diagnosis. The capability of performing NGS molecular studies on small biopsy material with confirmation of adequacy via rapid on-site evaluation (ROSE) has tremendous value in diagnosing DM/UM. Herein, we present the first reported case of metastatic DM/UM to the gall bladder arising in a 60-year-old female with a prior history of right knee melanoma. We also shed light on the cytomorphology of DM/UM, review the literature on such a challenging entity, and emphasize the crucial role of molecular testing in their diagnosis., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
35. Dermato-oncology.
- Author
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Hegazy S, Byrne B, Raulli G, and Dhonncha EN
- Subjects
- Humans, Skin Neoplasms, Melanoma
- Abstract
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
36. Cutis verticis gyrata diagnosed via magnetic resonance imaging of the brain.
- Author
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Harrington R, Hegazy S, and NicDhonncha E
- Subjects
- Humans, Magnetic Resonance Imaging, Brain diagnostic imaging, Scalp Dermatoses diagnostic imaging
- Published
- 2023
- Full Text
- View/download PDF
37. Athena: Speciality Certificate Examination case for infectious disease.
- Author
-
Byrne B, Hegazy S, and Marren P
- Subjects
- Humans, Communicable Diseases, Skin Diseases
- Abstract
Competing Interests: Conflicts of interest The authors declare they have no conflicts of interest.
- Published
- 2023
- Full Text
- View/download PDF
38. A survey of Irish dermatologists' awareness of the environmental impact of sunscreen.
- Author
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Hegazy S, Byrne B, and Murphy A
- Subjects
- Humans, Dermatologists, Surveys and Questionnaires, Environment, Sunscreening Agents, Dermatology
- Abstract
Competing Interests: Conflicts of interest the authors declare no conflicts of interest.
- Published
- 2023
- Full Text
- View/download PDF
39. Mutation-specific Mismatch Repair-deficient Benign Endometrial Glands in Endometrial Biopsies and Curettings Are a Biomarker of Lynch Syndrome and Associate With Endometrial Carcinoma Development.
- Author
-
Hegazy S, Brand RE, Dudley B, Karloski E, Lesnock JL, Elishaev E, and Pai RK
- Subjects
- Brain Neoplasms, Germ-Line Mutation, Colorectal Neoplasms, Biopsy, Microsatellite Instability, Neoplastic Syndromes, Hereditary, Biomarkers, Tumor genetics, Biomarkers, Tumor analysis, Female, Endometrium pathology, Humans, Mismatch Repair Endonuclease PMS2 genetics, Mismatch Repair Endonuclease PMS2 metabolism, DNA Mismatch Repair, MutL Protein Homolog 1 genetics, MutL Protein Homolog 1 metabolism, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Colorectal Neoplasms, Hereditary Nonpolyposis pathology, Endometrial Neoplasms genetics, Endometrial Neoplasms pathology
- Abstract
Endometrial carcinoma is the most common extraintestinal cancer in Lynch syndrome (LS). Recent studies have demonstrated mismatch repair (MMR) deficiency can be detected in benign endometrial glands in LS. We performed MMR immunohistochemistry in benign endometrium from endometrial biopsies and curettings (EMCs) from a study group of 34 confirmed LS patients and a control group of 38 patients without LS who subsequently developed sporadic MLH1-deficient or MMR-proficient endometrial carcinoma. MMR-deficient benign glands were only identified in patients with LS (19/34, 56%) and were not identified in any control group patient (0/38, 0%) ( P < 0.001). MMR-deficient benign glands were identified as large, contiguous groups in 18 of 19 cases (95%). MMR-deficient benign glands were identified in patients with germline pathogenic variants in MLH1 (6/8, 75%), MSH6 (7/10, 70%), and MSH2 (6/11, 55%) but not in patients with variants in PMS2 (0/4). MMR-deficient benign glands were seen in all EMC samples (100%) but in only 46% of endometrial biopsy samples ( P =0.02). Patients with MMR-deficient benign glands were significantly more likely to have endometrial carcinoma (53%) compared with LS patients with only MMR-proficient glands (13%) ( P =0.03). In conclusion, we demonstrated that MMR-deficient benign endometrial glands are frequently identified in EMB/EMC in women with LS and are a specific marker for LS. Women with LS with MMR-deficient benign glands were more likely to have endometrial carcinoma suggesting that MMR-deficient benign glands may be a biomarker of increased risk of endometrial carcinoma development in LS., Competing Interests: Conflicts of Interest and Source of Funding: R.K.P. is a consultant for Alimentiv, and this relationship is unrelated to the content of this manuscript. The remaining authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
40. Comparison of the efficacy and safety of continuous CO 2 laser and 1064 nm Q-switched Nd:YAG Laser for the treatment of xanthelasma palpebrarum.
- Author
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Konstantinou MP, Evangelou G, Hegazy S, Krasagakis K, and Bulai-Livideanu C
- Subjects
- Humans, Carbon Dioxide, Treatment Outcome, Lasers, Solid-State, Xanthomatosis, Skin Neoplasms, Lasers, Gas
- Published
- 2023
- Full Text
- View/download PDF
41. Random Skin Biopsy Is a Useful Procedure in the Evaluation of Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Literature.
- Author
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Hegazy S, Moesch J, Guerrero A, Ho J, and Karunamurthy A
- Subjects
- Humans, Female, Middle Aged, Biopsy, Bone Marrow pathology, Rituximab, Spleen pathology, Lymphohistiocytosis, Hemophagocytic pathology
- Abstract
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome, characterized by aberrant activation of T lymphocytes and macrophages leading to hypercytokinemia. HLH can be familial or a result of various secondary etiologies. We present a case of a 46-year-old woman with a past medical history of multiple sclerosis on rituximab who presented as a transfer from an outside hospital with numerous clinical abnormalities including recurrent episodes of fever of unknown origin for 3 weeks, persistent leukocytosis, hypertriglyceridemia, and steatohepatitis. Given the uncertain nature of her illness, she underwent a random skin biopsy from the abdominal region to exclude hematolymphoid malignancy. Histopathology revealed a brisk histiocytic rich dermal infiltrate accompanied by perivascular lymphocytic infiltrate. The histiocytes were enlarged and positive for muraminadase and CD68 stains exhibiting hemophagocytosis focally. As per the HLH-2004 protocol, our patient met the diagnostic criteria of HLH. Concurrent bone marrow biopsy revealed similar rare hemophagocytosis. Cytogenetics and molecular studies were negative, supporting secondary HLH., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
42. Intravenous Versus Wetting Solution Magnesium Sulphate to Counteract Epinephrine Cardiac Adverse Events in Abdominal Liposuction: A Randomized Controlled Trial.
- Author
-
Abu Sabaa MA, Elbadry AA, Hegazy S, and El Malla DA
- Abstract
Background: The increased frequency of liposuction has resulted in more complications being reported. Adding epinephrine to the wetting solution could induce some cardiac adverse effects, some of which may be fatal. For instance, magnesium sulfate (MgSO
4 ) is known for its cardioprotective effects., Objectives: This study aimed to evaluate the efficacy of intravenous (IV) versus wetting solution containing MgSO4 in decreasing such cardiac adverse events during abdominal liposuction., Methods: This randomized controlled study included 129 adult cases undergoing abdominal liposuction under general anesthesia. The participants were divided into 3 groups: Group I (control group) was only subjected to the injection of the wetting fluid (1 mL 1/1000 epinephrine added to every 1000 mL of normal saline), group II was subjected to IV MgSO4 (40 mg/kg over 1 minute) at the same time of installing the wetting solution, and group III was subjected to MgSO4 (40 mg/kg) added to the wetting solution., Results: Intraoperative isoflurane consumption, intraoperative heart rate (HR), mean arterial pressure (MAP), and postoperative pain scores were significantly lower in the MgSO4 groups (groups II and III) than group I. Cardiac adverse events (sinus tachycardia and premature ventricular contractions (PVCs)) were also significantly less frequent in groups II and III compared to group I., Conclusions: Adding MgSO4 , either through IV or subcutaneous routes, is associated with lower intraoperative HR, MAP, and postoperative pain scores and a remarkable decrease in epinephrine-induced cardiac adverse events during liposuction., Competing Interests: Conflict of Interests: There is none to be declared., (Copyright © 2022, Author(s).)- Published
- 2022
- Full Text
- View/download PDF
43. NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise.
- Author
-
Hegazy S, Marques MC, Canna SW, Goldbach-Mansky R, de Jesus AA, Reyes-Múgica M, and Salgado CM
- Subjects
- Child, Child, Preschool, Humans, I-kappa B Kinase genetics, Infant, Infant, Newborn, Male, NF-kappa B, Skin pathology, Hereditary Autoinflammatory Diseases diagnosis, Hereditary Autoinflammatory Diseases genetics, Hereditary Autoinflammatory Diseases pathology, Immunologic Deficiency Syndromes genetics, Panniculitis genetics, Panniculitis pathology
- Abstract
Abstract: A 15-month-old full-term boy of African descent with an asymptomatic sickle cell trait presented with episodes of transient erythematous subcutaneous nodules involving the entire body except the face, since 2 weeks of age. The skin lesions evolved to areas of lipoatrophy and hyperpigmentation. An initial skin biopsy, studied at a different department at 2 months, was initially misinterpreted as subcutaneous fat necrosis of the newborn, despite the lack of the typical radiated crystals and needle-shaped clefts characterizing that entity. At 4 months of age, he developed systemic inflammatory manifestations, including fever, a new rash, significant periorbital edema, and failure to thrive. An extensive workup showed leukocytosis, hypercalcemia, elevated inflammatory markers, hypertriglyceridemia, and transaminitis. A new skin biopsy of the eyelid was diagnosed as neutrophilic lobular panniculitis with necrotic adipocytes. An initial whole-exome sequencing did not identify any causative mutations, but a WES reanalysis focused on autoinflammatory disorders was requested based on additional clinicopathologic data and revealed a mosaic intronic mutation in IKBKG c. 671+3 G > C. This mutation encodes an mRNA missing exon 5 resulting in NF-kB essential modulator (NEMO) Δ-exon 5-autoinflammatory syndrome (NDAS). NEMO-NDAS is one of the systemic autoinflammatory diseases that may appear as an unexplained panniculitis in young children, who should be monitored for immunodeficiency and/or autoinflammatory diseases. The differential diagnosis of autoinflammatory disorders should be considered in such cases incorporating the use of the whole-genome/exome sequencing in the investigation. The inhibitor of kappa-B kinase regulatory subunit gamma (IKBKG) is located on chromosome Xq28 and encodes the NEMO, a critical molecule upstream of NF-kB activation., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
44. Detection of Enterococcus avium in a case of urinary tract infection and haematuria.
- Author
-
Abo-Zed A, Hegazy S, and Phan T
- Abstract
Enterococci have been recognized as major pathogens causing nosocomial and community-acquired infections. The emergence of antimicrobial-resistant enterococci is one of the major public health challenges worldwide. While many enterococcal species have been identified, Enterococcus avium is rarely detected in humans. Here we present an interesting case of urinary tract infection and haematuria involving E. avium in a 72-year-old patient. The patient underwent antibiotic therapy and surgical procedures with excellent improvement. This case report highlights the important role of E. avium in clinical settings., Competing Interests: The authors declare that there are no conflicts of interest., (© 2022 The Authors.)
- Published
- 2022
- Full Text
- View/download PDF
45. Keratitis caused by Nocardia farcinica in a contact lens wearer.
- Author
-
Hegazy S and Phan T
- Abstract
Bacterial keratitis is an infection of the cornea. This kind of infection can progress quickly and if left untreated, it can eventually cause complete blindness. While Staphylococcus aureus and Pseudomonas aeruginosa are most commonly responsible for this type of infection in the United States, Nocardia spp. is rarely encountered. Here we describe an interesting case of Nocardia farcinica keratitis in a 31-year-old male patient having an extended wear of contact lenses. The patient presented at the emergency department with irritation, foreign body sensation, redness, and pain of his left eye. Nocardia farcinica was isolated from a corneal scraping specimen, and determined by sequencing a region of 16S rRNA gene. The patient had antimicrobial therapy with good improvement. We highlight the important role of Nocardia farcinica in causing keratitis, and its accurate and timely diagnosis is needed to avoid poor visual outcomes., (© 2022 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.)
- Published
- 2022
- Full Text
- View/download PDF
46. Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies.
- Author
-
Cook N, Xu L, Hegazy S, Wheeler BJ, Anderson AR, Critelli N, Yost M, McElroy AK, Shurin MR, and Wheeler SE
- Subjects
- Antibodies, Neutralizing blood, Antibodies, Viral blood, COVID-19 blood, COVID-19 immunology, Humans, Immunoglobulin G blood, Immunoglobulin G immunology, Antibodies, Neutralizing immunology, Antibodies, Viral immunology, COVID-19 Serological Testing methods, SARS-CoV-2 immunology
- Abstract
Objectives: Detection of antibodies to multiple SARS-CoV-2 antigens in a single assay could increase diagnostic accuracy, differentiate vaccination from natural disease, and aid in retrospective exposure determination. Correlation of binding antibody assessment in clinical assays with neutralizing antibodies is needed to better understand the humoral response to SARS-CoV-2 infection and establish of correlates of protection., Methods: A cohort of 752 samples was used to assess specificity, sensitivity, and comparison to 6 other Conformitè Europëenne serologic assays for the BioRad SARS-CoV-2 IgG multiplex assay which measures receptor binding domain IgG (RBD), spike-S1 IgG (S1), spike-S2 IgG (S2), and nucleocapsid IgG (N). A subset of serial specimens from 14 patients was also tested for neutralizing antibodies (n = 61)., Results: Specificity for RBD and S1 IgG was 99.4% (n = 170) and 100% for S2 and N IgG (n = 170) in a cohort selected for probable interference. Overall assay concordance with other assays was >93% for IgG and total antibody assays and reached 100% sensitivity for clinical concordance at >14 days as a multiplex assay. RBD and S1 binding antibody positivity demonstrated 79-95% agreement with the presence of neutralizing antibodies., Conclusions: The BioRad SARS-CoV-2 IgG assay is comparable to existing assays, and achieved 100% sensitivity when all markers were included. The ability to measure antibodies against spike and nucleocapsid proteins simultaneously may be advantageous for complex clinical presentations, epidemiologic research, and in decisions regarding infection prevention strategies. Additional independent validations are needed to further determine binding antibody and neutralizing antibody correlations., (Copyright © 2021 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
47. Effect of specific retention biomaterials for ball attachment on the biomechanical response of single implant-supported overdenture: A finite element analysis.
- Author
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Gibreel M, Sameh A, Hegazy S, Närhi TO, Vallittu PK, and Perea-Lowery L
- Subjects
- Biocompatible Materials, Dental Stress Analysis, Finite Element Analysis, Humans, Mandible, Stress, Mechanical, Dental Implants, Denture, Overlay
- Abstract
Purpose: The purpose of this finite element analysis (FEA) was to evaluate the effect of specific retention biomaterials with different elastic modulus on the biomechanical response to the axial and off-axial biting loads of a mandibular midline single implant-supported overdenture (SIO) model., Methods: Five 3-dimensional (3D) finite element models of an edentulous mandible with SIO were designed as follows: model M with a titanium retentive element for ball attachment, model P with a PEEK retentive element, model S with a silicone resilient liner retentive element, model T with a thermoplastic acrylic resin retentive element made from a CAD-CAM material, and model A with a polyacetal resin retentive element. Posterior bilateral vertical load (PV) at the 1st molar areas and anterior oblique load (AO) at the incisal edge of the mandibular central incisors at a 30-degree angle of 100 N were applied. Stress values were recorded., Results: Stress values were higher for all models under (AO) loading than under (PV) loading. Model M recorded the highest stress values on the implant, its components, cortical, and cancellous bone under both loading conditions. Under (AO) loading condition, the ball abutment von Mises stress value in model S was almost 7 times lower than that of model M (19 and 130 MPa respectively) and the other 3 models (P, T, and A) (119, 121, and 120 MPa respectively). However, model S recorded the highest value of denture base stress at the attachment area., Conclusions: The elastic modulus of retention materials can affect stresses generated on the implant overdenture components and supporting structures., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
48. DNA mismatch repair-deficient non-neoplastic endometrial glands are common in Lynch syndrome patients and are present at a higher density than in the colon.
- Author
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Hegazy S, Brand RE, Dudley B, Karloski E, Bhargava R, Elishaev E, and Pai RK
- Subjects
- Adult, Aged, Aged, 80 and over, Colorectal Neoplasms, Hereditary Nonpolyposis pathology, Female, Humans, Middle Aged, Mucous Membrane pathology, Retrospective Studies, Colon pathology, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, DNA Mismatch Repair, DNA Repair Enzymes analysis, Endometrium pathology
- Abstract
Aims: The hallmark of Lynch syndrome (LS) is DNA mismatch repair protein (MMR) deficiency. Recently, MMR deficiency in non-neoplastic colonic crypts has been identified as a novel indicator of LS. We aimed to determine whether MMR-deficient non-neoplastic endometrial glands can distinguish patients with and without LS, and to compare the level of MMR deficiency in the normal endometrium and colon in LS patients., Methods and Results: We evaluated the immunohistochemical expression of MMR proteins in the normal endometrial mucosa from 64 patients, including 34 patients with confirmed LS (17 with endometrial cancer and 17 without cancer), 30 patients with endometrial cancer without LS (10 with tumours with MLH1 promoter hypermethylation and 20 with MMR-proficient tumours), and in the normal colonic mucosa from 30 LS patients. MMR-deficient non-neoplastic endometrial glands were identified in 47% of LS patients and in no patients without LS (P < 0.001). MMR-deficient non-neoplastic glands were more often identified in LS patients with endometrial cancer (65%) than in those without endometrial cancer (29%) (P = 0.04). In contrast to what was seen in the normal colon, MMR-deficient glands in the normal endometrium were seen as large, contiguous groups, ranging in number from two to 101 (87% versus 45%, P = 0.02). MMR-deficient glands were identified at a higher density in the endometrium than in the colon in LS patients (median number of MMR-deficient glands, 22 versus two, P = 0.02)., Conclusions: Our findings indicate that MMR-deficient non-neoplastic endometrial glands constitute an indicator of LS, and that MMR-deficient glands in the endometrium are present in a pattern of contiguous large groups., (© 2021 John Wiley & Sons Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
49. Tapinarof-induced folliculitis: The paradigm of activation of the aryl hydrocarbon signaling pathway.
- Author
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Konstantinou MP, Jendoubi F, Hegazy S, Bouznad A, Tauber M, Bulai-Livideanu C, and Paul C
- Subjects
- Humans, Resorcinols, Signal Transduction, Folliculitis chemically induced, Stilbenes
- Abstract
Competing Interests: Conflicts of interest Dr Konstantinou has served as a paid speaker for AbbVie, Eli Lilly and Company, and Novartis. Dr Jendoubi has served as a consultant with honoraria for Sanofi and Janssen. Dr Tauber has served as a paid speaker for Janssen. Dr Bulai-Livideanu has served as a consultant with honoraria and as a paid speaker for AbbVie, Eli Lilly and Company, Janssen, UCB Pharma, and Novartis. Dr Paul has received research grants and has been consultant for Almirall, Amgen, AbbVie, BMS, Boehringer, Celgene, Eli Lilly, Janssen, Leo Pharma, Merck, Mylan, Novartis, Pfizer, Pierre Fabre, Sanofi, and UCB pharma. Drs Hegazy and Bouznad have no conflicts of interest to declare.
- Published
- 2021
- Full Text
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50. Efficacy and tolerability of long-pulse Alexandrite laser hair removal for hidradenitis suppurativa.
- Author
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Fradet M, Bulai Livideanu C, Katoulis A, Hegazy S, Bouznad A, Jendoubi F, Carlet C, Paul C, and Konstantinou MP
- Published
- 2021
- Full Text
- View/download PDF
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