Search

Your search keyword '"Heidenreich, Axel"' showing total 1,289 results
Start Over Author "Heidenreich, Axel" Language english
1,289 results on '"Heidenreich, Axel"'

4. Safety and Efficacy of 177Lu-PSMA Therapy Following 223Radium Treatment: A Retrospective Multinational Real-World Analysis

Author

Giannini, Giulia, Kafka, Mona, Neuwirt, Hannes, Artamonova, Nastasiia, Santo, Gianpaolo di, Virgolini, Irene, Dotzauer, Robert, Deiss, Emil, Paffenholz, Pia, Heidenreich, Axel, Rasul, Sazan, Tsaur, Igor, Rausch, Steffen, Einspieler, Holger, la Fougère, Christian, Trautwein, Nils F., Zattoni, Fabio, Sepulcri, Matteo, and Heidegger, Isabel

Published
2025
Full Text
View/download PDF

6. Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database

Author

Lauritsen, Jakob, Sauvé, Nicolas, Tryakin, Alexey, Jiang, Di Maria, Huddart, Robert, Heng, Daniel Y. C., Terbuch, Angelika, Winquist, Eric, Chovanec, Michal, Hentrich, Marcus, Fankhauser, Christian D., Shamash, Jonathan, del Muro, Xavier Garcia, Vaughn, David, Heidenreich, Axel, Sternberg, Cora N., Sweeney, Christopher, Necchi, Andrea, Bokemeyer, Carsten, Bandak, Mikkel, Jandari, Abolghassem, Collette, Laurence, Gillessen, Silke, Beyer, Joerg, and Daugaard, Gedske

Published
2023
Full Text
View/download PDF

9. Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography: Results of a Multicenter European Study

Author

Rajwa, Pawel, Robesti, Daniele, Chaloupka, Michael, Zattoni, Fabio, Giesen, Alexander, Huebner, Nicolai A., Krzywon, Aleksandra, Miszczyk, Marcin, Moll, Matthias, Stando, Rafał, Cisero, Edoardo, Semko, Sofiya, Checcucci, Enrico, Devos, Gaëtan, Apfelbeck, Maria, Gatti, Cecilia, Marra, Giancarlo, van den Bergh, Roderick C.N., Goldner, Gregor, Rasul, Sazan, Ceci, Francesco, Dal Moro, Fabrizio, Porpiglia, Francesco, Gontero, Paolo, Bjartell, Anders, Stief, Christian, Heidenreich, Axel, Joniau, Steven, Briganti, Alberto, Shariat, Shahrokh F., and Gandaglia, Giorgio

Published
2024
Full Text
View/download PDF

10. Real-world Outcomes and Predictive Biomarkers for 177Lutetium Prostate-specific Membrane Antigen Ligand Treatment in Metastatic Castration-resistant Prostate Cancer: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Observational Study

Author

Kafka, Mona, Horninger, Andreas, di Santo, Gianpaolo, Virgolini, Irene, Neuwirt, Hannes, Unterrainer, Lena M., Kunte, Sophie C., Deiss, Emil, Paffenholz, Pia, Heidenreich, Axel, Rasul, Sazan, Einspieler, Holger, Shariat, Shahrokh F., Rajwa, Pawel, Dozauer, Robert, Tsaur, Igor, Medlock, Ellen, Rölz, Niklas, Rausch, Steffen, la Fougère, Christian, Trautwein, Nils, Roesch, Marie C., Merseburger, Axel S., Zattoni, Fabio, Sepulcri, Matteo, Ladurner, Michael, Bektic, Jasmin, Gandaglia, Giorgio, Horninger, Wolfgang, and Heidegger, Isabel

Published
2024
Full Text
View/download PDF

12. Impact of teratoma on survival probabilities of patients with metastatic non-seminomatous germ cell cancer: Results from the IGCCCG Update Consortium

Author

Bührer, Emanuel, D'Haese, David, Daugaard, Gedske, de Wit, Ronald, Albany, Costantine, Tryakin, Alexey, Fizazi, Karim, Stahl, Olof, Gietema, Jourik A., De Giorgi, Ugo, Cafferty, Fay H., Hansen, Aaron R., Tandstad, Torgrim, Huddart, Robert A., Necchi, Andrea, Sweeney, Christopher J., Garcia-Del-Muro, Xavier, Heng, Daniel Y.C., Lorch, Anja, Chovanec, Michal, Winquist, Eric, Grimison, Peter, Feldman, Darren R., Terbuch, Angelika, Hentrich, Marcus, Bokemeyer, Carsten, Negaard, Helene, Fankhauser, Christian, Shamash, Jonathan, Vaughn, David J., Sternberg, Cora N., Heidenreich, Axel, Collette, Laurence, Gillessen, Silke, and Beyer, Jörg

Published
2024
Full Text
View/download PDF

18. An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading

Author

Tolkach, Yuri, Ovtcharov, Vlado, Pryalukhin, Alexey, Eich, Marie-Lisa, Gaisa, Nadine Therese, Braun, Martin, Radzhabov, Abdukhamid, Quaas, Alexander, Hammerer, Peter, Dellmann, Ansgar, Hulla, Wolfgang, Haffner, Michael C., Reis, Henning, Fahoum, Ibrahim, Samarska, Iryna, Borbat, Artem, Pham, Hoa, Heidenreich, Axel, Klein, Sebastian, Netto, George, Caie, Peter, and Buettner, Reinhard

Published
2023
Full Text
View/download PDF

20. Predicting Limited Survival Following Inguinal Lymph Node Dissection in Penile Cancer: Should We Revisit the Goals of Care?

Author

Hugar, Lee A., Peak, Taylor C., Naqvi, Mahrukh, Kim, Youngchul, Bandini, Marco, Pederzoli, Filippo, Marandino, Laura, Albersen, Maarten, Roussel, Eduard, Zhu, Yao, Ye, Ding-Wei, Ornellas, Antonio A., Catanzaro, Mario, Hakenberg, Oliver W., Heidenreich, Axel, Haidl, Friederike, Watkin, Nick, Ager, Michael, Briganti, Alberto, Salvioni, Roberto, Chakiryan, Nicholas H., Montorsi, Francesco, Necchi, Andrea, and Spiess, Philippe E.

Published
2023
Full Text
View/download PDF

21. Rucaparib for the Treatment of Metastatic Castration-resistant Prostate Cancer Associated with a DNA Damage Repair Gene Alteration: Final Results from the Phase 2 TRITON2 Study

Author

Abida, Wassim, Campbell, David, Patnaik, Akash, Bryce, Alan H., Shapiro, Jeremy, Bambury, Richard M., Zhang, Jingsong, Burke, John M., Castellano, Daniel, Font, Albert, Ganju, Vinod, Hardy-Bessard, Anne-Claire, McDermott, Ray, Sautois, Brieuc, Spaeth, Dominique, Voog, Eric, Piulats, Josep M., Pintus, Elias, Ryan, Charles J., Merseburger, Axel S., Daugaard, Gedske, Heidenreich, Axel, Fizazi, Karim, Loehr, Andrea, Despain, Darrin, Simmons, Andrew D., Dowson, Melanie, Go, Jowell, Watkins, Simon P., and Chowdhury, Simon

Published
2023
Full Text
View/download PDF

22. European Association of Urology Guidelines on Testicular Cancer: 2023 Update

Author

Patrikidou, Anna, Cazzaniga, Walter, Berney, Daniel, Boormans, Joost, de Angst, Isabel, Di Nardo, Domenico, Fankhauser, Christian, Fischer, Stefanie, Gravina, Carmen, Gremmels, Hendrik, Heidenreich, Axel, Janisch, Florian, Leão, Ricardo, Nicolai, Nicola, Oing, Christoph, Oldenburg, Jan, Shepherd, Robert, Tandstad, Torgrim, and Nicol, David

Published
2023
Full Text
View/download PDF

24. Risk of residual cancer after complete response following first-line chemotherapy in men with metastatic non-seminomatous germ cell tumour and International Germ Cell Cancer Cooperative Group intermediate/poor prognosis: A multi-institutional retrospective cohort study

Author

Antonelli, Luca, Ardizzone, Davide, Ravi, Praful, Bagrodia, Aditya, Mego, Michal, Daneshmand, Siamak, Nicolai, Nicola, Nazzani, Sebastiano, Giannatempo, Patrizia, Franza, Andrea, Heidenreich, Axel, Paffenholz, Pia, Saoud, Ragheed, Eggener, Scott, Ho, Matthew, Oswald, Nathaniel, Olson, Kathleen, Tryakin, Alexey, Fedyanin, Mikhail, Naoun, Natacha, Javaud, Christophe, Fizazi, Karim, King, Jennifer M., Adra, Nabil, Douglawi, Antoin, Cary, Clint, Sweeney, Christopher, and Fankhauser, Christian D.

Published
2023
Full Text
View/download PDF

27. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries

Author

Heidegger, Isabel, Resch, Johannes Mischinger Irene, Turba, Simon, Zeder, Robin, Lodeta, Braninimir, Van Praet, Charles, Ghysel, Christophe, Arentsen, Harm C., Beysens, Matthias, Vinckier, Marie-Hélène, Mottrie, Alexandre, de Groote, Ruben, Timev, Aleksandar Ivanov, Georgiev, Marincho Ivanov, Yanev, Krassimir Prodanov, Mladenov, Boris, Ivanov, Atanas Slavchev, Antonov, Petar, Valkanov, Stanislav, Tomašković, Igor, Kulis, Tomislav, Bokarica, Pero, Pavlović, Oliver, Krajina, Vinko, Situm, Marijan, Boban, Toni, Soric, Tomislav, Vidic, Ivan, Benko, Goran, Peršec, Zoran, Sović, Tomislav, Zachoval, Roman, Stejskal, Jiri, Capoun, Otakar, Pitra, Tomáš, Gojdič, Marek, Babjuk, Marek, Novák, Vojtěch, Grepl, Michal, Broul, Marek, Novák, Jan, Lund, Lars, Nordström Joensen, Ulla, Borre, Michael, Veskimäe, Priit, Baum, Peep, Tamm, Toomas, Okas, Rauno, Jämsä, Pyry, Lahdensuo, Kanerva, Siltari, Sirkku, Seikkula, Heikki, Palmberg, Christian, Isotalo, Taina, Fiard, Gaelle, Verrier, Cecile, Wiedemann, Laura, Lecornet, Emilie, Leon, Priscilla, Millet, Clementine, Ponzio, Charles, Ploussard, Guillaume, Xylinas, Evanguelos, Ingels, Alexandre, Bigot, Pierre, Le Corre, Vincent, Audenet, François, Berg, Sebastian, Palisaar, Rein-Jueri, Heidenreich, Axel, Seelemeyer, Felix, Krege, Susanne, Leyh-Bannurah, Sami-Ramzi, Witt, Jörn H., Abdirahman, Ayanle, Truß, Michael C., Kranz, Jennifer, Andreas, Karagiannis, Vassileios, Tzortzis, Andreas, Andreou, Paparidis, Spyridon, Davis, Nikolaos Ferakis Niall F., Keane, Kevin G., Fuentes, Adrian, Scuderi, Simone, Barletta, Francesco, Manfredi, Matteo, Porpiglia, Francesco, Cerruto, Maria Angela, Antonelli, Alessandro, Esperto, Francesco, Rossanese, Marta, Veneziano, Domenico, Castelli, Tommaso, Mantica, Roberto La Rocca Marcello Scarcia Guglielmo, Rebuffo, Silvia, Pomara, Giorgio, Pavan, Nicola, Silvestri, Tommaso, Reale, Giulio Francesco, Polara, Andrea, Falagario, Ugo Giovanni, Carrieri, Giuseppe, Ferrari, Giovanni, Brausi, Maurizio, Orecchia, Luca, Annino, Filippo, Kazlauskas, Gražvydas, Stavridis, Sotir, Radovic, Nenad, Vukovic, Marko, van der Slot, Margaretha Adriana, Bruins, Harman Maxim, van Oort, Inge, Witjes, Fred, van der Poel, Henk, Beisland, Christian, Lilleåsenm, Gunder, Müller, Stig, Haug, Erik S., Dimmen, Magne, Czech, Anna K., Nyk, Lukasz, Jaskulski, Jaroslaw, Ratajczyk, Krzysztof, Azevedo, Nuno, Braga, Isaac, Pereira, João, Lúcio, Rui, Pina, João, da Silva, Edgar Miguel Calvo Loureiro Tavares, Furriel, Frederico, Mota, Paulo, Rodrigues, Miguel, Radavoi, George Daniel, Crisan, Nicolae, Andras, Iulia, Robert, Stoica, Bratu, Ovidiu, Surcel, Cristian, Kotov, Sergei, Malkhasyan, Vigen, Petrov, Sergei, Reva, Sergei, Bumbasirevic, Uros, Kováčik, Viktor, Perečinský, Ivan, Rybár, Ľuboš, Šulgan, Ján, Briš, Lukáš, Jursová, Katarína, Chovan, Miroslav, Kička, Tomáš, Taskovska, Milena, Kovačič, Rok, Miklavžina, Andraž, Alvarez-Maestro, Mario, De Castro, Javier Mayor, Aragón-Chamizo, Juan, Sutil, Raquel Sopeña, Perrello, Carmen Garau, Vilaseca, Antoni, Perez, Jorge Huguet, Ovide, Julia Aumatell, Planas, Jacques, Borque-Fernando, Angel, Sánchez-Izquierdo, Elena, Jimenez, Jose Luis Marenco, Lendínez-Cano, Guillermo, Puche-Sanz, Ignacio, Garcia-Baquero, Rodrigo, Esteban, Mario Domínguez, Pérez-Fentes, Daniel, Serván, Patricia Parra, Koskela, Lotta Renström, Stranne, Johan, Scholtz, Bianca, Torbrand, Christian, Wagenius, Magnus, Ugge, Henrik, Örtegren, Joakim, Langenauer, Janine, Zumstein, Valentin, Schmid, Hans Peter, Rieken, Malte, Saba, Karim, Strebel, Raeto T., Mortezavi, Ashkan, Rentsch, Cyrill, Roth, Beat, Eberli, Daniel, Pascal, Oechslin, Auer, Rebecca, John, Hubert, Thalmann, George N., Baltacı, Sümer, Mungan, Aydın, Sözen, Sinan, Cetin, Serhat, Aslan, Guven, Türkeri, Levent, İzol, Volkan, Demirdağ, Çetin, Ozden, Sami Berk, Toktaş, Gökhan, Sarikaya, Şaban, Tinay, İlker, Müezzinoğlu, Talha, Erbatu, Oguzcan, Sagnak, Levent, Akdoğan, Bülent, Can, Cavit, Şahin, Hayrettin, Yazıcı, Cenk Murat, Volkov, Serhii, Shulyak, Olexandr, Douglas, David, Hemmant, Joshua, El-Taji, Omar, Ahmad, Imran, Nalagatla, Sarika, Janebdar, Husay, Veeratterapillay, Rajan, Rai, Bhavan, Conroy, Samantha, Cumberbatch, Marcus, Malde, Sachin, MacLennan, Steven, Duncan, Eilidh, Dunsmore, Jennifer, Fullwood, Louise, Lumen, Nicolaas, Plass, Karin, Ribal, Maria J., Roobol, Monique J., Nieboer, Daan, Schouten, Natasha, Skolarus, Ted A., Smith, Emma Jane, N'Dow, James, Mottet, Nicolas, and Briganti, Alberto

Published
2023
Full Text
View/download PDF

31. Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy

Author

Terbuch, Angelika, Posch, Florian, Bauernhofer, Thomas, Jost, Philipp J., Partl, Richard, Stranzl-Lawatsch, Heidi, Baciarello, Giulia, Fizazi, Karim, Giannatempo, Patrizia, Verzoni, Elena, Sweeney, Christopher, Ravi, Praful, Tran, Ben, Basso, Umberto, White, Jeff, Vincenzi, Bruno, Oing, Christoph, Cutuli, Hernan Javier, Dieckmann, Klaus Peter, Gamulin, Marija, Chovanec, Michal, Fankhauser, Christian Daniel, Heidenreich, Axel, Mohamad, Osama, Thibault, Constance, Fischer, Stefanie, and Gillessen, Silke

Published
2022
Full Text
View/download PDF

33. Feasibility and Optimal Time Point of [68Ga]Gallium-labeled Prostate-specific Membrane Antigen Ligand Positron Emission Tomography Imaging in Patients Undergoing Cytoreductive Surgery After Systemic Therapy for Primary Oligometastatic Prostate Cancer: Implications for Patient Selection and Extent of Surgery

Author

Huebner, Nicolai, Rasul, Sazan, Baltzer, Pascal, Clauser, Paola, Hermann Grubmüller, Karl, Mitterhauser, Markus, Hacker, Marcus, Heidenreich, Axel, Rajwa, Pawel, Fajkovic, Harun, Shariat, Shahrokh F., and Grubmüller, Bernhard

Published
2022
Full Text
View/download PDF

34. Definition and Impact on Oncologic Outcomes of Persistently Elevated Prostate-specific Antigen After Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer After Radical Prostatectomy: Clinical Implications for Multimodal Therapy

Author

Bravi, Carlo A., Droghetti, Matteo, Fossati, Nicola, Gandaglia, Giorgio, Suardi, Nazareno, Mazzone, Elio, Cucchiara, Vito, Scuderi, Simone, Barletta, Francesco, Schiavina, Riccardo, Osmonov, Daniar, Juenemann, Klaus-Peter, Boeri, Luca, Karnes, R. Jeffrey, Kretschmer, Alexander, Buchner, Alexander, Stief, Christian, Hiester, Andreas, Nini, Alessandro, Albers, Peter, Devos, Gaëtan, Joniau, Steven, Van Poppel, Hendrik, Grubmüller, Bernhard, Shariat, Shahrokh F., Heidenreich, Axel, Pfister, David, Tilki, Derya, Graefen, Markus, Gill, Inderbir S., Mottrie, Alexandre, Karakiewicz, Pierre I., Montorsi, Francesco, and Briganti, Alberto

Published
2022
Full Text
View/download PDF

35. Trophoblast cell surface antigen‐2: a promising new biomarker and potential therapeutic target in penile squamous cell carcinoma.

Author

Weiten, Richard, Storz, Enno, Kessler, Carolina, Sperber, Laurenz, Spohn, Hanna Elisa, Pfister, David, Nestler, Tim, Tolkach, Yuri, Linden, Friederike, Wirtz, Ralph, von Brandenstein, Melanie, Krausewitz, Philipp, and Heidenreich, Axel

Subjects
IMMUNOSTAINING, SQUAMOUS cell carcinoma, LYMPHATIC metastasis, GENE expression, BLOOD proteins
Abstract

Objective: To evaluate the potential utility of antibody‐drug conjugates targeting trophoblast cell surface antigen‐2 (TROP‐2) in patients with primary penile squamous cell carcinoma (PSCC), patients with recurrence (REC cohort), and patient‐matched distant metastases (MET cohort), and to assess the potential use of TROP‐2 as a predictive non‐invasive biomarker in PSCC. Methods: A cohort comprising a PRIM (n = 37), REC (n = 5) and MET subcohort (n = 7), with MET including lymph node and lung metastases, was analysed using quantitative real‐time PCR, ELISA and immunohistochemical staining with evaluation of H‐score. Results: TROP‐2 mRNA and serum protein levels were significantly increased in primary and recurrent PSCC compared to cancer‐free controls (both P < 0.001). Immunohistochemical analysis revealed that most of the PRIM cohort (n = 34/37, median H‐score 260, interquartile range [IQR] 210–300), as well as all patients in the REC (median [IQR] H‐score 200 [165–290]) and MET cohorts (median [IQR] H‐score 280 [260–300]) exhibited moderate to strong membranous TROP‐2 expression. Additionally, The H‐score (membranous TROP‐2 expression) was positively correlated with TROP‐2 mRNA (ρ = 0.69, P < 0.0001, R2 = 0.70) and protein levels (ρ = 0.86, P < 0.0001, R2 = 0.59), indicating its potential as a non‐invasive biomarker in PSCC. Conclusion: In summary, our results support further studies on TROP‐2 as a diagnostic and therapeutic target in primary, recurrent and metastatic PSCC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

36. Cost‐effectiveness analysis of different treatment modalities in BCG‐unresponsive NMIBC.

Author

Rieger, Constantin, Schlüchtermann, Jörg, Storz, Enno, Kastner, Lucas, Pfister, David, and Heidenreich, Axel

Subjects
MONTE Carlo method, SALVAGE therapy, MARKOV processes, DOCETAXEL, PEMBROLIZUMAB
Abstract

Objective: Radical cystectomy (RC) is the standard of care (SOC) in BCG‐unresponsive NMIBC and is associated with a significant health‐related quality‐of‐life burden. Recently, promising results have been published on Gemcitabine/Docetaxel, Pembrolizumab, and Hyperthermic Intravesical Chemotherapy (HIVEC) as salvage therapy options trying to increase the rate of bladder preservation. Here, we performed a Cost‐Effectiveness‐Analysis of those treatment modalities. Patients and Methods: We developed a Markov model from a payer's perspective drawing on clinical data of single‐arm trials testing intravesical gemcitabine/docetaxel and pembrolizumab in BCG‐unresponsive NMIBC, as well as clinical data from patients receiving hyperthermic intravesical chemotherapy HIVEC (n = 29) as intravesical salvage chemotherapy at our uro‐oncological centre in Cologne. Costs were simulated utilising a non‐commercial diagnosis‐related groups grouper, utilities were derived from comparable cost‐effectiveness studies. We used a Monte Carlo simulation to identify the optimal treatment, comparing the incremental cost effectiveness ratios (ICERs) at a willingness‐to‐pay threshold of €50 000 (euro)/quality‐adjusted life year (QALY). Results: Over a horizon of 10 years, gemcitabine/docetaxel, HIVEC, and pembrolizumab were associated with costs of €48 353, €64 438, and €204 580, as well as a gain of QALYs of 6.16, 6.48, and 6.00, resulting in an ICER of €26 482, €42 567, and €184 533 respectively, in comparison to RC with total costs of €21 871 and a gain of QALYs of 5.01. Monte Carlo simulation identified HIVEC as the treatment of choice under assumption of a WTP of <€50 000. Conclusion: Considering a WTP of <€50 000/QALY, gemcitabine/docetaxel and HIVEC are highly cost‐effective therapeutic options in BCG‐refractory NMIBC, while RC remains the cheapest option. At its current price, pembrolizumab would only be cost‐effective assuming a price reduction of at least 70%. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

37. Preservation of the native urethral plate and corpus spongiosum combined with buccal mucosa graft plus Orandi's penile skin flap as an alternative to staged urethroplasty for narrow penile strictures.

Author

Karapanos, Leonidas, Halbe, Luisa, Storz, Enno, Rieger, Constantin, Weiten, Richard, Ergashev, Bobirjon, and Heidenreich, Axel

Subjects
URETHRA stricture, URINARY diversion, DIVERTICULUM, URETHROPLASTY, MUCOUS membranes, CORPORA
Abstract

Objective: In narrow anterior urethral strictures, the combined buccal mucosa graft (BMG) with pedicled penile skin flap (PSF) represents a well‐known effective alternative to staged urethroplasty. We hypothesized that if the native urethral plate and adjacent corpus spongiosum were preserved, a narrower flap would be needed, and reinforced ventral stability could be achieved without compromising the surgical outcome. Methods: Twelve patients with narrow penile urethral strictures underwent single‐stage augmentation urethroplasty using a combined technique. A BMG was quilted to the corpora cavernosa in a dorsal onlay approach, and a longitudinal ventral PSF was transposed ventrally and sutured to the scarred native urethral mucosa on one side and to the BMG on the other side to form a neourethra of triangular form. The preserved corpus spongiosum was wrapped and fixed around the flap ventrally. Results: The median age was 47 years (IQR 35–59), and the median stricture length was 5 cm (IQR 3, 8–7). The median surgical time was 205 min (IQR 172–236). The overall success rate (SR) was 91.7% without sacculation or diverticula formation after a median follow‐up period of 38 months (IQR 33–40). Three transient fistulas healed through prolonged urinary diversion. Five patients (41.7%) reported postvoid dribbling following urethroplasty. Conclusion: Preservation of the native urethral plate is a valuable adjunct to the combination of graft and flap for single‐stage augmentation urethroplasty for narrow urethral strictures, with satisfactory mid‐term success and an acceptable complication rate. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

39. Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study

Author

Marcq, Gautier, Foerster, Beat, Abufaraj, Mohammad, Matin, Surena F., Azizi, Mounsif, Gupta, Mohit, Li, Wei-Ming, Seisen, Thomas, Clinton, Timothy, Xylinas, Evanguelos, Mir, M. Carmen, Schweitzer, Donald, Mari, Andrea, Kimura, Shoji, Bandini, Marco, Mathieu, Romain, Ku, Ja H., Guruli, Georgi, Grabbert, Markus, Czech, Anna K., Muilwijk, Tim, Pycha, Armin, D’Andrea, David, Petros, Firas G., Spiess, Philippe E., Bivalacqua, Trinity, Wu, Wen-Jeng, Rouprêt, Morgan, Krabbe, Laura-Maria, Hendricksen, Kees, Egawa, Shin, Briganti, Alberto, Moschini, Marco, Graffeille, Vivien, Autorino, Riccardo, John, Patricia, Heidenreich, Axel, Chlosta, Piotr, Joniau, Steven, Soria, Francesco, Pierorazio, Phillip M., Shariat, Shahrokh F., and Kassouf, Wassim

Published
2022
Full Text
View/download PDF

44. Association Between Human Papillomavirus Infection and Outcome of Perioperative Nodal Radiotherapy for Penile Carcinoma

Author

Bandini, Marco, Ross, Jeffrey S., Zhu, Yao, Ye, Ding-Wei, Ornellas, Antonio A., Watkin, Nick, Ayres, Benjamin A., Hakenberg, Oliver W., Heidenreich, Axel, Salvioni, Roberto, Catanzaro, Mario, Raggi, Daniele, Giannatempo, Patrizia, Marandino, Laura, Haidl, Friederike, Pederzoli, Filippo, Briganti, Alberto, Montorsi, Francesco, Chipollini, Juan, Azizi, Mounsif, De Meerleer, Gert, Brouwer, Oscar R., Grass, G. Daniel, Johnstone, Peter A., Albersen, Maarten, Spiess, Philippe E., and Necchi, Andrea

Published
2021
Full Text
View/download PDF

46. Impact of Pelvic Lymph Node Dissection and Its Extent on Perioperative Morbidity in Patients Undergoing Radical Prostatectomy for Prostate Cancer: A Comprehensive Systematic Review and Meta-analysis

Author

Cacciamani, Giovanni E., Maas, Marissa, Nassiri, Nima, Ortega, David, Gill, Karanvir, Dell’Oglio, Paolo, Thalmann, George N., Heidenreich, Axel, Eastham, James A., Evans, Christopher P., Karnes, R. Jeffrey, De Castro Abreu, Andre L., Briganti, Alberto, Artibani, Walter, Gill, Inderbir, and Montorsi, Francesco

Published
2021
Full Text
View/download PDF

47. The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

Author

Seidel, Christoph, Daugaard, Gedske, Nestler, Tim, Tryakin, Alexey, Fedyanin, Mikhail, Fankhauser, Christian Daniel, Hermanns, Thomas, Aparicio, Jorge, Heinzelbecker, Julia, Paffenholz, Pia, Heidenreich, Axel, De Giorgi, Ugo, Cathomas, Richard, Lorch, Anja, Fingerhut, Anna, Gayer, Fabian, Bremmer, Felix, Giannatempo, Patrizia, Necchi, Andrea, Raggi, Daniele, Aurilio, Gaetano, Casadei, Chiara, Hentrich, Marcus, Tran, Ben, Dieckmann, Klaus-Peter, Brito, Margarido, Ruf, Christian, Mazzocca, Alessandro, Vincenzi, Bruno, Stahl, Olof, Bokemeyer, Carsten, and Oing, Christoph

Published
2021
Full Text
View/download PDF

50. Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum.

Author

Seidel, Christoph, Paulsen, Finn-Ole, Nestler, Tim, Cathomas, Richard, Hentrich, Marcus, Paffenholz, Pia, Bokemeyer, Carsten, Heidenreich, Axel, Nettersheim, Daniel, and Bremmer, Felix

Abstract

Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component, i.e. choriocarcinoma (CC), may be assumed. To characterize cases described as pure seminoma with high serum hCG levels, tissue samples and DNA were analyzed. Patient files from an international registry were screened for patients with SEM and extraordinarily high hCG serum levels. IHC and qRT-PCR analysis was performed for markers of SEM, embryonal carcinoma (EC) and CC/trophoblast cells. The cell lines TCam-2 (SEM), 2102EP, NCCIT, NT2/D1 (EC) and JAR, JEG3 and BeWo (CC) were included for comparison. Of 1031 SEM patients screened, 39 patients (3.7%) showed hCG serum levels > 1000 U/l. Of these, tumor material for IHC and RNA for qRT-PCR was available from n = 7 patients and n = 3 patients, respectively. Median pre-orchiectomy serum hCG level was 5356 U/l (range: 1224–40909 U/L). Histopathologically, all investigated samples were classified as SEM with syncytiotrophoblast sub-populations. SEM cells were SALL4+ / OCT3/4+ / D2-40+, while syncytiotrophoblast cells were hCG+ / GATA3+ / p63+ and SOX2−/CDX2−. qRT-PCR analysis detected trophoblast stem cell markers CDX2, EOMES and TFAP2C as well as the trophectoderm-specifier TEAD4, but not GATA3. Additionally, SOX17 and PRAME, but not SOX2, were detected, confirming the pure SEM-like gene expression signature of the analyzed samples. In conclusion, excessively increased hCG serum levels can appear in patients with pure SEM. To explain detectable hCG serum levels, it is important to diagnose the subtype of a SEM with syncytiotrophoblasts. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results