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Your search keyword '"Heynck S"' showing total 14 results

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14 results on '"Heynck S"'

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1. Telomerase activation by genomic rearrangements in high-risk neuroblastoma.

2. Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

3. A framework for identification of actionable cancer genome dependencies in small cell lung cancer.

4. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

5. ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

6. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.

7. Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

8. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

9. Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

10. Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation.

11. Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling.

12. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.

13. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.

14. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.

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