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Your search keyword '"Holland, C.M."' showing total 7 results
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7 results on '"Holland, C.M."'

1. Unilateral inguinofemoral lymphadenectomy in patients with early-stage vulvar squamous cell carcinoma and a unilateral metastatic sentinel lymph node is safe

Author

Levenback, C.F., Hermans, R.H., Bouda, J., Sharma, A., Luesley, D., Ellis, P., Cruickshank, D.J., Duncan, T.J., Kieser, K., Palle, C., Spirtos, N.M., O'Malley, D.M., Leitao, M.M., Geller, M., Dhar, K., Asher, V., Tobias, D.H., Borgfeldt, C., Lea, J.S., Lood, M., Bailey, J., Eyjolfsdottir, B., Attard-Montalto, S., Tewari, K.S., Persson, P., Manchanda, R., Jensen, P., Van Le, L., Van der Kolk, W.L., Van der Zee, A.G.J., Slomovitz, B.M., Baldwin, P.J.W., Van Doorn, H.C., De Hullu, J.A., Van der Velden, J., Gaarenstroom, K.N., Slangen, B.F.M., Kjolhede, P., Brännström, M., Vergote, I., Holland, C.M., Coleman, R., Van Dorst, E.B.L., Van Driel, W.J., Nunns, D., Widschwendter, M., Nugent, D., DiSilvestro, P.A., Mannel, R.S., Tjiong, M.Y., Boll, D., Cibula, D., Covens, A., Provencher, D., Runnebaum, I.B., Monk, B.J., Zanagnolo, V., Tamussino, K., and Oonk, M.H.M.

Published
2022
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4. Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer.

Author

Holland, C.M., Day, K., Evans, A., and Smith, S.K.

Subjects
*NEOVASCULARIZATION, *VASCULAR endothelium, *GROWTH factors, *GENE expression, *ENDOMETRIAL tumors
Abstract

Angiogenesis is critical for the growth and metastasis of endometrial cancer and is therefore an important therapeutic target. Vascular endothelial growth factor-A (VEGF-A) is a key molecule in angiogenesis, but the identification of related molecules and the angiopoietins suggests a more complex picture. We investigated the presence of transcripts for VEGF-A, VEGF-B, VEGF-C, VEGF-D, Angiopoietin-1 and Angiopoietin-2 in benign endometrium, atypical complex hyperplasia (ACH) and endometrioid endometrial carcinoma using in situ hybridisation. We confirmed the presence of VEGF-A mRNA in the epithelial cells of cancers examined (13 out of 13), but not in benign endometrium or ACH. We also demonstrate, using quantitative polymerase chain reaction, that levels of VEGF-B mRNA are significantly lower in endometrial cancer than benign endometrium. We conclude that loss of VEGF-B may contribute to the development of endometrial carcinoma by modulating availability of receptors for VEGF-A.British Journal of Cancer (2003) 89, 891-898. doi:10.1038/sj.bjc.6601194 www.bjcancer.com [ABSTRACT FROM AUTHOR]

Published
2003
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