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4. Karyological Variation of Clonal Malignant Cell Lines

Author

Sasaki, Kazuhiko, Nakada, Taishi, Tanaka, Rikuo, Honjou, Kazumitsu, Homma, Yutaka, Nakanishi, Takashi, and Murakami, Tomoyuki

Subjects
Flow cytometry (FCM), Clone, Karyotype, Instability, 医学, Malignant cell
Abstract

Chromosomal analysis and DNA flow cytometry were performed on HeLa, malignant fibrous histiocytoma (MFH) and their clonal sublines. Two HeLa clones attained confluency in a 60-mm dish on the 45th day after cloning. In MFH two clonal sublines began to increase cell numbers at the first. One continued growth and became confluent on the 177th day but the other ceased to grow. The chromosome number in all parent and clonal sublines showed a wide range of distribution, mostly in the hypotriploid range. In spite of single cell origen, remarkable karyological variation were seen in all clonal sublines. DNA histogram of all tumor lines measured by flow cytometry displayed distinct G1-peak which was narrower than expected from the distribution of chromosome numbers. All G1-peak as well as modal chromosome numbers were in hyportriploid region. From karyological variation in clonal sublines, chromosomal alteration may occur during growth. Furthermore, it is suggestive that the cell with near-triploid might be advantageous for proliferation, so that the cell with extremely small and large number of chromosomes can not progress.

Published
1991

5. Effects of rotation on the P13 mid-latency auditory evoked potential in Rat.

Author

Homma, Yuko, Homma, Yutaka, Teneud, Luis, Skinner, Robert D., Dornhoffer, John, Williams, D. Keith, and Garcia-Rill, Edgar

Subjects
*AUDITORY evoked response, *AUDITORY perception, *AROUSAL (Physiology), *ROTATIONAL motion, *RATS
Abstract

The P13 mid-latency auditory evoked potential in Rat is a sleep state-dependent response thought to be equivalent to the human P50 potential, a measure of the output of the reticular activating system. The amplitude of these potentials can be considered a measure of level of arousal, while, using a paired stimulus paradigm, the degree of habituation of the responses also can be assessed. Different durations of rotation were found to reduce the amplitude of the P13 potential, which recovered in a duration-dependent manner. Different durations of rotation led to decreases in habituation of the P13 potential again in a duration-dependent manner. These results suggest that rotation may affect the level of arousal as well as habituation to repetitive sensory inputs. Such effects could be interpreted to imply the presence, following rotation of sufficient duration, of a deficit in sensory gating, or distractibility, and are relevant for the study of the effects of space motion sickness. [ABSTRACT FROM AUTHOR]

Published
2003
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8. Effects of rotation on the P13 mid-latency auditory evoked potential in rat.

Author

Homma Y, Homma Y, Teneud L, Skinner RD, Dornhoffer J, Williams DK, and Garcia-Rill E

Subjects
Animals, Arousal physiology, Electroencephalography, Electromyography, Habituation, Psychophysiologic physiology, Rats, Rats, Sprague-Dawley, Reaction Time, Rotation, Evoked Potentials, Auditory physiology, Reticular Formation physiology
Abstract

The P13 mid-latency auditory evoked potential in Rat is a sleep state-dependent response thought to be equivalent to the human P50 potential, a measure of the output of the reticular activating system. The amplitude of these potentials can be considered a measure of level of arousal, while, using a paired stimulus paradigm, the degree of habituation of the responses also can be assessed. Different durations of rotation were found to reduce the amplitude of the P13 potential, which recovered in a duration-dependent manner. Different durations of rotation led to decreases in habituation of the P13 potential again in a duration-dependent manner. These results suggest that rotation may affect the level of arousal as well as habituation to repetitive sensory inputs. Such effects could be interpreted to imply the presence, following rotation of sufficient duration, of a deficit in sensory gating, or distractibility, and are relevant for the study of the effects of space motion sickness.

Published
2002

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