126 results on '"Hsia, Ning-Yi"'
Search Results
2. MULTIMODAL IMAGING OF ACUTE MULTIFOCAL HEMORRHAGIC RETINAL VASCULITIS: A CASE REPORT
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Meng, Ping-Ping, Lin, Chun-Ju, Hsia, Ning-Yi, Lai, Chun-Ting, Bair, Henry, Lin, Jane-Ming, and Tsai, Yi-Yu
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- 2023
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3. Assessing Uveitis Risk following Pediatric Down Syndrome Diagnosis: A TriNetX Database Study.
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Hsu, Alan Y., Wang, Yu-Hsun, Lin, Chun-Ju, Li, You-Ling, Hsia, Ning-Yi, Lai, Chun-Ting, Kuo, Hou-Ting, Chen, Huan-Sheng, Tsai, Yi-Yu, and Wei, James Cheng-Chung
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IRIDOCYCLITIS ,SYNDROMES in children ,UVEITIS ,DOWN syndrome ,DATABASES ,PEOPLE with Down syndrome - Abstract
Background and Objectives: The risks of uveitis development among pediatric patients with Down syndrome (DS) remain unclear. Therefore, we aimed to determine the risk of uveitis following a diagnosis of DS. Materials and Methods: This multi-institutional retrospective cohort study utilized the TriNetX database to identify individuals aged 18 years and younger with and without a diagnosis of DS between 1 January 2000 and 31 December 2023. The non-DS cohort consisted of randomly selected control patients matched by selected variables. This included gender, age, ethnicity, and certain comorbidities. The main outcome is the incidence of new-onset uveitis. Statistical analysis of the uveitis risk was reported using hazard ratios (HRs) and 95% confidence intervals (CIs). Separate analyses of the uveitis risk among DS patients based on age groups and gender were also performed. Results: A total of 53,993 individuals with DS (46.83% female, 58.26% white, mean age at index 5.21 ± 5.76 years) and 53,993 non-DS individuals (45.56% female, 58.28% white, mean age at index 5.21 ± 5.76 years) were recruited from the TriNetX database. Our analysis also showed no overall increased risk of uveitis among DS patients (HR: 1.33 [CI: 0.89–1.99]) compared to the non-DS cohort across the 23-year study period. Subgroup analyses based on different age groups showed that those aged 0–1 year (HR: 1.36 [CI: 0.68–2.72]), 0–5 years (HR: 1.34 [CI: 0.75–2.39]), and 6–18 years (HR: 1.15 [CI: 0.67–1.96]) were found to have no association with uveitis risk compared to their respective non-DS comparators. There was also no increased risk of uveitis among females (HR: 1.49 [CI: 0.87–2.56]) or males (HR: 0.82 [CI: 0.48–1.41]) with DS compared to their respective non-DS comparators. Conclusions: Our study found no overall increased risk of uveitis following a diagnosis of DS compared to a matched control population. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
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Shen, Yi-Chen, Hsia, Ning-Yi, Wu, Wan-Hua, Lin, Cheng-Li, Shen, Te-Chun, and Huang, Wei-Chien
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- 2021
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5. Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease
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Bair, Pei-Jane, Hsia, Ning-Yi, Lin, Cheng-Li, Yang, Yu-Cih, Shen, Te-Chun, and Li, Chi‐Yuan
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- 2021
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6. Risk factors for repeated dexamethasone intravitreal implant therapy for macular edema due to treatment-naïve branch retinal vein occlusion
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Huang, Yu-Te, Lin, Chun-Ju, Chen, Huan-Sheng, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Lin, Jane-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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- 2021
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7. Epstein–Barr Virus Uveitis Confirmed via Aqueous Humor Polymerase Chain Reaction and Metagenomics—A Case Report.
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Hsia, Ning-Yi, Bair, Henry, Lin, Chih-Ying, Lin, Chun-Ju, Lai, Chun-Ting, Chang, Chieh-Min, Lin, Jane-Ming, and Tsai, Yi-Yu
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AQUEOUS humor ,POLYMERASE chain reaction ,EPSTEIN-Barr virus ,METAGENOMICS ,UVEITIS ,IRIDOCYCLITIS ,HERPES zoster - Abstract
This is a case report of Epstein–Barr virus (EBV) uveitis confirmed via aqueous humor polymerase chain reaction (PCR) and metagenomics. This 72-year-old male with a history of diabetes and herpes zoster complained of redness and blurred vision in his right eye for eight months. Mild conjunctival injection, anterior chamber cells, mutton-fat keratic precipitates, and vitreous haze were noted. Fluorescein angiography revealed dye leakage from retinal vessels without retinal ischemic changes. Only the serum anti-cytomegalovirus (CMV) IgG was positive while the aqueous humor PCR for VZV (Varicella-zoster virus), HSV (Herpes simplex viruses), CMV, and EBV was initially negative. Inflammation recurred and vitreous haze worsened after discontinuing nine-month topical ganciclovir and oral prednisolone. the aqueous humor PCR was repeated due to persistent low-grade inflammation. The EBV PCR turned out to be positive. Shotgun metagenomics revealed 1459 classified sequences (1.62%) and confirmed the EBV infection. Topical ganciclovir and methylprednisolone treatment was resumed. Conjunctival injection improved while pigmented keratic precipitates lessened. Elderly patients with diabetes or under immunosuppression may be susceptible to chronic uveitis associated with subsequent EBV infection. Repeated aqueous humor PCR and shotgun metagenomics are important tools in the diagnosis of this case of chronic indolent panuveitis. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Reply to comment on "The risk assessment of uveitis after COVID‐19 diagnosis by Wu et al. 2024".
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Hsu, Alan Y., Lin, Chun‐Ju, Hsia, Ning‐Yi, Wang, Yu‐Hsun, Li, Jing‐Xing, Chen, Huan‐Sheng, Wei, James Cheng‐Chung, and Tsai, Yi‐Yu
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SARS-CoV-2 ,UVEITIS ,COVID-19 testing - Abstract
This document is a reply to a comment on a study about the risk of uveitis after a COVID-19 diagnosis. The authors address concerns raised about the study's generalizability to different ethnic backgrounds, the sensitivity of PCR testing, the impact of age on the results, the presence of undiagnosed uveitis cases, and the exclusion criteria for self-limited incident uveitis. They propose modifications to address these concerns and provide additional analysis to support their original findings. The authors acknowledge that uveitis can occur independently of COVID-19 but maintain that their study's large sample size and rigorous methodology support the association between COVID-19 and uveitis. [Extracted from the article]
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- 2024
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9. Periodontitis and the subsequent risk of glaucoma: results from the real-world practice
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Sun, Kuo-Ting, Shen, Te-Chun, Chen, Shih-Chueh, Chang, Chia-Ling, Li, Ching‐Hao, Li, Xin, Palanisamy, Kalaiselvi, Hsia, Ning-Yi, Chang, Wen-Shin, Tsai, Chia-Wen, Bau, Da-Tian, and Li, Chi-Yuan
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- 2020
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10. RISK OF AGE-RELATED MACULAR DEGENERATION IN PATIENTS WITH PERIODONTITIS: A Nationwide Population-Based Cohort Study
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Sun, Kuo-Ting, Hsia, Ning-Yi, Chen, Shih-Chueh, Lin, Cheng-Li, Chen, I-An, Wu, I-Ting, Palanisamy, Kalaiselvi, Shen, Te-Chun, and Li, Chi-Yuan
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- 2020
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11. Intraocular endoscopy for the evaluation and treatment of hypotony due to a traumatic cyclodialysis: a case report
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Bair, Henry, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, and Tsai, Yi-Yu
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- 2020
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12. The risk assessment of uveitis after COVID‐19 diagnosis: A multicenter population‐based study.
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Hsia, Ning‐Yi, Hsu, Alan Y., Wang, Yu‐Hsun, Li, Jing‐Xing, Chen, Huan‐Sheng, Wei, James Cheng‐Chung, Lin, Chun‐Ju, and Tsai, Yi‐Yu
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COVID-19 testing ,UVEITIS ,COVID-19 ,RISK assessment ,IRIDOCYCLITIS - Abstract
Reports on uveitis after COVID‐19 have been limited. Our objective was to examine the risk of uveitis among COVID‐19 patients. This was a retrospective cohort study based on the TriNetX platform. The exposure group was patients with positive laboratory test result for SARS‐CoV‐2 and the comparison group was those tested negative for COVID‐19 throughout the study period. The endpoint is the new diagnoses of uveitis. This study composed of 2 105 424 patients diagnosed with COVID‐19 (55.4% female; 62.5% white; mean age at index 40.7 years) and 2 105 424 patients (55.4% female; 62.4% white; mean age at index 40.7 years) who never had COVID‐19. There was significantly increased risk of new diagnosis of uveitis since the first month after diagnosis of COVID‐19 compared with matched controls (HR: 1.18, 95% CI: 1.03–1.34) up to 24 months (HR: 1.16, 95% CI: 1.09–1.22). Our findings strengthen those previously raised by case series with a larger and multicenter study. We found that uveitis was significantly associated with COVID‐19 infection. Our findings reiterate the need for careful investigation as well as increased awareness from ophthalmologists in considering the possibility of COVID‐19 in vulnerable patients with new presentation of uveitis. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Diagnosis and Treatment of Tubercular Uveitis in Taiwan - Consensus of Expert Panels.
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Lin, Chun-Ju, Hsia, Ning-Yi, Hwang, De-Kuang, Hwang, Yih-Shiou, Chang, Yo-Chen, Hsu, Yung-Ray, Yeh, Po-Ting, Lin, Chang-Ping, Hsu, Alan Y., Ho, Mao-Wang, and Sheu, Shwu-Jiuan
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There is currently a lack of guidelines with regard to tubercular uveitis (TBU) management in Taiwan. We therefore propose an evidence-based consensus on the management for TBU. The Taiwan Ocular Inflammation Society conducted a meeting that included nine ophthalmologist and one infection disease expert that focused on three broad areas of (1) nomenclature for TBU, (2) assessment and diagnosis for TBU, and (3) treatment of TBU. Brief literature review on TBU diagnosis and management was conducted that informed this panel meeting in order to make decisions on each consensus statements. In terms of our results, a consensus statements and recommendations for the diagnosis and management of TBU were developed. This consensus statement provides an algorithmic approach toward diagnosing and managing TBU. These statements are meant to enhance but not replace individual clinician–patient interactions and to facilitate real-world clinical practice improvement in terms of TBU patients care. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Bilateral optic disc edema as a possible complication of cabozantinib use–a case report.
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Huang, Yu-Te, Lin, Chun-Ju, Tsai, Yi-Yu, and Hsia, Ning-Yi
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- 2023
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15. Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema after Ranibizumab Injections.
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Chang, Yen-Chieh, Huang, Yu-Te, Hsu, Alan Y., Meng, Ping-Ping, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, Chen, Huan-Sheng, Tien, Peng-Tai, Lin, Jane-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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OPTICAL coherence tomography ,LASER photocoagulation ,MACULAR edema ,DIABETIC retinopathy ,POLYPOIDAL choroidal vasculopathy ,TREATMENT effectiveness ,INJECTIONS ,RANIBIZUMAB - Abstract
Background and Objectives: The identification of possible biomarkers that can predict treatment response among DME eyes is important for the individualization of treatment plans. We investigated optical coherence tomography (OCT)-based biomarkers that may predict the one-year real-life outcomes among diabetic macular edema (DME) eyes following treatment by intravitreal ranibizumab (IVR) injections. Materials and Methods: A total of 65 eyes from 35 treatment-naïve patients with DME treated with ranibizumab injection were recruited. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP), and OCT scans were retrospectively recorded at baseline before treatment and at 3 months, 6 months, and 12 months after treatment. The OCT scans were evaluated for biomarkers of interest, which included central retinal thickness (CRT), amount and locations of hyperreflective foci (HRF), subretinal fluid (SRF), intraretinal cysts (IRC), large outer nuclear layer cyst (LONLC), ellipsoid zone disruption (EZD), disorganization of retinal inner layers (DRIL), hard exudates (HE), epiretinal membrane (ERM), and vitreomacular interface (VMI). Correlations between these OCT biomarkers and outcome measures (visual and structural) were statistically analyzed. Results: A total of 65 eyes from 35 patients with DME were enrolled. The mean age was 64.2 ± 10.9 years old. Significant improvement in terms of mean BCVA (p < 0.005) and mean CRT was seen at final follow-up compared to baseline. The biomarkers of DRIL, LONLC, and SRF were found to be predictive for at least 50 μm CRT reduction after treatment (with odds ratio of 8.69, 8.5, and 17.58, respectively). The biomarkers of IRC, LONLC, and SRF were predictive for significant improvement in terms of BCVA and CRT after treatment. Finally, the number of HRF was predictive for both BCVA improvement and a CRT reduction of less than 100 μm after treatment. No serious complications were reported during the study. Conclusion: Our study demonstrated the utility of OCT biomarkers as therapeutic predictors of ranibizumab treatment among DME eyes. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Short-Term Effects of Brolucizumab in the Treatment of Wet Age-Related Macular Degeneration or Polypoidal Choroidopathy Refractory to Previous Anti-Vascular Endothelial Growth Factor Therapy.
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Hsu, Alan Y., Lin, Chih-Ying, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, Lin, Jane-Ming, Tien, Peng-Tai, Meng, Ping-Ping, Ku, Wei-Ning, Chen, Wen-Lu, and Tsai, Yi-Yu
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MACULAR degeneration ,ENDOTHELIAL growth factors ,VISUAL acuity ,TREATMENT effectiveness - Abstract
Background and objectives: To report the initial response to a single intravitreal brolucizumab (IVI-B) injection in wet age-related macular degeneration (wAMD) or polypoidal choroidopathy (PCV) complicated with either persistent subretinal fluid (SRF) or pigment epithelial detachment refractory to previous anti-vascular endothelial growth factor (anti-VEGF) therapy. Material and methods: In this retrospective study, all eyes received a single IVI-B (6 mg/0.05 mL) for wAMD or PCV with treatment-resistant SRF or PED. Outcome measures included assessment in central retinal thickness (CRT), visual acuity, and evaluation for changes in the SRF or PED on OCT. Follow-up was prior to the first brolucizumab injection, then at 1 week and 5 weeks afterwards. Results: In total, 10 eyes of 10 patients (6 women [60%]) were enrolled. Five patients had wAMD and five patients had PCV. Average age of participants was 67.6 years. All patients received one IVI-B. All patients were not treatment-naïve to anti-VEGF agents. At the first week and fifth week following the first IVI-B, seven out of seven patients (100%) had resolved SRF. However, seven out of nine patients (78%) had no improvement of their PED at 5 weeks follow-up. Mean PED height and width before the first IVI-B was 339.77 µm and 2233.44 µm, respectively. Mean PED height and width at the fifthweek following the first IVI-B was 328.125 µm and 2129.5 µm, respectively. Overall mean visual acuity before the first IVI-B was 0.224; and 5 weeks following the first IVI-B was 0.38. Conclusions: Treatment with brolucizumab resulted in anatomical improvement for all patients with persistent SRF. Limited efficacy was seen for persistent PED. Brolucizumab appears to be a safe and effective option for treatment-resistant SRF. Future multicenter collaborative studies are warranted. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Chronic Kidney Disease as A Potential Risk Factor for Uveitis: A 13-Year Nationwide Population-Based Cohort Study in Taiwan.
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Lin, Chun-Ju, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Chang, Cheng-Hsien, Bair, Henry, Chen, Huan-Sheng, Yang, Yu-Cih, Lin, Jan-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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DISEASE risk factors ,IRIDOCYCLITIS ,UVEITIS - Abstract
To investigate whether patients with chronic kidney disease (CKD) are at increased risk of uveitis. Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with CKD between 2000 and 2012. The endpoint of interest was a diagnosis of uveitis. 30,256 CKD patients and 121,024 matched comparisons were analyzed. CKD patients were found to have a significantly higher cumulative uveitis incidence. Through multivariate Cox regression analysis, the CKD group was found to have higher risk of developing uveitis (adjusted hazard ratio 1.51). After stratified by gender, age, and comorbidities (hypertension, diabetes, and hyperlipidemia), the increased risk of uveitis in CKD patients remained significant. Patients with CKD were found to have higher risk of developing uveitis. For patients over 18 years old and with hypertension, diabetes, or hyperlipidemia, the presence of CKD was demonstrated as an additional crucial factor for uveitis development. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Use of Ultra-Widefield Fluorescein Angiography to Guide the Treatment to Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis—Case Report and Literature Review.
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Meng, Ping-Ping, Lin, Chun-Ju, Hsia, Ning-Yi, Lai, Chun-Ting, Bair, Henry, Lin, Jane-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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FLUORESCENCE angiography ,VASCULITIS ,LASER photocoagulation ,OPTICAL coherence tomography ,POLYPOIDAL choroidal vasculopathy ,ANEURYSMS - Abstract
Purpose: To review the clinical features, diagnosis, and treatment of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) and to report a case with the use of ultra-widefield fluorescein angiography (UWFA) for confirming the precise staging of IRVAN and aid in early treatment. The patient improved after being treated with intravitreal aflibercept injection. Results: A 26-year-old female complained of progressive blurred vision OD for one week. Her BCVA was 0.6 OD and 1.0 OS. Fundus examination showed vitritis, retinal hemorrhage, and vasculitis over bilateral eyes. Fluorescein angiography (FA) with a 55 degree of view revealed aneurysmal dilations of the peripapillary arteriole, peripapillary focal leakage, venous leakage, and capillary nonperfusion area. Stage 2 IRVAN was impressed OU. Oral prednisolone was administered. After four months, she experienced decreased visual acuity OS. Optical coherence tomography (OCT) revealed subretinal and intraretinal fluid with hyperreflective material. One posterior subtenon triamcinolone and one intravitreal aflibercept injection were performed OS, and macular edema subsided. A 105-degree ultra-widefield fluorescein angiography (UWFA) showed multiple peripheral background hypofluorescence areas corresponding to capillary nonperfusion. Retinal neovascularization (NV) was found OS, which had not been revealed by the previous 55-degree FA. Stage 3 IRVAN was made OS and panretinal laser photocoagulation (PRP) was performed. Oral prednisone and cyclosporine were prescribed. Her vision improved to 1.0 OU. Conclusion: UWFA provides visualization of peripheral retinal pathology and for precise staging. It also had direct implications in the follow-up and treatment strategy. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Cataract Development Among Pediatric Patients With Uveitis.
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Hsu, Alan Y., Kuo, Hou-Ting, Lin, Chun-Ju, Hsia, Ning-Yi, Kuo, Shu-Chun, Wei, Chang-Ching, Lai, Chun-Ting, Chen, Huan-Sheng, Wang, Yu-Hsun, Wei, James Cheng-Chung, and Tsai, Yi-Yu
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- 2024
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20. Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease
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Hsia, Ning-Yi, Lin, Chun-Ju, Lai, Chun-Ting, Bair, Henry, Chang, Cheng-Hsien, Lin, Jane-Ming, and Tsai, Yi-Yu
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genetic structures ,Article Subject ,sense organs ,eye diseases - Abstract
We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal neovascularization following retinal photocoagulation, periocular triamcinolone, and intravitreal ranibizumab injection. Retinal neovascularization initially regressed, but recurred after 5 months along with macular edema. Two more intravitreal aflibercept injections were given, and retinal neovascularization with macular edema regressed. Her vision improved to 20/25 and remained stable after 43 months. Case 2 was a 27-year-old female. Intravitreal aflibercept was administered after persistent retinal neovascularization and macular edema following periocular triamcinolone injection. The macular edema initially subsided but recurred after 3 months. Intravitreal aflibercept injections were then administered once every three months to maintain her vision 20/20. The patient has been followed up for 28 months. Intravitreal aflibercept was effective as a rescue therapy in the treatment of Eales disease to regress retinal neovascularization, though repeated injections were necessary in cases of recurrence.
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- 2021
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21. Changes of Estimated Glomerular Filtration Rate and Glycated Hemoglobin A1c in Diabetic Macular Edema Patients Treated by Ranibizumab and Aflibercept in the Tertiary Referral Hospital.
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Ku, Wei-Ning, Tien, Peng-Tai, Lin, Chun-Ju, Chiang, Chun-Chi, Hsia, Ning-Yi, Lai, Chun-Ting, Muo, Chih-Hsin, Bair, Henry, Chen, Huan-Sheng, Lin, Jane-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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GLYCOSYLATED hemoglobin ,GLOMERULAR filtration rate ,MACULAR edema ,AFLIBERCEPT ,VASCULAR endothelial growth factors - Abstract
Background and Objectives: Intravitreal injections (IVI) of vascular endothelial growth factor (VEGF) inhibitors are guideline-indicated treatments for diabetic macular edema (DME). However, some recent data have suggested that IVI VEGF inhibitors might, through systemic absorption, lead to a reduction in renal function. Our study aims to compare changes in glycated hemoglobin A1c (HbA1c) and estimated glomerular filtration rate (eGFR) between patients who received IVI ranibizumab and aflibercept treatment and patients who have not received IVI treatments. Materials and Methods: There were 17,165 DME patients with documented ophthalmology visits in the China Medical University Hospital-Clinical Research Data Repository. Those with a history of ESRD or bevacizumab treatment history, and those with missing information on HbA1c or eGFR, were excluded. After matching by age (±2 years), gender, and the year of clinical visit, 154 patients with medical treatment (including ranibizumab and aflibercept) and 154 patients without medical treatment were included in the study. The difference between HbA1c and eGFR at baseline and 3 and 12 months after the index date between the two groups was assessed. Results: Mean HbA1c and eGFR decreased between baseline and 12 months after the index date in both groups (p < 0.05). Compared with the non-treatment group, the treatment group had significantly lower HbA1c 3 and 12 months after the index date. There was no significant difference in eGFR between the two groups. In the generalized estimating equations (GEE) model, HbA1c in the treatment group was lower than the non-treatment group (−0.44%, 95% CI = −0.75, −0.14), but eGFR was similar after adjusting for age, gender, and index-year. HbA1c and eGFR decreased with the time in the adjusted GEE model (p < 0.0001) in both groups. Conclusions: This study showed that eGFR decreased with age and time and was not related to IVI anti-VEGF treatments in our tertiary referral hospital. IVI anti-VEGF therapy was also associated with better HbA1c control. It is suggested that DME patients can receive intravitreal VEGF inhibitors without inducing more renal impairment. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Increased Risk of Refractive Errors and Amblyopia among Children with Ptosis: A Nationwide Population-Based Study.
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Hsia, Ning-Yi, Wen, Li-Yen, Chou, Ching-Ying, Lin, Cheng-Li, Wan, Lei, and Lin, Hui-Ju
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REFRACTIVE errors , *MYOPIA , *ANISOMETROPIA , *AMBLYOPIA , *ASTIGMATISM , *HYPEROPIA , *AGE groups - Abstract
Background: This study aimed to investigate the risk of refractive errors (astigmatism, myopia, and hyperopia) and amblyopia in children with ptosis and association between age at diagnosis of ptosis and subsequent risks of vision problems. Methods: Retrospective claims data from the Taiwan National Health Insurance Research Database (NHIRD) were analyzed. We identified 1799 children aged 0–18 years who were newly diagnosed with ptosis between 2000 and 2012 and 7187 individuals without the disease. Both cohorts were followed up until 2013 to estimate the incidence of refractive errors and amblyopia. Results: Children with ptosis had 5.93-fold, 3.46-fold, 7.60-fold, and 13.45-fold increases in the risk of developing astigmatism, myopia, hyperopia, and amblyopia, respectively, compared with the control cohort (astigmatism: adjusted hazard ratio, aHR = 5.93, 95% confidence interval, CI = 5.16–6.82; myopia: aHR = 3.46, 95% CI = 3.13–3.83; hyperopia: aHR = 7.60, 95% CI = 5.99–9.63; amblyopia: aHR = 13.45, 95% CI = 10.60–17.05). Children diagnosed with ptosis at an age older than 3 years old had a higher risk of myopia than patients diagnosed with ptosis before age 3. There was no significant difference of the risk of astigmatism, amblyopia, and hyperopia between age groups. Conclusions: Children with ptosis may exhibit a higher risk of astigmatism, myopia, hyperopia, and amblyopia than children without ptosis. The risk of myopia is higher in children with ptosis diagnosed at >3 years than those diagnosed at ≤3 years. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study.
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Huang, Yu-Te, Wang, I, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, Chen, Huan-Sheng, Tien, Peng-Tai, Bair, Henry, Lin, Jane-Ming, Chen, Wen-Lu, Chen, Chang-He, Wu, Wen-Chuan, and Tsai, Yi-Yu
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RETINAL vein occlusion ,CHOROID ,MACULAR edema ,OPTICAL coherence tomography ,AFLIBERCEPT - Abstract
This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-naïve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p < 0.05), and densities of SCP and DCP of BRVO sectors were significantly lower at baseline than fellow eye counterparts and remained persistently lower during treatment, particularly in the aflibercept group (p < 0.05). SCP density, DCP density of both BRVO sectors (p = 0.0001, p < 0.0001), and non-BRVO sectors (p < 0.0001, p < 0.0001) were significantly correlated with final BCVA for diseased eyes. Using multivariate general linear model analysis, and including OCTA parameters only, but not all of the available clinical data, DCP density of BRVO sectors in both eyes was the most predictive factor for final visual outcome (probability p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-naïve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Clinical Manifestations and Outcomes of Tubercular Uveitis in Taiwan—A Ten-Year Multicenter Retrospective Study.
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Lin, Chun-Ju, Hsia, Ning-Yi, Hwang, De-Kuang, Hwang, Yih-Shiou, Chang, Yo-Chen, Lee, Yueh-Chang, Hsu, Yung-Ray, Yeh, Po-Ting, Lin, Chang-Ping, Chen, Hsi-Fu, Jan, Wei-Chun, Chiang, Wei-Yu, and Tsai, Ming-Ling
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SYMPTOMS ,INTERFERON gamma release tests ,BURULI ulcer ,UVEITIS ,AQUEOUS humor ,TUBERCULIN test - Abstract
Background andObjectives: This 10-year multicenter retrospective study reviewed the clinical manifestations, diagnostic tests, and treatment modalities of tubercular uveitis (TBU), including direct infection and indirect immune-mediated hypersensitivity to mycobacterial antigens in Taiwan. Materials and Methods: This retrospective chart review of patients with TBU was conducted at 11 centers from 1 January 2008 to 31 December 2017. We used a multiple regression model to analyze which factors influenced best-corrected visual acuity (BCVA) improvement. Results: A total of 79 eyes from 51 patients were included in the study. The mean age was 48.9 ± 16.4 years. The mean change of LogMAR BCVA at last visit was −0.21 ± 0.45. Diagnostic tools used include chest X-ray, chest computed tomography, Mantoux test, interferon gamma release test (QuantiFERON-TB Gold test), intraocular fluid tuberculosis polymerase chain reaction, and bronchial alveolar lavage. The clinical manifestations included 48% posterior uveitis and 37% panuveitis. In the sample, 55% of the cases were bilateral and 45% unilateral. There was 60.76% retinal vasculitis, 35.44% choroiditis, 21.52% serpiginous-like choroiditis, 17.72% vitreous hemorrhage, 12.66% posterior synechiae, 6.33% retinal detachment, and 3.80% choroidal granuloma. Treatment modalities included rifampicin, isoniazid, pyrazinamide, ethambutol, oral steroid, posterior triamcinolone, non-steroidal anti-inflammatory drugs, vitrectomy, and immunosuppressants. BCVA improved in 53.2% of eyes and remained stable in 32.9% of eyes. In the final model of multiple regression, worse initial BCVA, pyrazinamide, and receiving vitrectomy predicted better BCVA improvement. Ethambutol was associated with worse visual outcomes. Seven eyes experienced recurrence. Conclusions: This is the largest 10-year multicenter retrospective study of TBU in Taiwan to date, demonstrating the distribution of clinical manifestations and clinical associations with better treatment outcomes. The study provides a comprehensive description of TBU phenotypes in Taiwan and highlights considerations for the design of further prospective studies to reliably assess the role of ATT and vitrectomy in patients with TBU. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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25. Relationship between Uveitis and Thyroid Disease: A 13-Year Nationwide Population-based Cohort Study in Taiwan.
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Lin, Chun-Ju, Tien, Peng-Tai, Chang, Cheng-Hsien, Hsia, Ning-Yi, Yang, Yu-Cih, Lai, Chun-Ting, Bair, Henry, Chen, Huan-Sheng, Tsai, Yi-Yu, and Chang, Cheng-Hsien MD, PhD
- Subjects
THYROID diseases ,UVEITIS ,NATIONAL health insurance ,COHORT analysis ,AGE groups ,DATABASES ,RETROSPECTIVE studies ,DISEASE incidence ,NATIONAL health services ,LONGITUDINAL method - Abstract
Purpose: To investigate whether patients with thyroid disease are at increased risk of uveitis.Methods: Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with thyroid disease from 2000 to 2012. The endpoint of interest was a diagnosis of uveitis.Results: In analyzing 21,396 patients with thyroid disease, yielding 85,584 matched comparisons, patients with thyroid disease to have a significantly higher cumulative incidence of uveitis when compared to the control cohort with the Kaplan-Meier analysis. This result was further confirmed by Cox regression analysis. The increased risk was persistent in both genders. The association between thyroid disease and uveitis was stronger in patients without diabetes or hypertension.Conclusion: Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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26. MultiColor imaging in urticarial vasculitis with recurrent branch retinal artery occlusion in a case with positive toxoplasma IgG and interferon-gamma release assay - Case report
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Bair, Henry, Lin, Chun-Ju, Li, You-Ling, Hsia, Ning-Yi, Lai, Chun-Ting, Lin, Jane-Ming, Chen, Wen-Lu, Chiang, Chun-Chi, and Tsai, Yi-Yu
- Published
- 2022
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27. Astigmatism Management with Astigmatism-Correcting Intraocular Lens Using Two Toric Calculators – A Comparative Case Series.
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Huang, Yu-Te, Lin, Chun-Ju, Lai, Chun-Ting, Hsia, Ning-Yi, Tien, Peng-Tai, Bair, Henry, Chen, Huan-Sheng, Chiang, Chun-Chi, Lin, Jane-Ming, Chen, Wen-Lu, Wu, Wen-Chuan, and Tsai, Yi-Yu
- Subjects
ASTIGMATISM ,INTRAOCULAR lenses ,CALCULATORS ,VECTOR analysis ,ABERROMETRY ,CORNEAL topography ,CORNEA ,PHACOEMULSIFICATION - Abstract
Background: To compare refractive outcomes after phacoemulsification and toric IOL implantation using two different toric calculators for initial astigmatism assessment in a real-world setting. Methods: This was a retrospective, comparative, interventional case series. Patients over 30-year-old who underwent phacoemulsification and toric IOL implantation (AcrySof
® Toric IOL) by the same surgeon between 2017 and 2018 were included. Eyes with irregular astigmatism, previous corneal refractive surgery, intraocular surgery, corneal pathology, macular pathology and pupil abnormalities were excluded. IOL toricity was determined by using a calculator provided by the AcrySof Toric calculator before 2018 and Barrett Toric Calculator after 2018. Patient demographics, corneal topography, vector and preoperative and postoperative refraction were collected and analyzed at three months postoperative. Results: Thirty-two eyes of 32 patients were included in the final analysis. 0.1D for surgically induced astigmatism was used. Group 1 included 14 eyes assessed with the original (AcrySof) toric IOL calculator, and group 2 included 18 eyes assessed with the Barrett toric IOL calculator. In group 1, postoperative astigmatism less than − 1.00D, − 0.75 D, and − 0.5D was achieved in 88.2%, 76.1% and 53.7% of eyes, respectively, while, in group 2, 89% eyes achieved postoperative residual astigmatism less than 0.5D and all eyes achieved postoperative residual astigmatism less than 0.75D. The proportion of patients with lower postoperative astigmatism was significantly higher in Group 2 (p< 0.05 by chi-square test), a pattern that still held when we divided patients into multiple groups. Vector analysis with the Alpins methods also supported better outcomes in the Barrett group (0.71 D vs 0.35 D). Conclusion: The Barrett Toric calculator resulted in better results in the prediction of residual astigmatism than original (AcrySof) toric calculators. [ABSTRACT FROM AUTHOR]- Published
- 2021
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28. Preoperative Vision, Gender, and Operation Time Predict Visual Improvement After Epiretinal Membrane Vitrectomy: A Retrospective Study.
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Bair, Henry, Kung, Wei-Hsun, Lai, Chun-Ting, Lin, Chun-Ju, Chen, Huan-Sheng, Chang, Cheng-Hsien, Lin, Jane-Ming, Hsia, Ning-Yi, Chen, Wen-Lu, Tien, Peng-Tai, Wu, Wen-Chuan, and Tsai, Yi-Yu
- Subjects
VITRECTOMY ,GENDER ,VISION ,LOGISTIC regression analysis ,REGRESSION analysis ,RETROSPECTIVE studies - Abstract
Background: To evaluate the efficacy of micro-incision vitrectomy surgery using a non-contact wide-angle viewing system for fovea-attached type epiretinal membrane, and to report the factors influencing the outcome. Methods: A retrospective, comparative case series that included 50 patients with fovea-attached type epiretinal membrane who received micro-incision vitrectomy surgery using a non-contact wide-angle viewing system. Results: All patients were followed-up for a minimum of 12 months. Seven cases were classified as group 1A (mainly outer retinal thickening), 17 were group 1B (more tenting of outer retina and distorted inner retina), and 26 were group 1C (prominent inner retina thickening and inward tenting of outer retina). Outcome measures included operation time, recurrent rate, postoperative BCVA, and CRT. The mean operative time was 26.2 minutes. The mean change of BCVA (LogMAR) was − 0.43 (p< 0.001). The mean change of CRT was 135.3 μm (p< 0.001). The mean change of CRT was significantly higher in group 1C. Worse preoperative BCVA, male gender, and longer operative time can predict better postoperative BCVA found by multivariate logistic regression and multiple regression models. Conclusion: Significant improvement in BCVA and CRT is noted after micro-incision vitrectomy surgery to operate fovea-attached type epiretinal membranes. Worse preoperative BCVA, male, and longer operation time could predict better improvement. These findings may assist surgeons in better evaluating the potential of this method to help their patients with epiretinal membranes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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29. Foveal photoreceptors loss and then recovery after treatment in a chronic myelogenous leukemia patient.
- Author
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Hsia, Ning-Yi, Lin, Chun-Ju, Lin, Hui-Ju, and Wu, Kang-Hsi
- Subjects
- *
CHRONIC myeloid leukemia , *PHOTORECEPTORS , *OPTICAL coherence tomography , *VISUAL acuity - Abstract
We report a 10-year-old boy with chronic myelogenous leukemia (CML)-related retinopathy of the eyes. Foveal photoreceptors loss was noted in the right eye, but it was restored with a continued ellipsoid zone after systemic 6-week imatinib mesylate and hydroxyurea treatment. Spectral-domain optical coherence tomography images of the foveal photoreceptors change in the right eye were taken. His best-corrected visual acuity of the right eye recovered from 20/100 to 20/20. Prompt treatment of the underlying CML could result in improvement or resolution of the ocular findings, and even foveal photoreceptors loss might be reversible with good visual acuity recovery. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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30. Significant improvement of ocular clinical pictures of iris metastasis from small-cell lung cancer after systemic chemotherapy.
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Huang, Li-Ying, Hsia, Ning-Yi, Lai, Chun-Ting, Tien, Peng-Tai, Lin, Chun-Ju, Lin, Jane-Ming, Tsai, Yi-Yu, and Chen, Wen-Lu
- Abstract
The uveal tract is the most common ophthalmic site of ocular metastasis from systemic tumors due to the luxurious blood flow within the choroidal tissue. However, iris metastasis from systemic cancer is uncommon, accounting for only 8% of cases of uveal metastasis. There are several methods for the treatment of iris tumor. Here, we reported a case of iris metastasis from small-cell lung cancer. The tumor shrunk after systemic treatment for lung cancer and showed no recurrence after a 4-month follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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31. Population based retrospective cohort study on risk of retinopathy of prematurity in twins.
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Tseng, Hui-Chen, Sung, Fung-Chang, Mou, Chih-Hsin, Lin, Hsiang Yu, Chiang, Chun-Chi, Hsia, Ning-Yi, and Tzeng, Ya-Ling
- Subjects
RETROLENTAL fibroplasia ,TWINS ,METROPOLITAN areas ,COHORT analysis ,FETOFETAL transfusion ,INFANTS ,PREMATURE infants - Abstract
Background: Twin infants are likely at great risk for ROP, but studies reported conflicting findings and population studies examining the risk of retinopathy of prematurity (ROP) in twins is limited. We aimed to evaluate the ROP risk in the cohort of one of twins, comparing to singletons. Material and methods: Using insurance claims data of a half of children in Taiwan ages 18 and less, we established a twin cohort (N = 27830) born in 1998–2009 and a randomly selected singleton cohort (N = 111080) frequency matched by sex, birth year, residential area and parental occupation and followed up to 2012 years. Results: The overall incidence rate of ROP was 13.6-fold greater in the twin cohort than in the singleton cohort (35.1 vs. 2.58 per 10,000 person-years; adjusted HR = 13.4, 95% CI = 11.7–15.3; p <0.0001). The ROP incidence was slightly higher in boys than in girls, higher in children in more urbanized areas and born to mothers without works. The incident ROP increased with decreasing birthweight. For children with birthweight <1000 grams, the ROP incidence was 1.2-fold greater in the twin cohort than in the singleton cohort (1243.2 vs. 1016.3 per 10,000 person-years). The use of mechanical ventilation was associated with increased ROP risk for both cohorts, particularly for infants who were under invasive treatment. Conclusion: Infants who were born as twins or born with low birthweight were at an elevated risk of developing ROP. Extreme cautious and close monitor are required for new born with low birthweight and have undergone with mechanical ventilation. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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32. Rescue effects of intravitreal aflibercept in the treatment of neovascular age-related macular degeneration
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Hsia, Ning-Yi, Lin, Chun-Ju, Lin, Jane-Ming, Chen, Wen-Lu, Tien, Peng-Tai, Ho, Yi-Hao, Kuo, Chung-Yuan, and Tsai, Yi-Yu
- Published
- 2015
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33. Increased risk of peptic ulcer in patients with early-onset cataracts: A nationwide population-based study.
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Hsia, Ning-Yi, Tsai, Yi-Yu, Lin, Cheng-Li, and Chiang, Chun-Chi
- Subjects
- *
PEPTIC ulcer , *TREATMENT of cataracts , *NATIONAL health insurance , *MEDICAL statistics , *CONFIDENCE intervals - Abstract
Early-onset cataracts (EOC) are associated with an increased inflammatory response; therefore, a potential risk of other inflammatory diseases, like peptic ulcer, may be related. This study investigated the risk of peptic ulcer after being diagnosed with EOC. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Study subjects comprised patients with EOC (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9- CM] codes 366.00, 366.01, 366.02, 366.03, 366.04, 366.09, 366.17 and 366.18), aged 20–55 years and newly diagnosed between 2000 and 2010 (n = 1910), and a comparison cohort without the disease (n = 7515). Both cohorts were followed up until 2010 to estimate the incidences of peptic ulcer. We used the Poisson regression model to compare incidence rate ratios and the 95% confidence interval (CI). Cox proportional hazards regression was used to assess the hazard ratio (HR) of peptic ulcer associated with EOC. The overall incidence rate of peptic ulcer was higher in the EOC cohort than in the comparison cohort (10.3 vs 7.68 per 1000 person-years) with an adjusted HR of 1.33 (95% CI = 1.05, 1.69). The present study suggests that patients with EOC are at an increased risk of being diagnosed with peptic ulcer in subsequent years. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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34. Ultra-widefield angiography in the diagnosis and management of uveitis.
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Hsia, Ning-Yi, Li, You-Ling, Lin, Chun-Ju, Bair, Henry, Lai, Chun-Ting, Lin, Jane-Ming, Chen, Wen-Lu, Tien, Peng-Tai, Kuo, Chung-Yuan, and Tsai, Yi-Yu
- Abstract
PURPOSE: The aim of this study is to evaluate the clinical use of ultra-widefield angiography (UWFA) in uveitis. MATERIALS AND METHODS: We showed the UWFA and traditional 55° fluorescein angiography (FA) of four cases with Eales' disease, idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome, Behçet's disease, and idiopathic panuveitis in a tertiary medical center. Comparison of UWFA with traditional 55°FA in the diagnosis and management of uveitis and review of the literature is also presented. RESULTS: Ultra-widefield FA revealed far-peripheral vascular imaging. This information would not have been easily obtained from traditional FA. With more information of the peripheral retina, it may facilitate appropriate diagnosis and monitoring, and the management may be revised. CONCLUSION: University of Western Australia played an important role to confirm the diagnosis of uveitis and to determine the corresponding treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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35. Short-term anatomic response of the choroid to tropicamide in myopic patients.
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Lin, Chih-Ying, Wang, I., Lin, Chun-Ju, Lai, Chun-Ting, Bair, Henry, Chen, Wen-Lu, Lin, Jane-Ming, Tien, Peng-Tai, Hsia, Ning-Yi, and Tsai, Yi-Yu
- Published
- 2022
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36. The incidence of uveitis after systemic lymphoma in Taiwan: An 18-year nationwide population-based cohort study.
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Huang, Yu-Te, Lin, Chun-Ju, Liao, Pei-Lun, Hsu, Min-Yen, Chang, Cheng-Hsien, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Bair, Henry, Chen, Huan-Sheng, Chiang, Chun-Chi, Tsai, Yi-Yu, and Shen., Lishuang
- Published
- 2022
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37. Exposure to Ambient NO 2 Increases the Risk of Dry Eye Syndrome in Females: An 11-Year Population-Based Study.
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Chung, Chi-Jung, Hsia, Ning-Yi, Wu, Chih-Da, Lai, Ting-Ju, Chen, Jein-Wen, and Hsu, Hui-Tsung
- Published
- 2021
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38. Chronic kidney disease as a potential risk factor for retinal vascular disease: A 13-year nationwide population-based cohort study in Taiwan.
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Lin, Chun-Ju, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Chang, Cheng-Hsien, Yang, Yu-Cih, Bair, Henry, Chen, Huan-Sheng, Wu, Wen-Chuan, and Tsai, Yi-Yu
- Published
- 2021
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39. Tinnitus as a Potential Risk Factor for Uveitis: A 14-Year Nationwide Population-Based Cohort Study in Taiwan.
- Author
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Chen, Yi-Jye, Hsu, Alan Y., Lin, Chun-Ju, Hsia, Ning-Yi, Meng, Ping-Ping, Liao, Pei-Lun, Hsu, Min-Yen, Tien, Peng-Tai, Lai, Chun-Ting, Chen, Huan-Sheng, Chiang, Chun-Chi, and Tsai, Yi-Yu
- Abstract
Background Methods Results Conclusion Tinnitus and uveitis have shared commonality in pathophysiology in terms of autoimmunity. However, no studies that have linked any association between the conditions of tinnitus and uveitis.This is a retrospective study conducted from the Taiwan National Health Insurance database in order to investigate whether tinnitus patients are at increased risk of uveitis. Patients newly diagnosed with tinnitus between 2001 and 2014 were recruited and followed up until 2018. The endpoint of interest was a diagnosis of uveitis.A total of 31,034 tinnitus patients and 124,136 matched comparisons were analyzed. Tinnitus patients were found to have a significantly higher cumulative incidence for uveitis than those without the diagnosis of tinnitus with incidence rate of 1.68 (95% CI 1.55–1.82) per 10 000 person-months for tinnitus group and 1.48 (95% CI 1.42–1.54) per 10 000 person-months for non-tinnitus group.Tinnitus patients were found to have increased risk of developing uveitis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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40. Reevaluating the link between Down Syndrome and uveitis.
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Hsu AY, Wang YH, Lin CJ, Hsia NY, Chiang CC, Lai CT, Chen HS, Tsai YY, and Wei JC
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- 2024
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41. Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk.
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Hu PS, Hsia NY, Wang ZH, Chen HC, Hsia TC, Lin ML, Wang YC, Chang WS, Bau DT, and Tsai CW
- Subjects
- Humans, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease, Genotype, Matrix Metalloproteinase 7 genetics, Polymorphism, Single Nucleotide, Taiwan epidemiology, Conjunctiva abnormalities, Matrix Metalloproteinase 2 genetics, Pterygium genetics
- Abstract
Background/aim: In the literature, the studies about the role of matrix metalloproteinase-2 (MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of MMP-2 variants has never been examined. The aim of this study was to examine the association of MMP-2 genotypes with pterygium risk., Materials and Methods: MMP-2 rs243865 and rs2285053 were genotyped in 140 pterygium cases and 280 non-pterygium controls by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping technology., Results: The genotypic frequency of MMP-2 rs243865 CC, CT and TT were 86.4%, 12.9% and 0.7% in the pterygium group and 81.1%, 17.1% and 1.8% in the non-pterygium group (p for trend=0.3389). The variant CT and TT carriers had a 0.70- and 0.38-fold pterygium risk (95%CI=0.39-1.26 and 0.04-3.25, p=0.2982 and 0.6686, respectively). As for MMP-2 rs2285053, the genotypic frequency of CC, CT and TT were 67.1%, 28.6% and 4.3% in the pterygium group, non-significantly different from those in non-pterygium group (p for trend=0.7081). The CT and TT carriers had a 0.88- and 0.71-fold pterygium risk (95%CI=0.56-1.38 and 0.27-1.88, p=0.6612 and 0.6456, respectively). The allelic analysis results showed that MMP-2 rs243865 variant T allele was not associated with pterygium risk (7.1% versus 10.4%, OR=0.67, 95%CI=0.39-1.13, p=0.1649). As for MMP-2 rs2285053, the T allele was not associated with pterygium risk either (18.6% versus 21.1%, OR=0.85, 95%CI=0.59-1.23, p=0.4136)., Conclusion: The genotypes at MMP-2 rs243865 or rs2285053 played minor role in determining individual susceptibility for pterygium among Taiwanese., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2024
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42. Taiwan ocular inflammation society consensus recommendations for the management of juvenile idiopathic arthritis-associated uveitis.
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Chen WD, Wu CH, Wu PY, Lin CP, Ou LS, Hwang DK, Sheu SJ, Chiang WY, Chang YC, Lin CJ, Chan WC, Fang YF, Chien-Chieh Huang J, Kao TE, Chiu FY, Hsia NY, and Hwang YS
- Abstract
We presented the development of a consensus guideline for managing juvenile idiopathic arthritis-associated uveitis (JIAU) in Taiwan, considering regional differences in manifestation and epidemiology. The Taiwan Ocular Inflammation Society (TOIS) committee formulated this guideline using a modified Delphi approach with two panel meetings. Recommendations were based on a comprehensive evidence-based literature review and expert clinical experiences, and were graded according to the Oxford Centre for Evidence-Based Medicine's "Levels of Evidence" guideline (March 2009). The TOIS consensus guideline consists of 10 recommendations in four categories: screening and diagnosis, treatment, complications, and monitoring, covering a total of 27 items. These recommendations received over 75% agreement from the panelists. Early diagnosis and a coordinated referral system between ophthalmologists and pediatric rheumatologists are crucial to prevent irreversible visual impairment in children with JIAU. However, achieving a balance between disease activity and medication use remains a key challenge in JIAU management, necessitating further clinical studies., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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43. Association between immune checkpoint inhibitor medication and uveitis: a population-based cohort study utilizing TriNetX database.
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Kuo HT, Chen CY, Hsu AY, Wang YH, Lin CJ, Hsia NY, Tsai YY, and Wei JC
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Immune Checkpoint Inhibitors, Cohort Studies, Retrospective Studies, Anesthetics, Local, Chorioretinitis, Neoplasms
- Abstract
Objective: To explore the associations between the use of immune checkpoint inhibitors (ICIs) and the risk of developing uveitis among cancer patients., Methods: Cancer patients who received ICI therapy and a comparison group of cancer patients who did not receive ICI therapy were retrospectively recruited from the TriNetX electronic heath-record registry. The outcome of interest was the development of new-onset uveitis. Propensity score matching based on a 1:1 ratio was conducted in order to reduce bias. Multi-variate cox proportional hazard models and Kaplan Meier method were also utilized to assess for the risk of uveitis among cancer patients who received ICI therapy., Results: 71931 cancer patients (54.7% male; 76.5% white; mean age at index 63.6 ± 12.2 years) who received ICI treatment (ICI group) and 71931 cancer patients (54.7% male; 77% white; mean age at index 63.5 ± 12.4 years) who never received ICI (comparison group) were recruited. Associated Kaplan-Meier curves showed significantly increased uveitis risk among the ICI group for all follow-up years (p<0.001). The risk of uveitis was also higher among the ICI group during the 144-month follow-up period with a hazard ratio (HR) of 2.39 (95% CI: 2.07-2.75). Increased risk for specific uveitis diseases, such as iridocyclitis, chorioretinal inflammation, retinal vasculitis, unspecified purulent endophthalmitis, pan-uveitis and sympathetic uveitis were found. Subgroup analysis demonstrated an elevated hazard ratio for the development of uveitis among ICI recipients, spanning individuals below the age of 65 as well as those aged 65 and older. The elevated hazard ratio for uveitis development among ICI recipients was also observed across all genders, among those of white and Asian ethnicities, those with smoking history, and those with comorbid conditions such as hypertension and dyslipidemia, in comparison to their non-ICI counterparts. An additional subgroup analysis on monotherapy versus combinatory ICI regimens was also conducted. Individuals who received monotherapy from the class of anti-PD-1 (HR:1.98 [CI: 1.65-2.37]) and anti-CTLA-4 (HR:5.86 [CI:1.99-17.24]) exhibited elevated hazard ratios for uveitis development compared to their non-ICI comparators. Those exposed to combinatory ICI regimens, specifically a combination of anti-PD-1 and anti-CTLA4 (HR: 5.04 [CI:3.55-7.16]), showed increased hazard ratios for uveitis development compared to their non-ICI comparators. In contrast, individuals exposed to a combination of anti-PD-1 and anti-PD-L1 (HR: 2.47 [CI:0.81-7.50]) did not demonstrate an increased risk for uveitis compared to their non-ICI comparators., Conclusion: A significantly increased risk for uveitis diseases was found among the ICI group from the first year of follow-up. Increased awareness should be promoted on the occurrence of uveitis among cancer patients receiving ICI therapy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Kuo, Chen, Hsu, Wang, Lin, Hsia, Tsai and Wei.)
- Published
- 2024
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44. The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Helicobacter Pylori Infection to Gastric Cancer.
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Fu CK, Mong MC, Tzeng HE, Yang MD, Chen JC, Hsia TC, Hsia NY, Tsai CW, Chang WS, Chen CP, and Bau DT
- Subjects
- Humans, Alcohol Drinking adverse effects, Case-Control Studies, Genetic Predisposition to Disease, Genotype, Interleukin-16 genetics, Polymorphism, Single Nucleotide, Risk Factors, Smoking adverse effects, Helicobacter Infections complications, Helicobacter Infections genetics, Helicobacter pylori, Stomach Neoplasms genetics, Stomach Neoplasms complications
- Abstract
Background/aim: Elevated serum interleukin-16 (IL-16) levels have been reported in gastric cancer (GC) tissues; however, the role of IL-16 genotypes in GC susceptibility remains largely unexplored. This study aimed to investigate the contribution of IL-16 genotypes to GC susceptibility and to assess their interactions with smoking, alcohol drinking, and Helicobacter pylori (H. pylori) infection., Materials and Methods: Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology was employed to determine IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics in 161 patients with GC and 483 controls., Results: Significant differences were observed in the distribution of genotypic (p=0.0009) and allelic (p=0.0002) frequencies of IL-16 rs11556218 among cases and controls. Specifically, the frequencies of TG and GG genotypes of IL-16 rs11556218 were 37.3% and 6.8% among patients with GC, respectively, which were higher than those among the controls (26.7% and 2.7%). In contrast, no significant differences were found concerning IL-16 rs4778889 or rs4072111. Notably, individuals with IL-16 rs11556218 TT genotypes exhibited significant protective effects against GC when exposed to risk factors, such as smoking, alcohol drinking, and H. pylori infection., Conclusion: IL-16 rs11556218 T allele was associated with reduced susceptibility to GC. Furthermore, carriers of the TT genotype showed protection against GC risk factors, including smoking, alcohol drinking, and H. pylori infection. These findings provide valuable insights into the potential role of IL-16 genotypes in GC development and their interactions with lifestyle and infectious factors., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2024
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45. Prevalence of uveitis in syphilis patients in Taiwan.
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Chen CY, Kuo HT, Hsu AY, Lin CJ, Hsia NY, Tien PT, Lai CT, Chen HS, and Tsai YY
- Subjects
- Male, Humans, Retrospective Studies, Risk Factors, Taiwan epidemiology, Prevalence, Incidence, Syphilis epidemiology, Uveitis epidemiology, Uveitis diagnosis
- Abstract
Few population-based studies have looked at the risk of uveitis among syphilis patients. Our study addresses the knowledge gap by reporting on uveitis risk in syphilis patients through a retrospective cohort study. The Taiwan National Health Insurance database was used for this study, covering the period from January 1st, 2009, to December 31st, 2020. We created a 1:4 propensity score matched cohort between the syphilis patients and controls, which accounted for gender, age, and comorbidities. The primary endpoint was the incidence of newly recorded uveitis. The assessment of uveitis risk in syphilis patients included the use of the Kaplan-Meier method and multivariate Cox proportional hazard model. A total of 31,597 syphilis patients and 126,379 matched comparisons were recruited. The uveitis incidence rate from our syphilis patients was 1.25 per 1000 person-years. The uveitis incidence rate from our non-syphilis group was 0.8 per 1000 person-years. After matching, the syphilis group was found to have a higher risk of developing uveitis (adjusted hazard ratio (aHR) [95% CI]: 1.57 [1.36-1.81], P < .001). Among males and individuals aged 20-34 years, subgroup analysis showed an increased risk of uveitis in the presence of syphilis infection. The Kaplan-Meier survival curve showed a significant difference in uveitis incidence between syphilis and non-syphilis groups (log-rank test P < .001). In summary, our study revealed that Taiwanese syphilis patients were at a higher risk of developing uveitis. These results highlight the need for regular ocular monitoring and screening in individuals with syphilis.
- Published
- 2024
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46. Diabetic retinopathy as a potential risk factor for ptosis: A 13-year nationwide population-based cohort study in Taiwan.
- Author
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Lin CJ, Hsu AY, Tien PT, Chang CH, Lai CT, Hsia NY, Yang YC, Bair H, Chen HS, Chen WL, and Tsai YY
- Abstract
Purpose: To determine the risk of ptosis among diabetic retinopathy (DR) patients., Methods: This is a population-based, retrospective, matched-cohort study where DR patients were recruited from the Taiwan National Health Insurance Research Database (NHIRD) to investigate the risk of developing ptosis. Preexisting co-factors of interest included smoking status and medical comorbidities of hyperlipidemia and hypertension. Statistical analysis was performed using T -test, Cox-proportional hazard ratios adjusted for comorbidities (aHR), Wilcoxon rank sum test, Kaplan-Meier estimators, and log rank tests., Results: Follow-up data of 9,494 patients with DR and 37,976 matched control cohort (non-DR) from 2000 to 2012 were analyzed. DR patients were found to have significantly increased risk of developing ptosis (adjusted hazard ratio (HR) [95% CI]: 2.76 [1.74-4.38], p < 0.001) when compared to the control cohort. From analysis in different strata, adult age and non-smokers were shown to have higher risk for ptosis development among DR patients. Furthermore, DR patients was also found to have increased risk of developing ptosis when compared to matched controls, regardless of whether they had medical comorbidities of lipid metabolism disorders or hypertension., Conclusions: In this large-scale study using real-world data, our results showed that DR patients were found to have increased risk of developing ptosis. Female gender, adult age, and non-smokers were also shown to increase the risk of ptosis among DR patients. This has implications towards the care of diabetic patients, complications such as ptosis should be properly screened for when encountering such patients. Before ptosis surgery, the possibility of underlying diabetes or DR should be also scrutinized and treated properly to avoid undesirable postoperative dissension., Competing Interests: H-SC was employed by NephroCare Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Lin, Hsu, Tien, Chang, Lai, Hsia, Yang, Bair, Chen, Chen and Tsai.)
- Published
- 2023
- Full Text
- View/download PDF
47. Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese.
- Author
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Wu MF, Chen LH, Hsia NY, Shen YC, Shen TC, Wang ZH, Yang YC, Wang YC, Chang WS, Hsia TC, Bau DT, and Tsai CW
- Subjects
- Genetic Predisposition to Disease, Genotype, Humans, Polymorphism, Single Nucleotide, Interleukin-18 genetics, Lung Neoplasms genetics
- Abstract
Background/aim: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer., Materials and Methods: IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology., Results: The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137., Conclusion: IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese., (Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2022
- Full Text
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48. Protective Effects of Gamma-mangostin on Hydrogen Peroxideinduced Cytotoxicity in Human Retinal Pigment Epithelial Cells.
- Author
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Hu PS, Hsia NY, Chien WC, Mong MC, Hsia TC, Chang HM, Wang YC, Chang WS, Bau DT, and Tsai CW
- Subjects
- Apoptosis, Cell Survival, Epithelial Cells metabolism, Humans, Hydrogen pharmacology, Oxidative Stress, Reactive Oxygen Species metabolism, Retinal Pigments metabolism, Retinal Pigments pharmacology, Xanthones, Antioxidants metabolism, Antioxidants pharmacology, Hydrogen Peroxide toxicity
- Abstract
Background: The role of epigenetic alterations in the pathogenesis of retinal degenerative diseases, such as macular degeneration is not well established. This study aimed to evaluate whether treatments with gamma-mangostin can rescue the hydrogen peroxide (H
2 O2 )-induced cytotoxicity in human retinal pigment epithelial (ARPE-19) cells., Materials and Methods: ARPE-19 cells were treated with H2 O2 alone or with gamma-mangostin plus H2 O2 to investigate changes relating to cell viability, appearance of sub-G1 cells, antioxidant enzymes, and apoptotic-related proteins., Results: The data showed that under H2 O2 treatment of 400 μM, there was a significant decrease in cell viability and enhanced apoptosis, together with an increased expression of Bax, Bad, cleaved-caspase-3, -8, and -9 at the protein level. On the contrary, the protein expression levels of Bcl2 and Bcl-xl were decreased. Gamma-mangostin pre-treatments (2-16 μM) could effectively prevent all alterations., Conclusion: Gamma-mangostin may conduct its eye-protective effects against H2 O2 -induced oxidative damage via anti- apoptotic and antioxidant mechanisms in ARPE-19 cells., (Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)- Published
- 2022
- Full Text
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49. Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants.
- Author
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Huang YT, Chang YC, Meng PP, Lin CJ, Lai CT, Hsia NY, Chen HS, Tien PT, Bair H, Lin JM, Chen WL, and Tsai YY
- Abstract
Purpose: To identify optical coherence tomography (OCT) biomarkers that may predict functional and anatomical outcomes in diabetic macular edema (DME) patients treated with intravitreal dexamethasone (DEX) implant., Materials and Methods: Sixty-four eyes from 50 patients with DME were enrolled. Best-corrected visual acuity (BCVA) and OCT biomarkers including central retinal thickness (CRT), subretinal fluid (SRF), intraretinal cysts (IRC), ellipsoid zone disruption (EZD), disorganization of retinal inner layers (DRIL), hard exudate (HE), hyperreflective foci (HRF), epiretinal membrane (ERM), and vitreomacular interface (VMI) changes were evaluated at baseline and at 3, 6, and 12 months after treatment. Multiple logistic analysis was performed to evaluate each OCT biomarker as a predictive factor for functional and anatomical improvement at the end of treatment., Results: The presence of SRF at baseline was associated with a favorable outcome, with CRT improving by more than 100 μm after treatment from multivariate logistic regression analysis [odds ratio 6.16 (1.75-21.6)]. In addition, baseline SRF predicted a greater CRT improvement from multiple regression analysis (model R-square 0.11, p = 0.006). The reduction of DRIL, SRF, LONLC, IRC, and EZD were correlated with better CRT improvement (more than 100 μm) ( P < 0.05). SRF and EZD recovery can also predict better visual prognosis ( P < 0.05)., Conclusion: OCT biomarkers can be used to predict who may benefit the most after DEX treatment. We suggest that the DEX implant should be considered as a first line treatment in DME patients with SRF., Competing Interests: H-SC was employed by NephroCare Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Huang, Chang, Meng, Lin, Lai, Hsia, Chen, Tien, Bair, Lin, Chen and Tsai.)
- Published
- 2022
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50. Temporal and double inverted internal limiting membrane flap for bilateral choroidal ruptures complicated by bilateral macular holes.
- Author
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Huang LY, Lin CJ, Lai CT, Hsia NY, Bair H, Tien PT, Chen WL, Lin JM, Chiang CC, and Tsai YY
- Abstract
Choroidal ruptures occur in 5% to 10% closed-globe injuries with wide variation in visual prognosis, which depending on the visual acuity at presentation, the location of the rupture, and other associated ocular injuries. We reported a case of bilateral traumatic choroidal rupture with a large macular hole. We performed surgery in the right eye of microincisional vitrectomy, temporally inverted internal limiting membrane (ILM) flap, and C3F8 tamponade; then microincisional vitrectomy, fibrotic scar removal, double inverted ILM flap, and C3F8 tamponade in the left eye. After surgery, she achieved both good anatomical and visual acuity improvement in the right eye, but limited visual acuity improvement in the left eye due to subfoveal choroidal scar formation., Competing Interests: The authors declare that there are no conflicts of interests of this paper., (Copyright: © 2022 Taiwan J Ophthalmol.)
- Published
- 2022
- Full Text
- View/download PDF
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