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49. R2* mapping and reduced field‐of‐view diffusion‐weighted imaging for preoperative assessment of nonenlarged lymph node metastasis in rectal cancer.

Author

Wang, Jing, Hu, Shan, Liang, Ping, Hu, Xuemei, Shen, Yaqi, Peng, Yang, Kamel, Ihab, and Li, Zhen

Subjects
DIFFUSION magnetic resonance imaging, LYMPHATIC metastasis, RECTAL cancer, LOGISTIC regression analysis, MAGNETIC resonance imaging
Abstract

The aim of the current study is to investigate the diagnostic value of R2* mapping versus reduced field‐of‐view diffusion‐weighted imaging (rDWI) of the primary lesion of rectal cancer for preoperative prediction of nonenlarged lymph node metastasis (NLNM). Eighty‐one patients with pathologically confirmed rectal cancer underwent preoperative R2* mapping and rDWI sequences before total mesorectal excisions and accompanying regional lymph node dissections. Two radiologists independently performed whole‐tumor measurements of R2* and apparent diffusion coefficient (ADC) parameters on primary lesions of rectal cancer. Patients were divided into positive (NLNM+) and negative (NLNM‐) groups based on their pathological analysis. The tumor location, maximum diameter of the tumor, and maximum short diameter of the lymph node were assessed. R2* and ADC, pT stage, tumor grade, status of mesorectal fascia, and extramural vascular invasion were also studied for their potential relationships with NLNM using multivariate logistic regression analysis. The NLNM+ group had significantly higher R2* (43.56 ± 8.43 vs. 33.87 ± 9.57, p < 0.001) and lower ADC (1.00 ± 0.13 vs. 1.06 ± 0.22, p = 0.036) than the NLNM‐ group. R2* and ADC were correlated to lymph node metastasis (r = 0.510, p < 0.001 for R2*; r = −0.235, p = 0.035 for ADC). R2* and ADC showed good and moderate diagnostic abilities in the assessment of NLNM status with corresponding area‐under‐the‐curve values of 0.795 and 0.636. R2* provided a significantly better diagnostic performance compared with ADC for the prediction of NLNM status (z = 1.962, p = 0.0498). The multivariate logistic regression analysis demonstrated that R2* was a compelling factor of lymph node metastasis (odds ratio = 56.485, 95% confidence interval: 5.759–554.013; p = 0.001). R2* mapping had significantly higher diagnostic performance than rDWI from the primary tumor of rectal cancer in the prediction of NLNM status. [ABSTRACT FROM AUTHOR]

Published
2024
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