595 results on '"Hubbuch, Jürgen"'
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2. Predicting multimodal chromatography of therapeutic antibodies using multiscale modeling
3. Correction to: Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements
4. Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements
5. Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors
6. Antibody sequence-based prediction of pH gradient elution in multimodal chromatography
7. Modeling of biopharmaceutical UF/DF from laboratory to manufacturing scale
8. Connected mechanistic process modeling to predict a commercial biopharmaceutical downstream process
9. Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
10. Bio-based material formulation for extrusion printing by dityrosine crosslinking of unmodified casein
11. Automated and dynamic extrusion pressure adjustment based on real-time flow rate measurements for precise ink dispensing in 3D bioprinting
12. Integrated process model for the prediction of biopharmaceutical manufacturing chromatography and adjustment steps
13. Steric exclusion chromatography of lentiviral vectors using hydrophilic cellulose membranes
14. Modeling the Gibbs–Donnan effect during ultrafiltration and diafiltration processes using the Poisson–Boltzmann theory in combination with a basic Stern model
15. Kinetic models towards an enhanced understanding of diverse ADC conjugation reactions.
16. Exploration of fiber-based cation exchange adsorbents for the removal of monoclonal antibody aggregates
17. Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
18. Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach
19. High throughput screening of fiber-based adsorbents for material and process development
20. Image analysis as PAT-Tool for use in extrusion-based bioprinting
21. Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination
22. Raman-based PAT for VLP precipitation: systematic data diversification and preprocessing pipeline identification.
23. Spectroscopic insights into multi-phase protein crystallization in complex lysate using Raman spectroscopy and a particle-free bypass.
24. On the analysis of chromatographic biopharmaceutical data by curve resolution techniques in the framework of the area of feasible solutions
25. Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design
26. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation
27. Time-Dependent Multi-Light-Source Image Classification Combined With Automated Multidimensional Protein Phase Diagram Construction for Protein Phase Behavior Analysis
28. Kinetic reaction modeling for antibody-drug conjugate process development
29. Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography
30. Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants
31. A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
32. Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange
33. Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging
34. A phase diagram-based toolbox to assess the impact of freeze/thaw ramps on the phase behavior of proteins
35. Prediction uncertainty assessment of chromatography models using Bayesian inference
36. Factorization of preparative protein chromatograms with hard-constraint multivariate curve resolution and second-derivative pretreatment
37. Monitoring of antibody-drug conjugation reactions with UV/Vis spectroscopy
38. Generative data augmentation and automated optimization of convolutional neural networks for process monitoring.
39. Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.
40. 3D bioprinting – Flow cytometry as analytical strategy for 3D cell structures
41. Application of Empirical Phase Diagrams for Multidimensional Data Visualization of High-Throughput Microbatch Crystallization Experiments
42. Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates
43. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography
44. In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography
45. Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression
46. An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration
47. Precipitation of complex antibody solutions: influence of contaminant composition and cell culture medium on the precipitation behavior
48. Automated image processing as an analytical tool in cell cryopreservation for bioprocess development
49. Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation
50. Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process
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