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Plaited jersey fabrics are always engineered to enhance the thermal conductivity characteristics, providing thermal equilibrium among the wearer and clothing during hot weather. These can also be architected with higher thermal resistance/heat insulation characteristics and is a crucial area of interest; however there isn't any significant literature reporting this. The study focuses on developing plaited jersey gloves using Thermolite®, acrylic, and wool yarns in alternative main and plaiting configurations for winterwear. Thermal characterizations were conducted to ascertain heat and mass transfer properties, such as fluid transmission and thermal resistance. Infrared (IR) imaging visualized heat retention in terms of temperature gradients. Mechanical characteristics, such as pilling and bursting, were assessed to determine the gloves durability to physical abrasions and stresses. Thermolite® knitted gloves possessed superior heat and mass transfer properties with improved fluid transmission and thermal resistance. Infrared imaging revealed highest body temperature rise of 34.43oC for Thermolite®, and mechanical properties were also found adequate. Fluid transfer (air permeability) was acquired highest for wool samples (1770 mm/sec); however, Thermolite® exhibited 28% lower air permeability than wool, validating its heat retention. Thermolite® knits with the lowest areal density of 226 g/m2 and the smoothest Thermolite® surface had the highest OMMC (overall moisture management capacity) index of 0.46 due to generated capillaries. The statistical analysis of the characterization data indicated the significance (p -value <0.05) of the main and plating yarns, proving the plaiting a solution to achieve desired heat and mass transfer characteristics. [ABSTRACT FROM AUTHOR]

Speculative negative Poisson's ratio (NPR) materials exhibit an auxetic response to strain in a predetermined direction due to their unusual morphologies, making them highly suitable for various specialized applications. For the rationale, these materials have immense potential in various specialized contexts. In weft-knitted auxetic fabrics, uneven tension in the purl loops leads to the distinctive curling architecture. Due to their inherent curly structure and adaptability, weft-knitted fabrics are an excellent choice for emulating NPR materials. In this study, 3D weft-knitted auxetic fabrics were created using flatbed purl knitting technology. Two distinctive patterns, comprising knit and tuck stitches, were employed. The number of stitches per repeat (SPR) was varied to assess the impact of grid size on NPR behavior. Additionally, the variation in measurement points within standard-sized characterization specimens was analyzed, revealing slight differences in auxeticity. Increasing the SPR size initially enhanced NPR behavior, up to a certain limit, beyond which the trend declined. A significant shift in NPR was observed due to material variation and inter-yarn friction, with a 27% and 28% shift of Poisson's ratio was experienced above and below the mean, respectively. Poisson's ratio was also positively correlated with energy absorption, suggesting that the designed materials could be effective for protective and energy-absorbing applications. [ABSTRACT FROM AUTHOR]

Cell wall polysaccharides (dietary fiber) in cereal grains contribute to health benefits. The novelty of the current study was an effort to explore the in vivo therapeutic potential of different cereal bran cell walls against hypercholesterolemia. For this purpose, the cell walls were isolated from different cereal brans (wheat, maize, oats, and barley), and the intake of these cereal bran cell walls was evaluated for their anti‐lipidemic activity in normal and hypercholesterolemic rats. The serum taken from the rats was tested for cholesterol, lipid, and triglyceride profiles before and after treatment. The outcomes of the current study have shown that the cereal cell wall has a significant hypercholesterolemia effect. The biochemical parameters of the control animals were within the normal clinical ranges, indicating that the experimental diets were safe. Among cereal bran cell walls, barley bran significantly decreased cholesterol (56.35 ± 1.35 mg/dL), low‐density lipoprotein (56.35 ± 1.05 mg/dL), triglycerides (105.29 ± 1.95 mg/dL), and increased high‐density lipoprotein level (48.35 ± 1.35 mg/dL). These findings provide conclusive evidence that the cereal cell wall is beneficial in the treatment of hypercholesterolemia and may potentially provide protection against other acute, recurring, or chronic illnesses. [ABSTRACT FROM AUTHOR]

Inducing auxetic nature is one of the emerging techniques to enhance impact tolerance in 3D woven composites due to their unique bidimensional-energy dissipation capability. The conventional 3D orthogonal structure has inherent auxetic nature; however, such auxeticity is completely restricted due to brittle thermoset resins-based composites. To overcome this problem, three types of 3D woven auxetic structures were developed and used as reinforcement with thermoplastic resins, that is, polycarbonate (PC) and polyvinyl butyral (PVB). The results revealed that the warp interlock structure showed the highest auxeticity, while the bidirectional interlock structure showed the least auxeticity. Charpy and low-velocity impact tests were performed to evaluate the effect of auxeticity on the impact properties of corresponding composites. Warp interlock with PC showed 49% and 47% higher Charpy impact strength and force, respectively, than bidirectional interlock with PC resin. Similarly, the low-velocity impact test results of warp interlock showed 32% and 32.5% higher impact force and absorbed energy, respectively, in warp direction than bidirectional interlock with PC resin. [ABSTRACT FROM AUTHOR]

The present work presents a new approach to the parameters of the thermoforming process for jute fiber commingled thermoplastic composites based on pressure control. Effect of gradual pressure on the microstructures of jute fiber and their mechanical properties has been investigated. The singeing of Jute yarn and subsequent co-twisting with Polypropylene (PP) was done to make reinforcement. Jute/PP composites were developed using Jute/PP commingled reinforcement. Flexural and Charpy impact tests were conducted to analyze the mechanical performance of composites made using gradual and instant loading on the compression hot press. It is found that application of gradual pressure not only decreases fiber damages, but also increase flexural strength by 82%, impact strength by 43% and impact energy by 93% as compared to composite fabricated using instant pressure. Further, the complete analysis of microstructure of fibers of both type of composites is done to compare the effect of both fabrication techniques. [ABSTRACT FROM AUTHOR]

Probiotics have growing medical importance as a result of their potential in the prevention and therapeutic support of several complex diseases, including different types of cancers. The anticarcinogenic properties of probiotics are attributed to various mechanisms, including alterations in the composition of the intestinal microbiota, suppression of cell proliferation, stimulation of apoptosis, inhibition of NF-kB, reduction in levels of H2AX, 8-hydroxy-deoxyguanosine, RIG-I, downregulation of IL-17, and TNF signaling pathway. Furthermore, probiotics have demonstrated significant advantages in the prevention and management of other complex diseases, including diabetes, obesity, and cardiovascular diseases. Probiotics had a considerable effect in reducing inflammatory infiltration and the occurrence of precancerous lesions. Additionally, the administration of probiotics led to a decrease in the appearance level of genes related to proinflammatory pathways, including NF-κB, IL-17, and TNF signaling pathways. However, further research studies are required to comprehend the processes via which probiotics exert their effects and to authenticate their potential as alternative therapeutic interventions. [ABSTRACT FROM AUTHOR]

The current study is aimed at modifying the structural makeup of potato starch through the application of heat and moisture to better control the postprandial glycemic response. Heat-moisture treatment (HMT) was used to prepare potato starch using different moisture levels and temperatures. The samples were digested with pancreatin to determine the % of easily digestible, slowly digestible, and resistant starch. Subjects were given pudding made with HMT potato starch, and their postprandial glycemic response was tracked by measuring their blood glucose levels. In addition, incremental and total incremental areas under the curve (IAUC, TIAUC) were also assessed. The current findings of in vitro enzymatic digestibility of potato starch showed inconsistent results as measured at different time intervals. Adding moisture and heating the mixture to 30 and 70°C both increased the amount of rapidly digestible starch in all of the treatments from 20 to 40%. The maximum value of slowly digestible starch was 43.63% when the sample was heated to 30°C with a moisture content of 30%. The highest value (68.46%) for resistant starch was achieved at 20% moisture level and 30°C. After eating pudding, blood sugar spiked for the first 60 and 90 min before gradually dropping off over the next 240 min. As a whole, the highest IAUC and TIAUC values, as well as the glycemic index and load, were observed in potato starch heated to 70°C, which contained 40% moisture. Most parameters achieved their highest values when 40% moisture was added and the heat was applied at 70°C. [ABSTRACT FROM AUTHOR]

Kaempferol is a flavonoid present in many eatable plants. Researchers discovered a link between consuming foods high in kaempferol and lowering the threat for acquiring many diseases, including cardiovascular disease, diabetes, obesity and cancer. Kaempferol can inhibit AHR transcription, modulate ERK signalling pathway and NF-κB pathways, block MAPK and AP1 signalling pathways and perform more anticancer roles. Kaempferol also has the ability to act against diabetes via suppressed phosphorylation of (IKK) IkB kinase, (IRS-1) insulin receptor substrate-1 and (IKK) IkB kinase through the hepatic IKK/NF-B signalling pathways and significantly enhanced insulin secretion and synthesis. Kaempferol protects cardiomyocytes from anoxia/reoxygenation (A/R)-induced damage by lowering LDH release, improving cell survival, reducing A/R-induced ROS formation, and release of cytochrome c. This knowledge may aid in understanding health advantages of medicinal plants that contain kaempferol and may lead to the development of the flavonoid as a potential agents for disease aversion and therapy. [ABSTRACT FROM AUTHOR]

Cancer is the second leading cause of death in the world and one of the major public health problems. Curcumin has anticancer activity including inducing apoptosis and inhibiting proliferation and invasion of tumours by suppressing a variety of cellular signalling pathways. It also possesses anti-tumour activity on different human cancers such as breast cancer, lung cancer, head and neck squamous cell carcinoma, prostate cancer, and brain tumours. In vitro and in vivo trails, curcumin inhibits tumour development and metastasis by inhibiting many pathways that regulate signalling in malignant cells, including Ras, p53, extracellular signal-regulated kinases (ERK), Wnt-protein kinase B (Akt), MAPKs, and PI3K. Curcumin can also inhibit IKK, EGFR, -catenin, cyclin D1, tumour necrosis factor (TNF), and anti-apoptotic genes such as Bcl-X and Bcl-2 along with downregulating nuclear transcription factors like NF-κB, which reduces the formation of pro-inflammatory cytokines like chemokines, TNF-, Interleukins and IL-1, IL-2, IL-6, IL-8, IL-12. [ABSTRACT FROM AUTHOR]

Resveratrol (RVT) is well known for its chemo-preventive and therapeutic attributes against the various kinds of cancers such as breast, prostate, pancreatic, oral, brain, lung and liver. It has been found to inhibit glioblastoma cell growth, declining uPAR and its mediator ERK1/2, inhibiting the cell lines (EC-9706) growth and ADAM9 expression, up-regulating the lncRNAs and PPARγ, inhibition of MTA1 to modulate oncogenic miR-34a, miR-22 and miR-17, enhance the E-cadherin expression and decreased the expressions of Twist1 and vimentin, inhibiting ADAM9 expression, downregulation of ATP2A2 and ATP2A3 genes expressions in different breast cell lines, reduction in IL-6 and COX-2 expression, inhibition of Tax activity of LTR and HTLV-1 in SIRT1 deacetylase, suppression of epithelial-to-mesenchymal transition (EMT) and eEF1A expression and fracas interactions between TEAD and YAP and activation of Hippo/YAP signalling. Consequently, it can be suggested that RVT is a promising agent for treating aforementioned cancers due to its curing characteristics. [ABSTRACT FROM AUTHOR]

Argyrolobium roseum (Camb.) Jaub & Spach (Papilionaceae) is a medicinal plant, cultivated in northern areas of Pakistan. The consumption of trace minerals (lead) is very toxic to the vital organs of the body, therefore the overcome of these minerals is very necessary. In this regard, this study aimed to assess the potential pharmacological effect of aqueous and ethanolic extract of Argyrolobium roseum (Camb.) Jaub & Spach against pb‐induced oxidative stress, histological changes in Pb‐induced rats' liver and kidney, and anti‐inflammatory effect. The metal concentrations in liver and kidney homogenates were measured through atomic absorption spectrophotometer. The antioxidant activity was measured through DPPH and FRAP assay. Pb concentrations were significantly higher in liver and kidney homogenates after injection of Pb acetate was given intraperitoneally (45.2 ± 6.8 and 58.8 ± 7.9, respectively; p <.0001). The level of Pb in liver and kidney homogenates was significantly reduced by aqueous and ethanolic extracts of Argyrolobium roseum (Camb.) Jaub & Spach. The Pb + Aq‐600 mg/kg‐treated rats exhibited a protective effect on hepatocytes cells against Pb‐induced liver injury and restored the cells of the kidney. Pb + Aq‐600 mg/kg showed higher antioxidant activity as compared to other treated groups. The highest decreased MDA level was found in liver and kidney homogenate of Pb + Aq‐600 mg/kg rats (11.2 ± 1.51 nmol/mg; p <.001) and GSH and CAT levels tended to normal after treatment of Pb + Aq‐600 mg/kg in rats. The ALAD, ALT, AST, and ALP level were enhanced and tended to be normal after the Aq‐400 and Aq‐600 mg/kg treatment in Pb‐exposed rats. The result showed that 600 mg/kg Aq + Pb exhibited significant (p <.001) anti‐inflammatory activity. The findings of this study concluded that treatment of the aqueous extract of Argyrolobium roseum (Camb.) Jaub & Spach reduces the renal and hepatic damage in Pb‐induced rats and it also decreases oxidative stress via improving antioxidant components. [ABSTRACT FROM AUTHOR]

Agriculture and textiles have the highest production yields among all sectors to meet mankind's basic needs, i.e., feeding and clothing; however, they are top contributors to environmental pollution and global waste generation. Their wastes and byproducts are precious organic materials, they have great potential as raw materials for the manufacturing of valuable products. This review sheds light on various textile and agricultural wastes, waste management issues, and their existing utilization. Current waste processing methods are mostly based on waste-to-energy routes or material reclamation; however, both methods are hazardous for the environment and are inefficient. During the past decade, many researchers have utilized agriculture and textile wastes in the fabrication of composites. Textile and agricultural wastes and byproducts can be efficiently used for composite fabrication and can be suitable alternatives to existing raw materials. Using textiles and agricultural wastes for composite manufacturing can not only address waste management issues and replace non-eco-friendly materials in the composite industry but also significantly improve composite properties. [ABSTRACT FROM AUTHOR]

Calcium is imperative in maintaining a quality life, particularly during later ages. Its deficiency results in a wide range of metabolic disorders such as dental changes, cataracts, alterations in brain function, and osteoporosis. These deficiencies are more pronounced in females due to increased calcium turnover throughout their life cycle, especially during pregnancy and lactation. Vitamin D perform a central role in the metabolism of calcium. Recent scientific interventions have linked calcium with an array of metabolic disorders in females including hypertension, obesity, premenstrual dysphoric disorder, polycystic ovary syndrome (PCOS), multiple sclerosis, and breast cancer. This review encompasses these female metabolic disorders with special reference to calcium and vitamin D deficiency. This review article aims to present and elaborate on available data regarding the worldwide occurrence of insufficient calcium consumption in females and allied health risks, to provide a basis for formulating strategies and population‐level scientific studies to adequately boost calcium intake and position where required. [ABSTRACT FROM AUTHOR]

Food allergy is the reaction of the immune system of the body that occurs after consuming specific foods. During specific physiological ages of pregnancy, women are more prone to different allergic reactions and mostly these reactions may prolong and have long‐term effects. The hypersensitivity of different types of allergens is mainly linked with the adversity of reactions. The chances of suffering food allergies in women are greater than in men; women are usually more prone to get allergic to some foods during their specific physiological age of pregnancy. Food allergies are more common in pregnant women as every fifth pregnant woman is affected by some kind of allergy. The specific reasons and evidence of the causes of these food allergies during pregnancies have yet to be explored. A pregnant woman should take a balanced diet and avoid consuming known allergic foods to minimize the risk and complications. This review aimed to broaden the knowledge on food allergies during pregnancies, their onset in the babies, and to make it easy for pregnant women to cope with the complications caused by these food allergies. It also aimed to figure out the certain food that might be responsible for the onset of allergies in women during pregnancy and the effect of these allergies on their babies. [ABSTRACT FROM AUTHOR]

Water pollution faces an environmental crisis that makes water unhealthy or decreases the availability of water resources. Water pollution refers to the presence of dangerous chemical compounds and biological agents in water that may exceed certain compounds in water, which may endanger freshwater resources, human health, and the environment as well. Water is a necessary component for all living things to survive. Fresh water exists in the form of groundwater, lakes, and rivers. Apart from the physical scarcity of water, Pakistan is a country facing economic disaster. With the growing population, the pressure on the limited source of fresh water is increasing every day and the state of affairs is getting worse. Water quality and quantity are decreasing with the growing populace and due to climate change. In Pakistan, water quantity has decreased by 400 from 5,600 cubic meters in 1947 to 1,038 cubic meters in 2021. In these situations, water pollution is a threat to water resources. In this context, our study has been conducted to assess the national laws and regulations for water pollution prevention in Pakistan and to establish their extent and effectiveness. This study points out their flaws and barriers and offers potential solutions. [ABSTRACT FROM AUTHOR]

Agriculture waste is rising continuously across the globe due to enormous industrial, food processing, and household activities. Proper valorization of this waste could be a promising source of various essential bioactive and functional ingredients. Okara is a major residue produced as result of soybean processing and has a rich nutritional profile. The nutritional profile of okara is affected by the processing conditions, variety, pre‐treatment, post‐production treatments, and processing techniques. Owing to the high fibers, lipids, proteins, and bioactive components, it is being used as an essential industrial ingredient in various food processing industries. The prebiotic potential and nutritional profile can be increased by various techniques, that is, enzymatic, chemical, biotransformation, high‐pressure microfludization, and fermentation. The prebiotic potential of okara makes it suitable as a therapeutic agent to prevent a variety of metabolic disorders such as diabetes, obesity, hypercholesterolemia, and hyperlipidemia. The current review highlights the structural, nutritional, functional, therapeutic, and industrial applications of okara. [ABSTRACT FROM AUTHOR]

Pomegranate (Punica granatum L.), commonly known as a seeded or granular apple, is a delectable fruit eaten worldwide. Pomegranate is one of the healthiest fruits, with a high concentration of phenolic compounds. Large quantities of byproducts, such as seeds and peels, are produced during the pomegranate juice extraction process, which causes disposal problems and environmental contamination. Pomegranate peel (PoP), which accounts for around 30%–40% of the fruit component, is a byproduct of the fruit juice manufacturing industry. PoP is a rich source of polyphenols including phenolic acids, tannins, and flavonoids, especially anthocyanin. These peels offer several functional and nutraceutical qualities owing to their bioactive ingredients, including lowering blood pressure, reducing oxidative stress, lowering cholesterol levels, and restoring heart health. PoPs have a variety of biological effects, including the ability to resist pathogenic microbes effectively, and used as an additive in various food applications. The current review focuses on the PoP's nutritional and practical attributes, as well as their functions as food additives and functional food preparations. [ABSTRACT FROM AUTHOR]

The Coronavirus disease 2019 (COVID‐19) has spread across the globe and is causing widespread disaster. The impact of gut microbiota on lung disease has been widely documented. Diet, environment, and genetics all play a role in shaping the gut microbiota, which can influence the immune system. Improving the gut microbiota profile through customized diet, nutrition, and supplementation has been shown to boost immunity, which could be one of the preventative methods for reducing the impact of various diseases. Poor nutritional status is frequently linked to inflammation and oxidative stress, both of which can affect the immune system. This review emphasizes the necessity of maintaining an adequate level of important nutrients to effectively minimize inflammation and oxidative stress, moreover to strengthen the immune system during the COVID‐19 severity. Furthermore, the purpose of this review is to present information and viewpoints on the use of probiotics, prebiotics, and synbiotics as adjuvants for microbiota modification and its effects on COVID‐19 prevention and treatment. [ABSTRACT FROM AUTHOR]

3D woven composites are currently used in high‐tech applications due to their better mechanical properties than 2D laminated composites. To further enhance the mechanical performance of 3D woven composites, auxetic structures can be used as reinforcement. The auxetic structures showed better mechanical properties due to bidimensional energy dissipation capability. Orthogonal 3D woven structures showed inherent auxetic nature, however, the use of brittle thermoset resins in composites fully limits their auxeticity. To overcome this issue, three types of 3D woven auxetic structures (warp, weft, and bidirectional interlocks) were developed and used as reinforcement with thermoplastic resins (PC and PVB). Auxeticity of woven reinforcement, and tensile, flexural (3‐point), and short beam shear (SBS) tests of composites were conducted. Auxeticity results revealed that the warp interlock structure showed the highest auxeticity, while the bidirectional interlock structure exhibited the least auxeticity due to the high number of intersections and crimp %. Furthermore, warp interlock composite structure showed 47%, 49.5%, and 37% higher tensile, flexural, and shear strength values, respectively than bidirectional interlock structure in warp direction with PC resin. The overall results showed that auxetic reinforcement improved the mechanical performance of 3D woven composites. [ABSTRACT FROM AUTHOR]

There is a significant load of degenerative and chronic illnesses, especially cancer, which is one of the main reasons for morbidity and death globally. Polyphenolic phytochemicals found in many plant diets have been shown in epidemiologic and preclinical studies to have chemopreventive activities against numerous cancer types. As a result, there is growing interest in possible cancer chemopreventive medicines derived from natural compounds, such as polyphenols, which may provide a novel, cost-effective way to reduce the global cancer burden. Various epidemiologic researchers have found a link between a soy-rich diet and tumor avoidance, which has been linked to the existence of genistein, a phenolic component found in soy-based diets. Genistein controlled strong anti-inflammatory actions through the blocking of different signaling pathways such as (PGs) Prostaglandins, pro-inflammatory (ROS) reactive oxygen species and cytokines, (iNOS) inducible nitric oxide synthase and (NF-κB) nuclear factor kappa-B. Furthermore, therapeutic effects of genistein have been conveyed in various pathological situations through modifying intracellular paths such as Akt, mTOR, PI3K, PPARγ, NF-κB, Nrf2 and AMPK. Genistein works as a chemotherapeutic drug against several cancers, primarily through modifying the cell cycle, apoptosis, and angiogenesis, as well as limiting metastasis. Genistein also exhibits a synergistic attitude with renowned anticancer medicines including adriamycin, tamoxifen and docetaxel indicating a possible role in grouping treatment. The study presents the recent data available on genistein's beneficial effects against various forms of cancers. [ABSTRACT FROM AUTHOR]

In the current study, the most effective concentrations of moringa leaf extract (MLE), aloe vera gel (AV gel), ascorbic acid (1 mM) and oxalic acid (5 mM) were used. Physically mature fruits harvested from a commercial orchard were dipped in aqueous solutions of different edible coatings and kept at ambient conditions (25±2ºC & 55-60% RH) for evaluation of the quality and enzymatic parameters on daily basis till marketability. Current results revealed that 5 mM ascorbic acid treatment resulted in 57% reduced fruit weight loss; while 20% AV gel coating increased firmness by 60% over a 5-day ambient storage period. Application 6% MLE exhibited 50.7% and 49.7% reduced respiration rate and ethylene production respectively. Fruit biochemical quality parameters were also improved with the lowest accumulation of total soluble solids as a result of slow respiration, higher titratable acidity, ascorbic acid contents, carotenoids and anthocyanin contents in all treated fruit. While, total phenolic contents and total antioxidants along with superoxide dismutase, catalase, peroxidase, and anthocyanins were higher in ascorbic acid treated fruits. The activity of poly phenol oxidase enzyme was lowest in fruits treated with 5 mM ascorbic acid solution. Conclusively, the application of different edible coatings was proved to be beneficial as numerous fruit biochemical and antioxidative attributes were improved by ascorbic acid treatment; furthermore, MLE, AV gel and oxalic acid treatments were also helpful in maintaining fruit quality of strawberry fruits over a 5-days ambient storage period. [ABSTRACT FROM AUTHOR]

Chocolate is the most popular food type and flavor in this world. The key ingredient in many chocolate products is cocoa butter due to its unique fatty acid profile. Due to the expensive nature of cocoa butter, it has stimulated extensive research for fats that are cheaper and more easily available and can be used as cocoa butter substitutes. The mango (Mangifera indica) is known as the king of fruit due to its rich nutritive profile. The major parts of mango fruit are peel, pulp, and seed. Mango seed is usually discarded as waste which is a source of edible oil (7–12%). The current study was designed to produce chocolate with mango seed oil as a cocoa butter replacer. Mango seed oil was extracted using the soxhlet apparatus and its physiochemical properties were evaluated. Extracted oil was used in chocolate preparation with different proportions (0%, 30%, 70%, and 100%). Furthermore, chocolate was subjected to explore the effect of storage (21days) on product quality and sensory with 7days interval. Current results show that mango seed oil has a valuable fat profile containing palmitic acid (C16:0) 26%, stearic acid (C18:0) 36%, and oleic acid (C18:2) 33%. Moreover, innovative chocolate showed higher antioxidant activity as compared to control in different storage intervals. In addition, chocolate prepared with different proportions of mango seed oil showed higher sensory scores as compared to the control sample. The findings suggest that mango seed oil can replace cocoa butter in chocolate and reduce/manage mango seed waste to improve its antioxidant activity and nutritional value. [ABSTRACT FROM AUTHOR]

Plants are excellent food and medicinal resources because of their unique composition. Researchers have discovered that thousands of plants can help in achieving the desired health status through advanced research. This research article reveals the nutritional composition and significance of Tribulus terrestris. In addition, it also analyzed the physio-chemical evolution of nutraceutical products from Tribulus terrestris. From the proximate analysis, it was found that T. terrestris is rich in fiber and fat 24.28 ± 0.93% and 14.49 ± 1.42%, respectively. The rheological properties of the product were observed. The results reveal that water activity, stability of product, and dough development time increased 59.0 ± 0.06%, 15.0 ± 0.06 min, and 4.3 ± 0.07 min, respectively, by increasing the powder percentage. The functional behavior of the samples was examined, and significant results were depicted. Bulk density and oil absorption increased by increasing the percentage of powder 83.86 ± 1.36% and 69.16 ± 3.61%. The results of emulsifying stability were recorded as non-significant. Results regarding color analysis showed non-significant behavior of supplemented biscuits. The textural behavior of the product increased from 1.47 Nm−2 to 2.27 Nm−2. Results regarding the spread factor increased from 3.01 ± 0.04 to 3.83 ± 0.01 from T1 to T4. The sensory results indicated that T1 (2% Tribulus powder), T2 (3% Tribulus powder), T3 (4% Tribulus powder), and T4 (5% Tribulus powder) were acceptable after the control group. Thus, Tribulus terrestris can be used as a nutraceutical and functional ingredient in baked goods. [ABSTRACT FROM AUTHOR]

In the current study, Lactobacillus acidophilus was encapsulated in sodium alginate and whey protein isolate, with the addition of antacids CaCO3 or Mg(OH)2. The obtained microgels were observed by scanning electron microscopy. Encapsulated and free probiotics were subjected to vitality assay under stressed conditions. Furthermore, dried apple snack was evaluated as a carrier for probiotics for 28 days. A significant (p ≤.05) effect of antacid with an encapsulating agent was observed under different stressed conditions. During exposure to simulated gastrointestinal conditions, there were observations of 1.24 log CFU and 2.17 log CFU, with corresponding 0.93 log CFU and 2.63 log CFU decrease in the case of SA + CaCO3 and WPI + CaCO3 respectively. Likewise, high viability was observed under thermal and refrigerated conditions for probiotics encapsulated with SA + CaCO3. In conclusion, the results indicated that alginate microgels with CaCO3 are effective in prolonging the viability of probiotics under stressed conditions. [ABSTRACT FROM AUTHOR]

Natural fibers are gaining importance due to environmental concerns and sustainability issues. However, their mechanical performance is not up to the mark. To overcome this problem, natural fiber-based 3D woven structures are used in structural applications. The mechanical performance of 3D woven structures can be further enhanced by adding auxetic mechanisms to the structures. Auxetic structures have exceptional mechanical properties due to a negative Poisson’s ratio. In the present study, 3D woven orthogonal warp, weft, and bidirectional interlock structures were developed with jute yarn, and the effect of interlocking pattern on the auxeticity and different mechanical properties (tensile, stiffness, tear) of the structures was investigated. The results revealed that the 3D warp interlock structure showed the highest auxeticity, while the bidirectional interlock depicted the least auxeticity. Due to higher auxeticity, the thickness of the warp interlock structure was increased after applying force to it. The change in the thickness of the woven structure also increases its energy dissipation capability. Furthermore, structures having higher auxeticity also manifest higher tensile, stiffness, and tear properties as compared to other structures. The results are also statistically analyzed using one-way ANOVA (Tukey). [ABSTRACT FROM AUTHOR]

An Amyand hernia is a rare type of inguinal hernia, accounting for less than 1% of all inguinal hernias, in which the appendix is found within the hernia sac, and is more common in males. The treatment of Amyand hernias is surgical, and the type of surgery depends on the extent of the hernia and the condition of the appendix. In this report, we will discuss the case of a 65-year-old male patient who presented with a reducible right inguinal swelling. During surgery, the hernia was found to contain an inflamed appendix, which was removed. The patient was treated with appendectomy along with mesh repair with postoperative antibiotic course. We discuss the diagnosis and management of Amyand hernias, also highlight the need for prompt diagnosis and treatment to prevent serious complications. We conclude that although Amyand hernias are rare, they should be considered in the differential diagnosis of inguinal hernias, especially in male patients. [ABSTRACT FROM AUTHOR]

Quercetin, a flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its anticancer potential. It is an antioxidant that has a significant role in reducing different human cancers such as breast, pancreatic, prostate, colon, blood, and oral. Being as an additional anti-cancer agent, it can stop cancer cell invasion and metastasis, induce apoptosis and autophagy, decrease cancer cell growth and proliferation. Multiple mechanisms, including suppression of pathways involved in cell survival, angiogenesis, and inflammation, are thought to be responsible for these anticancer effects. Quercetin has anti-inflammatory properties in both in vitro and in vivo tests, which is important as chronic inflammation is a major contributor to cancer. Preventing the synthesis of cytokines and chemokines that encourage inflammation can support to lessen inflammation and stop the spread of cancer. In cancer cells, quercetin can cause programmed cell death, which can stop the cells from rapidly multiplying and replicating. It provides protection against degradation of DNA induced by radiation and other carcinogens. The PI3K/Akt/mTOR pathway, the NF-κB system, and the Wnt/β-catenin pathway is few of the signaling pathways that quercetin modulates. It can activate the process of autophagy, which breaks the growth and range of cancer by having cells terminate and recover damaged or unwanted cellular mechanisms. The best treatment plans for various cancer kinds will need to be determined through additional research, which will also help confirm its safety and effectiveness in humans. [ABSTRACT FROM AUTHOR]

The target delivery of sensitive components to get the intended benefits is a challenge for the global food industry. One of the principal strategies used to boost individualized absorptivity, nutrient stability, and enhanced food quality is the application of liposomal systems in the food industry, which allows controlled release of bioactive compounds. Lipid-oriented encapsulation strategies such as liposomes are superior for encapsulating sensitive components, increasing product solubility and bioavailability, and accurately targeting encapsulated content in food and nutraceutical production. In this review, the nature, composition, and different methodologies for the preparation of liposomes, such as the Bangham Method, ethanol injection method, microfluidic channel method, and freeze-drying method summarized. Moreover, the crucial role of liposomes in delivering sensitive bioactive compounds to cure different health maladies has been emphasized. [ABSTRACT FROM AUTHOR]

Honey, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential to stop cancer cells growth. Chrysin cancer therapeutic potential is of great interest and numerous studies have been done to illustrate this potential. It is associated protein pathways effectively suppress tumor growth within the body. It is shown to have the ability to kill breast, prostate, lung, liver, and stomach cancerous cells. It can block Phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling in different animals against various cancers. Chrysin has the potential to kill breast cancer cells in a laboratory setting by inhibiting their cell division. Chrysin strongly suppresses Matrix metalloproteinase-9 (MMP-9), Urokinase plasminogen activator (uPA) and Vascular endothelial growth factor (VEGF), i.e. factors that can cause cancer. Chrysin has the ability to suppress the androgen receptor (AR), a protein necessary for prostate cancer development and metastasis. It starts the caspase cascade and blocks protein synthesis to kill lung cancer cells. Unnecessary apoptosis can be prevented by stopping certain protein pathways. Chrysin significantly decreased lung cancer metastasis in various animal-modeled studies. Chrysin induces apoptosis and stops colon cancer cells in the G2/M cell cycle phase. Chrysin suppresses colon cancer-promoting cyclin B1 and cyclin-dependent kinase 2. Chrysin suppressed cyclin B1 and CDK2 production in order to stop cancerous growth. Chrysin prevents tumor growth and cancer spread by blocking blood vessel expansion. Chrysin's solubility, accessibility and bioavailability may limit its medical use. Chrysin targets numerous cancer-related communication pathways present in cells. Chrysin may reduce the chances of the onset of cancer, it can also serve as an alternative treatment as a whole to prevent and treat various cancers, but more clinical trials and research studies are needed to fully unlock its potential. [ABSTRACT FROM AUTHOR]

Apigenin (4,'5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications. [ABSTRACT FROM AUTHOR]

The core objective of the current study was to extract heteroxylans from banana peel. Firstly, banana peels were dried to make fine powder, and their nutritional profile including moisture, crude fat, crude ash, crude protein, crude fiber, and nitrogen-free extract (NFE) was noted. Secondly, the heteroxylans were extracted from banana peels, and their bioactive profile was assessed, including total phenols and flavonoids contents, and their activity was assessed through commonly used antioxidant assays including DPPH, FRAP, and ABTS+. Heteroxylans were extracted through alkali extraction method, and their structural characterization was assessed through XRD and FTIR. The results showed that moisture content in banana peels were 60.73 ± 0.85% and 15.77 ± 0.33% in air dried and grounded banana peels, respectively, crude fat 3.94 ± 0.10%, crude protein 6.06 ± 0.15%, and NFE 48.13 ± 0.32%. The total dietary fiber of banana peel powder was 45.3 ± 0.45%, insoluble dietary fiber 34.23 ± 0.30%, and soluble dietary fiber 15.63 ± 0.25%. The bioactive profile of heteroxylans content in banana peels include TPC (19.83 ± 1.10 mg GAE/g), TFC (22.73 ± 0.90 mg QE/g), DPPH (40.73 ± 0.80 mg TE/g), FRAP (39.63 ± 0.73 mg TE/g), and ABTS+ (83.43 ± 0.70 (mg TE/g). The yield of extracted heteroxylans was 9.95 ± 0.17 g/100 g. Further, the structural characterization through XRD showed the amorphous nature of banana peels heteroxylans, and FTIR showed the typical spectra in which different functional groups were observed. Conclusively, the current study showed that banana peels' heteroxylans has unique nutritional, bioactive, and structural profile and can be utilized for various industrial purposes to enhance technological and nutritional properties using as food additive and way toward the sustainability [ABSTRACT FROM AUTHOR]

Ber (Ziziphus mauritiana), also known as "Chinese date" or "jujube," belongs to the Rhamnaceae family. The current research was designed to assess the effect of storage temperatures (5°C and 15°C) on ascorbic acid content, reducing sugar content, and titratable acidity of four ber (Z. mauritiana) varieties, i.e. Karela, Aakash, Pak white, and Dil-Bahar. For this purpose, fresh ber (Z. mauritiana) varieties were acquired from the Regional Agriculture Research Institute (RARI), Bahawalpur. In the first phase, these ber (Z. mauritiana) varieties were subjected to proximate analysis of reducing sugar contents, titratable acidity, antioxidant activity, and total phenolic contents. Maximum total phenolic content (144.38 ± 0.03 mgGAE/100 g) and antioxidant activity (39 ± 0.06%) were observed in Dil-Bahar variety. In the second phase, stored ber (Z. mauritiana) varieties were subjected to a storage study at 0, 7th, and 14th days for comparative evaluation based on titratable acidity, reducing sugar content, and ascorbic acid content. The results showed that the fruits stored at 5°C showed a maintained level of ascorbic acid content (31.26 ± 0.02 mg/100 g), reducing sugars (41.25 ± 0.02%), and titratable acidity (3.36 ± 0.01%) in Karela. On the contrary, Karela stored at 15°C showed a reduction in ascorbic acid content (28.12 ± 0.02 mg/100 g) and titratable acidity (1.21 ± 0.01%) and an increase in reduced sugar content (46.48 ± 0.03%). Moreover, Dil-Bahar variety showed higher ascorbic acid content (51.69 ± 0.05 mg/100 g), titratable acidity (3.51 ± 0.02%), and reducing sugar content (33.29 ± 0.01%) at 5°C. It was concluded that cultivars showed the best results at low storage temperatures of 5°C. [ABSTRACT FROM AUTHOR]

In the current study, wheat varieties Inqulab-91 and AS-2002 were milled from a roller mill and analyzed for chemical characteristics through Near Infra-Red spectroscopy. Friabilin was extracted with Triton X-114 buffer and evaluated on sodium dodecyl sulfate polyacrylamide gel electrophoresis against known molecular weight protein standards. Current results show that the chemical constituents and friabilin revealed significant variation and uneven distribution among flour streams. In both wheat varieties, break streams showed higher protein, moisture, gluten, Zeleny and ash values. Inqualb-91 break streams had a higher lipid content than AS-2002 flour streams, but no clear trend was identified. The 15 kDa band was absent in M3, T2, sizing and low-grade flour of Inqulab-91 while the faint band was present in the remaining streams. Among the remaining AS-2002 mill streams, B2, B4, M3, M5, T1, and sizing showed a prominent 15 kDa band, while the rest showed a faint band. Friabilin depicted a positive correlation with all constituents except fat in AS-2002 while a negative correlation with gluten, Zeleny and fat contents for Inqulab-91. [ABSTRACT FROM AUTHOR]

The current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P >.05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P <.05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P >.05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). [ABSTRACT FROM AUTHOR]

Dairy waste management to reduce environmental pollution through its utilization in various food and non-food products is a major concern of the dairy industry. Whey and buttermilk are regarded as the major waste materials of the dairy industry. Therefore, the current review aimed to summarize the various extraction methods and potential application of buttermilk and cheese whey in production of different products, i.e., microencapsulation matrix, beverages, baked products, microorganisms' cultivation, edible films, exopolysaccharides, organic acids, and essential fatty acids. These wasted components can be extracted from the dairy products by utilizing various extraction methods such as conventional homogenization, ultra-high-pressure homogenization, ultrafiltration, reverse osmosis, and nanofiltration. In microencapsulation technology, these have been used to encapsulate various essential oils, probiotics and several bioactive substances. Whey and buttermilk-based beverages have also been prepared to accentuate their application in the beverage industry. Whey and buttermilk-based microbial fermented products have a significant role in value-added food production. Edible coatings prepared from whey protein concentrate are more accessible, environmentally friendly, nontoxic, and low cost. In addition, several bioactive substances such as exopolysaccharides, bioactive peptides, essential fatty acids, and organic acids have been extracted from the whey and buttermilk. Moreover, these have the potential to improve the physicochemical, organoleptic, and rheological properties (i.e. water absorption, gelatinization temperature, dough development time) of baked goods in the bakery industry. In conclusion, utilization of dairy waste materials in various products can be proved beneficial in introducing various dairy-based healthy products, reduction of environmental pollution and economic growth of the country. [ABSTRACT FROM AUTHOR]