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Abstract Background Although there is a striking impact of epilepsy on sexual functions, this issue is avoided by the patients, because they consider it as a taboo that brings much shame to the complainer and also largely ignored by physicians and neurologists who involved in epileptic patient management. Our aim was to investigate the prevalence and forms of sexual dysfunction (SD) in Egyptian men with epilepsy and relating this dysfunction to the type of epilepsy and the existing sex hormone disturbance. Methods We recruited seventy male epileptic patients on anti-seizure medications and seventy healthy males aged-matched control subjects. We assessed their sexual functions using IIEF-15. Results The prevalence of SD in epileptic patients in our study was as follows: erectile function (64.3%), sexual desire (45.7%), intercourse satisfaction (37.2%) and orgasmic function (15.7%). We found statistically significant lower IIEF scores in uncontrolled versus controlled epileptic patients, in spite that total and free testosterone were not statistically significantly different between the two groups. Although a lower IIEF score in focal versus generalized epilepsy was noticed, but only orgasmic function achieved statistical significance (P = 0.049). Our results exhibited no statistically significant difference as regard treatment therapy in relation to sexual function and hormonal plasma level. Conclusions A higher prevalence of sexual dysfunction was observed in the epileptic patients especially in those with uncontrolled seizures. For that reason, the issues related to sexual activity should be clarified by physicians how are involved in managing the patients suffering from epilepsy.

Background: Although there is a striking impact of epilepsy on sexual functions, this issue is avoided by the patients, because they consider it as a taboo that brings much shame to the complainer and also largely ignored by physicians and neurologists who involved in epileptic patient management. Our aim was to investigate the prevalence and forms of sexual dysfunction (SD) in Egyptian men with epilepsy and relating this dysfunction to the type of epilepsy and the existing sex hormone disturbance. Methods: We recruited seventy male epileptic patients on anti-seizure medications and seventy healthy males aged-matched control subjects. We assessed their sexual functions using IIEF-15. Results: The prevalence of SD in epileptic patients in our study was as follows: erectile function (64.3%), sexual desire (45.7%), intercourse satisfaction (37.2%) and orgasmic function (15.7%). We found statistically significant lower IIEF scores in uncontrolled versus controlled epileptic patients, in spite that total and free testosterone were not statistically significantly different between the two groups. Although a lower IIEF score in focal versus generalized epilepsy was noticed, but only orgasmic function achieved statistical significance (P = 0.049). Our results exhibited no statistically significant difference as regard treatment therapy in relation to sexual function and hormonal plasma level. Conclusions: A higher prevalence of sexual dysfunction was observed in the epileptic patients especially in those with uncontrolled seizures. For that reason, the issues related to sexual activity should be clarified by physicians how are involved in managing the patients suffering from epilepsy. [ABSTRACT FROM AUTHOR]

To investigate the frequency and risk factors of ED in haemodialysis patients (HDps) and kidney transplantation (KTx) recipients (KTxRs). HDps and KTxRs between the ages of 18–65 were compared in terms of ED. IEFF‐15 (International Index of Erectile Function) score was used to evaluation of ED. Fifty‐seven male HDps and 52 male KTxRs with a mean age of 45.6 ± 10.4 years were included in our study. DM, CAD, hyperlipidaemia, smoking and beta blocker use were higher HDps (p = 0.037, p < 0.001, p = 0.001, p = 0.001 and p = 0.031 respectively). There was no ED in five (8.8%) HDps and 27(51.9%) KTxRx. Severity of ED was significantly higher in HDps (p < 0.001). In multiple logistic regression analysis, KTx was found the most relevant associated factor with ED. KTxRs had decreased risk for ED (OR = 0.09, 95% CI 0.02–0.30, p < 0.001). ED is significantly more common in HDps than KTxRs. Known risk factors for ED, HT, DM, CAD, HL, smoking, obesity and beta‐blocker use were not related to ED in the HDps and KTxRs, and the KTx was positively effective for ED in patients undergoing renal replacement therapy. [ABSTRACT FROM AUTHOR]

In this retrospective study, we aimed to evaluate the relationship between erectile dysfunction ( ED) and chronic lead intoxication ( CLI) as well as the role of depression in this relationship. We compared the findings of 26 male patients with CLI and 24 male patients as the control group between November 2008 and January 2009. The blood lead levels and smoking index of patients were evaluated for both groups. The International Index of Erectile Dysfunction-erectile function domain ( EFD) and Beck Depression Inventory ( BDI) were obtained and reviewed in both groups. The mean blood lead levels of patients in the CLI and control groups were 42.1 and 3.2 μg dl−1 respectively ( P < 0.01). The mean interval of lead exposure of patients in CLI group was 71.5 (6-360) months. EFD scores of patients in CLI group were significantly lower, and number of patients with ED in CLI group was statistically higher ( P < 0.05). BDI scores of patients in CLI group were significantly higher ( P < 0.05). We detected a mildly negative and statistically significant relationship between the EFD scores and blood lead levels ( r = −0.453 and P < 0.05). Our results showed that the increased frequency of ED is an independent factor in CLI group. [ABSTRACT FROM AUTHOR]

ABSTRACT Introduction. Erectile dysfunction (ED) is common among elderly men and patients suffering from chronic diseases, the latter probably including also HIV infection. No studies, however, compared the prevalence of ED in HIV-infected and HIV-uninfected individuals using the International Index of Erectile Function (IIEF-15). Aim. The aim of this study is to compare ED prevalence in young to middle-aged men with and without HIV infection using the IIEF-15 questionnaire. Methods. We conducted a cross-sectional, observational, controlled study on 444 HIV-infected men and 71 HIV-uninfected men. Main Outcomes Measures. The IIEF-15 questionnaire was used to assess ED. A cutoff score of ≤25 of the erectile domain was used to diagnose ED. Serum testosterone, demographic, and anthropometric (weight, height, and body mass index [BMI]) characteristics were obtained from all participants. Statistics included the T-test, the Fisher's test, univariable and multivariable logistic regression, and univariate and multivariate Spearman's correlation analysis. Results. The HIV-uninfected group was significantly younger than the HIV-infected group and presented a higher BMI ( P < 0.001). The prevalence of mild, moderate, and severe ED was higher in HIV-infected men than in HIV-uninfected men of all decades of age. In univariate analysis, HIV infection was associated with ED (odds ratio [OR] = 34.19, P < 0.001). In multivariable logistic regression analysis, HIV infection remained the strongest predictors of ED (OR = 42.26, P < 0.001) followed by hypogonadism, after adjusting for age and BMI. Conclusions. This study demonstrates a clear association between ED and HIV infection, after adjusting for age and BMI. Other than HIV infection, hypogonadism was associated with ED. In addition, the prevalence of ED was higher in HIV-infected men than in HIV-uninfected men, in all decades of age. The early onset of ED in HIV-infected men could be considered a peculiar clinical hallmark of HIV and confirms precocious aging in these patients. ED should be of concern to clinicians when managing HIV-infected men even if the latter are young or middle aged. Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, and Rochira V. Erectile dysfunction is more common in young, middle-aged HIV-infected men than in HIV-uninfected men. J Sex Med 2012;9:1940-1947. [ABSTRACT FROM AUTHOR]

Introduction. The prevalence of erectile dysfunction (ED) is mainly studied in older males, whereas we measured prevalence of ED in young healthy males using a validated questionnaire. Aim. Assessing the prevalence of ED in young adult men using the International Index of Erectile Function (IIEF-15) and creating a benchmark for ED in this young age group for further research. Methods. Male students were randomly asked to participate. Men with history of sexual dysfunction or urologic disease were excluded. Age, having a relationship and the IIEF-15 were filled out anonymously and in private. Outcomes of all domains were separately analysed based on relationship and intercourse frequency. Main Outcome Measures. ED measured by the IIEF-15. Results. One hundred and fifty-one students, aged 21.8 years (17–35, SD 2.98) participated and 14 were excluded. Of 137 students, 81% reported to have an intimate relationship. ED appeared to be present in 46 students (33.6%). The answer “no sexual activity,” resulting in a 0-score, was given inconsistently. Outcomes were analysed for students who gave this answer at least once compared with those who never did. Nobody had ED in the group “without 0-scores” (n = 91). All students in the group “with (inconsistent) 0-scores” (n = 46) had ED. Students with a relationship had ED in 24.3% compared with 73.1% in those without a relationship ( P < 0.001). Conclusion. When men with inconsistently answered IIEF-15 questionnaires are excluded, a 0% prevalence of ED is found in this age-group. The current scoring method however does not state that these questionnaires should be excluded, and results in a prevalence of ED of 34%. Possibly, the scoring method of the IIEF-15 needs to be reviewed when this questionnaire is used in young, healthy men in order to accurately measure the prevalence of ED. Rynja S, Bosch R, Kok E, Wouters G, and de Kort L. IIEF-15: Unsuitable for assessing erectile function of young men? J Sex Med 2010;7:2825–2830. [ABSTRACT FROM AUTHOR]