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Your search keyword '"Ide-Iwata, Noriko"' showing total 12 results
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12 results on '"Ide-Iwata, Noriko"'

1. Clonality of Mouse and Human Cardiomyogenesis in Vivo

Author

Hosoda, Toru, D'Amario, Domenico, Cabral-Da-Silva, Mauricio Castro, Zheng, Hanqiao, Padin-Iruegas, M. Elena, Ogorek, Barbara, Ferreira-Martins, João, Yasuzawa-Amano, Saori, Amano, Katsuya, Ide-Iwata, Noriko, Cheng, Wei, Rota, Marcello, Urbanek, Konrad, Kajstura, Jan, Anversa, Piero, Leri, Annarosa, and Prockop, Darwin J.

Published
2009
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5. Inhibition of Notch1-Dependent Cardiomyogenesis Leads to a Dilated Myopathy in the Neonatal Heart.

Author

Urbanek, Konrad, Cabral-da-Silva, Mauricio Castro, Ide-Iwata, Noriko, Maestroni, Silvia, Delucchi, Francesca, Zheng, Hanqiao, Ferreira-Martins, João, Ogórek, Barbara, D'Amario, Domenico, Bauer, Michael, Zerbini, Gianpaolo, Rota, Marcello, Hosoda, Toru, Liao, Ronglih, Anversa, Piero, Kajstura, Jan, and Leri, Annarosa

Subjects
CARDIOMYOPATHIES, GENE expression, GENETIC regulation, MUSCLE cells, STEM cells
Abstract

The article presents a study which explored the effect of the inhibition of notch1-dependent cardiomyogenesis on the development of dilated myopathy in the neonatal heart. The researchers examined whether the neonatal heart contains a pool of cardiac stem cells (CSC) which are essential to the expansion of the compartment of the parenchymal cell. They found that the CSC found in the neonatal heart are lineage multipotent as well as self-renewing.

Published
2010
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6. Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth.

Author

Ferreira-Martins, João, Rondon-Clavo, Carlos, Tugal, Derin, Korn, Justin A., Rizzi, Roberto, Padin-Iruegas, Maria Elena, Ottolenghi, Sergio, De Angelis, Antonella, Urbanek, Konrad, Ide-Iwata, Noriko, D'Amario, Domenico, Hosoda, Toni, Leri, Annarosa, Kajstura, Jan, Anversa, Piero, and Rota, Marcello

Subjects
INTRACELLULAR calcium, HEART cells, CELL communication, GROWTH factors, CALCIUM
Abstract

The article focuses on a research that aims to identify the pathways that regulate intracellular Ca2+ in human cardiac progenitor cells (hCPCs) and to evaluate whether Ca2+ are triggered by hCPCs and cardiomyocytes' interaction. It states that Ca2+ indicator and Fluo-3 and 2-photon microscopy were used to measure cytosolic Ca2+ levels. Results show that hCPCs show spontaneous elevations in intracellular Ca2+.

Published
2009
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9. Abstract 60.

Author

Sanada, Fumihiro, Mangano, Emily, Kim, Junghyung, Arranto, Christian, Ferreira-Martins, Joao, Signore, Sergio, Fiorini, Claudia, Ide-Iwata, Noriko, Pesapane, Ada, Ricciardi, Mario, Zheng, Hanqiao, Gurusamy, Narasimman, Wybieralska, Ewa, Caballero, Virginia, Cimini, Maria, Goichberg, Polina, Rota, Marcello, Hosoda, Toru, Kajstura, Jan, and Anversa, Piero

Published
2012

10. Abstract 256.

Author

Sanada, Fumihiro, Zheng, Hanqiao, Cappetta, Donato, Mangano, Emily, Kim, Junghyun, Arranto, Christian, Ide-Iwata, Noriko, Pesapane, Ada, Ricciardi, Mario, Gurusamy, Narasimman, Goichberg, Polina, Rota, Marcello, Hosoda, Toru, Kajstura, Jan, Anversa, Piero, and Leri, Annarosa

Published
2012

11. Abstract 20.

Author

Ogórek, Barbara, Ferreira-Martins, João, Cappetta, Donato, Matsuda, Alex, Signore, Sergio, D'Amario, Domenico, Kostyla, James, Steadman, Elisabeth, Caballero, Virginia, Ide-Iwata, Noriko, Sanada, Fumihiro, Hosoda, Toru, Anversa, Piero, Leri, Annarosa, Rota, Marcello, and Kajstura, Jan

Published
2012

12. Human cardiac stem cell differentiation is regulated by a mircrine mechanism.

Author

Hosoda T, Zheng H, Cabral-da-Silva M, Sanada F, Ide-Iwata N, Ogórek B, Ferreira-Martins J, Arranto C, D'Amario D, del Monte F, Urbanek K, D'Alessandro DA, Michler RE, Anversa P, Rota M, Kajstura J, and Leri A

Subjects
Adult Stem Cells physiology, Animals, Cell Differentiation physiology, Cell Division physiology, Cells, Cultured, Coculture Techniques, Disease Models, Animal, Gap Junctions physiology, Gene Expression physiology, Humans, Myocardial Infarction pathology, Myocytes, Cardiac physiology, Polypyrimidine Tract-Binding Protein, RNA-Binding Proteins genetics, Rats, Regeneration physiology, SOXD Transcription Factors genetics, Adult Stem Cells cytology, MicroRNAs physiology, Myocardial Infarction therapy, Myocytes, Cardiac cytology, Stem Cell Transplantation
Abstract

Background: Cardiac stem cells (CSCs) delivered to the infarcted heart generate a large number of small fetal-neonatal cardiomyocytes that fail to acquire the differentiated phenotype. However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics., Methods and Results: On the basis of results of in vitro and in vivo assays, we report that the commitment of human CSCs (hCSCs) to the myocyte lineage and the generation of mature working cardiomyocytes are influenced by microRNA-499 (miR-499), which is barely detectable in hCSCs but is highly expressed in postmitotic human cardiomyocytes. miR-499 traverses gap junction channels and translocates to structurally coupled hCSCs favoring their differentiation into functionally competent cells. Expression of miR-499 in hCSCs represses the miR-499 target genes Sox6 and Rod1, enhancing cardiomyogenesis in vitro and after infarction in vivo. Although cardiac repair was detected in all cell-treated infarcted hearts, the aggregate volume of the regenerated myocyte mass and myocyte cell volume were greater in animals injected with hCSCs overexpressing miR-499. Treatment with hCSCs resulted in an improvement in ventricular function, consisting of a better preservation of developed pressure and positive and negative dP/dt after infarction. An additional positive effect on cardiac performance occurred with miR-499, pointing to enhanced myocyte differentiation/hypertrophy as the mechanism by which miR-499 potentiated the restoration of myocardial mass and function in the infarcted heart., Conclusions: The recognition that miR-499 promotes the differentiation of hCSCs into mechanically integrated cardiomyocytes has important clinical implications for the treatment of human heart failure.

Published
2011
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