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3 results on '"Irineu Francisco Delfino Silva Massaia"'

1. The effects of temperature variation treatments on embryonic development: a mouse study

Author

Dóris Ferreira Moriyama, Dimitra Makri, Mary-Naya Maalouf, Petra Adamova, Gabrielle Ferrante Alves de Moraes, Marcela de Oliveira Pinheiro, Danilo Lessa Bernardineli, Irineu Francisco Delfino Silva Massaia, Walid E. Maalouf, and Edson Guimarães Lo Turco

Subjects
Medicine, Science
Abstract

Abstract Since the development of ART, embryos have been cultured at 37 °C in an attempt to mimic the in vivo conditions and the average body temperature of an adult. However, a gradient of temperatures within the reproductive tract has been demonstrated in humans and several other mammalian species. Therefore, the aim of this study was to evaluate the effects of temperature variation treatments on mouse embryo quality through morphokinetic events, blastocyst morphology, the relative gene expression of Igf2, Bax, Bcl2 and Apaf1 and the metabolomics of individual culture media. Study groups consisted of 2 circadian treatments, T1 with embryos being cultured at 37 °C during the day and 35.5 °C during the night, T2 with 38.5 °C during the day and 37 °C during the night and a control group with constant 37 °C. Our main findings are that the lower-temperature group (T1) showed a consistent negative effect on mouse embryo development with “slow” cleaving embryos, poor-quality blastocysts, a higher expression of the apoptotic gene Apaf1, and a significantly different set of amino acids representing a more stressed metabolism. On the other hand, our higher-temperature group (T2) showed similar results to the control group, with no adverse effects on blastocyst viability.

Published
2022
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2. Dengue in an elderly patient Dengue em paciente idosa

Author

Milton Luiz Gorzoni, Irineu Francisco Delfino Silva Massaia, and Sueli Luciano Pires

Subjects
Dengue, Elderly, Iatrogenesis, Drugs, Communicable Diseases, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Although elderly populations are more exposed to the risk of getting dengue, the clinical peculiarities of this disease in this age range are not well known. This report is about an 80-year-old woman with dengue complications, self-medicated with salicylate. Literature indicates a more severe clinical condition, high hospitalization rate and significant mortality. This is caused by previous infections by other serotypes of this arbovirus, presence of chronic diseases, immunosenescence and high drug consumption, especially salicylates and the like. Analyses are required in a public health perspective in order to help health professionals that care for patients with dengue in this age range.Embora cada vez mais populações idosas estejam expostas ao risco de contrair dengue, pouco se sabe sobre peculiaridades clínicas desta doença nesta faixa etária, fato este que motivou este relato sobre octogenária com dengue agravada por automedicação de salicilato. A literatura consultada aponta para quadro clínico mais grave, elevado índice de hospitalizações e mortalidade significativa. Deve-se isto a infecções prévias com outros sorotipos desta arbovirose, presença de doenças crônico degenerativas, imunosenescência e alto consumo de medicamentos, particularmente salicilatos e similares. Análises, sob a ótica da saúde pública, são necessárias para auxiliar aos profissionais de saúde que assistem pacientes com dengue nesta faixa etária

Published
2010
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3. Risk of venous thromboembolism in users of contraception and menopausal hormone therapy during the COVID-19 pandemic

Author

José Mendes Aldrighi, José Maria Soares-Júnior, Irineu Francisco Delfino Silva Massaia, Andréa Larissa Ribeiro Pires, José Gomes Batista, Diego Medeiros Delgado, and Edson Santos Ferreira-Filho

Subjects
medicine.medical_specialty, Medicine (General), Hormone Replacement Therapy, Pneumonia, Viral, Anticoncepção, Disease, 030204 cardiovascular system & hematology, Infecções por coronavírus, 03 medical and health sciences, Betacoronavirus, Betacoronavírus, 0302 clinical medicine, R5-920, medicine, Humans, Medical prescription, Social isolation, Tromboembolia venosa/prevenção e controle, Intensive care medicine, Pandemics, 030219 obstetrics & reproductive medicine, SARS-CoV-2, business.industry, Public health, COVID-19, Venous Thromboembolism, General Medicine, medicine.disease, Venous Thromboembolism/prevention & control, Coronavirus, Menopause, Contraception, Hormonal contraception, Transgender hormone therapy, Terapia de reposição hormonal, Hormonal therapy, Female, medicine.symptom, business, Coronavirus Infections
Abstract

SUMMARY OBJECTIVES The outbreak of coronavirus disease (COVID-19) is a public health emergency of international concern. Inflammatory changes are part of COVID-19 pathophysiology and this might generate a higher thromboembolic risk in patients using combined hormonal contraception and menopausal hormone therapy. We aimed to discuss the main aspects related to this issue and propose management strategies for women affected by COVID-19. METHODS This narrative review collected information from several articles published since the beginning of the outbreak of the new coronavirus disease about the pathophysiology, stage of the disease, the occurrence of thrombotic events, and the risk of thromboembolism in users of contraception and hormonal therapy. RESULTS This article consolidates clinical parameters about the risk of venous thromboembolism in users of contraception and menopausal hormone therapy emphasizing the probable increase of that risk in women with suspected or confirmed COVID-19 and bringing safer recommendations. CONCLUSIONS In this scenario, apart from the fundamental orientations of preventive measures, like social isolation and hygiene, it is important that all female health professionals have knowledge of the new rules and adopt safety measures, especially on the prescription of hormonal therapy and contraception. RESUMO OBJETIVOS A pandemia da COVID-19 é um problema de saúde pública emergente e que tem repercussão internacional. As alterações inflamatórias fazem parte da fisiopatologia da COVID-19 e isso pode acarretar um maior risco tromboembólico em mulheres que fazem uso de contracepção e terapia hormonal da menopausa. Discutimos os principais aspectos relacionados a esse risco e propomos uma estratégia de seguimento das mulheres acometidas da COVID-19. MÉTODOS Esta revisão narrativa coletou informações de vários artigos publicados desde o início da pandemia do novo coronavírus, no que tange à sua fisiopatologia, estágios da doença e ocorrência de eventos trombóticos, bem como sobre o risco de tromboembolismo venoso em usuárias de contracepção e terapia hormonal da menopausa. RESULTADOS Este artigo consolida alguns parâmetros clínicos sobre o risco de tromboembolismo em usuárias de contracepção e terapia hormonal na menopausa, enfatizando o provável aumento desse risco em mulheres com suspeita ou confirmação do novo coronavírus, e traz uma recomendação de uma conduta mais segura. CONCLUSÃO Nesse cenário, além das fundamentais orientações de medidas preventivas, como o isolamento social e a higiene, é importante que os profissionais que trabalham na atenção à saúde feminina tenham conhecimentos da nova realidade e adotem condutas seguras, especialmente na prescrição de THM e contracepção.

Published
2020

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