Search

Your search keyword '"Israel Science Foundation"' showing total 178 results
Start Over Author "Israel Science Foundation" Language english
178 results on '"Israel Science Foundation"'

26. Batsheva de Rothschild Seminar on Biochemistry, Biology and Pathology of MAP Kinases, 14-18 October 2012, Maale Hachamisha, Jerusalem Hills, Israel

Author

An Aharon Katzir-Katchalski Meeting and an Israel Science Foundation Conference

Subjects
Meeting, lcsh:Biology (General), MAP Kinases, Conference, Israel, lcsh:QH301-705.5, abstract book
Abstract

This abstract book contains most of the abstracts presented to the Batsheva de Rothschild Seminar on Biochemistry, Biology and Pathology of MAP Kinases. An Aharon Katzir-Katchalski Meeting and an Israel Science Foundation Conference, 14-18 October 2012, Maale Hachamisha, Jerusalem Hills, Israel.

Published
2012

27. Transverse target spin asymmetries in exclusive $\rho^0$ muoproduction

Author

Adolph, C.Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10, Akhunzyanov, R.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Alekseev, M.G.(Trieste Section of INFN, 34127 Trieste, Italy), Alexakhin, V.Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Alexandrov, Yu.(Lebedev Physical Institute, 119991 Moscow, Russia), Alexeev, G.D.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Amoroso, A.(University of Turin, Department of Physics, 10125 Turin, Italy), Andrieux, V.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Anosov, V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Austregesilo, A.(CERN, 1211 Geneva 23, Switzerland), Badełek, B.(University of Warsaw, Faculty of Physics, 00-681 Warsaw, Poland 19), Balestra, F.(University of Turin, Department of Physics, 10125 Turin, Italy), Barth, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Baum, G.(Universität Bielefeld Fakultät für Physik, 33501 Bielefeld, Germany 10 10 Supported by the German Bundesministerium für Bildung und Forschung.), Beck, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Bedfer, Y.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Berlin, A.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Bernhard, J.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Bertini, R.(University of Turin, Department of Physics, 10125 Turin, Italy), Bicker, K.(CERN, 1211 Geneva 23, Switzerland), Bieling, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Birsa, R.(Trieste Section of INFN, 34127 Trieste, Italy), Bisplinghoff, J.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Bodlak, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Boer, M.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Bordalo, P.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Bradamante, F.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Braun, C.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Bravar, A.(Trieste Section of INFN, 34127 Trieste, Italy), Bressan, A.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Büchele, M.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Burtin, E.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Capozza, L.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Chiosso, M.(University of Turin, Department of Physics, 10125 Turin, Italy), Chung, S.U.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Cicuttin, A.(Abdus Salam ICTP, 34151 Trieste, Italy), Crespo, M.L.(Abdus Salam ICTP, 34151 Trieste, Italy), Curiel, Q.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Dalla Torre, S.(Trieste Section of INFN, 34127 Trieste, Italy), Dasgupta, S.S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Dasgupta, S.(Trieste Section of INFN, 34127 Trieste, Italy), Denisov, O.Yu.(Torino Section of INFN, 10125 Turin, Italy), Donskov, S.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Doshita, N.(Yamagata University, Yamagata, 992-8510, Japan 15), Duic, V.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Dünnweber, W.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Dziewiecki, M.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Efremov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Elia, C.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Eversheim, P.D.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Eyrich, W.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Faessler, M.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Ferrero, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Filin, A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Finger, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Fischer, H.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Franco, C.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), du Fresne von Hohenesche, N.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Friedrich, J.M.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Frolov, V.(CERN, 1211 Geneva 23, Switzerland), Garfagnini, R.(University of Turin, Department of Physics, 10125 Turin, Italy), Gautheron, F.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Gavrichtchouk, O.P.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Gerassimov, S.(Lebedev Physical Institute, 119991 Moscow, Russia), Geyer, R.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Giorgi, M.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Gnesi, I.(University of Turin, Department of Physics, 10125 Turin, Italy), Gobbo, B.(Trieste Section of INFN, 34127 Trieste, Italy), Goertz, S.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Gorzellik, M.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Grabmüller, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Grasso, A.(University of Turin, Department of Physics, 10125 Turin, Italy), Grube, B.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Gushterski, R.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Guskov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Guthörl, T.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Haas, F.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), von Harrach, D.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Hahne, D.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Hashimoto, R.(Yamagata University, Yamagata, 992-8510, Japan 15), Heinsius, F.H.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Herrmann, F.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Heß, C.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Hinterberger, F.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Höppner, Ch.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Horikawa, N.(Nagoya University, 464 Nagoya, Japan 15), d'Hose, N.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Huber, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Ishimoto, S.(Yamagata University, Yamagata, 992-8510, Japan 15), Ivanov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ivanshin, Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Iwata, T.(Yamagata University, Yamagata, 992-8510, Japan 15), Jahn, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Jary, V.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Jasinski, P.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Joerg, P.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Joosten, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Kabuß, E.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Kang, D.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Ketzer, B.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Khaustov, G.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Khokhlov, Yu.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kisselev, Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Klein, F.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Klimaszewski, K.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Koivuniemi, J.H.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Kolosov, V.N.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kondo, K.(Yamagata University, Yamagata, 992-8510, Japan 15), Königsmann, K.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Konorov, I.(Lebedev Physical Institute, 119991 Moscow, Russia), Konstantinov, V.F.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kotzinian, A.M.(University of Turin, Department of Physics, 10125 Turin, Italy), Kouznetsov, O.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kral, Z.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Krämer, M.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Kroumchtein, Z.V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kuchinski, N.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kunne, F.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Kurek, K.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Kurjata, R.P.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Lednev, A.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Lehmann, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Levorato, S.(Trieste Section of INFN, 34127 Trieste, Italy), Lichtenstadt, J.(Tel Aviv University, School of Physics and Astronomy, 69978 Tel Aviv, Israel 18 18 Supported by the Israel Science Foundation, founded by the Israel Academy of Sciences and Humanities.), Maggiora, A.(Torino Section of INFN, 10125 Turin, Italy), Magnon, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Makke, N.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Mallot, G.K.(CERN, 1211 Geneva 23, Switzerland), Marchand, C.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Martin, A.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Marzec, J.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Matousek, J.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Matsuda, H.(Yamagata University, Yamagata, 992-8510, Japan 15), Matsuda, T.(University of Miyazaki, Miyazaki 889-2192, Japan 15 15 Supported by the MEXT and the JSPS under the Grants Nos. 18002006, 20540299 and 18540281, Daiko Foundation and Yamada Foundation.), Meshcheryakov, G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Meyer, W.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Michigami, T.(Yamagata University, Yamagata, 992-8510, Japan 15), Mikhailov, Yu.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Miyachi, Y.(Yamagata University, Yamagata, 992-8510, Japan 15), Nagaytsev, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Nagel, T.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Nerling, F.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Neubert, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Neyret, D.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Nikolaenko, V.I.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Novy, J.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Nowak, W.-D.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Nunes, A.S.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Orlov, I.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Olshevsky, A.G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ostrick, M.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Panknin, R.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Panzieri, D.(University of Eastern Piedmont, 15100 Alessandria, Italy), Parsamyan, B.(University of Turin, Department of Physics, 10125 Turin, Italy), Paul, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Pesek, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Peshekhonov, D.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Piragino, G.(University of Turin, Department of Physics, 10125 Turin, Italy), Platchkov, S.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Pochodzalla, J.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Polak, J.(Technical University in Liberec, 46117 Liberec, Czech Republic 11), Polyakov, V.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Pretz, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Quaresma, M.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Quintans, C.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Ramos, S.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Reicherz, G.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Rocco, E.(CERN, 1211 Geneva 23, Switzerland), Rodionov, V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Rondio, E.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Rossiyskaya, N.S.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ryabchikov, D.I.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Samoylenko, V.D.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Sandacz, A.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Sapozhnikov, M.G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sarkar, S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Savin, I.A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sbrizzai, G.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Schiavon, P.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Schill, C.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schlüter, T.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Schmidt, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Schmidt, K.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schmitt, L.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Schmïden, H.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Schönning, K.(CERN, 1211 Geneva 23, Switzerland), Schopferer, S.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schott, M.(CERN, 1211 Geneva 23, Switzerland), Shevchenko, O.Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Silva, L.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Sinha, L.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Sirtl, S.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Slunecka, M.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sosio, S.(University of Turin, Department of Physics, 10125 Turin, Italy), Sozzi, F.(Trieste Section of INFN, 34127 Trieste, Italy), Srnka, A.(Institute of Scientific Instruments, AS CR, 61264 Brno, Czech Republic 11 11 Supported by Czech Republic MEYS Grants ME492 and LA242.), Steiger, L.(Trieste Section of INFN, 34127 Trieste, Italy), Stolarski, M.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Sulc, M.(Technical University in Liberec, 46117 Liberec, Czech Republic 11), Sulej, R.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Suzuki, H.(Yamagata University, Yamagata, 992-8510, Japan 15), Szabelski, A.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Szameitat, T.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Sznajder, P.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Takekawa, S.(Torino Section of INFN, 10125 Turin, Italy), Ter Wolbeek, J.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Tessaro, S.(Trieste Section of INFN, 34127 Trieste, Italy), Tessarotto, F.(Trieste Section of INFN, 34127 Trieste, Italy), Thibaud, F.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Uhl, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Uman, I.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Vandenbroucke, M.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Virius, M.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Vondra, J.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Wang, L.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Weisrock, T.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Wilfert, M.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Windmolders, R.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Wiślicki, W.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Wollny, H.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Zaremba, K.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Zavertyaev, M.(Lebedev Physical Institute, 119991 Moscow, Russia), Zemlyanichkina, E.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Zhuravlev, N.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), and Ziembicki, M.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19)

Subjects
GENERALIZED PARTON DISTRIBUTIONS, SCATTERING, ddc:530, High Energy Physics::Experiment, VECTOR-MESON ELECTROPRODUCTION, QCD, Nuclear Experiment, Particle Physics - Experiment, High Energy Physics - Experiment
Abstract

Exclusive production of $\rho^0$ mesons was studied at the COMPASS experiment by scattering 160 GeV/$c$ muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of $Q^2$, $x_{Bj}$, or $p_{T}^{2}$. The $\sin \phi_S$ asymmetry is found to be $-0.019 \pm 0.008(stat.) \pm 0.003(syst.)$. All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions., Comment: 14 pages, two tables, 5 figures, bibliography updated

Published
2013
Full Text
View/download PDF

35. XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Author

Ido Yofe, Shir Shlomi-Loubaton, Yana Davidov, Oranit Cohen-Ezra, Oren Barboy, Diego Jaitin, David Goitein, Dominik Pfister, Aleksandra Deczkowska, Amir Giladi, Merav Cohen, Chamutal Gur, Mathias Heikenwalder, Michael Safran, Susanne Roth, Sandrine Henri, Assaf Weiner, Eylon Lahat, Ziv Ben-Ari, Gil Ben Yakov, Bernard Malissen, Mengjie Qiu, Ido Amit, Shing Kam, Hila Hermon, Yousuf Suhail, Mariya Likhter, Achim Weber, Eran Elinav, Eyal David, Pierluigi Ramadori, Weizmann Institute of Science [Rehovot, Israël], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], The Hebrew University Hadassah Medical School, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), UniversitätsKlinikum Heidelberg, University hospital of Zurich [Zurich], Centre d'Immunophénomique (CIPHE), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), A.D. is a recipient of Short-Term EMBO Fellowship no. 7395 and is supported by Eden and Steven Romick. D.P. is supported by the Helmholtz Future, Inflammation and Immunology. M.H.W. is supported by an ERC Consolidator grant (HepatoMetaboPath), an EOS grant, SFBTR179, SFBTR 209, SFBTR1335, Horizon 2020, Research Foundation Flanders under grant 30826052 (EOS Convention MODEL-IDI), Deutsche Krebshilfe projects 70113166 and 70113167, German-Israeli Cooperation in Cancer Research (DKFZ-MOST) and the Helmholtz-Gemeinschaft, Zukunftsthema ‘Immunology and Inflammation’ (ZT-0027). E.E. is supported by the Leona M. and Harry B. Helmsley Charitable Trust, Adelis Foundation, Pearl Welinsky Merlo Scientific Progress Research Fund, Park Avenue Charitable Fund, The Hanna and Dr. Ludwik Wallach Cancer Research Fund, Daniel Morris Trust, The Wolfson Family Charitable Trust and The Wolfson Foundation, Ben B. and Joyce E. Eisenberg Foundation, White Rose International Foundation, Estate of Malka Moskowitz, Estate of Myron H. Ackerman, Estate of Bernard Bishin for the WIS-Clalit Program, Else Kroener Fresenius Foundation, Jeanne and Joseph Nissim Center for Life Sciences Research, Aliza Moussaieff, Miel de Botton, Vainboim Family, Alex Davidoff, the V. R. Schwartz Research Fellow Chair, the Swiss Society Institute for Cancer Prevention Research at the Weizmann Institute of Science, Rehovot, Israel and by grants funded by the European Research Council, Israel Science Foundation, Israel Ministry of Science and Technology, Israel Ministry of Health, the Helmholtz Foundation, Garvan Institute, European Crohn’s and Colitis Organization, Deutsch-Israelische Projektkooperation, IDSA Foundation, and Welcome Trust. E.E. is the incumbent of the Sir Marc and Lady Tania Feldmann Professorial Chair, a senior fellow, Canadian Institute of Advanced Research, and an international scholar, The Bill and Melinda Gates Foundation and Howard Hughes Medical Institute. I.A. is an Eden and Steven Romick Professorial Chair, supported by Merck KGaA, Darmstadt, Germany, the Chan Zuckerberg Initiative, the Howard Hughes Medical Institute International Scholar award, the European Research Council Consolidator Grant 724471-HemTree2.0, a Single Cell Analysis (SCA) award of the Wolfson Foundation and Family Charitable Trust, the Thompson Family Foundation, a Melanoma Research Alliance Established Investigator Award (509044), the Israel Science Foundation (703/15), the Ernest and Bonnie Beutler Research Program for Excellence in Genomic Medicine, the Helen and Martin Kimmel award for innovative investigation, the NeuroMac DFG/Transregional Collaborative Research Center Grant, an International Progressive MS Alliance/NMSS PA-1604 08459, the ISF Israel Precision Medicine Program (IPMP) 607/20 grant and an Adelis Foundation grant., We thank T. Wiesel and T. Bigdary from the Scientific Illustration unit of the Weizmann Institute for artwork, C. Raanan for histology, M. Guilliams, A. Schlitzer and members of the Amit laboratory for fruitful discussions. We thank A. Leshem, H. Keren-Shaul, F. Sheban, L. Geirsdottir, E. Tatirovsky, F. Müller, J. Hetzer and D. Heide for technical support., European Project: 724471,ERC-2016-COG,HemTree2.0(2017), Tel Aviv University (TAU), Vougny, Marie-Christine, and Single cell genomic analysis and perturbations of hematopoietic progenitors: Towards a refined model of hematopoiesis - HemTree2.0 - - ERC-2016-COG2017-10-01 - 2022-09-30 - 724471 - VALID

Subjects
0301 basic medicine, Cirrhosis, [SDV.IMM] Life Sciences [q-bio]/Immunology, T cell, medicine.disease_cause, digestive system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, business.industry, Fatty liver, nutritional and metabolic diseases, General Medicine, Immune dysregulation, medicine.disease, digestive system diseases, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, [SDV.IMM]Life Sciences [q-bio]/Immunology, Bone marrow, Steatohepatitis, Liver cancer, business
Abstract

International audience; Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this disease are poorly understood. Here, using single-cell transcriptomic analysis, we comprehensively profiled the immune composition of the mouse liver during NASH. We identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDCs) and further defined their source as NASH-induced boost in cycling of cDC progenitors in the bone marrow. Analysis of blood and liver from patients on the NAFLD/NASH spectrum showed that type 1 cDCs (cDC1) were more abundant and activated in disease. Sequencing of physically interacting cDC-T cell pairs from liver-draining lymph nodes revealed that cDCs in NASH promote inflammatory T cell reprogramming, previously associated with NASH worsening. Finally, depletion of cDC1 in XCR1DTA mice or using anti-XCL1-blocking antibody attenuated liver pathology in NASH mouse models. Overall, our study provides a comprehensive characterization of cDC biology in NASH and identifies XCR1+ cDC1 as an important driver of liver pathology.

Published
2021
Full Text
View/download PDF

36. Water vapor detection in the transmission spectra of HD 209458 b with the CARMENES NIR channel

Author

Jorge Sanz-Forcada, Núria Casasayas-Barris, Enric Palle, S. Czesla, Víctor J. S. Béjar, Ignasi Ribas, A. Kaminski, Jürgen H. M. M. Schmitt, Bernd Funke, A. Sánchez-López, D. Galadí-Enríquez, M. Stangret, M. Salz, Luisa Lara, Evangelos Nagel, Ansgar Reiners, Martin Kürster, F. F. Bauer, Ignas Snellen, Mathias Zechmeister, Guillem Anglada-Escudé, E. W. Guenther, F. J. Alonso-Floriano, Lev Tal-Or, Pedro J. Amado, Juan Carlos Morales, M. Lampón, D. Montes, Manuel López-Puertas, M. R. Zapatero Osorio, Jose A. Caballero, Th. Henning, Lisa Nortmann, Andreas Quirrenbach, Max Planck Society, Consejo Superior de Investigaciones Científicas (España), European Commission, Ministerio de Economía y Competitividad (España), Ministry of Science, Research and Art Baden-Württemberg, German Research Foundation, Junta de Andalucía, Universidad Complutense de Madrid, Universidad Autónoma de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Israel Science Foundation, Centros de Excelencia Severo Ochoa, INSTITUTO DE ASTROFISICA DE ANDALUCIA (IAA), SEV-2017-0709, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, Sánchez López, A. [0000-0002-0516-7956], Alonso Floriano, F. J. [0000-0003-1202-5734], Snellen, I. [0000-0003-1624-3667], Zapatero Osorio, M. R. [0000-0001-5664-2852], Ministerio de Ciencia e Innovación (MICINN), Israel Science Foundation (ISF), Agencia Estatal de Investigación (AEI), Ministerio de Economía y Competitividad (MINECO), Science Foundation grant, Centro de Excelencia Científica Severo Ochoa Instituto de Astrofísica de Andalucía CSIC, Max-Planck-Gesellschaft (MPG), European Commission (EC), Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (MWK), Deutsche Forschungsgemeinschaft (DFG), Universidad Complutense de Madrid (UCM), and Universidad Autónoma de Madrid (UAM)

Subjects
Astrofísica, individual: HD 209458b [Planets and satellites], 010504 meteorology & atmospheric sciences, planets and satellites: individual: hd 209458 b, FOS: Physical sciences, Astrophysics, 01 natural sciences, Spectral line, planets and satellites, atmospheres, individual, HD 209458 b, techniques, spectroscopic, infrared, planetary systems, Atmosphere, Planet, 0103 physical sciences, Hot Jupiter, infrared: planetary systems, planetary systems [infrared], 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, planets and satellites: atmospheres, Earth and Planetary Astrophysics (astro-ph.EP), Physics, Near-infrared spectroscopy, Astronomy and Astrophysics, atmospheres [planets and satellites], Blueshift, Radial velocity, 13. Climate action, Space and Planetary Science, individual: hd 209458 b [planets and satellites], spectroscopic [techniques], techniques: spectroscopic, Water vapor, Astrophysics - Earth and Planetary Astrophysics
Abstract

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Aims: We aim at detecting water vapor in the atmosphere of the hot Jupiter HD 209458 b and perform a multi-band study in the near infrared with CARMENES. Methods: The water vapor absorption lines from the atmosphere of the planet are Doppler-shifted due to the large change in its radial velocity during transit. This shift is of the order of tens of km s-1, whilst the Earth's telluric and the stellar lines can be considered quasi-static. We took advantage of this shift to remove the telluric and stellar lines using SYSREM, which performs a principal component analysis including proper error propagation. The residual spectra contain the signal from thousands of planetary molecular lines well below the noise level. We retrieve the information from those lines by cross-correlating the residual spectra with models of the atmospheric absorption of the planet. Results: We find a cross-correlation signal with a signal-to-noise ratio (S/N) of 6.4, revealing H2O in HD 209458 b. We obtain a net blueshift of the signal of -5.2 -1.3+2.6 km s-1 that, despite the large error bars, is a firm indication of day- to night-side winds at the terminator of this hot Jupiter. Additionally, we performed a multi-band study for the detection of H2O individually from the three near infrared bands covered by CARMENES. We detect H2O from its 0.96-1.06 ¿m band with a S/N of 5.8, and also find hints of a detection from the 1.06-1.26 ¿m band, with a low S/N of 2.8. No clear planetary signal is found from the 1.26-1.62 ¿m band. Conclusions: Our significant H2O signal at 0.96-1.06 ¿m in HD 209458 b represents the first detection of H2O from this band individually, the bluest one to date. The unfavorable observational conditions might be the reason for the inconclusive detection from the stronger 1.15 and 1.4 ¿m bands. H2O is detected from the 0.96-1.06 ¿m band in HD 209458 b, but hardly in HD 189733 b, which supports a stronger aerosol extinction in the latter, in line with previous studies. Future data gathered at more stable conditions and with larger S/N at both optical and near-infrared wavelengths could help to characterize the presence of aerosols in HD 209458 b and other planets.© A. Sánchez-López et al. 2019, CARMENES is funded by the German Max-Planck-Gesellschaft (MPG), the Spanish Consejo Superior de Investigaciones Cientificas (CSIC), the European Union through European Regional Fund (FEDER/ERF), the Spanish Ministry of Economy and Competitiveness, the state of Baden-Wurttemberg, the German Science Foundation (DFG), and the Junta de Andalucia, with additional contributions by the members of the CARMENES Consortium (Max-Planck-Institut fur Astronomie, Instituto de Astrofisica de Andalucia, Landessternwarte Konigstuhl, Institut de Ciencies de l'Espai, Institut fur Astrophysik Gottingen, Universidad Complutense de Madrid, Thuringer Landessternwarte Tautenburg, Instituto de Astrofisica de Canarias, Hamburger Sternwarte, Centro de Astrobiologia, and the Observatorio de Calar Alto). Financial support was also provided by the Universidad Complutense de Madrid, the Comunidad Autonoma de Madrid, the Spanish Ministerios de Ciencia e Innovacion and of Economia y Competitividad, the Fondo Europeo de Desarrollo Regional (FEDER/ERF), the Agencia estatal de investigacion, and the Fondo Social Europeo under grants AYA2011-30 147-C03-01, -02, and -03, AYA2012-39612-C03-01, ESP2013-48391-C4-1-R, ESP2014-54062-R, ESP 2016-76076-R, ESP2016-80435-C2-2-R, ESP2017-87143-R, BES-2015-073500, and BES-2015-074542. IAA authors acknowledge financial support from the State Agency for Research of the Spanish MCIU through the >Center of Excellence Severo Ochoa> award SEV-2017-0709. L.T.-O. acknowledges support from the Israel Science Foundation (grant No. 848/16). Based on observations collected at the Observatorio de Calar Alto. We thank the anonymous referee for their insightful comments, which contributed to improve the quality of the manuscript.

Published
2019

37. Differential impacts of FtsZ proteins on plastid division in the shoot apex of Arabidopsis

Author

Reinat Nevo, Shlomi Dagan, Neora Swid, Denis Falconet, Dana Charuvi, Ruti Kapon, Zach Adam, Vladimir Kiss, Ziv Reich, Orli Snir, The Robert H. Smith Institute of Plant Sciences & Genetics, Faculty of Agriculture, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem (HUJ), Agricultural Research Organization - the Volcani Center, Weizmann Institute of Science, Department of Biomolecular Sciences, Physiologie cellulaire et végétale (LPCV), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Israel Science Foundation (1034/12), Human Frontier Science Program (RGP0005/2013), National Science Foundation-United States-Israel Binational Science Foundation (NSF-BSF) Molecular and Cellular Biosciences Program (2015839), Grant from the F.I.R.S.T. (Bikura) program of the Israel Science Foundation (No.1282/09), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Weizmann Institute of Science [Rehovot, Israël]

Subjects
0301 basic medicine, FtsZ proteins, Chloroplasts, Meristem, Arabidopsis, 03 medical and health sciences, chloroplast, shoot apex, Division (horticulture), proplastid, Protein Isoforms, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Plastid, FtsZ, Molecular Biology, ComputingMilieux_MISCELLANEOUS, shoot apical meristem, biology, Arabidopsis Proteins, fungi, food and beverages, Cell Biology, biology.organism_classification, Cell biology, Plant Leaves, Chloroplast, plastid division, 030104 developmental biology, Proplastid, biology.protein, Green algae, Developmental Biology
Abstract

International audience; FtsZ proteins of the FtsZ1 and FtsZ2 families play important roles in the initiation and progression of plastid division in plants and green algae. Arabidopsis possesses a single FTSZ1 member and two FTSZ2 members, FTSZ2-1 and FTSZ2-2. The contribution of these to chloroplast division and partitioning has been mostly investigated in leaf mesophyll tissues. Here, we assessed the involvement of the three FtsZs in plastid division at earlier stages of chloroplast differentiation. To this end, we studied the effect of the absence of specific FtsZ proteins on plastids in the vegetative shoot apex, where the proplastid-to-chloroplast transition takes place. We found that the relative contribution of the two major leaf FtsZ isoforms, FtsZ1 and FtsZ2-1, to the division process varies with cell lineage and position within the shoot apex. While FtsZ2-1 dominates division in the Ll and L3 layers of the shoot apical meristem (SAM), in the L2 layer, FtsZ1 and FtsZ2-1 contribute equally toward the process. Depletion of the third isoform, FtsZ2-2, generally resulted in stronger effects in the shoot apex than those observed in mature leaves. The implications of these findings, along with additional observations made in this work, to our understanding of the mechanisms and regulation of plastid proliferation in the shoot apex are discussed.

Published
2018
Full Text
View/download PDF

38. Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells

Author

Clotilde Guyon, Erez Y. Levanon, Matthieu Giraud, Miri Danan-Gotthold, Jakub Abramson, The Mina & Everard Goodman Faculty of Life Sciences [Ramat Gan, Israël], Université Bar-Ilan [Israel], [Institut Cochin] Departement Infection, immunité, inflammation, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Immunology [Rehovot, Israël], Weizmann Institute of Science, This work was supported by EYL: The European Research Council (grant no. 311257), the I-CORE Program of the Planning and Budgeting Committee in Israel (grant nos. 41/11 and 1796/12), and the Israel Science Foundation (1380/14).JA: Israel Science Foundation (1825/10), Sy Syms Foundation, Dr. Celia Zwillenberg-Fridman and Dr. Lutz Fridman Career Development Chair.MGi: The Agence Nationale de Recherche (2011-CHEX-001-R12004KK).MDG is grateful to the Azrieli Foundation for the award of an Azrieli Fellowship., Bos, Mireille, Bar-Ilan University [Israël], Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Weizmann Institute of Science [Rehovot, Israël]

Subjects
0301 basic medicine, Cell type, RNA editing, [SDV]Life Sciences [q-bio], T-Lymphocytes, Thymus Gland, Biology, Self-tolerance, Autoantigens, 03 medical and health sciences, Mice, Immune system, Antigen, Gene expression, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Gene, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [ SDV ] Life Sciences [q-bio], Research, Alternative splicing, RNA sequencing, Cell Differentiation, Epithelial Cells, Molecular biology, Cell biology, Thymus, Alternative Splicing, 030104 developmental biology, Self Tolerance, Medullary thymic epithelial cells (mTECs), Gene Expression Regulation, RNA splicing, Transcription Factors
Abstract

Background In order to become functionally competent but harmless mediators of the immune system, T cells undergo a strict educational program in the thymus, where they learn to discriminate between self and non-self. This educational program is, to a large extent, mediated by medullary thymic epithelial cells that have a unique capacity to express, and subsequently present, a large fraction of body antigens. While the scope of promiscuously expressed genes by medullary thymic epithelial cells is well-established, relatively little is known about the expression of variants that are generated by co-transcriptional and post-transcriptional processes. Results Our study reveals that in comparison to other cell types, medullary thymic epithelial cells display significantly higher levels of alternative splicing, as well as A-to-I and C-to-U RNA editing, which thereby further expand the diversity of their self-antigen repertoire. Interestingly, Aire, the key mediator of promiscuous gene expression in these cells, plays a limited role in the regulation of these transcriptional processes. Conclusions Our results highlight RNA processing as another layer by which the immune system assures a comprehensive self-representation in the thymus which is required for the establishment of self-tolerance and prevention of autoimmunity. Electronic supplementary material The online version of this article (doi:10.1186/s13059-016-1079-9) contains supplementary material, which is available to authorized users.

Published
2016
Full Text
View/download PDF

39. Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

Author

Mikael Koutero, Noam Stern-Ginossar, J. R. Mellin, Daniel Dar, Pascale Cossart, Rotem Sorek, Maya Shamir, Weizmann Institute of Science [Rehovot, Israël], Interactions Bactéries-Cellules (UIBC), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Israel Science Foundation [1303/12], Israel Science Foundation (I-CORE) [1796/12], Human Frontier Science Program [RGP0011/2013], Abisch-Frenkel, European Project: 260432,EC:FP7:ERC,ERC-2010-StG_20091118,PROKRNA(2011), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration, and Prokaryotic RNomics: Unravelling the RNA-mediated regulatory layers - PROKRNA - - EC:FP7:ERC2011-01-01 - 2016-06-30 - 260432 - VALID

Subjects
0301 basic medicine, Riboswitch, [SDV]Life Sciences [q-bio], MESH: Listeria monocytogenes, MESH: Genome, Bacterial, Ribosome, Gene expression, Enterococcus faecalis, MESH: Sequence Analysis, RNA, messenger-rna structure, 3' Untranslated Regions, bacillus-subtilis, MESH: High-Throughput Nucleotide Sequencing, Regulation of gene expression, transcriptional attenuation mechanism, MESH: Gene Expression Regulation, Bacterial, Multidisciplinary, Human microbiome, High-Throughput Nucleotide Sequencing, controls gene-expression, MESH: 3' Untranslated Regions, Anti-Bacterial Agents, [SDV] Life Sciences [q-bio], Bacillus subtilis, MESH: Enterococcus faecalis, 030106 microbiology, Computational biology, Biology, MESH: Gastrointestinal Microbiome, Bacterial genetics, Microbiology, 03 medical and health sciences, MESH: Transcription Termination, Genetic, MESH: Anti-Bacterial Agents, Drug Resistance, Bacterial, MESH: Drug Resistance, Bacterial, Humans, MESH: Humans, Sequence Analysis, RNA, RNA, Gene Expression Regulation, Bacterial, MESH: Bacillus subtilis, biology.organism_classification, Listeria monocytogenes, Gastrointestinal Microbiome, 030104 developmental biology, Transcription Termination, Genetic, MESH: Genome-Wide Association Study, synthetic biology, listeria-monocytogenes, Ribosomes, MESH: Ribosomes, Genome, Bacterial, Bacteria, Genome-Wide Association Study, MESH: Riboswitch
Abstract

How bacteria switch between tracks Bacterial riboswitches prevent the formation of full-length messenger RNA, and hence proteins, via transcriptional termination in response to metabolites. However, identifying riboswitches within the genome has previously required comparative analysis, which may miss species- and environmentally specific responses. Dar et al. developed a method called term-seq to document all riboswitches in a bacterial genome, as well as their metabolite counterparts (see the Perspective by Sommer and Suess). The method revealed a role for pathogenic bacterial riboswitches in antibiotic resistance. Thus, transcription may be one way pathogens fend off antibiotic attack. Science , this issue p. 10.1126/science.aad9822 ; see also p. 144

Published
2016
Full Text
View/download PDF

40. Conformal Prediction with Missing Values

Author

Zaffran, Margaux, Dieuleveut, Aymeric, Josse, Julie, Romano, Yaniv, EDF R&D (EDF R&D), EDF (EDF), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria), Centre de Mathématiques Appliquées - Ecole Polytechnique (CMAP), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Médecine de précision par intégration de données et inférence causale (PREMEDICAL), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Technion - Israel Institute of Technology [Haifa], Scholarship for Mathematics granted by the Séphora Berrebi Foundation, Hi! Paris, ISRAEL SCIENCE FOUNDATION (grant No. 729/21), ANR-11-LABX-0056,LMH,LabEx Mathématique Hadamard(2011), ANR-19-CHIA-0002,SCAI,Inférence statistique, méthodes numériques et Intelligence Artificielle(2019), and ANR-16-IDEX-0006,MUSE,MUSE(2016)

Subjects
FOS: Computer and information sciences, [STAT]Statistics [stat], Distribution-Free Uncertainty Quantification, Computer Science - Machine Learning, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Missing Values, Statistics - Machine Learning, Machine Learning (stat.ML), Conformal Prediction, Machine Learning (cs.LG)
Abstract

Conformal prediction is a theoretically grounded framework for constructing predictive intervals. We study conformal prediction with missing values in the covariates -- a setting that brings new challenges to uncertainty quantification. We first show that the marginal coverage guarantee of conformal prediction holds on imputed data for any missingness distribution and almost all imputation functions. However, we emphasize that the average coverage varies depending on the pattern of missing values: conformal methods tend to construct prediction intervals that under-cover the response conditionally to some missing patterns. This motivates our novel generalized conformalized quantile regression framework, missing data augmentation, which yields prediction intervals that are valid conditionally to the patterns of missing values, despite their exponential number. We then show that a universally consistent quantile regression algorithm trained on the imputed data is Bayes optimal for the pinball risk, thus achieving valid coverage conditionally to any given data point. Moreover, we examine the case of a linear model, which demonstrates the importance of our proposal in overcoming the heteroskedasticity induced by missing values. Using synthetic and data from critical care, we corroborate our theory and report improved performance of our methods., Code for our experiments can be found at https://github.com/mzaffran/ConformalPredictionMissingValues . To be published in the proceedings of the 40th International Conference on Machine Learning, Honolulu, Hawaii, USA

Published
2023

41. A non-homogeneous model of chromosome-number evolution to reveal shifts in the transition patterns across the phylogeny

Author

Shafir, Anat, Halabi, Keren, Escudero Lirio, Marcial, Mayrose, Italy, Universidad de Sevilla. Departamento de Biología Vegetal y Ecología, Israel Science Foundation, and Ministerio de Ciencia e Innovación (MICIN). España

Subjects
Dysploidy, Polyploidy, Rate heterogeneity, Chromosome-number evolution, Evolutionary models, Convergent evolution
Abstract

Changes in chromosome numbers, including polyploidy and dysploidy events, play a key role in eukaryote evolution as they could expediate reproductive isolation and have the potential to foster phenotypic diversification. Deciphering the pattern of chromosome-number change within a phylogeny currently relies on probabilistic evolutionary models. All currently available models assume time homogeneity, such that the transition rates are identical throughout the phylogeny. Here, we develop heterogeneous models of chromosome-number evolution that allow multiple transition regimes to operate in distinct parts of the phylogeny. The partition of the phylogeny to distinct transition regimes may be specified by the researcher or, alternatively, identified using a sequential testing approach. Once the number and locations of shifts in the transition pattern are determined, a second search phase identifies regimes with similar transition dynamics, which could indicate on convergent evolution. Using simulations, we study the performance of the developed model to detect shifts in patterns of chromosome-number evolution and demonstrate its applicability by analyzing the evolution of chromosome numbers within the Cyperaceae plant family. The developed model extends the capabilities of probabilistic models of chromosome-number evolution and should be particularly helpful for the analyses of large phylogenies that include multiple distinct subclades. Israel Sciencie Foundation 961/17 Israel Science Foundation 1843/21 Ministerio de Ciencia e Innovación PID2021-122715NB-I00

Published
2023

42. A High-valent Ru-PCP Pincer Catalyst for the Hydrogenation of Organic Carbonates

Author

Shrouq Mujahed, Maria S. Richter, Evgueni Kirillov, Evamarie Hey‐Hawkins, Dmitri Gelman, The Hebrew University of Jerusalem (HUJ), Universität Leipzig, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), GIF (German-Israeli Foundation for research and development) [I-1508-302.5/2019], ISF (Israel Science Foundation) [370/20], Neubauer Family Foundation, and Deutscher Akademischer Austauschdienst (DAAD)

Subjects
high-valent ruthenium, hydrogenation of esters, pincer complexes, [CHIM]Chemical Sciences, General Chemistry, cooperative catalysis
Abstract

International audience; In this communication, we report on the successful application of a high-valent Ru-IV bifunctional catalyst (1) for mild hydrogenation of cyclic and acyclic carbonates. Our experimental and theoretical studies suggest that the hydrogenation mechanism is operated by an unusual formally zwitterionic Ru-IV complex. According to our hypothesis, the positively charged high-valent metal center is responsible for stronger hydrogen coordination. On the other hand, the proximate negatively charged ligand site facilitates heterolytic H-2 bond activation, which leads to efficient catalysis.

Published
2023
Full Text
View/download PDF

43. Sub-nanometer mapping of strain-induced band structure variations in planar nanowire core-shell heterostructures

Author

Sara Martí-Sánchez, Marc Botifoll, Eitan Oksenberg, Christian Koch, Carla Borja, Maria Chiara Spadaro, Valerio Di Giulio, Quentin Ramasse, F. Javier García de Abajo, Ernesto Joselevich, Jordi Arbiol, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Generalitat de Catalunya, Agencia Estatal de Investigación (España), Universidad Autónoma de Barcelona, Science and Technology Facilities Council (UK), Engineering and Physical Sciences Research Council (UK), Fundación 'la Caixa', Consejo Superior de Investigaciones Científicas (España), Israel Science Foundation, European Research Council, and Fundació Privada Cellex

Subjects
Electronic properties and materials, Multidisciplinary, Structural properties, Nanowires, General Physics and Astronomy, General Chemistry, Transmission electron microscopy, General Biochemistry, Genetics and Molecular Biology
Abstract

Strain relaxation mechanisms during epitaxial growth of core-shell nanostructures play a key role in determining their morphologies, crystal structure and properties. To unveil those mechanisms, we perform atomic-scale aberration-corrected scanning transmission electron microscopy studies on planar core-shell ZnSe@ZnTe nanowires on α-Al2O3 substrates. The core morphology affects the shell structure involving plane bending and the formation of low-angle polar boundaries. The origin of this phenomenon and its consequences on the electronic band structure are discussed. We further use monochromated valence electron energy-loss spectroscopy to obtain spatially resolved band-gap maps of the heterostructure with sub-nanometer spatial resolution. A decrease in band-gap energy at highly strained core-shell interfacial regions is found, along with a switch from direct to indirect band-gap. These findings represent an advance in the sub-nanometer-scale understanding of the interplay between structure and electronic properties associated with highly mismatched semiconductor heterostructures, especially with those related to the planar growth of heterostructured nanowire networks., J.A., S.M.-S., M.B., and M.C.S. were supported by the Severo Ochoa program from Spanish MCIN/AEI /10.13039/501100011033/ (Grant No. SEV-2017-0706) and are funded by the CERCA Program / Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science Ph.D. program. J.A., S.M.-S., M.B., and M.C.S. acknowledge funding from Generalitat de Catalunya 2017SGR327. S.M.S. acknowledges funding from ICN2 SO EXEM project. The HAADF-STEM microscopy was conducted in the Laboratorio de Microscopias Avanzadas at Instituto de Nanociencia de Aragon-Universidad de Zaragoza. Additional imaging and electron energy loss spectroscopy was carried out at SuperSTEM, the UK National Research Facility for Advanced Electron Microscopy, supported by the Engineering and Physical Sciences Research Council (EPSRC). Authors acknowledge the LMA-INMA for offering access to their instruments and expertise. We acknowledge support from CSIC Research Platform on Quantum Technologies PTI-001 (QTEP). M.B. acknowledges support from SUR Generalitat de Catalunya and the EU Social Fund; project ref. 2020 FI 00103. C.K. acknowledges funding from InPhINIT Scholarships LaCaixa Foundation. M.C.S. have received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 754510 (PROBIST). J.G.d.A. has been supported by European Research Council (Advanced Grant 789104-eNANO). V.D.G. and J.G.d.A have received funding from Spanish MCINN (PID2020-112625GB-I00 and CEX2019-000910-S), Fundació Cellex, Fundació Mir-Puig, and Generalitat de Catalunya (CERCA, AGAUR). E.J. acknowledges support from the Israel Science Foundation (Grant No. 2444/19). J.A., S.M.-S., M.B. and M.C.S. were supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1), by Generalitat de Catalunya and by “ERDF A way of making Europe”, by the “European Union”.

Published
2022

44. Evolving genealogies for branching populations under selection and competition

Author

Blancas, Airam, Gufler, Stephan, Kliem, Sandra, Tran, Viet-Chi, Wakolbinger, Anton, Instituto Tecnológico Autónomo de México (ITAM), Department of mathematics, Goethe-university, Goethe-University Frankfurt am Main, Mathematisches Institut der Universität Leipzig, Universität Leipzig [Leipzig], Laboratoire Analyse et Mathématiques Appliquées (LAMA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, CONACyT, Zeff Fellowship, a postdoctoral fellowship of the Minerva Foundation, Israel Science Foundation (ISF) grant No. 1382/17, Binational Science Foundation (BSF) award 2018330, Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) research grant contract number 2337/1-1, project 432176920, DFG - Project number 393092071, Chaire 'Modélisation Mathématique et Biodiversité' of Veolia Environnement-Ecole Polytechnique-Museum National d'Histoire Naturelle-Fondation X, DFG project WA 967/4-2 in the SPP 1590, Institute for Mathematical Sciences, National University of Singapore, European Union (ERC-AdG SINGER-101054787), ANR-11-LABX-0007,CEMPI,Centre Européen pour les Mathématiques, la Physique et leurs Interactions(2011), ANR-10-LABX-0058,Bézout,Models and algorithms: from the discrete to the continuous(2010), Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) research grant contract number 2337/1-1, Tran, Viet Chi, Laboratoires d'excellence - Centre Européen pour les Mathématiques, la Physique et leurs Interactions - - CEMPI2011 - ANR-11-LABX-0007 - LABX - VALID, and Laboratoires d'excellence - Models and algorithms: from the discrete to the continuous - - Bézout2010 - ANR-10-LABX-0058 - LABX - VALID

Subjects
[MATH.MATH-PR] Mathematics [math]/Probability [math.PR], tree-valued processes, lookdown process, Probability (math.PR), selection, fluctuating population size, 60J80, 60K35, 92D10, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Birth-death particle system, FOS: Mathematics, genealogy, Mathematics - Probability, selective lookdown space, density-dependent competition
Abstract

For a continuous state branching process with two types of individuals which are subject to selection and density dependent competition, we characterize the joint evolution of population size, type configurations and genealogies as the unique strong solution of a system of SDE's. Our construction is achieved in the lookdown framework and provides a synthesis as well as a generalization of cases considered separately in two seminal papers by Donnelly and Kurtz (1999), namely fluctuating population sizes under neutrality, and selection with constant population size. As a conceptual core in our approach we introduce the selective lookdown space which is obtained from its neutral counterpart through a state-dependent thinning of ``potential'' selection/competition events whose rates interact with the evolution of the type densities. The updates of the genealogical distance matrix at the ``active'' selection/competition events are obtained through an appropriate sampling from the selective lookdown space. The solution of the above mentioned system of SDE's is then mapped into the joint evolution of population size and symmetrized type configurations and genealogies, i.e. marked distance matrix distributions. By means of Kurtz' Markov mapping theorem, we characterize the latter process as the unique solution of a martingale problem. For the sake of transparency we restrict the main part of our presentation to a prototypical example with two types, which contains the essential features. In the final section we outline an extension to processes with multiple types including mutation., This version takes the suggestions of two anonymous referees into account, which led to an improvement in the presentation and to some corrections in the proofs in Section 5

Published
2022

45. Tunneling spectroscopy of few-monolayer NbSe 2 in high magnetic fields: Triplet superconductivity and Ising protection

Author

M. Kuzmanović, T. Dvir, D. LeBoeuf, S. Ilić, M. Haim, D. Möckli, S. Kramer, M. Khodas, M. Houzet, J. S. Meyer, M. Aprili, H. Steinberg, C. H. L. Quay, Laboratoire de Physique des Solides (LPS), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Aalto University School of Science and Technology [Aalto, Finland], The Hebrew University of Jerusalem (HUJ), Delft University of Technology (TU Delft), Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratory of Quantum Theory (GT), PHotonique, ELectronique et Ingénierie QuantiqueS (PHELIQS), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Centro de Fisica de Materiales (CFM), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Laboratoire national des champs magnétiques intenses - Toulouse (LNCMI-T), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), ANR-10-LABX-0051,LANEF,Laboratory of Alliances on Nanosciences - Energy for the Future(2010), European Project: 637928,H2020,ERC-2014-STG,TUNNEL(2015), Council for Higher Education (Israel), Agence Nationale de la Recherche (France), European Commission, European Research Council, Israel Science Foundation, Azrieli Foundation, Superconducting Qubits and Circuit QED, Hebrew University of Jerusalem, Université Grenoble Alpes, Université Paris-Saclay, Department of Applied Physics, Aalto-yliopisto, and Aalto University

Subjects
[PHYS]Physics [physics], [SPI]Engineering Sciences [physics]
Abstract

In conventional Bardeen-Cooper-Schrieffer superconductors, Cooper pairs of electrons of opposite spin (i.e., singlet structure) form the ground state. Equal-spin triplet pairs (ESTPs), as in superfluid 3He, are of great interest for superconducting spintronics and topological superconductivity, yet remain elusive. Recently, odd-parity ESTPs were predicted to arise in (few-)monolayer superconducting NbSe2, from the noncollinearity between the out-of-plane Ising spin-orbit field (due to the lack of inversion symmetry in monolayer NbSe2) and an applied in-plane magnetic field. These ESTPs couple to the singlet order parameter at finite field. Using van der Waals tunnel junctions, we perform spectroscopy of superconducting NbSe2 flakes, of 2–25 monolayer thickness, measuring the quasiparticle density of states (DOS) as a function of applied in-plane magnetic field up to 33 T. In flakes ≲15 monolayers thick the DOS has a single superconducting gap. In these thin samples, the magnetic field acts primarily on the spin (vs orbital) degree of freedom of the electrons, and superconductivity is further protected by the Ising field. The superconducting energy gap, extracted from our tunneling spectra, decreases as a function of the applied magnetic field. However, in bilayer NbSe2, close to the critical field (up to 30 T, much larger than the Pauli limit), superconductivity appears to be more robust than expected from Ising protection alone. Our data can be explained by the above-mentioned ESTPs., This work was funded by a Maimonides-Israel grant from the Israeli-French High Council for Scientific and Technological Research; JCJC (SPINOES), PIRE (HYBRID), and PRC (TRIPRES) grants from the French Agence Nationale de Recherche; European Research Council Starting Grant No. ERC-2014-STG 637928 (TUNNEL); Israel Science Foundation Grants No. 861/19 and No. 2665/20, and the Laboratoire d’Excellence LANEF in Grenoble (ANR10-LABX-51-01). T.D. is grateful to the Azrieli Foundation for an Azrieli Fellowship. Part of this work has been performed at the Laboratoire National de Champs Magnétiques Intenses (LNCMI), a member of the European Magnetic Field Laboratory (EMFL).

Published
2022
Full Text
View/download PDF

46. XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Author

Charlotte Blessing, Katja Apelt, Diana van den Heuvel, Claudia Gonzalez-Leal, Magdalena B. Rother, Melanie van der Woude, Román González-Prieto, Adi Yifrach, Avital Parnas, Rashmi G. Shah, Tia Tyrsett Kuo, Daphne E. C. Boer, Jin Cai, Angela Kragten, Hyun-Suk Kim, Orlando D. Schärer, Alfred C. O. Vertegaal, Girish M. Shah, Sheera Adar, Hannes Lans, Haico van Attikum, Andreas G. Ladurner, Martijn S. Luijsterburg, Molecular Genetics, National Institutes of Health (US), Netherlands Organization for Scientific Research, German Research Foundation, Dutch Cancer Society, European Research Council, International Cancer Genome Consortium, Israel Science Foundation, National Cancer Institute (US), Université Laval, Natural Sciences and Engineering Research Council of Canada, Israel Cancer Research Fund, Israel Cancer Association USA, and Dutch Research Council

Subjects
DNA-Binding Proteins, Poly Adenosine Diphosphate Ribose, Multidisciplinary, DNA Repair, General Physics and Astronomy, General Chemistry, DNA, Poly(ADP-ribose) Polymerase Inhibitors, General Biochemistry, Genetics and Molecular Biology, Chromatin, DNA Damage
Abstract

Cells employ global genome nucleotide excision repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-destabilizing DNA lesions, but binds poorly to lesions such as CPDs that do not destabilize DNA. How difficult-to-repair lesions are detected in chromatin is unknown. Here, we identify the poly-(ADP-ribose) polymerases PARP1 and PARP2 as constitutive interactors of XPC. Their interaction results in the XPC-stimulated synthesis of poly-(ADP-ribose) (PAR) by PARP1 at UV lesions, which in turn enables the recruitment and activation of the PAR-regulated chromatin remodeler ALC1. PARP2, on the other hand, modulates the retention of ALC1 at DNA damage sites. Notably, ALC1 mediates chromatin expansion at UV-induced DNA lesions, leading to the timely clearing of CPD lesions. Thus, we reveal how chromatin containing difficult-to-repair DNA lesions is primed for repair, providing insight into mechanisms of chromatin plasticity during GGR., This research was supported by an LUMC Research Fellowship, ENW-M (OCENW.KLEIN.090), and ALW-VIDI grants (ALW.016.161.320) from the Dutch Research Council (NWO) to M.S.L. This research was further funded by the DFG (German Research Foundation) through Project-ID 213249687 - SFB 1064 and Project-ID 325871075 - SFB 1309, as well as LMU to A.G.L. C.B. was the recipient of a grant from the Stiftungskommission of the LMU Medical Faculty. R.G-P was the recipient of a Young Investigator Grant from the Dutch Cancer Society (KWF-YIG 11367). A.C.O.V. was funded by an ERC grant (310913). H.L. and M.v.d.W. were funded by the Netherlands Organization for Scientific Research (711.018.007 and CancerGenomiCs.nl) and the Oncode Institute, which is partly financed by the Dutch Cancer Society. O.D.S. was supported by the Korean Institute of Basic Science (IBS-R022-A1) and the National Cancer Insitute (USA, P01-CA092584). G.M.S. was supported by grants from the Research Centre of CHU de Quebec Laval University as well as from the Natural Sciences and Engineering Research Council of Canada through the Discovery Grant (RGPIN-2016-05868) and the Discovery Accelerator Supplement Grant (RGPAS-492875-2016). S.A. was funded by the Israel Cancer Research Fund Research Career Development Award (3013004741), the Israel Cancer Association grant (20210078), and Israel Science Foundation grant (1710/17) administered by the Israeli Academy of Science and Humanities and is the recipient of the Jacob and Lena Joels memorial senior lectureship. H.v.A. was funded by a VICI grant from the Dutch Research Council (NWO-VICI grant VI.C.182.052).

Published
2022
Full Text
View/download PDF

47. Neutrophil phenotypes and functions in cancer

Author

Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andrés Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. Wagner, Ping Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes, Canadian Institutes of Health Research, Terry Fox Research Institute, UK Research and Innovation, Medical Research Council (Reino Unido), National Institutes of Health (Estados Unidos), Israel Science Foundation, Rosetrees Trust, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Fundación ProCNIC, Wellcome Trust, and Swiss National Science Foundation

Subjects
Model organisms, Inflammation, Phenotype, Neutrophils, Stem Cells, Neoplasms, Immunology, Humans, Immunity, Innate, Neoplasms/genetics, Immunology and Allergy, Tumour Biology, Genetics & Genomics
Abstract

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer. Acknowledgments This consensus statement is dedicated to our esteemed colleagues, Zena Werb and Paul S. Frenette, who attended and participated in the Banbury Center meeting and encouraged a collective effort by attendees to write this report. Both made significant contributions to ideas and discussions that are represented here. The Banbury Center meeting was organized by M. Egeblad, P. Kubes, K.E. de Visser, R. Leshan, and Banbury Center staff. The meeting was supported financially by Cold Spring Harbor Laboratory Northwell Health Affiliation. The funder had no involvement with the writing of this consensus statement. D.F. Quail acknowledges funding from the Canadian Institutes of Health Research (PJT-159742, PJT-178306), Terry Fox Research Institute, and Tier II Canada Research Chair. B. Amulic acknowledges funding from the Medical Research Council (MR/R02149x/1). M. Aziz acknowledges funding from the National Institutes of Health (NIH; R01GM129633). B.J. Barnes acknowledges funding from the NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR065959-01) and Department of Defense (CDMRP LRP W81XWH-18-1-0674). E. Eruslanov acknowledges funding from the NIH National Cancer Institute (NCI; R01CA187392) and the Department of Defense (CDMRP W81XWH-15-1-0717). Z.G. Fridlender acknowledges funding from the the Israel Science Foundation (grant number 1708/20) and the Sasson and Luisa Naor Fund. H.S. Goodridge acknowledges funding from the NIH National Institute of Allergy and Infectious Diseases (R01AI134987). Z. Granot acknowledges funding from the Israel Science Foundation Grant 405/18, the Israel Cancer Research Fund, the Deutsche Forschungsgemeinschaft, and the Rosetrees Trust. A. Hidalgo acknowledges funding from FET-OPEN (861878) from the European Commission; the Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministerio de Ciencia e Innovacion and the Pro-CNIC Foundation. M.J. Kaplan acknowledges funding from the Intramural Research Program of the NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIAAR041199). I. Malanchi acknowledges funding from the European Research Council grant (ERC CoG-H2020-725492) and from the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001112), the UK Medical Research Council (FC001112), and the Wellcome Trust (FC001112). T. Merghoub acknowledges funding from the NIH/NCI Cancer Center Support Grant (P30 CA008748/NCI R01 CA056821), Swim Across America, Ludwig Institute for Cancer Research, Ludwig Center for Cancer Immunotherapy at Memorial Sloan Kettering, Cancer Research Institute, and Parker Institute for Cancer Immunotherapy. E. Meylan acknowledges funding from the Swiss National Science Foundation (310030_179324) and Fonds de la Recherche Scientifique (MISU F.6003.22). M.J. Pittet acknowledges funding from the Institut Suisse de Recherche Experimentale sur le Cancer Foundation, Ludwig Cancer Research, and the NIH (P01CA240239, R01CA218579). I.A. Udalova acknowledges funding from the Wellcome Trust Investigator Award (209422/Z/17/Z). T.K. van den Berg acknowledges funding from Byondis BV, the Dutch Ministry of Health, and the Dutch Cancer Society (10300). D.D. Wagner acknowledges funding from the NIH National Health, Lung and Blood Institute (R35HL135765). P. Wang acknowledges funding from the NIH National Institute of General Medical Sciences (R35GM118337). A. Zychlinsky acknowledges funding from the Max Planck Society. K.E. de Visser acknowledges funding from the Dutch Cancer Society (KWF10623, KWF10083, and KWF13191), Oncode Institute, and the Netherlands Organization for Scientific Research (NWO-VICI 91819616). M. Egeblad acknowledges funding from the Department of Defense, Congressional Directed Medical Research Program (W81XWH2010753). P. Kubes acknowledges funding from the Canadian Institutes of Health Research. Sí

Published
2022
Full Text
View/download PDF

48. Tunable photon-mediated interactions between spin-1 systems

Author

Cristian Tabares, Erez Zohar, Alejandro González-Tudela, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid, and Israel Science Foundation

Subjects
Quantum Physics, FOS: Physical sciences, Physics::Optics, Quantum Physics (quant-ph)
Abstract

20 pags., 15 figs., 3 tabs., The exchange of off-resonant photons between quantum optical emitters in cavity QED or quantum nanophotonic setups induces interactions between them which can be harnessed for quantum information and simulation purposes. So far, these interactions have been mostly characterized for two-level emitters, which restrict their application to engineering quantum gates among qubits or simulating spin-1/2 quantum many-body models. Here, we show how to harness multilevel emitters with several optical transitions to engineer a wide class of photon-mediated interactions between effective spin-1 systems. We characterize their performance through analytical and numerical techniques and provide specific implementations based on the atomic level structure of Alkali atoms. Our results expand the quantum simulation toolbox available in such cavity QED and quantum nanophotonic setups and open up different ways of engineering entangling gates among qutrits., C.T. and A.G.-T. acknowledge support from CSIC Research Platform on Quantum Technologies PTI-001, from Spanish Project No. PGC2018-094792-B-100(MCIU/AEI/FEDER, EU) and from the Proyecto Sinérgico CAM 2020 Y2020/TCS-6545 (NanoQuCo-CM). E.Z. acknowledges support from the Israel Science Foundation (Grant No. 523/20)

Published
2022

49. Infant-phase reddening by surface Fe-peak elements in a normal type Ia supernova

Author

Yuan Qi Ni, Dae-Sik Moon, Maria R. Drout, Abigail Polin, David J. Sand, Santiago González-Gaitán, Sang Chul Kim, Youngdae Lee, Hong Soo Park, D. Andrew Howell, Peter E. Nugent, Anthony L. Piro, Peter J. Brown, Lluís Galbany, Jamison Burke, Daichi Hiramatsu, Griffin Hosseinzadeh, Stefano Valenti, Niloufar Afsariardchi, Jennifer E. Andrews, John Antoniadis, Iair Arcavi, Rachael L. Beaton, K. Azalee Bostroem, Raymond G. Carlberg, S. Bradley Cenko, Sang-Mok Cha, Yize Dong, Avishay Gal-Yam, Joshua Haislip, Thomas W.-S. Holoien, Sean D. Johnson, Vladimir Kouprianov, Yongseok Lee, Christopher D. Matzner, Nidia Morrell, Curtis McCully, Giuliano Pignata, Daniel E. Reichart, Jeffrey Rich, Stuart D. Ryder, Nathan Smith, Samuel Wyatt, Sheng Yang, National Research Council of Canada, University of Toronto, Heising Simons Foundation, National Research Foundation of Korea, National Science Foundation (US), Israel Science Foundation, European Commission, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), Stavros Niarchos Foundation, and Hellenic Foundation for Research and Innovation

Subjects
Pediatric, High Energy Astrophysical Phenomena (astro-ph.HE), High-energy astrophysics, Transient astrophysical phenomena, Astrophysics - Solar and Stellar Astrophysics, FOS: Physical sciences, Time-domain astronomy, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Stars, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract

Ni, Y. Q., et al., Type Ia supernovae are thermonuclear explosions of white dwarf stars. They play a central role in the chemical evolution of the Universe and are an important measure of cosmological distances. However, outstanding questions remain about their origins. Despite extensive efforts to obtain natal information from their earliest signals, observations have thus far failed to identify how the majority of them explode. Here, we present infant-phase detections of SN 2018aoz from a very low brightness of −10.5 AB absolute magnitude, revealing a hitherto unseen plateau in the B band that results in a rapid redward colour evolution between 1.0 and 12.4 hours after the estimated epoch of first light. The missing B-band flux is best explained by line-blanket absorption from Fe-peak elements in the outer 1% of the ejected mass. The observed B − V colour evolution of the supernova also matches the prediction from an over-density of Fe-peak elements in the same outer 1% of the ejected mass, whereas bluer colours are expected from a purely monotonic distribution of Fe-peak elements. The presence of excess nucleosynthetic material in the extreme outer layers of the ejecta points to enhanced surface nuclear burning or extended subsonic mixing processes in some normal type Ia SN explosions., D.-S.M., M.R.D. and C.D.M. are supported by Discovery Grants from the Natural Sciences and Engineering Research Council of Canada. D.-S.M. was supported in part by a Leading Edge Fund from the Canadian Foundation for Innovation (project no. 30951). M.R.D. was supported in part by the Canada Research Chairs Program, the Canadian Institute for Advanced Research (CIFAR) and the Dunlap Institute at the University of Toronto. D.J.S. acknowledges support by NSF grant nos. AST-1821987, 1821967 and 1908972 and from the Heising–Simons Foundation under grant no. 2020-1864. S.G.-G. acknowledges support by FCT under project CRISP PTDC/FIS-AST-31546 and project UIDB/00099/2020. H.S.P. was supported in part by a National Research Foundation (NRF) of Korea grant funded by the Korean government (MSIT, Ministry of Science and ICT; no. NRF-2019R1F1A1058228). P.J.B. acknowledges support from the Swift GI program 80NSSC19K0316. S.V., Y.D. and K.A.B. acknowledge support by NSF grant nos. AST-1813176 and AST-2008108. C.M. acknowledges support by NSF grant AST-1313484. I.A. is a CIFAR Azrieli Global Scholar in the Gravity and the Extreme Universe Program and acknowledges support from that program, from the Israel Science Foundation (grant nos. 2108/18 and 2752/19), from the United States – Israel Binational Science Foundation (BSF) and from an Israeli Council for Higher Education Alon Fellowship. R.L.B. acknowledges support by NASA through Hubble Fellowship grant no. 51386.01 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA under contract no. NAS 5-26555. A.G.-Y. acknowledges support from the European Union via ERC grant no. 725161, the ISF GW Excellence Center, an IMOS space infrastructure grant and BSF/Transformative and GIF grants, as well as from the Benoziyo Endowment Fund for the Advancement of Science, the Deloro Institute for Advanced Research in Space and Optics, the Veronika A. Rabl Physics Discretionary Fund, P. and T. Gardner, the Yeda-Sela Center for Basic Research and a WIS-CIT joint research grant. A.G.-Y. is the recipient of the Helen and Martin Kimmel Award for Innovative Investigation. L.G. acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación (MCIN), the Agencia Estatal de Investigación (AEI) 10.13039/501100011033, the European Social Fund (ESF) ‘Investing in your future’ under the 2019 Ramón y Cajal program RYC2019-027683-I and the PID2020-115253GA-I00 HOSTFLOWS project, as well as from the Centro Superior de Investigaciones Científicas (CSIC) under the PIE project 20215AT016. G.P. acknowledges support from the Millennium Science Initiative through grant no. IC120009. J.A. is supported by the Stavros Niarchos Foundation (SNF) and the Hellenic Foundation for Research and Innovation (HFRI) under the 2nd Call of ‘Science and Society’ Action ‘Always strive for excellence – Theodoros Papazoglou’ (project no. 01431).

Published
2022

50. Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Author

Thomas W. Geisbert, Vered Padler-Karavani, Sylvain Baize, Hadas Cohen-Dvashi, Ron Amon, Krystle N. Agans, Aliza Borenstein-Katz, Ron Diskin, Robert W. Cross, Mathieu Mateo, Weizmann Institute of Science [Rehovot, Israël], Tel Aviv University (TAU), The University of Texas Medical Branch (UTMB), Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), BSL-4 experiments using MACV were supported by the Pasteur-Weizmann joint research program collaborative research grant S-CR18069-02 to M.M. and R.D. BSL-4 operations of the Galveston National Laboratory and Department of Microbiology and Immunology are supported by NIAID/NIH Grant No. UC7AI094660 to T.W.G. The lab of R.D. is supported by research grants from the Enoch Foundation, from the Abramson Family Center for Young Scientists, from Ms. Rudolfine Steindling, and from the I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (grants no. 1775/12 and 682/16)., Tel Aviv University [Tel Aviv], Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), and Bodescot, Myriam

Subjects
0301 basic medicine, New World Arenavirus, Viral protein, medicine.medical_treatment, Science, viruses, General Physics and Astronomy, Transferrin receptor, Biologics, Biology, Antibodies, Viral, medicine.disease_cause, Article, General Biochemistry, Genetics and Molecular Biology, Viral Proteins, 03 medical and health sciences, 0302 clinical medicine, Virology, Receptors, Transferrin, medicine, Arenaviridae Infections, Humans, lcsh:Science, X-ray crystallography, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Multidisciplinary, Transmission (medicine), Rational design, virus diseases, Arenavirus, General Chemistry, Immunotherapy, Antibodies, Neutralizing, Arenaviruses, 3. Good health, Hemorrhagic Fevers, 030104 developmental biology, Drug Design, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Biological warfare, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Receptors, Virus, lcsh:Q, 030217 neurology & neurosurgery
Abstract

Certain arenaviruses that circulate in rodent populations can cause life-threatening hemorrhagic fevers when they infect humans. Due to their efficient transmission, arenaviruses pose a severe risk for outbreaks and might be exploited as biological weapons. Effective countermeasures against these viruses are highly desired. Ideally, a single remedy would be effective against many or even all the pathogenic viruses in this family. However, despite the fact that all pathogenic arenaviruses from South America utilize transferrin receptor 1 (TfR1) as a cellular receptor, their viral glycoproteins are highly diversified, impeding efforts to isolate cross-neutralizing antibodies. Here we address this problem using a rational design approach to target TfR1-tropic arenaviruses with high potency and breadth. The pan-reactive molecule is highly effective against all arenaviruses that were tested, offering a universal therapeutic approach. Our design scheme avoids the shortcomings of previous immunoadhesins and can be used to combat other zoonotic pathogens., New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against pathogenic mammarenaviruses.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results