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Thomas Kaercher,1 Elisabeth M Messmer,2,3 Thomas Berninger,4 Klaudia K Huber-van der Velden,5 Raphaela Geiger,6 Pauline Cipriano-Bonvin,7 Christina Jacobi8,9 1Augenarztpraxis, Heidelberg, Germany; 2Department of Ophthalmology, Ludwig-Maximilian-University, Munich, Germany; 3Praxis Professor Kampik & Kollegen, Munich, Germany; 4Augenzentrum, Olching, Germany; 5Augenheilkunde Lindenthal, Köln-Lindenthal, Germany; 6TRB Chemedica AG, Feldkirchen, Germany; 7TRB Chemedica International SA, Geneva, Switzerland; 8Augen & Haut Zentrum-Praxis Dr. Jacobi, Nuremberg, Germany; 9Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, GermanyCorrespondence: Thomas Kaercher, Augenarztpraxis, 48 Dossenheimer Landstr, Heidelberg, 69121, Germany, Tel +49 6221 400 888, Fax +49 6221 412 203, Email thomas.kaercher@meibomius.dePurpose: To investigate the efficacy, safety and tolerability of topical omega-3 polyunsaturated fatty acids (PUFA) as an innovative treatment of dry eye disease (DED).Patients and Methods: In a pilot, multicenter, masked-observer, randomized, active-controlled, non-inferiority study in Germany, patients self-treated their eyes with daily instillations of eye drops containing either omega-3 PUFA or povidone as major components for three months. At four and twelve weeks, efficacy was among others evaluated based on Ocular Surface Disease Index (OSDI), ocular surface symptoms intensity, general clinical impression, tear break-up time (TBUT), corneal fluorescein staining using the Oxford grading scale, tear volume, and matrix metalloproteinase-9 (MMP-9) concentration in the tear film. Safety evaluation included visual acuity, intraocular pressure, and the incidence of adverse events. Co-primary endpoints were the mean percent changes from baseline of TBUT and OSDI after four weeks.Results: In total 80 patients were included, of whom 37 in the PUFA group and 39 in the povidone group were evaluable for the co-primary endpoints. Patients had a mean age of 52 years and > 80% were women. Both co-primary endpoints (TBUT and OSDI) significantly improved from baseline in both treatment groups, at Week 4 and Week 12 and the statistical analysis demonstrated topical omega-3 PUFA to be non-inferior to 2% povidone for these two parameters. Both treatments resulted in a significant improvement of most secondary efficacy endpoints as well, often with a slight difference in favor of PUFA, not reaching statistical significance though. One non-severe, treatment-related local AE was reported in each group.Conclusion: Omega-3 PUFA-based eye drops proved to be non-inferior to povidone-containing eye drops in the treatment of signs and symptoms of dry eye. This treatment may thus be an additional tool for the management of DED.Keywords: polyunsaturated fatty acids, povidone, dry eye disease, artificial tears, omega-3 fatty acid

Abstract Background Onchocerca volvulus, the causative agent of river blindness, is transmitted through the black fly Simulium damnosum s.l., which breeds in turbulent river waters. To date, the number of flies attacking humans has only been determined by standard fly collectors near the river or the village. In our study, we counted the actual number of attacking and successfully feeding S. damnosum s.l. flies landing on individual villagers during their routine day-time activities in two villages of the Sudan-savannah and rainforest of Cameroon. We compared these numbers to the number of flies caught by a standard vector-collector, one positioned near the particular villager during his/her daily activity and the other sitting at the nearest Simulium breeding site. Results Using these data obtained by the two vector-collectors, we were able to calculate the Actual Index of Exposure (AIE). While the AIE in the savannah was on average 6,3%, it was 34% in the rainforest. The Effective Annual Transmission Potential (EATP) for individual villagers was about 20 fold higher in the rainforest compared to the savannah. Conclusions Here we show for the first time that it is possible to determine the EATP. Further studies with more subjects are needed in the future. These data are important for the development of future treatment strategies.

Meteoroids of sub‐milligram sizes burn up high in the Earth's atmosphere and cause streaks of plasma trails detectable by meteor radars. The altitude at which these trails, or meteors, form depends on a number of factors including atmospheric density and the astronomical source populations from which these meteoroids originate. A previous study has shown that the altitude of these meteors is affected by long‐term linear trends and the 11‐year solar cycle related to changes in our atmosphere. In this work, we examine how shorter diurnal and seasonal variations in the altitude distribution of meteors are dependent on the geographical location at which the measurements are performed. We use meteoroid altitude data from 18 independent meteor radar stations at a broad range of latitudes and investigate whether there are local time (LT) and seasonal variations in the altitude of the peak meteor height, defined as the majority detection altitude of all meteors within a certain period, which differ from those expected purely from the variation in the visibility of their astronomical source. We find a consistent LT and seasonal response for the Northern Hemisphere locations regardless of latitude. However, the Southern Hemisphere locations exhibit much greater LT and seasonal variation. In particular, we find a complex response in the four stations located within the Southern Andes region, which indicates that the strong dynamical atmospheric activity, such as the gravity waves prevalent here, disrupts, and masks the seasonality and dependence on the astronomical sources. Plain Language Summary: Small meteoroids burn up high in the Earth's atmosphere producing trails of plasma detectable by ground‐based meteor radar instruments. The altitude at which these trails occur depends on a number of factors including atmospheric density and the astronomical source populations from which these meteoroids originate. Previous work demonstrated that the altitude at which the majority of these meteoroids burn up (termed "peak meteor altitude") is affected by long‐term atmospheric changes, such as those related to greenhouse gas emissions and the 11‐year solar cycle. Here, we focus on shorter timescales and analyze meteoroid altitude data from 18 geographically diverse meteor radars to examine the local time (LT) and seasonal variation in the peak meteor altitudes on a latitude basis. We find a consistent LT and seasonal response among the six Northern Hemisphere meteor radar station locations irrespective of latitude. However, we find a more complex response among the 12 Southern Hemisphere stations with much greater LT and seasonal variation. In particular, we found a complex response in the four stations located within the Southern Andes region, a geographic region known for intense atmospheric gravity wave activity, which acts to mask and disrupt the seasonality and dependence on the astronomical sources. Key Points: Local time (LT) and seasonal variations in the peak meteor height exist, which differ from those expected from astronomical variation aloneThere is a consistent LT and seasonal response in the Northern Hemisphere locations regardless of latitudeA complex response in the Andes region where a strong gravity wave component acts to mask seasonality and dependence on astronomical sources [ABSTRACT FROM AUTHOR]

The mesosphere/lower thermosphere (MLT, 80–100 km) region is an important boundary between Earth's atmosphere below and space above and may act as a sensitive indicator for anthropogenic climate change. Existing observational and modeling studies have shown the middle atmosphere and the MLT is cooling and contracting because of increasing greenhouse gas emissions. However, trend analyses are highly sensitive to the time periods covered, their length, and the measurement type and methodology used. We present for the first time the linear and 11‐year solar cycle responses in the meteor ablation altitude distributions observed by 12 meteor radars at different locations. Decreasing altitudes were seen at all latitudes (linear trends varying from −10.97 to −817.95 m dec−1), and a positive correlation with solar activity was seen for most locations. The divergence of responses at high latitudes indicates an important and complex interplay between atmospheric changes and dynamics at varying time scales. Plain Language Summary: High up in our atmosphere lies the mesosphere/lower thermosphere region (80–100 km); an important transition zone between the atmosphere below and space above. Existing studies indicate that this region is changing (cooling and contracting) in response to increasing greenhouse gas emissions, quite unlike the net warming we see near the surface. However these trend studies are often highly sensitive to choice and length of time period covered, and the methodology and type of measurements used. Here we present for the first time a self‐consistent methodology applied to 12 different meteor radar station datasets located at a diverse range of latitudes. We looked at changes in the mean peak altitude of individual meteoroid detections, and found decreasing peak altitudes at all locations examined (linear trends varying from −10.97 to −817.95 m decade−1) consistent with a global cooling and contracting of the upper atmosphere. We also examined the response to the 11‐year solar cycle and found a positive correlation with solar activity (i.e., increased meteoroid peak altitudes during solar maximum, and vice versa) for low and mid‐latitude locations. However we found an anti‐correlation at high latitudes suggestive of an important and complex interplay between atmospheric changes and dynamics at varying time scales. Key Points: Use of geographically diverse meteor radar peak detection altitudes to assess long‐term and 11‐year solar cycle (SC) trends in mesopause regionThe altitude of observed peak meteor height has decreased over time at all locations, regardless of latitude and data setPositive correlation at low‐ and mid‐latitude locations with the 11‐year SC, but more complex response at high‐latitudes [ABSTRACT FROM AUTHOR]