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During human childhood, brain development and body growth compete for limited metabolic resources, resulting in a trade‐off where energy allocated to brain development can decrease as body growth accelerates. This preregistered study explores the relationship between language skills, serving as a proxy for brain development, and body mass index at three distinct developmental stages, representing different phases of body growth. Longitudinal data from 2002 children in the EDEN mother‐child cohort were analyzed using structural equation modeling. Our findings reveal a compelling pattern of associations: girls with a delayed adiposity rebound, signaling slower growth rate, demonstrated better language proficiency at ages 5–6. Importantly, this correlation appears to be specific to language skills and does not extend to nonverbal cognitive abilities. Exploratory analyses show that early environmental factors contributing to enhanced cognitive development, such as higher parental socio‐economic status and increased cognitive stimulation, are positively associated with both language skills and the timing of adiposity rebound in girls. Overall, our findings lend support to the existence of an energy allocation trade‐off mechanism that appears to prioritize language function over body growth investment in girls. Research Highlights: The high energy demand of neurocognitive development leads to a trade‐off in human children between brain growth and other biological functions, including body growth.Previous studies indicate that around age 5, when the brain energy consumption peaks, children typically experience a decrease in body mass known as 'adiposity rebound'.A delayed adiposity rebound, indicating slower growth may be associated with enhanced language abilities in children.Our preregistered study confirms this correlation in girls and further associates early cognitive stimulation with improved language skills and delayed adiposity rebound time. [ABSTRACT FROM AUTHOR]

We present the Python Red Pitaya Lockbox (PyRPL), an open source software package that allows the implementation of automatic digital feedback controllers for quantum optics experiments on commercially available, affordable Field-Programmable Gate Array (FPGA) boards. Our software implements the digital generation of various types of error signals, from an analog input through the application of loop filters of high complexity and real-time gain adjustment for multiple analog output signals, including different algorithms for resonance search, lock acquisition sequences, and in-loop gain optimization. Furthermore, all necessary diagnostic instruments, such as an oscilloscope, a network analyzer, and a spectrum analyzer, are integrated into our software. Apart from providing a quickly scalable, automatic feedback controller, the lock performance that can be achieved by using PyRPL with imperfect equipment, such as piezoelectric transducers and noisy amplifiers, is better than the one achievable with standard analog controllers due to the higher complexity of implementable filters and possibilities of nonlinear operations in the FPGA. This drastically reduces the cost of added complexity when introducing additional feedback loops to an experiment. The open-source character also distinguishes PyRPL from commercial solutions, as it allows users to customize functionalities at various levels, ranging from the easy integration of PyRPL-based feedback controllers into existing setups to the modification of the FPGA functionality. A community of developers provides fast and efficient implementation and testing of software modifications. [ABSTRACT FROM AUTHOR]

Previous work has proposed that balancing energy expenditure towards body and brain development in an optimal fashion results in a negative relationship between somatic and neurocognitive growth during development. An important issue, largely overlooked so far, is the extent to which this energetic trade-off is influenced by early life environmental factors. In this study, we estimated the association between neurocognitive (measured by working memory ability) and somatic (measured by body-mass index) developmental trajectories, while taking into account multiple dimensions of early life adversity. Results of our initial growth curve model were consistent with this brain–body trade-off in both girls and boys. In a subsequent model, we showed that early life adversity had positive associations with somatic and negative associations with neurocognitive growth trajectories, although the direct negative coupling between them remained consistent. Finally, a multidimensional adversity model, separating the effects of deprivation, threat and unpredictability, revealed that the dimension of deprivation—reflecting lack of access to resources and cognitive stimulation—contributed the most to both somatic and neurocognitive growth patterns. These results suggest that the way individuals balance energy between these two biological constructs during development is partly linked to environmental influences through phenotypic plasticity. [ABSTRACT FROM AUTHOR]

Simple Summary: Tumor cells have high levels of metabolic activity, which makes the environment around them more acidic. This acidic environment encourages the aggressiveness and invasiveness of the tumor, which are linked to a worse prognosis. Cancer cells may control their internal acidity in different ways when exposed to an acidic environment. In this study, two types of brain tumor cells were exposed to different levels of acidity to characterize their response in terms on intracellular pH regulation. The results show that these cells do not handle acidity the same way. One cell type can reduce its internal acidity, while the other can withstand higher acidity levels. The ability to manage acidity seems to depend on the specific cell type and involves various mechanisms to keep the cells working properly. This study explored these cells in both 2D flat layers and 3D structures called spheroids. In spheroids, the regulation process of internal acidity appears to work differently than in 2D. These findings could influence treatment because the drug temozolomide, which is used to fight brain tumors, works better in certain pH environments. By adjusting the pH outside the cells, the effectiveness of the drug can be improved. This suggests that personalized treatment might be possible by combining temozolomide with substances that control pH. A well-known feature of tumor cells is high glycolytic activity, leading to acidification of the tumor microenvironment through extensive lactate production. This acidosis promotes processes such as metastasis, aggressiveness, and invasiveness, which have been associated with a worse clinical prognosis. Moreover, the function and expression of transporters involved in regulation of intracellular pH might be altered. In this study, the capacity of tumor cells to regulate their intracellular pH when exposed to a range of pH from very acidic to basic was characterized in two glioma cell lines (F98 and U87) using a new recently published method of fluorescence imaging. Our results show that the regulation of acidity in tumors is not the same for the two investigated cell lines; U87 cells are able to reduce their intracellular acidity, whereas F98 cells do not exhibit this property. On the other hand, F98 cells show a higher level of resistance to acidity than U87 cells. Intracellular regulation of acidity appears to be highly cell-dependent, with different mechanisms activated to preserve cell integrity and function. This characterization was performed on 2D monolayer cultures and 3D spheroids. Spatial heterogeneities were exhibited in 3D, suggesting a spatially modulated regulation in this context. Based on the corpus of knowledge available in the literature, we propose plausible mechanisms to interpret our results, together with some new lines of investigation to validate our hypotheses. Our results might have implications on therapy, since the activity of temozolomide is highly pH-dependent. We show that the drug efficiency can be enhanced, depending on the cell type, by manipulating the extracellular pH. Therefore, personalized treatment involving a combination of temozolomide and pH-regulating agents can be considered. [ABSTRACT FROM AUTHOR]

This cross-sectional study examines whether the emergence of borderline personality disorder is associated with the prioritization of immediate reproductive goals over longer-term somatic maintenance goals. Key Points: Question: Is borderline personality disorder (BPD) favored by prioritizing immediate reproductive goals over long-term somatic maintenance goals in response to early life adversity? Findings: In this cross-sectional study of more than 30 000 adults, the association of early life adversity with the risk of being diagnosed with BPD later in life was significantly mediated by an allocation trade-off favoring immediate reproduction over somatic maintenance. Meaning: BPD may be the psychobehavioral expression of a broader coping strategy whereby individuals deal with adversity by prioritizing the development of reproductive traits and behaviors. Importance: Borderline personality disorder (BPD) is often accompanied by a history of high-risk sexual behavior and somatic comorbidities. Yet, these features are most often considered in isolation and little is known about their underlying developmental pathways. Life history theory, a leading framework in evolutionary developmental biology, can help make sense of the wide range of behaviors and health issues found in BPD. Objective: To examine whether the emergence of BPD is associated with the prioritization of immediate reproductive goals over longer-term somatic maintenance goals, a life strategy that can be viewed as a developmental response to adverse early life experiences, providing rapid reproductive benefits despite costs to health and well-being. Design, Setting, and Participants: This study used cross-sectional data from the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions in 2004-2005 (n = 34 653). Civilian, noninstitutionalized individuals in the US, 18 years or older, and those with and without a DSM-IV diagnosis of BPD were included. Analysis took place between August 2020 and June 2021. Main Outcomes and Measures: Structural equation models were used to examine whether early life adversity was associated with the likelihood of a BPD diagnosis, either directly or indirectly through a life strategy whereby individuals trade somatic maintenance for immediate reproduction. Results: Analyses were performed on a sample of 30 149 participants (females: 17 042 [52%]; mean [SE] age, 48.5 [0.09]; males: 12 747 [48%]; mean [SE] age, 47 [0.08]). Of these, 892 (2.7%) had a diagnosis of BPD and 29 257 (97.3%) did not have BPD. Mean early life adversity, metabolic disorder score, and body mass index were significantly higher among participants with a diagnosis of BPD. In an analysis adjusted for age, individuals with BPD reported having significantly more children than those without BPD (b =0.06; SE, 0.01; t = 4.09; P <.001). Having experienced greater levels of adversity in early life was significantly associated with a greater risk of being diagnosed with BPD later in life (direct relative risk = 0.268; SE, 0.067; P <.001). Importantly, this risk was further increased by 56.5% among respondents who prioritized short-term reproductive goals over somatic maintenance (indirect relative risk = 0.565; SE, 0.056; P <.001). Similar patterns of associations were found in male and female individuals. Conclusions and Relevance: The hypothesis of a reproduction/maintenance life history trade-off mediating the association between early life adversity and BPD helps make sense of the high dimensionality that characterizes the physiological and behavioral correlates of BPD. Additional studies are needed to confirm these results using longitudinal data. [ABSTRACT FROM AUTHOR]

This review focuses on the evolving understanding that we have of tumor cell metabolism, particularly glycolytic and oxidative metabolism, and traces back its evolution through time. This understanding has developed since the pioneering work of Otto Warburg, but the understanding of tumor cell metabolism continues to be hampered by misinterpretation of his work. This has contributed to the use of the new concepts of metabolic switch and metabolic reprogramming， that are out of step with reality. The Warburg effect is often considered to be a hallmark of cancer, but is it really? More generally, is there a metabolic signature of cancer? We draw the conclusion that the signature of cancer cannot be reduced to a single factor, but is expressed at the tissue level in terms of the capacity of cells to dynamically explore a vast metabolic landscape in the context of significant environmental heterogeneities. [ABSTRACT FROM AUTHOR]

Self-disturbance is recognized as a key symptom of Borderline Personality Disorder (BPD). Although it is the source of significant distress and significant costs to society, it is still poorly specified. In addition, current research and models on the etiology of BPD do not provide sufficient evidence or predictions about who is at risk of developing BPD and self-disturbance, and why. The aim of this review is to lay the foundations of a new model inspired by recent developments at the intersection of social cognition, behavioral ecology, and developmental biology. We argue that the sense of agency is an important dimension to consider when characterizing self-disturbances in BPD. Second, we address the poorly characterized relation between self-disturbances and adverse life conditions encountered early in life. We highlight the potential relevance of Life-History Theory—a major framework in evolutionary developmental biology—to make sense of this association. We put forward the idea that the effect of early life adversity on BPD symptomatology depends on the way individuals trade their limited resources between competing biological functions during development. [ABSTRACT FROM AUTHOR]

Social information is immensely valuable. Yet we waste it. The information we get from observing other humans and from communicating with them is a cheap and reliable informational resource. It is considered the backbone of human cultural evolution. Theories and models focused on the evolution of social learning show the great adaptive benefits of evolving cognitive tools to process it. In spite of this, human adults in the experimental literature use social information quite inefficiently: they do not take it sufficiently into account. A comprehensive review of the literature on five experimental tasks documented 45 studies showing social information waste, and four studies showing social information being over-used. These studies cover 'egocentric discounting' phenomena as studied by social psychology, but also include experimental social learning studies. Social information waste means that human adults fail to give social information its optimal weight. Both proximal explanations and accounts derived from evolutionary theory leave crucial aspects of the phenomenon unaccounted for: egocentric discounting is a pervasive effect that no single unifying explanation fully captures. Cultural evolutionary theory's insistence on the power and benefits of social influence is to be balanced against this phenomenon. This article is part of the theme issue 'Foundations of cultural evolution'. [ABSTRACT FROM AUTHOR]

This introduction summarily describes an innovative programme jointly organised by the European Investment Bank and the Global Development Network that competitively recruited and trained young researchers from Africa and the Caribbean to research on the economic and social impact of private sector investments funded by the European Investment as part of their Impact Investing Envelope. The introduction also summarises the research articles that were produced as part of the programme and selected for publication in this special issue. [ABSTRACT FROM AUTHOR]

Abstract: An important challenge of embodied theories is to explain the comprehension of abstract sentences. The aim of the present study was to scrutinize the role of the motor cortex in this process. We developed a new paradigm to study the abstract-concrete dimension by combining concrete (i.e., action-related) and abstract (i.e., non-action-related) verbs with nouns of graspable and non-graspable objects. Using these verb-noun combinations we performed a Transcranial Magnetic Stimulation (TMS) on the left primary motor cortex while participants performed a sentence sensibility task. Single-TMS pulses were delivered 250ms after verb or noun presentation in each of four combinations of abstract and concrete verbs and nouns. To evaluate cortico-spinal excitability we registered the electromyographic activity of the right first dorsal interosseous muscle. As to verb-noun integration, analysis of motor evoked potentials (MEPs) after TMS pulse during noun presentation revealed greater peak-to-peak amplitude in phrases containing abstract rather than concrete verbs. Response times were also collected and showed that compatible (Concrete–Concrete and Abstract–Abstract) combinations were processed faster than mixed ones; moreover in combinations containing concrete verbs, participants were faster when the pulse was delivered on the first word (verb) than on the second one (noun). Results support previous findings showing early activation of hand-related areas after concrete verbs processing. The prolonged or delayed activation of the same areas by abstract verbs will be discussed in the framework of recent embodied theories based on multiple types of representation, particularly theories emphasizing the role of different acquisition mechanisms for concrete and abstract words (Borghi and Cimatti, 2009,2012). [Copyright &y& Elsevier]

Deep eutectic solvents (DES) based on choline chloride and hydrogen bond donors are shown to be efficient functional additives for thermoplastic starch, able to act as efficient plasticizers, water uptake inhibitors, and as compatibilizers in the case of blends with a hydrophobic phase. One of the DES tested also prevents the recrystallization of starch. Although such properties can also be obtained with an imidazolium chloride ionic liquid, DES present the advantage of being environmentally friendly and potentially cheaper. Their wide potential in terms of formulation, by adjusting the nature and content of the hydrogen bond donor, opens new perspectives for the development of efficient starch based biodegradable plastics and composites. [ABSTRACT FROM AUTHOR]

Learning about the function and use of tools through observation requires the ability to exploit one's own knowledge derived from past experience. It also depends on the detection of low-level local cues that are rooted in the tool's perceptual properties. Best known as 'affordances', these cues generate biomechanical priors that constrain the number of possible motor acts that are likely to be performed on tools. The contribution of these biomechanical priors to the learning of tool-use behaviors is well supported. However, it is not yet clear if, and how, affordances interact with higher-order expectations that are generated from past experience - i.e. probabilistic exposure - to enable observational learning of tool use. To address this question we designed an action observation task in which participants were required to infer, under various conditions of visual uncertainty, the intentions of a demonstrator performing tool-use behaviors. Both the probability of observing the demonstrator achieving a particular tool function and the biomechanical optimality of the observed movement were varied. We demonstrate that biomechanical priors modulate the extent to which participants' predictions are influenced by probabilistically-induced prior expectations. Biomechanical and probabilistic priors have a cumulative effect when they 'converge' (in the case of a probabilistic bias assigned to optimal behaviors), or a mutually inhibitory effect when they actively 'diverge' (in the case of probabilistic bias assigned to suboptimal behaviors). [ABSTRACT FROM AUTHOR]

Mobus is a cognitive orthotic designed for people with difficulties managing Activities of Daily Living (ADL), as encountered in schizophrenia. It provides a schedule manager as well as the possibility to report occurrences of symptomatic experiences. Receiving this information by Internet, caregivers can assist the patient rehabilitation process. Our aim was to explore the use and satisfaction of Mobus by people with schizophrenia. Nine outpatients tested Mobus for 6 weeks. Indicators of cognitive functioning and autonomy were measured with the CAmbridge Neuropsychological Tests Automated Battery (CANTAB) and the Independant Living Skills Scale (ILSS). On average, 42.6% of the planned ADL were validated and more than 1 symptom per week were reported. Mainly because of technical breakdown, more than 50% of the outpatients evaluated the Mobus satisfaction below 1.7/5, nevertheless 3 participants appreciated it greatly. Some enhancements were found on subscales of CANTAB and ILSS and some participants reported that they acquired planning skills by using Mobus. To ensure ease of use, refinements are needed from rehabilitation and technical approaches, especially to personalize the device. Discussions on ethical and methodological issues lead to an improved version of Mobus that will be tested with a larger sample size. [ABSTRACT FROM PUBLISHER]