1. Local Passive Heat for the Treatment of Hypertension in Autonomic Failure
- Author
-
Luis E. Okamoto, Jorge E. Celedonio, Emily C. Smith, Alfredo Gamboa, Cyndya A. Shibao, André Diedrich, Sachin Y. Paranjape, Bonnie K. Black, James A. S. Muldowney, Amanda C. Peltier, Ralf Habermann, Craig G. Crandall, and Italo Biaggioni
- Subjects
autonomic failure ,heat ,orthostatic hypotension ,supine hypertension ,thermoregulation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Supine hypertension affects a majority of patients with autonomic failure; it is associated with end‐organ damage and can worsen daytime orthostatic hypotension by inducing pressure diuresis and volume loss during the night. Because sympathetic activation prevents blood pressure (BP) from falling in healthy subjects exposed to heat, we hypothesized that passive heat had a BP‐lowering effect in patients with autonomic failure and could be used to treat their supine hypertension. Methods and Results In Protocol 1 (n=22), the acute effects of local heat (40–42°C applied with a heating pad placed over the abdomen for 2 hours) versus sham control were assessed in a randomized crossover fashion. Heat acutely decreased systolic BP by −19±4 mm Hg (versus 3±4 with sham, P
- Published
- 2021
- Full Text
- View/download PDF