244 results on '"Johnson, Douglas S."'
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2. COVID-19 Among US Dialysis Patients: Risk Factors and Outcomes From a National Dialysis Provider
3. Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
4. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
5. Studies on the stability and stabilization of trans-cyclooctenes through radical inhibition and silver (I) metal complexation
6. Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer's Disease.
7. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
8. Leading Integrated Kidney Care Entities of the Future
9. Integrated Care for People with Kidney Disease: The Perspective of a Nonprofit Dialysis Provider
10. Oral Intradialytic Nutritional Supplement Use and Mortality in Hemodialysis Patients
11. γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin
12. The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
13. Structure-Guided Inhibitor Design for Human FAAH by Interspecies Active Site Conversion
14. Going Upstream: Coordination to Improve CKD Care
15. Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB
16. Chapter 5 - Utility of chemical probes for mass spectrometry based chemical proteomics
17. Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
18. CC-1065 and the Duocarmycins: Unraveling the Keys to a New Class of Naturally Derived DNA Alkylating Agents
19. Target of γ‐secretase modulators, presenilin marks the spot
20. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
21. Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.
22. Fluorophosphonate‐Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics.
23. Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin
24. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity
25. PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.
26. Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474.
27. Delaying and Averting Dialysis Treatment: Patient Protection or Moral Hazard?
28. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
29. Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes.
30. Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
31. Development of clickable active site-directed photoaffinity probes for γ-secretase
32. Discovery of PF-00217830: Aryl piperazine napthyridinones as D 2 partial agonists for schizophrenia and bipolar disorder
33. Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
34. Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
35. Chapter 21 - Chemical Proteomic Technologies for Drug Target Identification
36. Contributors
37. Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
38. PHOTOBIOMODULATION THERAPY IMPROVES PERFORMANCE AND ACCELERATES RECOVERY OF HIGH-LEVEL RUGBY PLAYERS IN FIELD TEST: A RANDOMIZED, CROSSOVER, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL STUDY.
39. Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective α 2C adrenergic receptor antagonist
40. Synthesis of fluorinated 1,8-naphthyridinone derivatives
41. Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines
42. Synthesis of chromanyl and dihydrobenzofuranyl piperazines
43. Nutrition, vitamin D, and health outcomes in hemodialysis: time for a feeding frenzy?
44. Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [11C]CURB.
45. A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
46. Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging.
47. Darunavir (Prezista): A HIV-1 Protease Inhibitor for Treatment of Multidrug-Resistant HIV.
48. Armodafinil (Nuvigil): A Psychostimulant for the Treatment of Narcolepsy.
49. Aliskiren (Tekturna), The First-in-Class Renin Inhibitor for Hypertension.
50. Bortezomib (Velcade): A First-in-Class Proteasome Inhibitor.
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