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2. A digital, decentralized trial of exercise therapy in patients with cancer

Author

Underwood, Whitney P., Michalski, Meghan G., Lee, Catherine P., Fickera, Gina A., Chun, Su S., Eng, Stefan E., Liu, Lydia Y., Tsai, Brandon L., Moskowitz, Chaya S., Lavery, Jessica A., Van Zee, Kimberly J., Gardner, Ginger J., Mueller, Jennifer J., Dang, Chau T., Ehdaie, Behfar, Laudone, Vincent P., Eastham, James A., Scott, Jessica M., Boutros, Paul C., and Jones, Lee W.

Published
2024
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3. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Author

Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E., Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin J. A., Boyer, Jacob A., Mezzadra, Riccardo, Wereski, Matthew G., Tuveson, David A., Levine, Ross L., Jones, Lee W., Sadelain, Michel, and Lowe, Scott W.

Published
2024
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5. Effect of a Home-based Walking Intervention on Cardiopulmonary Fitness and Quality of Life Among Men with Prostate Cancer on Active Surveillance: The Active Surveillance Exercise Randomized Controlled Trial

Author

Van Blarigan, Erin L., Kenfield, Stacey A., Olshen, Adam, Panchal, Neil, Encabo, Katriel, Tenggara, Imelda, Graff, Rebecca E., Bang, Alexander S., Shinohara, Katsuto, Cooperberg, Matthew R., Carroll, Peter R., Jones, Lee W., Winters-Stone, Kerri, Luke, Anthony, and Chan, June M.

Published
2024
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7. Association between physical activity and neoadjuvant chemotherapy completion and pathologic complete response in primary breast cancer: the CANTO study

Author

Baker, Jennifer L., Di Meglio, Antonio, Gbenou, Arnauld S., El Mouhebb, Mayssam, Iyengar, Neil M., Michiels, Stefan, Cottu, Paul, Lerebours, Florence, Coutant, Charles, Lesur, Anne, Tredan, Oliver, Vanlemmens, Laurence, Jouannaud, Christelle, Hrab, Iona, Everhard, Sibille, Martin, Anne-Laure, Arveux, Patrick, Fabrice, Andre, Vaz-Luis, Ines, and Jones, Lee W.

Published
2022
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9. A randomized controlled trial comparing changes in fitness with or without supervised exercise in patients initiated on enzalutamide and androgen deprivation therapy for non-metastatic castration-sensitive prostate cancer (EXTEND)

Author

Harrison, Michael R., Davis, Paul G., Khouri, Michel G., Bartlett, David B., Gupta, Rajan T., Armstrong, Andrew J., McNamara, Megan A., Zhang, Tian, Anand, Monika, Onyenwoke, Kelly, Edwardson, Sara, Craig, Danielle, Michalski, Meghan, Wu, Yuan, Oyekunle, Taofik, Coyne, Brian, Coburn, Aubrie, Jones, Lee W., and George, Daniel J.

Published
2022
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10. Case report: dynamic personalized physiological monitoring in lung cancer using wearable data.

Author

Bliss, Joshua W., Underwood, Whitney P., Carlson, Adele M., Scott, Jessica M., Daly, Robert, Li, Bob T., Drilon, Alexander, Stetson, Peter, Boutros, Paul C., and Jones, Lee W.

Subjects
WALKING speed, LUNG cancer, PATIENT monitoring, WEARABLE technology, CANCER patients
Abstract

Pretreatment prognostication, on-treatment monitoring, and early detection of physiological symptoms are considerable challenges in cancer. We describe the feasibility of high-resolution wearable data (steps per day, walking speed) to longitudinally profile physiological trajectories extracted from Apple Health data in three patients with lung cancer from diagnosis through cancer treatment after obtaining informed consent. We used descriptive statistics to describe our approach of building longitudinal physiological profiles. The wearable data monitoring period ranged from 58 to 135 weeks, with between 34,319 and 103,535 distinct digital physiological measures collected during this period--the equivalent to 41 measures per day/patient. Longitudinal profiling revealed that wearable data accurately captured physiological changes linked with clinical events such as surgery and hospitalizations as well as initiation (and cessation) of systemic cancer treatment in all three patients. These findings suggest that wearable devices could play a critical role in the management of lung cancer, although larger studies are needed to confirm these preliminary observations and validate their generalizability. Wearable devices hold significant promise for the development of personalized "digital biomarkers," which may enhance risk stratification and management in oncology. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Neoadjuvant Exercise Therapy in Prostate Cancer: A Phase 1, Decentralized Nonrandomized ControlledTrial.

Author

Jones, Lee W., Moskowitz, Chaya S., Lee, Catherine P., Fickera, Gina A., Chun, Su S., Michalski, Meghan G., Stoeckel, Kurtis, Underwood, Whitney P., Lavery, Jessica A., Bhanot, Umeshkumar, Linkov, Irina, Dang, Chau T., Ehdaie, Behfar, Laudone, Vincent P., Eastham, James A., Collins, Anne, Sheerin, Patricia T., Liu, Lydia Y., Eng, Stefan E., and Boutros, Paul C.

Published
2024
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14. Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study

Author

Di Meglio, Antonio, Michiels, Stefan, Jones, Lee W., El-Mouhebb, Mayssam, Ferreira, Arlindo R., Martin, Elise, Matias, Margarida, Lohmann, Ana Elisa, Joly, Florence, Vanlemmens, Laurence, Everhard, Sibille, Martin, Anne-Laure, Lemonnier, Jerome, Arveux, Patrick, Cottu, Paul H., Coutant, Charles, Del Mastro, Lucia, Partridge, Ann H., André, Fabrice, Ligibel, Jennifer A., and Vaz-Luis, Ines

Published
2020
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15. Body weight and return to work among survivors of early-stage breast cancer

Author

Di Meglio, Antonio, Menvielle, Gwenn, Dumas, Agnes, Gbenou, Arnauld, Pinto, Sandrine, Bovagnet, Thomas, Martin, Elise, Ferreira, Arlindo R., Vanlemmens, Laurence, Arsene, Olivier, Ibrahim, Mahmoud, Wassermann, Johanna, Martin, Anne Laure, Lemonnier, Jerome, Del Mastro, Lucia, Jones, Lee W., Partridge, Ann H., Ligibel, Jennifer A., Andre, Fabrice, Michiels, Stefan, and Vaz Luis, Ines

Published
2020
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16. Myocardial infarction accelerates breast cancer via innate immune reprogramming

Author

Koelwyn, Graeme J., Newman, Alexandra A.C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., and Moore, Kathryn J.

Subjects
Heart attack -- Models -- Complications and side effects, Immune response -- Health aspects, Breast cancer -- Models -- Development and progression, Biological sciences, Health
Abstract

Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity.sup.1 or surgery.sup.2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors.sup.3-5. While elevated risk and incidence of cardiovascular events in breast cancer is well established, whether such events impact cancer pathogenesis is not known. Here we show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. In mouse models of breast cancer, MI epigenetically reprogrammed Ly6C.sup.hi monocytes in the bone marrow reservoir to an immunosuppressive phenotype that was maintained at the transcriptional level in monocytes in both the circulation and tumor. In parallel, MI increased circulating Ly6C.sup.hi monocyte levels and recruitment to tumors and depletion of these cells abrogated MI-induced tumor growth. Furthermore, patients with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis had increased risk of recurrence and cancer-specific death. These preclinical and clinical results demonstrate that MI induces alterations in systemic homeostasis, triggering cross-disease communication that accelerates breast cancer. By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis., Author(s): Graeme J. Koelwyn [sup.1] , Alexandra A. C. Newman [sup.1] , Milessa S. Afonso [sup.1] , Coen van Solingen [sup.1] , Emma M. Corr [sup.1] , Emily J. Brown [...]

Published
2020
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26. Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association

Author

Gilchrist, Susan C., Barac, Ana, Ades, Philip A., Alfano, Catherine M., Franklin, Barry A., Jones, Lee W., La Gerche, Andre, Ligibel, Jennifer A., Lopez, Gabriel, Madan, Kushal, Oeffinger, Kevin C., Salamone, Jeannine, Scott, Jessica M., Squires, Ray W., Thomas, Randal J., Treat-Jacobson, Diane J., and Wright, Janet S.

Published
2019
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27. STACKED FOR WAR: A children's pastime is transformed after the Pearl Harbor attack sets America reeling

Author

Jones, Lee W.

Subjects
Trading cards -- Military aspects, United States (World War II) -- Social aspects, Wars -- Portrayals, Chewing gum, Fathers, Children, History, Military and naval science
Abstract

For America's youth, war brought dramatic fears and uncertainties, with fathers and brothers going off to fight in Asia and Europe, and threats of attack at home. It even touched [...]

Published
2019

40. The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Author

Patterson, Ruth E., Colditz, Graham A., Hu, Frank B., Schmitz, Kathryn H., Ahima, Rexford S., Brownson, Ross C., Carson, Kenneth R., Chavarro, Jorge E., Chodosh, Lewis A., Gehlert, Sarah, Gill, Jeff, Glanz, Karen, Haire-Joshu, Debra, Herbst, Karen Louise, Hoehner, Christine M., Hovmand, Peter S., Irwin, Melinda L., Jacobs, Linda A., James, Aimee S., Jones, Lee W., Kerr, Jacqueline, Kibel, Adam S., King, Irena B., Ligibel, Jennifer A., Meyerhardt, Jeffrey A., Natarajan, Loki, Neuhouser, Marian L., Olefsky, Jerrold M., Proctor, Enola K., Redline, Susan, Rock, Cheryl L., Rosner, Bernard, Sarwer, David B., Schwartz, J. Sanford, Sears, Dorothy D., Sesso, Howard D., Stampfer, Meir J., Subramanian, S. V., Taveras, Elsie M., Tchou, Julia, Thompson, Beti, Troxel, Andrea B., Wessling-Resnick, Marianne, Wolin, Kathleen Y., and Thornquist, Mark D.

Published
2013

44. The effects of neoadjuvant chemotherapy and interval debulking surgery on body composition in patients with ovarian cancer

Author

Vitarello, John, Goncalves, Marcus D., Zhou, Qin C., Iasonos, Alexia, Halpenny, Darragh F., Plodkowski, Andrew, Schwitzer, Emily, Mueller, Jennifer J., Zivanovic, Oliver, Jones, Lee W., Cadoo, Karen A., and Konner, Jason A.

Subjects
Article
Abstract

Background The aim of this study was to quantify changes in body composition during ovarian cancer treatment and relate these changes to rates of complete gross resection (CGR). Methods One hundred two patients with stage III or IV ovarian cancer who underwent neoadjuvant chemotherapy (NACT) followed by interval debulking surgery were a part of a prospectively collected database that included computed tomography scans at three time points—diagnosis, following NACT, and following debulking surgery. Skeletal muscle, visceral adipose, and subcutaneous adipose tissue volumes were obtained from a 30-mm volumetric slab beginning at the third lumbar vertebrae. Results Following NACT, skeletal muscle volume was significantly reduced (352.5 to 335.0 cm3, P < 0.001), whereas adiposity was unchanged. Body mass index (BMI) and skeletal muscle volume were significantly lower in patients who achieved CGR (P < 0.05). When these patients were stratified by BMI, the significant association of skeletal muscle to CGR was limited to patients with a BMI < 25 kg/m2 (P = 0.007). Conclusion Skeletal muscle volume was significantly reduced in patients undergoing NACT for ovarian cancer. Non-overweight patients were more likely to achieve CGR if they had lower skeletal muscle volume. Use of volumetric-based measurement for ascertaining body composition should be explored further.

Published
2020

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