1. Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise
- Author
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Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Kalyanov Alexander, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi, Tachtsidis, Ilias [0000-0002-8125-0313], and Apollo - University of Cambridge Repository
- Subjects
Optics and Photonics ,Phantoms, Imaging ,near-infrared spectroscopy ,Spectrum Analysis ,scattering ,Biomedical Engineering ,Reproducibility of Results ,phantom ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Biomaterials ,Laboratories ,absorption ,diffuse optics - Abstract
SIGNIFICANCE: Multi-laboratory initiatives are essential in performance assessment and standardization-crucial for bringing biophotonics to mature clinical use-to establish protocols and develop reference tissue phantoms that all will allow universal instrument comparison. AIM: The largest multi-laboratory comparison of performance assessment in near-infrared diffuse optics is presented, involving 28 instruments and 12 institutions on a total of eight experiments based on three consolidated protocols (BIP, MEDPHOT, and NEUROPT) as implemented on three kits of tissue phantoms. A total of 20 synthetic indicators were extracted from the dataset, some of them defined here anew. APPROACH: The exercise stems from the Innovative Training Network BitMap funded by the European Commission and expanded to include other European laboratories. A large variety of diffuse optics instruments were considered, based on different approaches (time domain/frequency domain/continuous wave), at various stages of maturity and designed for different applications (e.g., oximetry, spectroscopy, and imaging). RESULTS: This study highlights a substantial difference in hardware performances (e.g., nine decades in responsivity, four decades in dark count rate, and one decade in temporal resolution). Agreement in the estimates of homogeneous optical properties was within 12% of the median value for half of the systems, with a temporal stability of
- Published
- 2022