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The preparative methods for the synthesis of imidazolium and pyridinium room temperature task-specific ionic liquids possessing thiacalix[4]arene complexing groups in cationic or anionic fragments of the molecule are described. The cationic imidazolium and pyridinium derivatives of tetrabuthoxythiacalixarene existing in the conformation 1,3-alternate are capable to bind “soft” metal cations due to cooperative cation-π and ion–dipole interactions with spatially contiguous benzene rings and oxygen atoms of the thiacalixarene platform. The cone-shaped imidazolium salts of the tetrahydroxythiacalix[4]arene sulfonic acid can chelate cations of transition metals, lanthanides, and actinides by oxygen and sulfur atoms at the lower rim of macrocycle. [ABSTRACT FROM PUBLISHER]

Thiacalix[4]arenes bearing one, three, or four P=O containing groups at the upper or at the lower rim have been synthesized. Stereochemistry of the compounds was investigated by X-ray method. [ABSTRACT FROM AUTHOR]

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.