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9. Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury.

Author

Kang, Yoon‐Young, Kim, Dong‐Young, Lee, Sang‐Yong, Kim, Hee‐Joong, Kim, Taehawn, Cho, Jeong A., Lee, Taewon, and Choi, Eun Young

Subjects
LUNG injuries, MYELOID cells, ALVEOLAR macrophages, LUNGS, EPITHELIAL cells, BETA-glucans
Abstract

Innate immune training involves myelopoiesis, dynamic gene modulation, and functional reprogramming of myeloid cells in response to secondary heterologous challenges. The present study evaluates whether systemic innate immune training can protect tissues from local injury. Systemic pretreatment of mice with β‐glucan, a trained immunity agonist, reduces the mortality rate of mice with bleomycin‐induced lung injury and fibrosis, as well as decreasing collagen deposition in the lungs. β‐Glucan pretreatment induces neutrophil accumulation in the lungs and enhances efferocytosis. Training of mice with β‐glucan results in histone modification in both alveolar macrophages (AMs) and neighboring lung epithelial cells. Training also increases the production of RvD1 and soluble mediators by AMs and efferocytes. Efferocytosis increases trained immunity in AMs by stimulating RvD1 release, thus inducing SIRT1 expression in neighboring lung epithelial cells. Elevated epithelial SIRT1 expression is associated with decreased epithelial cell apoptosis after lung injury, attenuating tissue damage. Further, neutrophil depletion dampens the effects of β‐glucan on macrophage accumulation, epigenetic modification in lung macrophages, epithelial SIRT1 expression, and injury‐mediated fibrosis in the lung. These findings provide mechanistic insights into innate immune training and clues to the potential ability of centrally trained immunity to protect peripheral organs against injury‐mediated disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Striking a Balance: Exploring Optimal Functionalities and Composition of Highly Adhesive and Dispersing Binders for High‐Nickel Cathodes in Lithium‐Ion Batteries.

Author

Jeong, Daun, Kwon, Da‐Sol, Kim, Hee Joong, and Shim, Jimin

Subjects
LITHIUM-ion batteries, CATHODES, INTERFACIAL reactions, ENERGY density, SURFACE energy, UNIFORM spaces
Abstract

Nickel‐rich layered oxide, LiNixCoyMnzO2 (NCM, x > 0.8), has emerged as a promising cathode material for lithium‐ion batteries due to its high specific capacity and energy density. However, there remains a challenge regarding NCM degradation during cycling, associated with interfacial side reactions and microcrack formation. Herein, a functional poly(norbornene‐co‐norbornene dicarboxylic acid‐co‐heptafluorobutyl norbornene imide) (PNCI)‐based binder system is introduced, with controlled functionalities and monomer compositions, to preserve the structural integrity of NCM. The PNCI binder system incorporates three different norbornene‐derived monomers with distinct functionalities, allowing for multifunctionality, including electro‐chemo‐mechanical stability, strong adhesion, and dispersibility. By systematically adjusting the molar composition of the PNCI binders, the overall binder characteristics are fine‐tuned, optimizing the adhesion and dispersion of electrode components. The optimized PNCI binder, with desired adhesion strength, surface energy, and polarity, plays a crucial role in facilitating the formation of a uniform electrode structure with a high areal mass loading of NCM, ensuring long‐term cycling stability. This study highlights the significance of striking a balance between functionalities and composition in binder systems to achieve high‐performance NCM cathodes. [ABSTRACT FROM AUTHOR]

Published
2023
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15. The Influence of Styrene Content in Solution Styrene Butadiene Rubber on Silica-Filled Tire Tread Compounds.

Author

Um, Gi-Yong, Kwon, Taehoon, Lee, Seong Hwan, Kim, Woong, Kim, Jungsoo, Kim, Hee Joong, and Lee, Jin Hong

Subjects
TIRE treads, POLYBUTADIENE, STYRENE, ROLLING friction, PERFORMANCE of tires
Abstract

In tire tread applications, achieving enhanced abrasion resistance, wet grip, and rolling resistance is crucial for optimizing overall performance. To realize improvements in these attributes for silica-filled tire tread compounds, it becomes imperative to improve the dispersity of silica filler by investigating the effect of each component in the tire tread compound. In this work, we study the effect of styrene content within solution styrene butadiene rubber (SSBR) on the properties of tire tread compounds. A higher styrene segment within SSBR contributes to increased silica dispersion and crosslink density. Thus, tire tread compounds featuring SSBR with increased styrene content not only improve physical and mechanical properties, but also enhance major characteristics tailored for tire tread applications. These findings provide valuable insights into advancing the reinforced performance of tire tread compounds through the strategic utilization of SSBR enriched in styrene content. [ABSTRACT FROM AUTHOR]

Published
2023
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46. The effect of the discharge aging process on the surface state of MgO film in AC PDPs

Author

Choi, Kyung Cheol, Kim, Hee-Joong, and Shin, Bhum Jae

Subjects
Plasma display systems -- Testing, Plasma display systems -- Electric properties, Thin-film circuits -- Testing, Thin-film circuits -- Electric properties, Plasma display, Business, Electronics, Electronics and electrical industries
Abstract

The change in the surface condition of the MgO thin film in an ac plasma display panel during the discharge aging process is studied and reported. The superficial layer on the MgO thin film was created during the discharge aging process, which was related to the minimum sustain voltage and the light intensity emitted from the Neon+Xenon gas mixture discharge.

Published
2004

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