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Asian culture has been test-centric for over 1,400 years. U.S. education has been since the 1990s. Based on Kim's creative Climates, Attitudes, and Thinking skills (CATs), creativity indicators were developed using the 2015 PISA questionnaires. Study I examined: (1) relationships between students' PISA science scores and CATs; (2) differences between Asian and U.S. students in PISA scores and CATs; and (3) relationships between teachers' years of teaching and nurturing CATs. Study I found: (1) negative relationships between students' PISA scores and CATs; (2) Asian students demonstrating higher PISA scores but lower CATs than U.S. students; and (3) U.S. teachers decreasingly nurture CATs. Study II examined how U.S. CATs changed from 1990 through 2017 by analyzing TTCT norming data (N = 273,441) and found continued declines in CATs, especially in imagination and in young children.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of amyloid-beta plaques and hyperphosphorylated tau proteins, leading to cognitive decline and neuronal death. However, despite extensive research, there are still no effective treatments for this condition. In this study, a series of chloride-substituted Ramalin derivatives is synthesized to optimize their antioxidant, anti-inflammatory, and their potential to target key pathological features of Alzheimer's disease. The effect of the chloride position on these properties is investigated, specifically examining the potential of these derivatives to inhibit tau aggregation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) activity. Our findings demonstrate that several derivatives, particularly RA-3Cl, RA-4Cl, RA-26Cl, RA-34Cl, and RA-35Cl, significantly inhibit tau aggregation with inhibition rates of approximately 50%. For BACE-1 inhibition, Ramalin and RA-4Cl also significantly decrease BACE-1 expression in N2a cells by 40% and 38%, respectively, while RA-23Cl and RA-24Cl showed inhibition rates of 30% and 35% in SH-SY5Y cells. These results suggest that chloride-substituted Ramalin derivatives possess promising multifunctional properties for AD treatment, warranting further investigation and optimization for clinical applications. [ABSTRACT FROM AUTHOR]

To understand creativity is to recognize and develop the creative potential within oneself and others. This article examines what creativity is "not" and then what creativity "is". First, the six leading misconceptions about creativity are discussed: Creativity belongs solely to the arts; creativity is quickly recognizable; innovators always work alone; mental illness enhances creativity; creativity is a divine flash of inspiration; and newness is a prerequisite to creativity. Then, using the research-based CATs model, what creativity is and how creativity develops into innovation are discussed: (a) cultivate creative climates; (b) nurture creative attitudes; and (c) develop creative thinking skills. Creativity does not come from nature but from nurture, and developing gifted children's creativity should be the goal of parenting and education.

Background: The electronics industry has characteristics, such as the continuous occurrence of new hazards and risk factors due to rapid technological changes, the occurrence of safety and health blind spots due to the outsourcing of work, trade secrets, and a lack of information, so research is needed from a safety and health perspective. This study sought to determine the relationship between work-related health problems and the working conditions of electronics industry workers. Methods: The study subjects were 3354 workers in the electronics industry from the raw data of the 4th to 6th Korean Working Condition Survey (KWCS). The variables were divided into general, occupational, and working environment characteristics, and a logistic regression analysis was conducted to determine the relationship between work-related health problems and working conditions. Results: Among the general and occupational characteristics, gender, education, night work, and working time appropriateness were analyzed as effect factors. In terms of working environment characteristics, physical work risk, musculoskeletal work risk, possibility of risk to work, subjective health impact, and working environment satisfaction were found to have effects on work-related health problems. Conclusions: The results of this study are meaningful in that they identified the effect factors of work-related health problems in the working conditions of workers in the electronics industry, where prior studies are lacking. Therefore, improvements, such as the management of night workers, appropriate working time, reduction in exposure to work risk factors, and improvement in working environment satisfaction, appear to be necessary. [ABSTRACT FROM AUTHOR]

TRAF7-related disorders represent some of the rarest inherited disorders, exhibiting clinical features that overlap with cardiac, facial, and digital anomalies with developmental delay (CAFDADD) syndrome, as well as blepharophimosis-mental retardation syndrome (BMRS). A 36-year-old male, presenting with total blindness, blepharophimosis, and intellectual disability, was admitted for the assessment of resting dyspnea several months previously. He had a history of being diagnosed with obstructive sleep apnea (OSA). Transesophageal and transthoracic echocardiography unveiled right ventricular dilatation without significant pulmonary hypertension, bicuspid aortic valve with aortic root aneurysm, and aortic regurgitation in the proband. Sanger sequencing identified a de novo TRAF7 variant (c.1964G>A; p.Arg655Gln). Subsequently, aortic root replacement using the Bentall procedure was performed. However, despite the surgery, he continued to experience dyspnea. Upon re-evaluating OSA with polysomnography, it was discovered that continuous positive airway pressure support alleviated his symptoms. The underlying cause of his symptoms was attributed to OSA, likely exacerbated by the vertebral anomaly and short neck associated with CAFDADD syndrome. Clinicians should be attentive to the symptoms associated with OSA as it is a potentially serious medical condition in patients with TRAF7 variants. [ABSTRACT FROM AUTHOR]

Chromosome 17q12 deletion syndrome (OMIM #614527) is a rare genetic disorder associated with a heterozygous 1.4–1.5 Mb deletion at chromosome 17q12, leading to a spectrum of clinical manifestations, including kidney abnormalities, neurodevelopmental delay, maturity-onset diabetes of the young type 5 (MODY5), and Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome. We present the case of a 14-year-old Korean female diagnosed with chromosome 17q12 deletion syndrome, confirmed by chromosomal microarray analysis. The patient exhibited MODY5 with pancreatic agenesis, MRKH syndrome, dysmorphic facial features, developmental delay, kidney rotation anomaly, portal vein thrombosis with liver hypoplasia, short stature, and scoliosis. Management involved the initiation of multiple daily insulin injections for diabetes control, gynecological evaluation for MRKH syndrome, and multidisciplinary care for associated complications. This case highlights the complexity and varied organ involvement in chromosome 17q12 deletion syndrome. A comprehensive and multidisciplinary approach is crucial for the management of affected individuals, including regular monitoring, tailored interventions across various medical specialties, and providing psychosocial support. [ABSTRACT FROM AUTHOR]

With the passing of Korea's Gifted Education Act, creativity has come to the forefront in considering the future of Korea's economic prosperity in the global economy (Korean Educational Development Institute, 2003). The purpose of this study was to examine the understanding of creativity among Korean science teachers of gifted students. Sixty teachers participated in this study with an open-ended questionnaire about their understanding of creativity. The data were analyzed based on Urban's (1995) three components of creativity. The findings indicated that these science teachers had a thorough understanding of the cognitive component and a strong association of creativity with intellectual ability, but overidentified with the cognitive component, showing less awareness of the personal and environmental components of creativity. To shift their understanding to a more balanced view, personality and environmental components, as well as attributes in other component areas, should be emphasized.

Some research has shown that creativity test scores are independent from IQ scores, whereas other research has shown a relationship between the two. To clarify the cumulative evidence in this field, a quantitative review of the relationship between creativity test scores and IQ scores was conducted. Moderating influences of IQ tests, IQ score levels, creativity tests, creativity subscales, creativity test types, gender, age, and below and above the threshold (IQ 120) were examined. Four hundred forty-seven correlation coefficients from 21 studies and 45,880 participants were retrieved. The mean correlation coefficient was small (r = .174; 95% CI = .165 ? .183), but heterogeneous; this correlation coefficient indicates that the relationship between creativity test scores and IQ scores is negligible. Age contributed to the relationship between intelligence and creativity the most; different creativity tests contributed to it secondly. This study does not support threshold theory.

Given the widespread use of whole slide imaging (WSI) for primary pathological diagnosis, we evaluated its utility in assessing histological grade and biomarker expression (ER, PR, HER2, and Ki67) compared to conventional light microscopy (CLM). In addition, we explored the utility of digital image analysis (DIA) for assessing biomarker expression. Three breast pathologists assessed the Nottingham combined histological grade, its components, and biomarker expression through the immunohistochemistry of core needle biopsy samples obtained from 101 patients with breast cancer using CLM, WSI, and DIA. There was no significant difference in variance between the WSI and CLM agreement rates for the Nottingham grade and its components and biomarker expression. Nuclear pleomorphism emerged as the most variable histologic component in intra- and inter-observer agreement (kappa ≤ 0.577 and kappa ≤ 0.394, respectively). The assessment of biomarker expression using DIA achieved an enhanced kappa compared to the inter-observer agreement. Compared to each observer's assessment, DIA exhibited an improved kappa coefficient for the expression of most biomarkers with CLM and WSI. Using WSI to assess prognostic and predictive factors, including histological grade and biomarker expression in breast cancer, is acceptable. Furthermore, incorporating DIA to assess biomarker expression shows promise for substantially enhancing scoring reproducibility. [ABSTRACT FROM AUTHOR]

Aim: This study investigated the sex-specific association between thyroid function and various insulin resistance (IR) indices, including noninsulin-based IR indices, in euthyroid adolescents. Methods: A total of 465 adolescents (aged 12–18 years; 255 boys and 210 girls) based on data from the 2014–2015 Korea National Health and Nutrition Examination Survey were included. Serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (fT4) were used to assess thyroid function, whereas the homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), glucose/insulin ratio (GIR), triglyceride–glucose (TyG) index, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to assess IR. The relationship between thyroid function and IR was analyzed using multiple linear regressions stratified by sex, considering obesity status. Results: The relationship between thyroid function and IR varied depending on sex and was more pronounced in the overweight/obesity subgroup for both boys and girls. In overweight and obese boys and girls, fT4 was significantly associated with HOMA-IR and QUICKI with conflicting association directions. TSH was also positively associated with the TyG index in both sexes. Conclusions: The findings suggest that the relationship between thyroid function and IR in adolescents might vary depending on sex, and the degree of association was significant in obese adolescents. [ABSTRACT FROM AUTHOR]

Background: Water, sanitation, and hygiene (WASH) services and clean fuels are representative factors of a clean and safe residential environment. Uzbekistan faces environmental issues and ranks low among countries on the Environmental Performance Index. This study aimed to identify regional disparities and wealth inequalities in WASH services and clean fuels in Uzbekistan. Methods: We employed raw data from the 2021–2022 Uzbekistan Multiple Indicator Cluster Survey (MICS) and the WASH and clean fuels coverage were analyzed. For each of the variables with the lowest coverage within WASH services and clean fuels variables, we evaluated the disparities between urban and rural areas and calculated the concentration index (CI). Results: Among WASH services and clean fuels, basic handwashing and clean fuels for space heating demonstrated the lowest coverage. In most regions, urban areas had higher coverage of basic handwashing and clean fuels for space heating compared to rural areas. The CI of clean fuels for space heating was 0.2141 or higher in five areas. The CI was notably high in areas with low coverage of WASH services and clean fuel for space heating. Conclusions: Basic handwashing and clean fuels for space heating showed varied regional coverage patterns and wealth-related inequalities. The results of this study can provide evidence for policy formulation, particularly in addressing disparities. [ABSTRACT FROM AUTHOR]