1. Post COVID sequelae among COVID-19 survivors: insights from the Indian National Clinical Registry for COVID-19
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Balram Bhargava, Ashish Sharma, Rajnish Joshi, Amit Patel, Deepak Kumar, Ashish Pathak, Sudhir Bhandari, Manoj Kumar Panigrahi, Prasanta Raghab Mohapatra, Aparna Mukherjee, Pankaj Bhardwaj, Priyanka Ghosh, Gunjan Kumar, Simmi Dube, Nehal M Shah, Hemang M Purohit, Vikas Suri, Arti D Shah, Alka Turuk, Akhil Dhanesh Goel, Manoj Kumar Gupta, Ritin Mohindra, Ashish Bhalla, Star Pala, Balkishan Gupta, Damodar Sahu, Sourin Bhuniya, Abhishek Agrawal, Samiran Panda, Deepak Jain, Arunansu Talukdar, Janakkumar R Khambholja, Nikita Sharma, Geetha R Menon, Subhasis Mukherjee, Puspender Misra, Lokesh Kumar Sharma, Samita S, Himadri Das, Debasis Sarkar, Soumyadeep Ghosh, Moumita Dutta, Shreetama Chakraborty, Tridip Dutta Baruah, Pankaj Kumar Kannauje, Arvind Kumar Shukla, Nitesh Shah, Mary John, Kiranpreet Kaur, Vijay Nongpiur, Sachin K Shivnitwar, Bobba Rohil Krishna, Naveen Dulhani, Jigyasa Gupta, H K Aggarwal, Parshwa Naik, Manisha Panchal, Mayank Anderpa, Nyanthung Kikon, Christina Nzani Humtsoe, Rajaat Vohra, Lipilekha Patnaik, Jagdish Prasad Sahoo, Arun Kokane, Yogiraj Ray, Kruti Rajvansh, Arun Madharia, Neha Shrivastava, Sushila Kataria, Mohammad Shameem, Nazish Fatima, Saumitra Ghosh, Avijit Hazra, Himanshu D, Veeresh B Salgar, Santosh Algur, Kala Yadhav M L, Pavan Kumar M, and Mendu Vishnu Vardhana Rao
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Medicine (General) ,R5-920 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an objective to estimate the frequency of post COVID sequelae and subsequently, design a framework for holistic management of post COVID morbidities.Methods Follow-up data collected as part of a registry-based observational study in 31 hospitals across India since September 2020–October 2022 were used for analysis. All consenting hospitalised patients with COVID-19 are telephonically followed up for up to 1 year post-discharge, using a prestructured form focused on symptom reporting.Results Dyspnoea, fatigue and mental health issues were reported among 18.6%, 10.5% and 9.3% of the 8042 participants at first follow-up of 30–60 days post-discharge, respectively, which reduced to 11.9%, 6.6% and 9%, respectively, at 1-year follow-up in 2192 participants. Patients who died within 90 days post-discharge were significantly older (adjusted OR (aOR): 1.02, 95% CI: 1.01, 1.03), with at least one comorbidity (aOR: 1.76, 95% CI: 1.31, 2.35), and a higher proportion had required intensive care unit admission during the initial hospitalisation due to COVID-19 (aOR: 1.49, 95% CI: 1.08, 2.06) and were discharged at WHO ordinal scale 6–7 (aOR: 49.13 95% CI: 25.43, 94.92). Anti-SARS-CoV-2 vaccination (at least one dose) was protective against such post-discharge mortality (aOR: 0.19, 95% CI: 0.01, 0.03).Conclusion Hospitalised patients with COVID-19 experience a variety of long-term sequelae after discharge from hospitals which persists although in reduced proportions until 12 months post-discharge. Developing a holistic management framework with engagement of care outreach workers as well as teleconsultation is a way forward in effective management of post COVID morbidities as well as reducing mortality.
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- 2023
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