38 results on '"Kuo-Hsien Wang"'
Search Results
2. Annoying Psoriasis and Atopic Dermatitis: A Narrative Review
- Author
-
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, and Ai-Wei Lee
- Subjects
psoriasis ,atopic dermatitis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Skin is an important organ that mainly functions as a barrier. Skin diseases can damage a person’s self-confidence and reduce their willingness to socialize, as well as their social behavior and willingness. When the skin appearance is abnormal, in addition to affecting the quality of life, it often leads to personal, social, and psychological dysfunction and even induces depression. Psoriasis and atopic dermatitis are common chronic skin diseases. Their prevalence in the world is 3–10%, and there is an increasing trend year by year. These congenital or acquired factors cause the dysfunction of the immune system and then destroy the barrier function of the skin. Because these patients are flooded with a variety of inflammatory mediators, this causes skin cells to be in chronic inflammation. Therefore, psoriasis and atopic dermatitis are also considered systemic chronic inflammatory diseases. In the healthcare systems of developed countries, it is unavoidable to spend high costs to relieve symptoms of psoriasis and atopic dermatitis patients, because psoriasis and atopic dermatitis have a great influence on individuals and society. Giving a lot of attention and developing effective treatment methods are the topics that the medical community must work on together. Therefore, we used a narrative review manuscript to discuss pathogenesis, clinical classification, incidence, and treatment options, including topical medication, systemic therapeutics, immunosuppressive medication for psoriasis, and atopic dermatitis, as well as also comparing the differences between these two diseases. We look forward to providing readers with comprehensive information on psoriasis and atopic dermatitis through this review article.
- Published
- 2022
- Full Text
- View/download PDF
3. Purpuric halo around hemangioma as a clue for primary systemic amyloidosis: Case report and review of literature
- Author
-
Yin-Shuo Chang, Kuo-Hsien Wang, Hsiou-Hsin Tsai, Chung-Hong Hu, and Jan-Show Chu
- Subjects
Hemangioma ,Primary systemic amyloidosis ,Purpuric halo ,Plasma cell dyscrasia ,Target-like lesion ,Dermatology ,RL1-803 - Abstract
Mucocutaneous lesion appears in up to 40% of patients with primary systemic amyloidosis (AL amyloidosis). The cutaneous signs may be co-expressed with other organ involvement or even solely presented as the first clue. We reported a case of systemic AL amyloidosis who was initially presented as a solitary hemangioma with a purpuric halo. Excisional biopsy revealed a hemangioma with amyloid deposited in thickened vascular walls. Systemic AL amyloidosis was diagnosed after thorough survey. The stage of disease at the time of initial treatment is the greatest prognostic factor. To our knowledge, this is the first case of systemic AL amyloidosis initially presented as a purpuric halo around hemangioma in Taiwan. This target-like lesion should be linked to systemic AL amyloidosis and early diagnosis is extraordinary important.
- Published
- 2018
- Full Text
- View/download PDF
4. Eruptive melanocytic nevi with malignant transformations and the connection to BRAF and p16 mutations
- Author
-
Ting-Hua Yang, Kuo-Hsien Wang, Hsiou-Hsin Tsai, and Jan-Show Chu
- Subjects
BRAF V600E ,eruptive melanocytic nevi ,melanocytic malignancy ,melanocytic tumor of uncertain malignant potential ,p16 ,Dermatology ,RL1-803 - Abstract
Eruptive melanocytic nevi (EMN) is a rare phenomenon with an unclear pathogenesis. Mutation on a molecular basis has been proposed, but insufficient data are available to confirm this hypothesis. Theoretically, the possibility of malignant transformation is high, but no previous definite cases had been reported. Herein, we report the first case of a patient with EMN in whom hypopharyngeal low-grade melanocytic malignancies were detected using a fibrolaryngoscope. BRAF activation and p16 mutations were discovered through real-time polymerase chain reaction and immunohistochemical staining on EMN tissue samples, respectively. The significance of these findings has yet to be determined.
- Published
- 2017
- Full Text
- View/download PDF
5. Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice
- Author
-
Chun-Ming Shih, Chi-Kun Hsieh, Chien-Yu Huang, Chun-Yao Huang, Kuo-Hsien Wang, Tsorng-Harn Fong, Nguyen Thi Thu Trang, Kuan-Ting Liu, and Ai-Wei Lee
- Subjects
lycopene ,psoriasis ,Organic chemistry ,QD241-441 - Abstract
Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis of psoriasis. Here, we report that the topical use of a lycopene decreased imiquimod (IMQ)-induced psoriasis-like inflammatory responses, the progress of which was based on adhesion molecules. In vitro analysis showed that lycopene decreased keratinocyte and monocyte adhesion. Evidence suggests that intercellular adhesion molecule-1 (ICAM-1) is a main mediator of psoriasis pathogenesis. Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis. We expect that lycopene will with potential value in the treatment of psoriasis.
- Published
- 2020
- Full Text
- View/download PDF
6. The Roles of Lipoprotein in Psoriasis
- Author
-
Chun-Ming Shih, Chang-Cyuan Chen, Chen-Kuo Chu, Kuo-Hsien Wang, Chun-Yao Huang, and Ai-Wei Lee
- Subjects
lipid ,psoriasis ,inflammation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The association between psoriasis and cardiovascular disease risk has been supported by recent epidemiological data. Patients with psoriasis have an increased adjusted relative risk for myocardial infarction. As such, the cardiovascular risk conferred by severe psoriasis may be comparable to what is seen with other well-established risk factors, such as diabetes mellitus. Previous studies demonstrated that low-density lipoprotein (LDL) plays critical roles during atherogenesis. It may be caused by the accumulation of macrophages and lipoprotein in the vessel wall. Oxidized LDL (ox-LDL) stimulates the expression of adhesion molecules, such as ICAM-1 and VCAM-1, on endothelial cells and increases the attachment of mononuclear cells and the endothelium. Even though previous evidence demonstrated that psoriasis patients have tortuous and dilated blood vessels in the dermis, which results in the leakage of ox-LDL, the leaked ox-LDL may increase the expression of adhesion molecules and cytokines, and disturb the static balance of osmosis. Therefore, exploration of the relationship between hyperlipidemia and psoriasis may be another novel treatment option for psoriasis and may represent the most promising strategy.
- Published
- 2020
- Full Text
- View/download PDF
7. Hyperlipidemia Is Associated with Chronic Urticaria: A Population-Based Study.
- Author
-
Shiu-Dong Chung, Kuo-Hsien Wang, Ming-Chieh Tsai, Herng-Ching Lin, and Chao-Hung Chen
- Subjects
Medicine ,Science - Abstract
The etiology of chronic urticaria (CU) is diverse, with chronic infections and inflammation being reported as considerable contributing factors. Although the prevalence of metabolic syndrome was found to be significantly elevated in patients with CU, no one has specifically estimated the effects on CU following hyperlipidemia. This study aimed to examine the association between hyperlipidemia and CU using a population-based dataset in Taiwan. This study included 9798 adults with CU as cases and 9798 sex- and age-matched controls. These patients were examined for whether they had received a prior diagnosis of hyperlipidemia. We used conditional logistic regression analyses to calculate the odds ratio (OR) and its corresponding 95% confidence interval (CI) for having been previously diagnosed with hyperlipidemia between cases and controls. In total, 7066 (36.1%) patients had received a prior diagnosis of hyperlipidemia, including 4287 (43.8%) among CU cases and 2779 (28.4%) among controls. The conditional logistic regression revealed that the OR of prior hyperlipidemia for cases was 1.97 (95% CI: 1.85~2.09) compared to the controls. Furthermore, compared to patients without CU, patients with CU independently experienced a 1.65-fold (95% CI = 1.55~1.76; p
- Published
- 2016
- Full Text
- View/download PDF
8. Porocarcinoma in situ showing follicular differentiation: A case report
- Author
-
Chia-Lan Ou, Chien-Jui Cheng, and Kuo-Hsien Wang
- Subjects
apocrine ,follicular differentiation ,hidroacanthoma simplex ,porocarcinoma ,Dermatology ,RL1-803 - Abstract
Poroid neoplasm is a skin appendage tumor that has both benign and malignant counterparts. It has traditionally been regarded as of eccrine origin and has four types: intraepidermal poroma (hidroacanthoma simplex), poroma, dermal duct tumor, and poroid hidradenoma. Here we describe the case of a 64-year-old woman who had a verrucous, erythematous to brownish tumor on her left buttock for many years. Histopathology revealed an intra-epidermal poroid tumor with both benign and malignant parts. The benign part had intra-epidermal nests of poroid cells, which were smaller, monomorphic and sharply marginated from adjacent keratinocytes. The malignant part showed similar cell types, but had a higher nuclear/cytoplasmic ratio, pleomorphism, and prominent mitoses. Ductal structures were noted in neoplastic cells and an epithelial membrane antigen stain was strongly positive. Interestingly, peripheral palisading and primitive follicular germ formation were also observed in the neoplasm, which suggests follicular differentiation. We made a final diagnosis of porocarcinoma in situ with follicular differentiation, which may support the folliculosebaceous–apocrine unit theory, but a tumor with such a combination has not been described before.
- Published
- 2012
- Full Text
- View/download PDF
9. Palisaded neutrophilic and granulomatous dermatitis associated with the initiation of etanercept in rheumatoid arthritis: a case report
- Author
-
Chia-Lun Chou, Kuo-Hsien Wang, and Ying-Yi Chiang
- Subjects
palisaded neutrophilic and granulomatous dermatitis ,interstitial granulomatous dermatitis ,etanercept ,tumor necrosis factor-α inhibitor ,rheumatoid arthritis ,Dermatology ,RL1-803 - Abstract
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an unusual entity with variable clinical manifestations and histopathological features. It is associated with a variety of immune-mediated systemic diseases, most commonly in rheumatoid arthritis. We report a 42-year-old female with a long-standing history of rheumatoid arthritis, presenting with multiple pruritic erythematous papules and nodules on the lower legs 1 month after beginning treatment with etanercept. Microscopic examination of a fully developed lesion showed a diffuse dense interstitial lymphohistiocytic infiltrate interspersed with palisaded granulomas consisting of epithelioid histiocytes and multinucleated giant cells surrounding central zones of degenerated collagen, neutrophils and leukocytoclastic debris. A diagnosis of PNGD was made on the basis of typical histopathologic features. Withdrawal of etanercept led to gradual resolution of the skin lesions, with no new skin lesions appearing afterwards. Although the correlation between the use of tumor necrosis factor-α (TNF-α) antagonists and the development of PNGD remains controversial and warrants further investigation, PNGD should be considered in the differential diagnosis of skin eruptions within a setting of anti-TNF-α therapy.
- Published
- 2011
- Full Text
- View/download PDF
10. The many faces of necrobiosis lipoidica: a report of three cases with histologic variations
- Author
-
Pei-Shan Yen, Kuo-Hsien Wang, Wei-Yu Chen, Ya-Wen Yang, and Wen-Tsao Ho
- Subjects
Granuloma ,Histopathology ,Necrobiosis lipoidica ,Perineural ,Dermatology ,RL1-803 - Abstract
Necrobiosis lipoidica (NL) is a granulomatous disease with unknown etiology and pathogenesis. Clinically, it is characterized by yellow-brown atrophic plaques with inflammatory rims on shins. Histologically, it shows diffused palisade and interstitial granulomatous dermatitis with focal connective tissue degeneration (necrobiosis). We described three non-diabetic NL cases with unusual histologic features. All patients presented erythematous to brownish plaque(s) on the shin(s). In Case 1, in addition to the characteristics of NL, the biopsy showed dense perineural infiltration, which may explain the pathogenesis of the anesthesia of NL lesions. In Case 2, well-formed tuberculoid granulomas were of special interest. In Case 3, there was conspicuous lobular panniculitis. These histologic features present difficulties in the diagnosis and represent the broad spectrum of NL lesions, histologically.
- Published
- 2011
- Full Text
- View/download PDF
11. Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro
- Author
-
Chun-Ming Shih, Chien-Yu Huang, Kuo-Hsien Wang, Chun-Yao Huang, Po-Li Wei, Yu-Jia Chang, Chi-Kun Hsieh, Kuan-Ting Liu, and Ai-Wei Lee
- Subjects
oxLDL ,LOX-1 ,psoriasis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Psoriasis is a chronic inflammatory skin disease. Even though scientists predict that abnormalities in lipid metabolism play an important role in the pathogenesis of psoriasis, the actual underlying mechanisms are still unclear. Therefore, understanding the possible relationship between mechanisms of the occurrence of psoriasis and dyslipidemia is an important issue that may lead to the development of effective therapies. Under this principle, we investigated the influences of hyperlipidemia in imiquimod (IMQ)-induced psoriasis-like B6.129S2-Apoetm1Unc/J mice and oxidized low-density lipoprotein (oxLDL) in tumor necrosis factor (TNF)-α-stimulated Hacat cells. In our study, we showed that a high-cholesterol diet aggravated psoriasis-like phenomena in IMQ-treated B6.129S2-Apoetm1Unc/J mice. In vitro analysis showed that oxLDL increased keratinocyte migration and lectin-type oxLDL receptor 1 (LOX-1) expression. Evidence suggested that interleukin (IL)-23 was a main cytokine in the pathogenesis of psoriasis. High-cholesterol diet aggravated IL-23 expression in IMQ-treated B6.129S2-Apoetm1Unc/J mice, and oxLDL induced IL-23 expression mediated by LOX-1 in TNF-α-stimulated Hacat cells. Therefore, it will be interesting to investigate the factors for the oxLDL induction of LOX-1 in psoriasis. LOX-1 receptor expression may be another novel treatment option for psoriasis and might represent the most promising strategy.
- Published
- 2018
- Full Text
- View/download PDF
12. Fibrous papule of the face, similar to tuberous sclerosis complex-associated angiofibroma, shows activation of the mammalian target of rapamycin pathway: evidence for a novel therapeutic strategy?
- Author
-
Jung-Yi Lisa Chan, Kuo-Hsien Wang, Chia-Lang Fang, and Wei-Yu Chen
- Subjects
Medicine ,Science - Abstract
Fibrous papules of the face are hamartomas characterized by stellate-shaped stromal cells, multinucleated giant cells, and proliferative blood vessels in the dermis. The pathogenesis of fibrous papules remains unclear. There is a striking microscopic resemblance between fibrous papules and tuberous sclerosis complex (TSC)-associated angiofibromas. A germline mutation of the TSC1 or TSC2 gene, leading to activation of the mammalian target of rapamycin (mTOR) pathway, accounts for the pathogenesis of TSC-associated angiofibromas. Activated mTOR subsequently activates p70 ribosomal protein S6 kinase (p70S6K) and ribosomal protein S6 (S6) by phosphorylation. Rapamycin, a mTOR inhibitor, is effective in treating TSC-associated angiofibromas. The aim of this study was to understand whether the mTOR pathway is activated in fibrous papules. We studied immunoexpressions of phosphorylated (p-) mTOR effectors in fibrous papules, TSC-associated angiofibromas, and normal skin controls. P-mTOR, p-p70S6K and p-S6 were highly expressed in dermal stromal cells and epidermal keratinocytes in fibrous papules and TSC-associated angiofibromas but not in fibroblasts and epidermal keratinocytes of normal skin controls (p
- Published
- 2014
- Full Text
- View/download PDF
13. The Roles of Lipoprotein in Psoriasis
- Author
-
Kuo Hsien Wang, Ai Wei Lee, Chang Cyuan Chen, Chun Ming Shih, Chen Kuo Chu, and Chun Yao Huang
- Subjects
0301 basic medicine ,Endothelium ,Vascular Cell Adhesion Molecule-1 ,Inflammation ,Hyperlipidemias ,Review ,030204 cardiovascular system & hematology ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,03 medical and health sciences ,0302 clinical medicine ,lipid ,Diabetes mellitus ,Psoriasis ,Hyperlipidemia ,medicine ,Cell Adhesion ,Humans ,Myocardial infarction ,Physical and Theoretical Chemistry ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Cell adhesion molecule ,business.industry ,Organic Chemistry ,General Medicine ,medicine.disease ,Intercellular Adhesion Molecule-1 ,Computer Science Applications ,Lipoproteins, LDL ,030104 developmental biology ,medicine.anatomical_structure ,lcsh:Biology (General) ,lcsh:QD1-999 ,Gene Expression Regulation ,inflammation ,Immunology ,Cytokines ,medicine.symptom ,business ,Lipoprotein - Abstract
The association between psoriasis and cardiovascular disease risk has been supported by recent epidemiological data. Patients with psoriasis have an increased adjusted relative risk for myocardial infarction. As such, the cardiovascular risk conferred by severe psoriasis may be comparable to what is seen with other well-established risk factors, such as diabetes mellitus. Previous studies demonstrated that low-density lipoprotein (LDL) plays critical roles during atherogenesis. It may be caused by the accumulation of macrophages and lipoprotein in the vessel wall. Oxidized LDL (ox-LDL) stimulates the expression of adhesion molecules, such as ICAM-1 and VCAM-1, on endothelial cells and increases the attachment of mononuclear cells and the endothelium. Even though previous evidence demonstrated that psoriasis patients have tortuous and dilated blood vessels in the dermis, which results in the leakage of ox-LDL, the leaked ox-LDL may increase the expression of adhesion molecules and cytokines, and disturb the static balance of osmosis. Therefore, exploration of the relationship between hyperlipidemia and psoriasis may be another novel treatment option for psoriasis and may represent the most promising strategy.
- Published
- 2020
14. Purpuric halo around hemangioma as a clue for primary systemic amyloidosis: Case report and review of literature
- Author
-
Hsiou Hsin Tsai, Chung Hong Hu, Jan Show Chu, Yin Shuo Chang, and Kuo Hsien Wang
- Subjects
Pathology ,medicine.medical_specialty ,Amyloid ,Mucocutaneous zone ,Plasma cell dyscrasia ,Dermatology ,Lesion ,Hemangioma ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,AL amyloidosis ,lcsh:Dermatology ,030212 general & internal medicine ,Purpuric halo ,medicine.diagnostic_test ,business.industry ,lcsh:RL1-803 ,medicine.disease ,Target-like lesion ,medicine.symptom ,business ,Primary systemic amyloidosis - Abstract
Mucocutaneous lesion appears in up to 40% of patients with primary systemic amyloidosis (AL amyloidosis). The cutaneous signs may be co-expressed with other organ involvement or even solely presented as the first clue. We reported a case of systemic AL amyloidosis who was initially presented as a solitary hemangioma with a purpuric halo. Excisional biopsy revealed a hemangioma with amyloid deposited in thickened vascular walls. Systemic AL amyloidosis was diagnosed after thorough survey. The stage of disease at the time of initial treatment is the greatest prognostic factor. To our knowledge, this is the first case of systemic AL amyloidosis initially presented as a purpuric halo around hemangioma in Taiwan. This target-like lesion should be linked to systemic AL amyloidosis and early diagnosis is extraordinary important.
- Published
- 2018
15. Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro
- Author
-
Kuo Hsien Wang, Chien Yu Huang, Chi Kun Hsieh, Chun Yao Huang, Chun Ming Shih, Po Li Wei, Kuan Ting Liu, Yu Jia Chang, and Ai Wei Lee
- Subjects
Transcriptional Activation ,0301 basic medicine ,Receptor expression ,medicine.medical_treatment ,Interleukin-23 ,Article ,Catalysis ,Cell Line ,lcsh:Chemistry ,Inorganic Chemistry ,Mice ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,medicine ,Interleukin 23 ,Animals ,Humans ,Physical and Theoretical Chemistry ,Keratinocyte migration ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,oxLDL ,business.industry ,Organic Chemistry ,Interleukin ,General Medicine ,psoriasis ,Scavenger Receptors, Class E ,medicine.disease ,Computer Science Applications ,Lipoproteins, LDL ,HaCaT ,Cholesterol ,030104 developmental biology ,Cytokine ,LOX-1 ,lcsh:Biology (General) ,lcsh:QD1-999 ,Cancer research ,lipids (amino acids, peptides, and proteins) ,Tumor necrosis factor alpha ,business - Abstract
Psoriasis is a chronic inflammatory skin disease. Even though scientists predict that abnormalities in lipid metabolism play an important role in the pathogenesis of psoriasis, the actual underlying mechanisms are still unclear. Therefore, understanding the possible relationship between mechanisms of the occurrence of psoriasis and dyslipidemia is an important issue that may lead to the development of effective therapies. Under this principle, we investigated the influences of hyperlipidemia in imiquimod (IMQ)-induced psoriasis-like B6.129S2-Apoetm1Unc/J mice and oxidized low-density lipoprotein (oxLDL) in tumor necrosis factor (TNF)-&alpha, stimulated Hacat cells. In our study, we showed that a high-cholesterol diet aggravated psoriasis-like phenomena in IMQ-treated B6.129S2-Apoetm1Unc/J mice. In vitro analysis showed that oxLDL increased keratinocyte migration and lectin-type oxLDL receptor 1 (LOX-1) expression. Evidence suggested that interleukin (IL)-23 was a main cytokine in the pathogenesis of psoriasis. High-cholesterol diet aggravated IL-23 expression in IMQ-treated B6.129S2-Apoetm1Unc/J mice, and oxLDL induced IL-23 expression mediated by LOX-1 in TNF-&alpha, stimulated Hacat cells. Therefore, it will be interesting to investigate the factors for the oxLDL induction of LOX-1 in psoriasis. LOX-1 receptor expression may be another novel treatment option for psoriasis and might represent the most promising strategy.
- Published
- 2018
- Full Text
- View/download PDF
16. Porocarcinoma in situ showing follicular differentiation: A case report
- Author
-
Chien Jui Cheng, Kuo Hsien Wang, and Chia Lan Ou
- Subjects
medicine.medical_specialty ,Cell type ,Pathology ,hidroacanthoma simplex ,Hidradenoma ,Apocrine ,porocarcinoma ,Dermatology ,Biology ,lcsh:RL1-803 ,medicine.disease ,Stain ,Poroma ,Pleomorphism (cytology) ,apocrine ,medicine ,lcsh:Dermatology ,Neoplasm ,Histopathology ,follicular differentiation - Abstract
Poroid neoplasm is a skin appendage tumor that has both benign and malignant counterparts. It has traditionally been regarded as of eccrine origin and has four types: intraepidermal poroma (hidroacanthoma simplex), poroma, dermal duct tumor, and poroid hidradenoma. Here we describe the case of a 64-year-old woman who had a verrucous, erythematous to brownish tumor on her left buttock for many years. Histopathology revealed an intra-epidermal poroid tumor with both benign and malignant parts. The benign part had intra-epidermal nests of poroid cells, which were smaller, monomorphic and sharply marginated from adjacent keratinocytes. The malignant part showed similar cell types, but had a higher nuclear/cytoplasmic ratio, pleomorphism, and prominent mitoses. Ductal structures were noted in neoplastic cells and an epithelial membrane antigen stain was strongly positive. Interestingly, peripheral palisading and primitive follicular germ formation were also observed in the neoplasm, which suggests follicular differentiation. We made a final diagnosis of porocarcinoma in situ with follicular differentiation, which may support the folliculosebaceous–apocrine unit theory, but a tumor with such a combination has not been described before.
- Published
- 2012
17. Atypical Angioma Serpiginosum
- Author
-
Jainn-Shiun Chiu, Ju-Hsin Chen, Kuo-Hsien Wang, and Chung-Hong Hu
- Subjects
medicine.medical_specialty ,Pathology ,Hyperkeratosis ,Dermatologic Surgical Procedures ,Lasers, Dye ,Late onset ,Case Report ,Angioma serpiginosum ,Skin Diseases, Vascular ,Asymptomatic ,Foot Diseases ,medicine ,Humans ,Telangiectasis ,Buttocks ,Pathological ,Skin ,business.industry ,Papillary dermis ,dye laser treatment ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Extravasation ,medicine.anatomical_structure ,Treatment Outcome ,purpura ,Female ,medicine.symptom ,business - Abstract
Angioma serpiginosum is an uncommon, acquired vascular nevoid disorder with capillary dilation and proliferation in the papillary dermis. The eruptions are asymptomatic and characterized by grouped, erythematous to violaceous, serpiginous and punctate macules. The condition usually appears in females during adolescence on unilateral lower extremities and the buttocks. We report a rare case with a late onset and atypical distribution of lesions in a 48-year-old female patient who had groups of punctate lesions on her left foot for four to five years. Histopathological examination showed hyperkeratosis and multiple dilated and proliferated capillaries in the papillary dermis. Inflammation and extravasation of red blood cells were not found. According to the clinical and pathological findings, we established a diagnosis of angioma serpiginosum. She was treated with a pulsed dye laser, and the angiomatous lesions subsequently improved.
- Published
- 2008
18. A Two-Period Newsvendor Model with Product Extension and Shortage-Making Strategy
- Author
-
Yuan-Chih Huang, Che-Tsung Tung, and Kuo-Hsien Wang
- Subjects
Price elasticity of demand ,Extended newsvendor model ,Exponential distribution ,Article Subject ,Demand curve ,Computer science ,Market demand schedule ,Econometrics ,Newsvendor model ,Derived demand ,Profit (economics) - Abstract
This study deals with a two-period newsvendor setting in which the item in the second period is a product extension of the item in the first period. A shortage strategy toward the first item is intentionally made so as to stimulate more sales amounts of the second item. The stochastic demand of these two items is assumed to be a linear-additive pattern comprising a deterministic demand and an error demand, where the deterministic demand consists of a primary demand and a consumer price elasticity, and the error demand is hypothesized to be exponentially distributed. The objective of this study is to optimize system's overall expected profit by jointly determining the optimal order quantities and selling prices of these two items. We first compare our proposed model with the classical newsvendor model in light of profit performances, and it reveals that a higher shifting demand rate makes our model a more profitable setting. Impact on profit performances caused by an increasing primary demand of the second item is then demonstrated by numerical examples that an unthought-of ripple effect of an increasing error demand of the second item also occurs.
- Published
- 2013
- Full Text
- View/download PDF
19. Hesperidin-3′-O-Methylether Is More Potent than Hesperidin in Phosphodiesterase Inhibition and Suppression of Ovalbumin-Induced Airway Hyperresponsiveness
- Author
-
Chien Ming Chen, You Lan Yang, Kuo Hsien Wang, Hsin Te Hsu, Chao Sian Wang, and Wun-Chang Ko
- Subjects
biology ,Article Subject ,business.industry ,lcsh:Other systems of medicine ,Pharmacology ,respiratory system ,lcsh:RZ201-999 ,medicine.disease ,Hesperidin ,chemistry.chemical_compound ,Ovalbumin ,Complementary and alternative medicine ,chemistry ,Oral administration ,biology.protein ,Medicine ,Potency ,Antibody ,business ,Adverse effect ,Flavanone ,Asthma ,Research Article - Abstract
Hesperidin is present in the traditional Chinese medicine, “Chen Pi,” and recently was reported to have anti-inflammatory effects. Therefore, we were interested in comparing the effects of hesperidin and hesperidin-3′-O-methylether on phosphodiesterase inhibition and airway hyperresponsiveness (AHR) in a murine model of asthma. In the present results, hesperidin-3′-O-methylether, but not hesperidin, at 30 μmol/kg (p.o.) significantly attenuated the enhanced pause (Penh) value, suppressed the increases in numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, suppressed total and OVA-specific immunoglobulin (Ig)E levels in the serum and BALF, and enhanced the level of totalIgG2ain the serum of sensitized and challenged mice, suggesting that hesperidin-3′-O-methylether is more potent than hesperidin in suppression of AHR and immunoregulation. The different potency between them may be due to their aglycons, because these two flavanone glycosides should be hydrolyzed byβ-glucosidase after oral administration. Neither influenced xylazine/ketamine-induced anesthesia, suggesting that they may have few or no adverse effects, such as nausea, vomiting, and gastric hypersecretion. In conclusion, hesperidin-3′-O-methylether is more potent in phosphodiesterase inhibition and suppression of AHR and has higher therapeutic (PDE4H/PDE4L) ratio than hesperidin. Thus, hesperidin-3′-O-methylether may have more potential for use in treating allergic asthma and chronic obstructive pulmonary disease.
- Published
- 2012
20. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia
- Author
-
Chien Ming Chen, Chi Yin Lai, Chung Hung Shih, Kuo Hsien Wang, Hsin Te Hsu, Ling Hong Lin, and Wun-Chang Ko
- Subjects
Article Subject ,Pharmacology ,Immunoglobulin E ,chemistry.chemical_compound ,medicine ,biology ,medicine.diagnostic_test ,business.industry ,Hesperetin ,Phosphodiesterase ,Interleukin ,lcsh:Other systems of medicine ,respiratory system ,lcsh:RZ201-999 ,respiratory tract diseases ,Ovalbumin ,Bronchoalveolar lavage ,Complementary and alternative medicine ,chemistry ,Anesthesia ,biology.protein ,Methacholine ,Tumor necrosis factor alpha ,business ,medicine.drug ,Research Article - Abstract
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Therefore, we were interested in investigating its effects on ovalbumin- (OVA-) induced airway hyperresponsiveness, and clarifying its rationale for ameliorating asthma and chronic obstructive pulmonary disease (COPD). Hesperetin was revealed to have a therapeutic (PDE4H/PDE4L) ratio of >11. Hesperetin (10 ~ 30 μmol/kg, intraperitoneally (i.p.)) dose-dependently and significantly attenuated the airway hyperresponsiveness induced by methacholine. It also significantly suppressed the increases in total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF). It dose-dependently and significantly suppressed total and OVA-specific immunoglobulin E levels in the BALF and serum. However, hesperetin did not influence xylazine/ketamine-induced anesthesia, suggesting that hesperetin has few or no emetic effects. In conclusion, the rationales for ameliorating allergic asthma and COPD by hesperetin are anti-inflammation, immunoregulation, and bronchodilation.
- Published
- 2012
21. Risk of herpes zoster among patients with chronic obstructive pulmonary disease: a population-based study
- Author
-
Ya-Wen Yang, Yi Hua Chen, Hui Wen Lin, Chen Yi Wang, and Kuo Hsien Wang
- Subjects
Male ,medicine.medical_specialty ,Cross-sectional study ,Population ,Taiwan ,Comorbidity ,Kaplan-Meier Estimate ,Herpes Zoster ,Risk Assessment ,Severity of Illness Index ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,Age Distribution ,Internal medicine ,Severity of illness ,medicine ,Confidence Intervals ,Humans ,Sex Distribution ,education ,Aged ,Proportional Hazards Models ,education.field_of_study ,COPD ,business.industry ,Research ,Incidence ,Hazard ratio ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,respiratory tract diseases ,Surgery ,Cross-Sectional Studies ,Relative risk ,Cohort ,Female ,business ,Cohort study - Abstract
Background Systemic inflammation and dysregulated immune function in chronic obstructive pulmonary disease (COPD) is hypothesized to predispose patients to development of herpes zoster. However, the risk of herpes zoster among patients with COPD is undocumented. We therefore aimed to investigate the risk of herpes zoster among patients with COPD. Methods We conducted a cohort study using data from the Taiwan Longitudinal Health Insurance Database. We performed Cox regressions to compare the hazard ratio (HR) of herpes zoster in the COPD cohort and in an age- and sex-matched comparison cohort. We divided the patients with COPD into three groups according to use of steroid medications and performed a further analysis to examine the risk of herpes zoster. Results The study included 8486 patients with COPD and 33 944 matched control patients. After adjustment for potential confounding factors, patients with COPD were more likely to have incidents of herpes zoster (adjusted HR 1.68, 95% confidence interval [CI] 1.45-1.95). When compared with the comparison cohort, the adjusted HR of herpes zoster was 1.67 (95% CI 1.43-1.96) for patients with COPD not taking steroid medications. The adjusted HR of herpes zoster was slightly greater for patients with COPD using inhaled corticosteroids only (adjusted HR 2.09, 95% CI 1.38-3.16) and was greatest for patients with COPD using oral steroids (adjusted HR 3.00, 95% CI 2.40-3.75). Interpretation Patients with COPD were at increased risk of herpes zoster relative to the general population. The relative risk of herpes zoster was greatest for patients with COPD using oral steroids.
- Published
- 2011
22. A return-policy contract with a stock-dependent demand and inventory shrinkages.
- Author
-
Kuo-Hsien Wang, Yuan-Chih Huang, and Che-Tsung Tung
- Subjects
INVENTORIES ,SUPPLY chains ,SUPPLY & demand ,NEWSVENDOR model ,PARETO analysis - Abstract
We study a decentralized supply chain in which a manufacturer supplies a newsvendor-type item to a retailer in a stock-dependent demand market, considering temporary and permanent inventory shrinkages. The manufacturer offers a cheaper-wholesale-price, buy-all-back contract to operate the chain as a centralized supply chain. The purpose is to coordinate the chain and create a win-win situation by jointly determining the order quantity and negotiating the wholesale price. We consider the retailer's ignorance of inventory errors and unwillingness to share information, and we construct a range for the negotiated wholesale price in which it not only achieves Pareto efficiency but also encourages the retailer's cooperation with the inventory information. We find that the retailer bears more risk for inventory errors even when our contract is in place. We also learn that the impact of the stock-level demand stimulation effect on chain profit outweighs the impact of the inventory errors if the levels of inventory shrinkage are below our obtained upper bounds. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
23. A NEWSVENDOR SUPPLY CHAIN FOR SUBSTITUTABLE ITEMS WITH STOCK-LEVEL DEPENDENT DEMAND AND A RETURN-POLICY CONTRACT.
- Author
-
Kuo-Hsien Wang, Che-Tsung Tung, and Yuan-Chih Huang
- Subjects
PRODUCT returns ,NEWSVENDOR model ,SUPPLY chains - Abstract
Copyright of Commerce & Management Quarterly is the property of Chinese Association of Business & Management Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
24. Hesperidin-3'-O- Methylether Is More Potent than Hesperidin in Phosphodiesterase Inhibition and Suppression of Ovalbumin-Induced Airway Hyperresponsiveness.
- Author
-
You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Chao-Sian Wang, Chien- Ming Chen, and Wun-Chang Ko
- Abstract
Hesperidin is present in the traditional Chinese medicine, "Chen Pi," and recently was reported to have anti-inflammatory effects. Therefore, we were interested in comparing the effects of hesperidin and hesperidin-3'-O-methylether on phosphodiesterase inhibition and airway hyperresponsiveness (AHR) in a murine model of asthma. In the present results, hesperidin-3'-Omethylether, but not hesperidin, at 30 μmol/kg (p.o.) significantly attenuated the enhanced pause (Penh) value, suppressed the increases in numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, suppressed total and OVA-specific immunoglobulin (Ig)E levels in the serum and BALF, and enhanced the level of total IgG2a in the serum of sensitized and challenged mice, suggesting that hesperidin-3'-O-methylether is more potent than hesperidin in suppression of AHR and immunoregulation. The different potency between them may be due to their aglycons, because these two flavanone glycosides should be hydrolyzed by β-glucosidase after oral administration. Neither influenced xylazine/ketamine-induced anesthesia, suggesting that they may have few or no adverse effects, such as nausea, vomiting, and gastric hypersecretion. In conclusion, hesperidin-3'-O-methylether is more potent in phosphodiesterase inhibition and suppression of AHR and has higher therapeutic (PDE4H/PDE4L) ratio than hesperidin. Thus, hesperidin-3'-O-methylether may have more potential for use in treating allergic asthma and chronic obstructive pulmonary disease. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
25. Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.
- Author
-
Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien- Ming Chen, and Wun-Chang Ko
- Abstract
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, "Chen Pi." Therefore, we were interested in investigating its effects on ovalbumin- (OVA-) induced airway hyperresponsiveness, and clarifying its rationale for ameliorating asthma and chronic obstructive pulmonary disease (COPD). Hesperetin was revealed to have a therapeutic (PDE4H/PDE4L) ratio of >11. Hesperetin (10∼30 μmol/kg, intraperitoneally (i.p.)) dose-dependently and significantly attenuated the airway hyperresponsiveness induced by methacholine. It also significantly suppressed the increases in total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF). It dose-dependently and significantly suppressed total andOVA-specific immunoglobulin E levels in the BALF and serum.However, hesperetin did not influence xylazine/ketamineinduced anesthesia, suggesting that hesperetin has few or no emetic effects. In conclusion, the rationales for ameliorating allergic asthma and COPD by hesperetin are anti-inflammation, immunoregulation, and bronchodilation. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
26. Cutaneous reactive angiomatosis associated with cholesterol embolism.
- Author
-
Ya-Wen Yang, Chi-Long Chen, Wen-Tsao Ho, and Kuo-Hsien Wang
- Subjects
ARTERIAL occlusions ,CHOLESTEROL ,VASCULAR diseases ,FAT embolism ,GANGRENE ,CEREBRAL infarction ,CEREBROVASCULAR disease ,CELL proliferation - Abstract
Cholesterol embolism (CE) is characterized by emboli containing cholesterol crystal in the arterioles, most commonly found in the skin and the kidney. The skin presentations of CE include livedo reticularis, blue toe syndrome, ulceration and gangrene. Cutaneous reactive angiomatosis (CRA) is a recently proposed term to describe a group of reactive vascular proliferation in skin caused by various diseases. Its occurrence in association with CE is extremely uncommon. An 82-year-old man with a history of cerebral infarction and on long-term warfarin therapy developed progressive, multiple violaceous papules and nodules on the dorsal feet, soles and toes, simulating Kaposi's sarcoma. Skin biopsy showed marked vascular endothelial cell proliferations characteristic of CRA affecting the full thickness of dermis. In addition, cholesterol crystal emboli were found in dermal arterioles. The skin lesions improved after the warfarin dose was reduced. We emphasize the possible presence of CE in a patient presented with CRA, especially in those with a pre-existing atherosclerotic disease, on anticoagulation therapy, or having a prior history of invasive vascular procedure. Yang Y-W, Chen C-L, Ho W-T, Wang K-H. Cutaneous reactive angiomatosis associated with cholesterol embolism. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
27. Clear cell fibrous papule: report of a case mimicking a balloon cell nevus.
- Author
-
Ying-Yi Chiang, Hsiou-Hsin Tsai, Woan-Ruoh Lee, and Kuo-Hsien Wang
- Subjects
ACNE ,SEBACEOUS gland diseases ,SKIN inflammation ,IMMUNOHISTOCHEMISTRY ,CANCER patients - Abstract
Clear cell fibrous papule (FP) is a rare variant of FP. We report a 39-year-old female patient who presented with a dome-shaped papule on the nose. The diagnosis of clear cell FP was made based on histological and immunohistochemical studies. Interestingly, scattered S-100 cells were admixed within the lesion, a finding hitherto not reported. The S-100 positivity may be misleading and should be cautiously interpreted. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
28. Atypical Angioma Serpiginosum.
- Author
-
Ju-Hsin Chen, Kuo-Hsien Wang, Chung-Hong Hu, and Jainn-Shiun Chiu
- Abstract
Angioma serpiginosum is an uncommon, acquired vascular nevoid disorder with capillary dilation and proliferation in the papillary dermis. The eruptions are asymptomatic and characterized by grouped, erythematous to violaceous, serpiginous and punctate macules. The condition usually appears in females during adolescence on unilateral lower extremities and the buttocks. We report a rare case with a late onset and atypical distribution of lesions in a 48-year-old female patient who had groups of punctate lesions on her left foot for four to five years. Histopathological examination showed hyperkeratosis and multiple dilated and proliferated capillaries in the papillary dermis. Inflammation and extravasation of red blood cells were not found. According to the clinical and pathological findings, we established a diagnosis of angioma serpiginosum. She was treated with a pulsed dye laser, and the angiomatous lesions subsequently improved. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
29. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
- Author
-
Hungai, Shuen-lu, Chung, Wen-hung, Lioue, Lieh-bang, Chu, hen-chung, Hsien-ping Huanga, MarieL., Yen-ling Lina, Joung-liang, Li-cheng Yang, Hong-shang Hong, Ming-jing Chen, Ping-chin Lai, Mai-szu Wu, Chia-yu Chu, Kuo-hsien Wang, Chien-hsiun Chena, Cathy S. J. Fann, Jer-yuarn Wualk, and Yuan-tsong Chenaihim
- Subjects
HYPERURICEMIA ,URIC acid ,BIOMARKERS ,GENETIC markers ,DRUG metabolism ,CONFIDENCE intervals - Abstract
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol-SCAR, we carried out a case-control association study. We enrolled 51 patients with allopurinol-SCAR and 228 control individuals (135 allopurinol-tolerant subjects and 93 healthy subjects from the general population), and genotyped for 823 SNPs in genes related to drug metabolism and immune response. The initial screen revealed strong association between allopurinol-SCAR and SNPs in the MHC region, including BAT3 (encoding HLA-B associated transcript 3), MSHS (mutS homolog 5), and MICB (MHC class I polypeptide-related sequence B) (P < 10
-7 ). We then determined the alleles of HLA loci A, B, C, and DRBI. The HLA-B*5801 allele was present in all (100%) 51 patients with allopurinol-SCAR, but only in 20 (15%) of 135 tolerant patients [odds ratio 580.3 (95% confidence interval, 34.4-9780.9); corrected P value = 4.7 × 10-24 ] and in 19 (20%) of 93 of healthy subjects [393.51 (23.23-6665.26); corrected P value = 8.1 × 10-18 . HLA alteles A*3303, Cw*0302, and DRBI*0301 were in linkage disequilibrium and formed an extended haplotype with HLAeB*5801. Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B* 5801 allele is an important genetic risk factor for this life-threatening condition. [ABSTRACT FROM AUTHOR]- Published
- 2005
30. COMMUNICATIONS AND BRIEF REPORTS Erbium:YAG Laser Pretreatment Accelerates the Response of Bowen's Disease Treated by Topical 5-Fluorouracil.
- Author
-
Kuo-Hsien Wang, Marc R., Jia-You Fang, Chung-Hong Hu, Marc R., and Woan-Ruoh Lee, Marc R.
- Subjects
- *
ERBIUM , *LASERS , *DISEASES , *FLUOROURACIL , *HISTOLOGY , *THERAPEUTICS - Abstract
Topical 5-fluorouracil (5-FU) is a standard treatment for Bowen's disease. However, its efficacy may be limited by the presence of stratum corneum. The Er:YAG laser has shown a dramatic enhancement effect on the delivery of 5-FU in vitro by ablation of the stratum corneum. The efficacy of laser-assisted delivery of 5-FU has not been tested in human. To see whether Er:YAG laser pretreatment can improve the efficacy of topical 5-FU in the treatment of Bowen's disease. Three target lesions from a patient with multiple Bowen's disease were selected for a half-side comparison study. The Er:YAG laser was used to remove the cornified layer on one side of each lesion, followed by twice-daily application of 5-FU cream to both sides. Clinical and histologic responses were compared. Lesions pretreated with the Er:YAG laser showed more rapid clinical and histologic responses to topical 5-FU than those treated with 5-FU alone. Evaluation at 9 months after treatment showed no recurrences of lesions on both sides. Our preliminary study demonstrates that this Er:YAG laser-assisted modality is effective and shows accelerated clinical response and shortened treatment time compared with topical 5-FU as a single treatment. K.-H. WANG, MD, J.-Y. FANG, PHD, C.-H. HU, MD, AND W.-R. LEE, MD, DSC HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
31. Eruptive melanocytic nevi with malignant transformations and the connection to BRAF and p16 mutations
- Author
-
Ting Hua Yang, Hsiou-Hsin Tsai, Kuo-Hsien Wang, and Jan-Show Chu
- Subjects
Pathology ,medicine.medical_specialty ,melanocytic tumor of uncertain malignant potential ,p16 ,Dermatology ,medicine.disease_cause ,law.invention ,Malignant transformation ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,law ,lcsh:Dermatology ,medicine ,Polymerase chain reaction ,Eruptive melanocytic nevi ,Mutation ,business.industry ,BRAF V600E ,eruptive melanocytic nevi ,lcsh:RL1-803 ,melanocytic malignancy ,030220 oncology & carcinogenesis ,Cancer research ,Immunohistochemistry ,business - Abstract
Eruptive melanocytic nevi (EMN) is a rare phenomenon with an unclear pathogenesis. Mutation on a molecular basis has been proposed, but insufficient data are available to confirm this hypothesis. Theoretically, the possibility of malignant transformation is high, but no previous definite cases had been reported. Herein, we report the first case of a patient with EMN in whom hypopharyngeal low-grade melanocytic malignancies were detected using a fibrolaryngoscope. BRAF activation and p16 mutations were discovered through real-time polymerase chain reaction and immunohistochemical staining on EMN tissue samples, respectively. The significance of these findings has yet to be determined.
- Full Text
- View/download PDF
32. Lasers and Microdermabrasion Enhance and Control Topical Delivery of Vitamin C
- Author
-
Jia-You Fang, Kuo-Hsien Wang, Chung-Hong Hu, Shing-Chuan Shen, and Woan-Ruoh Lee
- Subjects
Vitamin ,medicine.medical_specialty ,skin ,medicine.medical_treatment ,Administration, Topical ,Skin Absorption ,Mice, Nude ,vitamin C ,Dermatology ,Ascorbic Acid ,Biochemistry ,chemistry.chemical_compound ,Mice ,medicine ,Stratum corneum ,Animals ,topical application ,Molecular Biology ,Transepidermal water loss ,Mice, Inbred BALB C ,Vitamin C ,integumentary system ,Dermabrasion ,Cell Biology ,Permeation ,Ascorbic acid ,Ablation ,medicine.anatomical_structure ,chemistry ,Female ,lasers ,Biomedical engineering - Abstract
The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascorbyl phosphate, the prodrug of vitamin C, was also examined in this study. All resurfacing techniques evaluated produced significant increases in the topical delivery of vitamin C across and/or into the skin. The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested. The laser fluence and spot size were found to play important parts in controlling drug absorption. An excellent correlation was observed in the Er:YAG laser fluence and transepidermal water loss, which is an estimation of skin disruption. Permeation of magnesium ascorbyl phosphate was not enhanced by the Er:YAG laser. The CO 2 laser at a lower fluence promoted vitamin C permeation with no ablation of the stratum corneum or epidermal layers. Further enhancement was observed with the CO 2 laser at higher fluences, which was accompanied by a prominent ablation effect. Microdermabrasion ablated the stratum corneum layers with minimal disruption of the skin barrier properties according to transepidermal water loss levels. The flux and skin deposition of vitamin C across microdermabrasion-treated skin was approximately 20-fold higher than that across intact skin. The techniques used in this study may be useful for basic and clinical investigations of enhancement of topical vitamin C delivery.
- Full Text
- View/download PDF
33. Carcinosarcoma Derived From Nevus Sebaceus.
- Author
-
Che-Yi Chou, Wei-Yu Chen, Kuo-Hsien Wang, and Ting-Jui Chen
- Published
- 2011
- Full Text
- View/download PDF
34. Pigmented Mammary Paget’s Disease Presenting as an Enlarged Areola.
- Author
-
Chao-Chin Wang, Kuo-Hsien Wang, Chieh-Jui Cheng, and Ju-Hsin Chen
- Subjects
- *
CASE studies , *DIFFERENTIAL diagnosis , *BREAST cancer diagnosis , *PERIODIC health examinations , *QUALITATIVE research - Abstract
The article presents a case study of a 66-year-old Taiwanese woman with an enlarged areola. It relates that the women's physical examination has indicated that her tumor cells were positive for cytokeratin-7 (CK-7) and mucicarmine. It notes that the findings suggest for the diagnosis of pigmented mammary Paget's disease (MPD), which need to consider differential diagnosis.
- Published
- 2009
- Full Text
- View/download PDF
35. Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio
- Author
-
Hsin Te Hsu, Cheng Ying Han, You Lan Yang, Chi Ming Chen, Kuo Hsien Wang, Chien Ming Chen, and Wun-Chang Ko
- Subjects
Male ,hesperetin-7,3'-O-dimethylether ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,lcsh:Medicine ,Pharmacology ,Hesperidin ,chemistry.chemical_compound ,Mice ,Pulmonary Disease, Chronic Obstructive ,cytokine ,Pharmacology (medical) ,Mice, Inbred BALB C ,biology ,Hesperetin ,General Medicine ,Cytokine ,Cytokines ,Female ,Bronchial Hyperreactivity ,Bronchoalveolar Lavage Fluid ,Rolipram ,allergic asthma ,medicine.drug ,medicine.medical_specialty ,Ovalbumin ,Guinea Pigs ,Immunoglobulins ,chronic obstructive pulmonary disease ,Therapeutic index ,Airway hyperresponsiveness ,In vivo ,Internal medicine ,medicine ,Animals ,phosphodiesterase-4 inhibitor ,Molecular Biology ,Biochemistry, medical ,Binding Sites ,business.industry ,Research ,Biochemistry (medical) ,lcsh:R ,Cell Biology ,Cyclic Nucleotide Phosphodiesterases, Type 1 ,In vitro ,Asthma ,Cyclic Nucleotide Phosphodiesterases, Type 3 ,Blood Cell Count ,Cyclic Nucleotide Phosphodiesterases, Type 4 ,Disease Models, Animal ,Endocrinology ,chemistry ,biology.protein ,Phosphodiesterase 4 Inhibitors ,business - Abstract
BackgroundHesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its selectivity on PDE4 and binding ability on high-affinity rolipram-binding sites (HARBs)in vitro, and its effects on ovalbumin-induced airway hyperresponsivenessin vivo, and clarifying its potential for treating asthma and chronic obstructive pulmonary disease (COPD).MethodsPDE1~5 activities were measured using a two-step procedure. The binding of HDME on high-affinity rolipram-binding sites was determined by replacing 2 nM [3H]-rolipram. AHR was assessed using the FlexiVent system and barometric plethysmography. Inflammatory cells were counted using a hemocytometer. Cytokines were determined using mouse T helper (Th)1/Th2 cytokine CBA kits, and total immunoglobulin (Ig)E or IgG2alevels were done using ELISA method. Xylazine (10 mg/kg)/ketamine (70 mg/kg)-induced anesthesia was performed.ResultsHDME revealed selective phosphodiesterase 4 (PDE4) inhibition with a therapeutic (PDE4H/PDE4L) ratio of 35.5in vitro.In vivo, HDME (3~30 μmol/kg, orally (p.o.)) dose-dependently and significantly attenuated the airway resistance (RL) and increased lung dynamic compliance (Cdyn), and decreased enhanced pause (Penh) values induced by methacholine in sensitized and challenged mice. It also significantly suppressed the increases in the numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF) of these mice. In addition, HDME (3~30 μmol/kg, p.o.) dose-dependently and significantly suppressed total and ovalbumin-specific immunoglobulin (Ig)E levels in the BALF and serum, and enhanced IgG2alevel in the serum of these mice.ConclusionsHDME exerted anti-inflammatory effects, including suppression of AHR, and reduced expressions of inflammatory cells and cytokines in this murine model, which appears to be suitable for studying the effects of drugs on atypical asthma and COPD, and for screening those on typical asthma. However, HDME did not influnce xylazine/ketamine-induced anesthesia. Thus HDME may have the potential for use in treating typical and atypical asthma, and COPD.
- Full Text
- View/download PDF
36. Milium-like syringoma: a case study on histogenesis.
- Author
-
Kuo-Hsien Wang, J. L., Jan-Show Chu, Yun-Ho Lin, J. L., Chung-Hong Hu, J. L., and Woan-Ruoh Lee, J. L.
- Subjects
- *
SYRINGOMYELIA , *EPIDERMIS , *HISTOLOGY , *CYSTS (Pathology) , *CARCINOEMBRYONIC antigen , *EPITHELIUM , *ENDOCRINE glands - Abstract
Milium-like syringoma is a variant of syringoma first described in 1987. Only few cases have been reported in the literature. It may be misleading clinically, and its histogenesis has not been clarified. We present a case of periorbital milium-like syringoma, with studies on the histopathologic, histochemical, and immunohistochemical features. Histology showed a large keratin-filled cyst in the upper portion of the lesion approximating the epidermis. Serial sections revealed that the cyst connected with the underlying syringomatous epithelial strands. Melanin was absent in the wall of the cyst, as demonstrated by Fontana–Masson stain. Cytokeratin 7 was expressed neither in the milia nor in the solid epithelial parts. Carcinoembryonic antigen (CEA) reactivity was seen in the luminal cells of the keratinous cysts. However, in the largest keratin-filled cyst clinically suggesting a milium, only the lower half of the cyst was positive for CEA. These results proved that the milia were part of syringoma with eccrine duct differentiation. Fusion of the upper half of the largest cyst with the epidermis may explain the absence of CEA positivity in this part, analogous with eccrine duct milia. Review of the literature indicated that this variant of syringoma occurs more often in Asians. We present evidence, and propose the histogenesis of milium-like syringoma, that it is a variant of syringoma with a prominent cystic component showing features of eccrine duct milia. Recognition of its nature is of therapeutic significance. Further studies are required to verify its clinical characteristics as compared with ordinary syringomas. Wang K-H, Chu J-S, Lin Y-H, Hu C-H, Lee W-R. Milium-like syringoma: a case study on histogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
37. ORIGINAL ARTICLE Lasers and Microdermabrasion Enhance and Control Topical Delivery of Vitamin C.
- Author
-
Woan-Ruoh Lee, George, Shing-Chuan Shen, Kuo-Hsien Wang, George, Chung-Hong Hu, George, and Jia-You Fang
- Subjects
- *
VITAMIN C , *MEDICAL lasers , *DERMABRASION - Abstract
The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascorbyl phosphate, the prodrug of vitamin C, was also examined in this study. All resurfacing techniques evaluated produced significant increases in the topical delivery of vitamin C across and/or into the skin. The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested. The laser fluence and spot size were found to play important parts in controlling drug absorption. An excellent correlation was observed in the Er:YAG laser fluence and transepidermal water loss, which is an estimation of skin disruption. Permeation of magnesium ascorbyl phosphate was not enhanced by the Er:YAG laser. The CO2 laser at a lower fluence promoted vitamin C permeation with no ablation of the stratum corneum or epidermal layers. Further enhancement was observed with the CO2 laser at higher fluences, which was accompanied by a prominent ablation effect. Microdermabrasion ablated the stratum corneum layers with minimal disruption of the skin barrier properties according to transepidermal water loss levels. The flux and skin deposition of vitamin C across microdermabrasion-treated skin was approximately 20-fold higher than that across intact skin. The techniques used in this study may be useful for basic and clinical investigations of enhancement of topical vitamin C delivery. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
38. Lasers and microdermabrasion enhance and control topical delivery of vitamin C.
- Author
-
Lee WR, Shen SC, Kuo-Hsien W, Hu CH, and Fang JY
- Subjects
- Administration, Topical, Animals, Ascorbic Acid administration & dosage, Female, Mice, Mice, Inbred BALB C, Mice, Nude, Skin cytology, Skin metabolism, Ascorbic Acid analogs & derivatives, Ascorbic Acid pharmacokinetics, Dermabrasion, Lasers, Skin Absorption
- Abstract
The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascorbyl phosphate, the pro-drug of vitamin C, was also examined in this study. All resurfacing techniques evaluated produced significant increases in the topical delivery of vitamin C across and/or into the skin. The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested. The laser fluence and spot size were found to play important parts in controlling drug absorption. An excellent correlation was observed in the Er:YAG laser fluence and transepidermal water loss, which is an estimation of skin disruption. Permeation of magnesium ascorbyl phosphate was not enhanced by the Er:YAG laser. The CO2 laser at a lower fluence promoted vitamin C permeation with no ablation of the stratum corneum or epidermal layers. Further enhancement was observed with the CO2 laser at higher fluences, which was accompanied by a prominent ablation effect. Microdermabrasion ablated the stratum corneum layers with minimal disruption of the skin barrier properties according to transepidermal water loss levels. The flux and skin deposition of vitamin C across microdermabrasion-treated skin was approximately 20-fold higher than that across intact skin. The techniques used in this study may be useful for basic and clinical investigations of enhancement of topical vitamin C delivery.
- Published
- 2003
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.