Search

Your search keyword '"Kuramatsu, Joji B"' showing total 286 results
Start Over Author "Kuramatsu, Joji B" Language english
286 results on '"Kuramatsu, Joji B"'

5. Large diameter hemicraniectomy does not improve long-term outcome in malignant infarction

Author

Lehrieder, Dominik, Müller, Hans-Peter, Kassubek, Jan, Hecht, Nils, Thomalla, Götz, Michalski, Dominik, Gattringer, Thomas, Wartenberg, Katja E., Schultze-Amberger, Jörg, Huttner, Hagen, Kuramatsu, Joji B., Wunderlich, Silke, Steiner, Hans-Herbert, Weissenborn, Karin, Heck, Suzette, Günther, Albrecht, Schneider, Hauke, Poli, Sven, Dohmen, Christian, Woitzik, Johannes, Jüttler, Eric, and Neugebauer, Hermann

Published
2023
Full Text
View/download PDF

7. The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study

Author

Abed-Maillard, Samia, Anderloni, Marco, Beretta, Alessandra, Cho, Sung-Min, Del Bianco, Silvia, Favre, Eva, Greil, Madeline E., Guglielmi, Angelo, Higuera Lucas, Juan, Iacca, Cosimo, Kuramatsu, Joji B., Lundberg, Linda Marie, Magni, Federico, Malgeri, Letterio, Mangili, Paolo, Melchionda, Isabella, Miroz, John-Paul, Monleón, Berta, Randazzo, Dominica, Salah, Samia, Scavone, Angela, Schilte, Clothilde, Silva, Serena, Sunde, Kjetil, Wang, Ruihao, Oddo, Mauro, Taccone, Fabio S, Petrosino, Matteo, Badenes, Rafael, Blandino-Ortiz, Aaron, Bouzat, Pierre, Caricato, Anselmo, Chesnut, Randall M, Feyling, Anders C, Ben-Hamouda, Nawfel, Hemphill, J Claude, Koehn, Julia, Rasulo, Frank, Suarez, Jose I, Elli, Francesca, Vargiolu, Alessia, Rebora, Paola, Galimberti, Stefania, and Citerio, Giuseppe

Published
2023
Full Text
View/download PDF

9. Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study

Author

Nguyen, Thanh N., Qureshi, Muhammad M., Strambo, Davide, Strbian, Daniel, Räty, Silja, Herweh, Christian, Abdalkader, Mohamad, Olive-Gadea, Marta, Ribo, Marc, Psychogios, Marios, Fischer, Urs, Nguyen, Anh, Kuramatsu, Joji B., Haupenthal, David, Köhrmann, Martin, Deuschl, Cornelius, Kühne Escola, Jordi, Yaghi, Shadi, Shu, Liqi, Puetz, Volker, Kaiser, Daniel P.O., Kaesmacher, Johannes, Mujanovic, Adnan, Marterstock, Dominique Cornelius, Engelhorn, Tobias, Klein, Piers, Haussen, Diogo C., Mohammaden, Mahmoud H., Abdelhamid, Hend, Souza Viana, Lorena, Cunha, Bruno, Fragata, Isabel, Romoli, Michele, Diana, Francesco, Virtanen, Pekka, Lappalainen, Kimmo, Clark, Judith, Matsoukas, Stavros, Fifi, Johanna T., Sheth, Sunil A., Salazar-Marioni, Sergio, Marto, João Pedro, Ramos, João Nuno, Miszczuk, Milena, Riegler, Christoph, Jadhav, Ashutosh P., Desai, Shashvat M., Maus, Volker, Kaeder, Maximilian, Siddiqui, Adnan H., Monteiro, Andre, Masoud, Hesham E., Suryadevara, Neil, Mokin, Maxim, Thanki, Shail, Siegler, James E., Khalife, Jane, Linfante, Italo, Dabus, Guilherme, Asdaghi, Negar, Saini, Vasu, Nolte, Christian H., Siebert, Eberhard, Meinel, Thomas R., Finitsis, Stefanos, Möhlenbruch, Markus A., Ringleb, Peter A., Berberich, Anne, Nogueira, Raul G., Hanning, Uta, Meyer, Lukas, Michel, Patrik, and Nagel, Simon

Published
2023
Full Text
View/download PDF

11. Influence of bundled care treatment on functional outcome in patients with intracerebral hemorrhage.

Author

Mrochen, Anne, Yu Song, Harders, Verena, Sembill, Jochen A., Sprügel, Maximilian I., Hock, Stefan, Lang, Stefan, Engelhorn, Tobias, Kallmünzer, Bernd, Volbers, Bastian, and Kuramatsu, Joji B.

Subjects
SYSTOLIC blood pressure, BLOOD pressure, CEREBRAL hemorrhage, GLYCEMIC control, BODY temperature
Abstract

Background and aims: General guideline recommendations in patients with intracerebral hemorrhage (ICH) include blood pressure-, temperature- and glucose management. The therapeutic effect of such a "care bundle" (blood pressure lowering, glycemic control, and treatment of pyrexia) on clinical outcomes becomes increasingly established. For the present study, we aimed to investigate associations of strict bundled care treatment (BCT) with clinical outcomes and characterize associations with key outcome effectors such as hematoma enlargement (HE) and peak perihemorrhagic edema (PHE). Methods: We screened consecutive ICH patients (n = 1,322) from the prospective UKER-ICH cohort study. BCT was defined as achieving and maintaining therapeutic ranges for systolic blood pressure (110-160 mmHg), glucose (80-180 mg/dL), and body temperature (35.5-37.5°C) over the first 72 h. The primary outcome was the functional outcome at 12 months (modified Rankin Scale (mRS) 0-3). Secondary outcomes included mortality at 12 months, the occurrence of hematoma enlargement, and the development of peak perihemorrhagic edema. Confounding was addressed by a doubly robust methodology to calculate the absolute treatment effect (ATE) and by calculating e-values. Results: A total of 681 patients remained for analysis, and 182 patients fulfilled all three BCT criteria and were compared to 499 controls. The ATE of BCT to achieve the primary outcome was 9.3%, 95% CI (1.7 to 16.9), p < 0.001; e-value: 3.1, CI (1.8). Mortality at 12 months was significantly reduced by BCT [ATE: -12.8%, 95% CI (-19.8 to -5.7), p < 0.001; e-value: 3.8, CI (2.2)], and no association was observed for HE or peak PHE. Significant drivers of BCT effect on the primary outcome were systolic blood pressure control (ATE: 15.9%) and maintenance of normothermia (ATE: 10.9%). Conclusion: Strict adherence to this "care bundle" over the first 72 h during acute hospital care in patients with ICH was independently associated with improved functional long-term outcome, driven by systolic blood pressure control and maintenance of normothermia. Our findings strongly warrant prospective validation to determine the generalizability especially in Western countries. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site.

Author

Strambo, Davide, Michel, Patrik, Nguyen, Thanh N., Abdalkader, Mohamad, Qureshi, Muhammad M., Strbian, Daniel, Herweh, Christian, Möhlenbruch, Markus A., Räty, Silja, Olivé-Gadea, Marta, Ribo, Marc, Psychogios, Marios, Fischer, Urs, Nguyen, Anh, Kuramatsu, Joji B., Haupenthal, David, Köhrmann, Martin, Deuschl, Cornelius, Kühne Escolà, Jordi, and Demeestere, Jelle

Published
2024
Full Text
View/download PDF

19. Hematoma Expansion and Clinical Outcomes in Patients With Factor-Xa Inhibitor–Related Atraumatic Intracerebral Hemorrhage Treated Within the ANNEXA-4 Trial Versus Real-World Usual Care

Author

Huttner, Hagen B., Gerner, Stefan T., Kuramatsu, Joji B., Connolly, Stuart J., Beyer-Westendorf, Jan, Demchuk, Andrew M., Middeldorp, Saskia, Zotova, Elena, Altevers, Julia, Andersohn, Frank, Christoph, Mary J., Yue, Patrick, Stross, Leonhard, and Schwab, Stefan

Published
2021
Full Text
View/download PDF

20. Association of non-contrast CT markers with long-term functional outcome in deep intracerebral hemorrhage.

Author

Kölbl, Kathrin, Hock, Stefan W., Mingming Xu, Sembill, Jochen A., Mrochen, Anne, Balk, Stefanie, Lang, Stefan, Volbers, Bastian, Engelhorn, Tobias, Kallmünzer, Bernd, and Kuramatsu, Joji B.

Subjects
CEREBRAL hemorrhage, CLINICAL deterioration, BASAL ganglia, BLACK holes, DATABASES
Abstract

Objective: Hematoma expansion (HE) is the most important therapeutic target during acute care of patients with intracerebral hemorrhage (ICH). Imaging biomarkers such as non-contrast CT (NCCT) markers have been associated with increasing risk for HE. The aim of the present study was to evaluate the influence of NCCT markers with functional long-term outcome and with HE in patients with deep (basal ganglia and thalamus) ICH who represent an important subgroup of patients at the highest risk for functional deterioration with HE due to the eloquence of the affected brain region. Methods: From our prospective institutional database, all patients maximally treated with deep ICH were included and retrospectively analyzed. NCCT markers were recorded at diagnostic imaging, ICH volume characteristics were volumetrically evaluated, and all patients received follow-up imaging within 0-48 h. We explored associations of NCCT makers with unfavorable functional outcome, defined as modified Rankin scale 4-6, after 12 months and with HE. Bias and confounding were addressed by multivariable regression modeling. Results: In 322 patients with deep ICH, NCCT markers were distributed as follows: irregular shape: 69.6%, heterogenous density: 55.9%, hypodensities: 52.5%, island sign: 19.3%, black hole sign: 11.5%, and blend sign: 4.7%. Upon multivariable regression analyses, independent associations were documented with the functional outcome for irregular shape (aOR: 2.73, 95%CI: 1.42-5.22, p = 0.002), heterogenous density (aOR: 2.62, 95%CI: 1.40-4.90, p = 0.003) and island sign (aOR: 2.54, 95%CI: 1.05-6.14, p = 0.038), and with HE for heterogenous density (aOR: 5.01, 95%CI: 1.93-13.05, p = 0.001) and hypodensities (aOR: 3.75, 95%CI: 1.63-8.62, p = 0.002). Conclusion: NCCT markers are frequent in deep ICH patients and provide important clinical implications. Specifically, markers defined by diverging intrahematomal densities provided associations with a 5-times higher risk for HE and a 2.5-times higher likelihood for unfavorable functional long-term outcome. Hence, these markers allow the identification of patients with deep ICH at high risk for clinical deterioration due to HE. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Describing Anisocoria in Neurocritically Ill Patients.

Author

Saju, Ciji, Barnes, Arianna, Kuramatsu, Joji B., Marshall, Jade L., Obinata, Hirofumi, Puccio, Ava M., Yokobori, Shoji, and Olson, DaiWai M.

Subjects
CRITICALLY ill, PATIENTS, REFLEXES, PUPIL (Eye), EYE
Abstract

Background: Anisocoria (unequal pupil size) has been defined using cut points ranging from greater than 0.3 mm to greater than 2.0 mm for absolute difference in pupil size. This study explored different pupil diameter cut points for assessing anisocoria as measured by quantitative pupillometry before and after light stimulus. Methods: An exploratory descriptive study of international registry data was performed. The first observations in patients with paired left and right quantitative pupillometry measurements were included. Measurements of pupil size before and after stimulus with a fixed light source were used to calculate anisocoria. Results: The sample included 5769 patients (mean [SD] age, 57.5 [17.6] years; female sex, 2558 patients [51.5%]; White race, 3669 patients [75.5%]). Anisocoria defined as pupil size difference of greater than 0.5 mm was present in 1624 patients (28.2%) before light stimulus; 645 of these patients (39.7%) also had anisocoria after light stimulus (P <.001). Anisocoria defined as pupil size difference of greater than 2.0 mm was present in 79 patients (1.4%) before light stimulus; 42 of these patients (53.2%) also had anisocoria after light stimulus (P <.001). Discussion: The finding of anisocoria significantly differed before and after light stimulus and according to the cut point used. At most cut points, fewer than half of the patients who had anisocoria before light stimulus also had anisocoria after light stimulus. Conclusion: The profound difference in the number of patients adjudicated as having anisocoria using different cut points reinforces the need to develop a universal definition for anisocoria. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Characteristics in Non–Vitamin K Antagonist Oral Anticoagulant–Related Intracerebral Hemorrhage

Author

Gerner, Stefan T., Kuramatsu, Joji B., Sembill, Jochen A., Sprügel, Maximilian I., Hagen, Manuel, Knappe, Ruben U., Endres, Matthias, Haeusler, Karl Georg, Sobesky, Jan, Schurig, Johannes, Zweynert, Sarah, Bauer, Miriam, Vajkoczy, Peter, Ringleb, Peter A., Purrucker, Jan C., Rizos, Timolaos, Volkmann, Jens, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, Erbguth, Frank, Nueckel, Martin, Schellinger, Peter D., Glahn, Jörg, Knappe, Ulrich J., Fink, Gereon R., Dohmen, Christian, Stetefeld, Henning, Fisse, Anna Lena, Minnerup, Jens, Hagemann, Georg, Rakers, Florian, Reichmann, Heinz, Schneider, Hauke, Rahmig, Jan, Ludolph, Albert Christian, Stösser, Sebastian, Neugebauer, Hermann, Röther, Joachim, Michels, Peter, Schwarz, Michael, Reimann, Gernot, Bäzner, Hansjörg, Schwert, Henning, Claßen, Joseph, Michalski, Dominik, Grau, Armin, Palm, Frederick, Urbanek, Christian, Wöhrle, Johannes C., Alshammari, Fahid, Horn, Markus, Bahner, Dirk, Witte, Otto W., Günther, Albrecht, Hamann, Gerhard F., Engelhorn, Tobias, Lücking, Hannes, Dörfler, Arnd, Schwab, Stefan, and Huttner, Hagen B.

Published
2019
Full Text
View/download PDF

30. Association of prothrombin complex concentrate administration and hematoma enlargement in non–vitamin K antagonist oral anticoagulant–related intracerebral hemorrhage

Author

Gerner, Stefan T., Kuramatsu, Joji B., Sembill, Jochen A., Sprügel, Maximilian I., Endres, Matthias, Haeusler, Karl Georg, Vajkoczy, Peter, Ringleb, Peter A., Purrucker, Jan, Rizos, Timolaos, Erbguth, Frank, Schellinger, Peter D., Fink, Gereon R., Stetefeld, Henning, Schneider, Hauke, Neugebauer, Hermann, Röther, Joachim, Claßen, Joseph, Michalski, Dominik, Dörfler, Arnd, Schwab, Stefan, Huttner, Hagen B., Horn, Markus, Bahner, Dirk, Hagemann, Georg, Rakers, Florian, Endres, Matthias, Haeusler, Karl Georg, Sobesky, Jan, Schurig, Johannes, Zweynert, Sarah, Bauer, Miriam, Vajkoczy, Peter, Fink, Gereon R., Dohmen, Christian, Stetefeld, Henning, Schwarz, Michael, Reimann, Gernot, Reichmann, Heinz, Schneider, Hauke, Rahmig, Jan, Gerner, Stefan T., Kuramatsu, Joji B., Bogenreuther, Christina, Sembill, Jochen A., Sprügel, Maximilian I., Hagen, Manuel, Knappe, Ruben, Köhrmann, Martin, Schwab, Stefan, Huttner, Hagen B., Kloska, Stephan P., Dörfler, Arnd, Ringwald, Jürgen, Hamann, Gerhard F., Röther, Joachim, Michels, Peter, Ringleb, Peter A., Purrucker, Jan, Rizos, Timolaos, Witte, Otto W., Günther, Albrecht, Wöhrle, Johannes C., Alshammari, Fahid, Claßen, Joseph, Michalski, Dominik, Grau, Armin, Palm, Frederick, Urbanek, Christian, Schellinger, Peter D., Glahn, Jörg, Knappe, Ulrich J., Wiendl, Heinz, Fisse, Anna Lena, Minnerup, Jens, Erbguth, Frank, Nueckel, Martin, Bäzner, Hansjörg, Schwert, Henning, Ludolph, Albert Christian, Stösser, Sebastian, Neugebauer, Hermann, Volkmann, Jens, Müllges, Wolfgang, Kraft, Peter, and Schubert, Anna‐Lena

Published
2018
Full Text
View/download PDF

34. Surgical hematoma evacuation of cortical intracerebral hemorrhage ≥10 ml reduces risk of subsequent epilepsy by more than 70%: A retrospective monocenter study.

Author

Welte, Tamara M., Steidl, Josephine, Stritzelberger, Jenny, Gollwitzer, Stephanie, Lang, Johannes D., Reindl, Caroline, Rampp, Stefan, Maslarova, Anna, Brandner, Sebastian, Hock, Stefan, Muehlen, Iris, Doerfler, Arnd, Kuramatsu, Joji B., Schwab, Stefan, Huttner, Hagen B., Sprügel, Maximilian I., and Hamer, Hajo M.

Subjects
INTRACEREBRAL hematoma, CEREBRAL hemorrhage, EPILEPSY, HEMATOMA, TEMPORAL lobectomy, VOICE mail systems, TELEPHONE interviewing, PEDIATRIC surgery
Abstract

Aim: The aim of this study was to re‐evaluate risk factors for post‐ICH epilepsy (PICHE) and examine the impact of surgical hematoma evacuation on epilepsy development after ICH. Background and purpose: Epilepsy is a common complication after intracerebral hemorrhage (ICH). Information on risk factors is still scarce and the role of ICH evacuation remains uncertain. Methods: We retrospectively included patients with spontaneous ICH treated in our hospital in 2006–2019. Patients' medical records were analyzed. In addition, mailed questionnaires and telephone interviews were used to complete the dataset. Uni‐ and multivariable hazard ratios (HRs) were applied to investigate risk factors for PICHE and the impact of surgical ICH evacuation. Results: Among 587 ICH patients available for analyses, 139 (23.7%) developed PICHE (mean follow‐up 1795 ± 1378 days). The median time of epilepsy onset was 7 months after ICH (range 1–132 months). Risk factors associated with PICHE were cortical hemorrhage (multivariable HR 1.65 [95% CI 1.14–2.37]; p = 0.008), ICH volume > 10 ml (multivariable HR 1.91 [95% CI 1.33–2.73]; p < 0.001) and acute symptomatic seizures (multivariable HR 1.81 [95% CI 1.20–2.75]; p = 0.005). Patients with cortical ICH > 10 ml who underwent surgical hematoma evacuation were less likely to develop epilepsy than those with conservative treatment alone (multivariable HR 0.26 [95% CI 0.08–0.84]; p = 0.025). Conclusions: Post‐ICH epilepsy is frequent and predicted by large cortical ICH and acute symptomatic seizures. Hematoma evacuation reduced the risk of PICHE by more than 70% in patients with large cortical ICH. This finding could be considered in the clinical decision making on the acute treatment of ICH. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

37. Oral Anticoagulation and Functional Outcome after Intracerebral Hemorrhage

Author

Biffi, Alessandro, Kuramatsu, Joji B., Leasure, Audrey, Kamel, Hooman, Kourkoulis, Christina, Schwab, Kristin, Ayres, Alison M., Elm, Jordan, Gurol, M. Edip, Greenberg, Steven M., Viswanathan, Anand, Anderson, Christopher D., Schwab, Stefan, Rosand, Jonathan, Testai, Fernando D., Woo, Daniel, Huttner, Hagen B., and Sheth, Kevin N

Published
2017
Full Text
View/download PDF

39. Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy.

Author

Sembill, Jochen A., Lusse, Christoph, Linnerbauer, Mathias, Sprügel, Maximilian I., Mrochen, Anne, Knott, Michael, Engelhorn, Tobias, Schmidt, Manuel Alexander, Doerfler, Arnd, Oberstein, Timo Jan, Maler, Juan Manuel, Kornhuber, Johannes, Lewczuk, Piotr, Rothhammer, Veit, Schwab, Stefan, and Kuramatsu, Joji B.

Published
2023
Full Text
View/download PDF

43. Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage: an individual participant data meta-analysis

Author

Kuramatsu, Joji B, Gerner, Stefan T, Falcone, Guido J, Selim, Magdy H, Lioutas, Vasileios-Arsenios, Endres, Matthias, Zweynert, Sarah, Vajkoczy, Peter, Ringleb, Peter A, Purrucker, Jan C, Volkmann, Jens, Neugebauer, Hermann, Ziai, Wendy, Erbguth, Frank, Schellinger, Peter D, Knappe, Ulrich J, Fink, Gereon R, Dohmen, Christian, Minnerup, Jens, Reichmann, Heinz, Schneider, Hauke, Röther, Joachim, Reimann, Gernot, Bardutzky, Jürgen, Schwarz, Michael, Bäzner, Hansjörg, Claßen, Joseph, Michalski, Dominik, Witte, Otto W, Günther, Albrecht, Hamann, Gerhard F, Lücking, Hannes, Dörfler, Arnd, Ishfaq, Muhammad Fawad, Sembill, Jochen A, Chang, Jason J, Testai, Fernando D, Woo, Daniel, Alexandrov, Andrei V, Staykov, Dimitre, Goyal, Nitin, Tsivgoulis, Georgios, Sheth, Kevin N, Awad, Issam A, Schwab, Stefan, Sprügel, Maximilian I, Hanley, Daniel F, Huttner, Hagen B, Collaborators, Sansing, Lauren, Matouk, Charles C, Leasure, Audrey, Sobesky, Jan, Bauer, Miriam, Schurig, Johannes, Rizos, Timolaos, Mrochen, Anne, Haeusler, Karl Georg, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, Stösser, Sebastian, Ludolph, Albert, Nueckel, Martin, Glahn, Jörg, Stetefeld, Henning, Rahmig, Jan, Kölbl, Kathrin, Fisse, Anna Lena, Michels, Peter, Schwert, Henning, Hagemann, Georg, Rakers, Florian, Wöhrle, Johannes C, Alshammari, Fahid, Horn, Markus, Bahner, Dirk, Urbanek, Christian, Ram, Malathi, Palm, Frederick, Grau, Armin, and Avadhani, Radhika

Subjects
Advanced and Specialized Nursing, drug therapy [Cerebral Hemorrhage], Fibrinolysis, diagnostic imaging [Cerebral Hemorrhage], intracerebral hemorrhage, mortality, Observational Studies as Topic, Treatment Outcome, Fibrinolytic Agents, standard of care, Drainage, Humans, Neurology (clinical), methods [Drainage], ddc:610, Cardiology and Cardiovascular Medicine, hydrocephalus, Cerebral Hemorrhage, Hydrocephalus
Abstract

Background: In patients with intracerebral hemorrhage (ICH), the presence of intraventricular hemorrhage constitutes a promising therapeutic target. Intraventricular fibrinolysis (IVF) reduces mortality, yet impact on functional disability remains unclear. Thus, we aimed to determine the influence of IVF on functional outcomes. Methods: This individual participant data meta-analysis pooled 1501 patients from 2 randomized trials and 7 observational studies enrolled during 2004 to 2015. We compared IVF versus standard of care (including placebo) in patients treated with external ventricular drainage due to acute hydrocephalus caused by ICH with intraventricular hemorrhage. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS; range: 0–6, lower scores indicating less disability) at 6 months, dichotomized into mRS score: 0 to 3 versus mRS: 4 to 6. Secondary outcomes included ordinal-shift analysis, all-cause mortality, and intracranial adverse events. Confounding and bias were adjusted by random effects and doubly robust models to calculate odds ratios and absolute treatment effects (ATE). Results: Comparing treatment of 596 with IVF to 905 with standard of care resulted in an ATE to achieve the primary outcome of 9.3% (95% CI, 4.4–14.1). IVF treatment showed a significant shift towards improved outcome across the entire range of mRS estimates, common odds ratio, 1.75 (95% CI, 1.39–2.17), reduced mortality, odds ratio, 0.47 (95% CI, 0.35–0.64), without increased adverse events, absolute difference, 1.0% (95% CI, −2.7 to 4.8). Exploratory analyses provided that early IVF treatment (≤48 hours) after symptom onset was associated with an ATE, 15.2% (95% CI, 8.6–21.8) to achieve the primary outcome. Conclusions: As compared to standard of care, the administration of IVF in patients with acute hydrocephalus caused by intracerebral and intraventricular hemorrhage was significantly associated with improved functional outcome at 6 months. The treatment effect was linked to an early time window

Published
2022

49. Hematoma enlargement characteristics in deep versus lobar intracerebral hemorrhage

Author

Sembill, Jochen A., Kuramatsu, Joji B., Gerner, Stefan T., Sprügel, Maximilian I., Roeder, Sebastian S., Madžar, Dominik, Hagen, Manuel, Hoelter, Philip, Lücking, Hannes, Dörfler, Arnd, Schwab, Stefan, and Huttner, Hagen B.

Subjects
Aged, 80 and over, Male, Clinical Trials as Topic, Hematoma, Vitamin K, Anticoagulants, Neurosciences. Biological psychiatry. Neuropsychiatry, Middle Aged, nervous system diseases, Cohort Studies, Germany, Humans, Female, Single-Blind Method, Registries, cardiovascular diseases, Neurology. Diseases of the nervous system, RC346-429, Cerebrum, Research Articles, Research Article, Aged, Cerebral Hemorrhage, Cerebral Intraventricular Hemorrhage, RC321-571
Abstract

Objective Hematoma enlargement (HE) is associated with clinical outcomes after supratentorial intracerebral hemorrhage (ICH). This study evaluates whether HE characteristics and association with functional outcome differ in deep versus lobar ICH. Methods Pooled analysis of individual patient data between January 2006 and December 2015 from a German‐wide cohort study (RETRACE, I + II) investigating ICH related to oral anticoagulants (OAC) at 22 participating centers, and from one single‐center registry (UKER‐ICH) investigating non‐OAC‐ICH patients. Altogether, 1954 supratentorial ICH patients were eligible for outcome analyses, which were separately conducted or controlled for OAC, that is, vitamin‐K‐antagonists (VKA, n = 1186) and non‐vitamin‐K‐antagonist‐oral‐anticoagulants (NOAC, n = 107). Confounding was addressed using propensity score matching, cox regression modeling and multivariate modeling. Main outcomes were occurrence, extent, and timing of HE (>33%/>6 mL) and its association with 3‐month functional outcome. Results Occurrence of HE was not different after deep versus lobar ICH in patients with non‐OAC‐ICH (39/356 [11.0%] vs. 36/305 [11.8%], P = 0.73), VKA‐ICH (249/681 [36.6%] vs. 183/505 [36.2%], P = 0.91), and NOAC‐ICH (21/69 [30.4%] vs. 12/38 [31.6%], P = 0.90). HE extent did not differ after non‐OAC‐ICH (deep:+59% [40–122] vs. lobar:+74% [37–124], P = 0.65), but both patients with VKA‐ICH and NOAC‐ICH showed greater HE extent after deep ICH [VKA‐ICH, deep: +94% [54–199] vs. lobar: +56% [35–116], P

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results