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36 results on '"Lagana, Bruno"'

1. Booster dose of SARS-CoV-2 messenger RNA vaccines strengthens the specific immune response of patients with rheumatoid arthritis: A prospective multicenter longitudinal study

Author

Farroni, Chiara, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Laganà, Bruno, Petruccioli, Elisa, Agrati, Chiara, Garbuglia, Anna Rosa, Meschi, Silvia, Lapa, Daniele, Cuzzi, Gilda, Petrone, Linda, Vanini, Valentina, Salmi, Andrea, Altera, Anna Maria Gerarda, Repele, Federica, Grassi, Germana, Bettini, Aurora, Vita, Serena, Mariano, Andrea, Damiani, Arianna, Infantino, Maria, Grossi, Valentina, Manfredi, Mariangela, Niccoli, Laura, Puro, Vincenzo, Rosa, Roberta Di, Salemi, Simonetta, Sesti, Giorgio, Scolieri, Palma, Bruzzese, Vincenzo, Benucci, Maurizio, Cantini, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Published
2022
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3. Enteropathic spondyloarthritis: Results from a large nationwide database analysis

Author

Zullo, Angelo, Caso, Francesco, Costa, Luisa, Tomietto, Paola, Fabio, Fischetti, Scolieri, Palma, Navarini, Luca, Cuccagna, Elisa, Severino Martin-Martin, Luis, Lia Scribano, Maria, Faggiani, Roberto, Pagnini, Cristiano, Mocci, Giammarco, Demurtas, Mauro, Tursi, Antonio, Festa, Stefano, Zerboni, Giulia, Pica, Roberta, Ridola, Lorenzo, Paroli, Marino, Baccini, Flavia, Baincone, Livia, Gabrielli, Armando, Afeltra, Antonella, Scarpa, Raffaele, Picchianti-Diamanti, Andrea, Lorenzetti, Roberto, Chimenti, Maria Sole, Luchetti, Michele Maria, Conigliaro, Paola, Canofari, Claudia, Benfaremo, Devis, Bruzzese, Vincenzo, Laganà, Bruno, and Perricone, Roberto

Published
2020
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4. Anti-polysaccharide and anti-diphtheria protective antibodies after 13-valent pneumococcal conjugate vaccination in rheumatoid arthritis patients under immunosuppressive therapy

Author

Caporuscio, Sara, Ieraci, Roberto, Valesini, Guido, Teloni, Raffaela, Mariotti, Sabrina, Spinelli, Francesca Romana, Ferlito, Claudia, Salemi, Simonetta, Picchianti Diamanti, Andrea, Meneguzzi, Giorgia, Markovic, Milica, Sgrulletti, Mayla, von Hunolstein, Christina, Ralli, Luisa, Pinto, Antonietta, Salerno, Gerardo, Canzoni, Marco, Sorgi, Maria Laura, Laganà, Bruno, Di Rosa, Roberta, Nisini, Roberto, and D'Amelio, Raffaele

Published
2018
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8. Myocardial Infarction with Normal Coronary Arteries in a Patient with Primary Antiphospholipid Syndrome: Case Report and Literature Review

Author

Lagana, Bruno, Baratta, Luigi, Tubani, Luigi, Golluscio, Vincenzina, Delfino, Massimo, and Fanelli, Filippo Rossi

Subjects
Heart attack -- Causes of -- Complications and side effects -- Risk factors, Antiphospholipid syndrome -- Complications and side effects -- Risk factors, Blood clot -- Risk factors -- Complications and side effects, Thrombosis -- Risk factors -- Complications and side effects, Health
Abstract

Primary antiphospholipid syndrome is associated with an increased risk of vascular thrombosis. The authors describe a young patient without any risk factor for coronary artery disease who was admitted to [...]

Published
2001

13. Classical test theory and Rasch analysis validation of the Recent-Onset Arthritis Disability questionnaire in rheumatoid arthritis patients

Author

Salaffi, F, Franchignoni, F, Giordano, A, Ciapetti, A, Gasparini, S, Ottonello, M, 'NEW INDICES' Study Group, Lagana', Bruno, Fausto, Salaffi, Franco, Franchignoni, Andrea, Giordano, Alessandro, Ciapetti, Stefania, Gasparini, Marcella, Ottonello, and Scarpa, Raffaele

Subjects
Adult, Male, Questionnaires, medicine.medical_specialty, Activities of daily living, Settore MED/16 - REUMATOLOGIA, Psychometrics, Motor Activity, Severity of Illness Index, Classical test theory, Arthritis, Rheumatoid, Disability Evaluation, Rheumatology, Surveys and Questionnaires, Rheumatoid, Activities of Daily Living, Outpatients, Medicine, Humans, Aged, Rasch model, business.industry, Arthritis, Reproducibility of Results, General Medicine, Middle Aged, Explained variation, Confirmatory factor analysis, Physical therapy, Patient-reported outcome, Observational study, Female, business
Abstract

Disability has been identified as a core outcome measure in rheumatoid arthritis (RA). The aim of this study was to perform a comprehensive psychometric analysis of the Recent-Onset Arthritis Disability (ROAD) questionnaire in patients with RA. The questionnaire was completed by 583 patients with RA: 196 subjects participating in the NEW INDICES study and 387 subjects who were taking part in a long-term observational study. At confirmatory factor analysis for categorical data, data fit for a three-factor model was adequate to good (non-normed fit index = 0.98, comparative fit index = 0.99, root mean square error of approximation = 0.079, standardized root mean square residual = 0.047), with standardized item-to-factor loadings ranging from 0.60 to 0.90 and a cumulative explained variance of 83 %. The bifactor model of ROAD presented a clean independent cluster structure. The loadings in the unidimensional model were very similar to those on the general factor in the bifactor model. Rasch analysis showed a correct functioning of rating categories, a good fit of the data to the model for all three subscales, and satisfactory separation indexes and respective reliability (for both persons and items). This study, using both classical test theory and Rasch analysis methods, provides psychometric evidence of the reliability and internal and structural validity of ROAD in RA patients. Our results support the use of separate subscores for upper limb function, lower limb function, and activities of daily living/work, and the appropriateness of reporting an overall score (i.e., the mean of the three subscales).

Published
2013

19. Microscopic polyangiitis with sexual and reproductive system involvement: first description of a case

Author

ROCCHIETTI MARCH, Massimiliano, DEL PORTO, Flavia, Proietta, M, Lagana', Bruno, D'Amelio, Raffaele, Aliberti, Giuseppe, and Trappolini, Massimo

Subjects
Pathology, medicine.medical_specialty, biology, business.industry, Cytoplasmic ANCA, medicine.disease, respiratory tract diseases, Peripheral neuropathy, immune system diseases, Myeloperoxidase, Necrotizing Vasculitis, Emergency Medicine, Internal Medicine, medicine, biology.protein, In patient, cardiovascular diseases, Reproductive system, skin and connective tissue diseases, Microscopic polyangiitis, business, Systemic vasculitis
Abstract

Microscopic polyangiitis (MPA) is a rare systemic vasculitis with an incidence of about 1–3/100,000/year [1]. MPA is defined as a necrotizing vasculitis, with few or no immune deposits, primarily affecting small vessels including capillaries, venules or arterioles [2]. MPA mainly affects kidneys and lungs, nevertheless cutaneous vasculitis, musculoskeletal symptoms, gastrointestinal involvement and peripheral neuropathy also occur [3]. Circulating antineutrophil cytoplasm antibodies (ANCA) are present in about 74.5% of patients with MPA, mainly perinuclear ANCA with specificity for myeloperoxidase (p-ANCA) [4], more rarely, in about 40% of the cases, cytoplasmic ANCA with specificity to proteinase-3 (c-ANCA) are present [5]. Depending on the extent of systemic vascular involvement, clinical findings can be quite variable; nevertheless, sexual and reproductive system involvement in patients with MPA has not previously been reported. Case report

Published
2008

27. Capacitive seat sensors for multiple occupancy detection using a low-cost setup.

Author

Zeeman, Adriaan S., Booysen, Marthinus J., Ruggeri, Giuseppe, and Lagana, Bruno

Abstract

The Minibus public transportation sector and road safety remains a significant challenge in Africa. We propose a low cost system to monitor the taxi industry and encourage safe driving. A low cost capacitive proximity sensor for seat occupancy detection based on the loading mode capacitive sensing technique is designed. The capacitive sensor uses a single electrode to detect an occupant. We use ZigBee modules for a dynamic wireless system integration where sensors can be added or removed without modifications. A mathematical model of the capacitive sensor is developed and we determine the capacitance on the sensor's electrode. The occupied capacitance is double the unoccupied capacitance. Our results show that the proposed capacitive sensor can distinguish clearly between an unoccupied and occupied seat. [ABSTRACT FROM PUBLISHER]

Published
2013
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28. Autoimmune disorders:a concept of treatment based on mechanisms of disease.

Author

Miesher, Peter A., Zavota, Laura, Ossandon, Alejandra, and Lagana, Bruno

Subjects
AUTOIMMUNE disease treatment, AUTOIMMUNITY, IMMUNOPATHOLOGY, IMMUNE response, IMMUNOSUPPRESSIVE agents, DRUG monitoring
Abstract

Focuses on the concept of treating autoimmune disorders based on the mechanisms of the disease. History of autoimmunity; Type of immune response involved in the autoantigen-driven immunopathology; Selection of appropriate immunosuppressive drugs and strategies of treatment, monitoring of drug toxicity, and importance of environmental factors.

Published
2003
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30. Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications.

Author

Pagnini, Cristiano, Picchianti-Diamanti, Andrea, Bruzzese, Vincenzo, Lorenzetti, Roberto, Luchetti, Michele Maria, Martin Martin, Louis Severino, Pica, Roberta, Scolieri, Palma, Scribano, Maria Lia, Zampaletta, Costantino, Chimenti, Maria Sole, Lagana, Bruno, and Nakase, Hiroshi

Subjects
INFLAMMATORY bowel diseases, VITAMIN D, VITAMIN D deficiency, DIETARY supplements, VITAMIN D receptors, BONE metabolism
Abstract

In the last decades, the comprehension of the pathophysiology of bone metabolism and its interconnections with multiple homeostatic processes has been consistently expanded. The branch of osteoimmunology specifically investigating the link between bone and immune system has been developed. Among molecular mediators potentially relevant in this field, vitamin D has been recently pointed out, and abnormalities of the vitamin D axis have been described in both in vitro and in vivo models of inflammatory bowel diseases (IBD) and arthritis. Furthermore, vitamin D deficiency has been reported in patients affected by IBD and chronic inflammatory arthritis, thus suggesting the intriguing possibility of impacting the disease activity by the administration vitamin D supplements. In the present review, the complex interwoven link between vitamin D signaling, gut barrier integrity, microbiota composition, and the immune system was examined. Potential clinical application exploiting vitamin D pathway in the context of IBD and arthritis is presented and critically discussed. A more detailed comprehension of the vitamin D effects and interactions at molecular level would allow one to achieve a novel therapeutic approach in gastro-rheumatologic inflammatory diseases through the design of specific trials and the optimization of treatment protocols. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Intra-articular injection of hyaluronic acid (MW 1,500-2,000 kDa; HyalOne) in symptomatic osteoarthritis of the hip: a prospective cohort study.

Author

Migliore A, Massafra U, Bizzi E, Lagana B, Germano V, Piscitelli P, Granata M, and Tormenta S

Subjects
Cohort Studies, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Molecular Weight, Osteoarthritis, Hip complications, Prospective Studies, Hyaluronic Acid administration & dosage, Osteoarthritis, Hip drug therapy, Viscosupplements administration & dosage
Abstract

Introduction: Clinical trials have demonstrated the safety and efficacy of hyaluronic acid-based products for the treatment of hip osteoarthritis, but data from observational studies of normal medical practice are scarce. This study investigated the long-term efficacy and tolerability of ultrasound-guided intra-articular sodium hyaluronate (MW 1,500-2,000 kDa; Hyalone) injections in daily clinical practice., Methods: In this observational, cohort study of patients with hip osteoarthritis, Hyalone was administered under the ultrasound guidance, every 6 months, with the possibility of an additional injection at the intervening 3-month intervals on clinical request. Efficacy measurements included the Lequesne algofunctional index, self-reported pain via the visual analogue scale (VAS), the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and safety. The patients were followed up for 18 months after the first intra-articular injection., Results: Data from 120 patients were collected. During the study, a statistically significant reduction in algofunctional indexes was demonstrated at 3 months after study product injection, while at 12 months 80% of the patients achieved a decrease of at least 30% in symptoms. These results were maintained over time through cyclical and personalized repetition of ultrasound guided injections, at least one injection every 6 months., Conclusions: The study treatment reduced pain and improved mobility in osteoarthritis of the hip. These results in daily clinical practice demonstrate a beneficial effect and the safety of the study product and suggest adding intra-articular injections of HyalOne to the armamentarium of conservative management of symptomatic hip osteoarthritis.

Published
2011
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