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413 results on '"Lalu, Manoj M."'

4. Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions

Author

Sharma, Neha, Chwastek, Damian, Dwivedi, Dhruva J., Schlechte, Jared, Yu, Ian-Ling, McDonald, Braedon, Arora, Jaskirat, Cani, Erblin, Eng, Mikaela, Engelberts, Doreen, Kuhar, Eva, Medeiros, Sarah K., Bourque, Stephane L., Cepinskas, Gediminas, Gill, Sean E., Jahandideh, Forough, Macala, Kimberly F., Panahi, Sareh, Pape, Cynthia, Sontag, David, Sunohara-Neilson, Janet, Fergusson, Dean A., Fox-Robichaud, Alison E., Liaw, Patricia C., Lalu, Manoj M., and Mendelson, Asher A.

Published
2023
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9. Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis

Author

Verret, Michael, Le, John B.P., Lalu, Manoj M., Jeffers, Matthew S., McIsaac, Daniel I., Nicholls, Stuart G., Turgeon, Alexis F., Ramchandani, Rashi, Li, Hongda, Hutton, Brian, Zivkovic, Fiona, Graham, Megan, Lê, Maxime, Geist, Allison, Bérubé, Mélanie, O'Hearn, Katie, Gilron, Ian, Poulin, Patricia, Daudt, Helena, Martel, Guillaume, McVicar, Jason, Moloo, Husein, and Fergusson, Dean A.

Published
2024
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27. A qualitative evaluation of treatment fidelity alongside a pilot trial of a novel therapy for pediatric Inflammatory Bowel Disease.

Author

Olson, Jenny L., Castillo, Gisell, Palumbo, Amelia, Harrison, Megan, Singleton, Ruth, Lalu, Manoj M., Fergusson, Dean A., Stintzi, Alain, Mack, David R., and Presseau, Justin

Subjects
INFLAMMATORY bowel diseases, GUT microbiome, PEDIATRIC therapy, STUDENT activities, SEMI-structured interviews
Abstract

Background: Process evaluations conducted alongside clinical trials can improve understanding of treatment fidelity and provide contextual knowledge to aide interpretations of trial outcomes. We adopted a multiple-goals perspective to investigate treatment fidelity in two related pilot clinical trials of an adjuvant treatment for pediatric-onset Inflammatory Bowel Disease. This included a focus on barriers and enablers of performing trial-specific activities and of integrating those activities into daily life. Methods: We conducted one-time semi-structured interviews with a sub-sample of participants of the Resistant Starch in Pediatric Inflammatory Bowel Disease (NCT04522271) and Optimized Resistant Starch in Inflammatory Bowel Disease pilot trials (NCT04520594) and their caregivers (N = 42). The trials examined the effects of personalized food-derived resistant starches as an adjuvant therapy on intestinal microbiome functioning. Interviews were conducted within 3-months of participants completing or withdrawing from the trials. Interview guides with age-appropriate language were developed and pilot tested. Codes were identified inductively though conventional content analysis and then mapped to personal projects analysis, to explore how participants navigated between activities. Results: Three themes were identified. The first described the potential impact of living with inflammatory bowel disease and taking prescribed medications. The second described characteristics of trial-specific activities that might impact on their enactment, including perceived difficulty, and challenges following procedures or using trial materials. The third described the integration of trial-specific activities with school, work, household demands, and social, and extracurricular activities. Conclusions: Adjusting to living with inflammatory bowel disease and managing its treatment can impact trial participation. Integrating trial-related activities into daily life can be challenging, which could heighten perceptions of goal conflict. Findings can inform interpretations of trial outcomes and development of strategies for trial optimization and implementation of the adjuvant therapy into clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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28. A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury.

Author

Kuhar, Eva, Chander, Nikesh, Stewart, Duncan J., Jahandideh, Forough, Haibo Zhang, Kristof, Arnold S., Bastarache, Julie A., Schmidt, Eric P., Taljaard, Monica, Thebaud, Bernard, Engelberts, Doreen, Fergusson, Dean A., and Lalu, Manoj M.

Subjects
SEX (Biology), LUNG injuries, LIPOPOLYSACCHARIDES
Abstract

It is unclear what effect biological sex has on outcomes of acute lung injury (ALI). Clinical studies are confounded by their observational design. We addressed this knowledge gap with a preclinical systematic review of ALI animal studies. We searched MEDLINE and Embase for studies of intratracheal/intranasal/aerosolized lipopolysaccharide administration (the most common ALI model) that reported sex-stratified data. Screening and data extraction were conducted in duplicate. Our primary outcome was histological tissue injury and secondary outcomes included alveolar-capillary barrier alterations and inflammatory markers. We used a random-effects inverse variance meta-analysis, expressing data as standardized mean difference (SMD) with 95% confidence intervals (CIs). Risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. We identified six studies involving 132 animals across 11 independent experiments. A total of 41 outcomes were extracted, with the direction of effect suggesting greater severity in males than females in 26/41 outcomes (63%). One study reported on lung histology and found that male mice exhibited greater injury than females (SMD: 1.61, 95% CI: 0.53–2.69). Meta-analysis demonstrated significantly elevated albumin levels (SMD: 2.17, 95% CI: 0.63–3.70) and total cell counts (SMD: 0.80, 95% CI: 0.27–1.33) in bronchoalveolar lavage fluid from male mice compared with female mice. Most studies had an “unclear risk of bias.” Our findings suggest sex-related differences in ALI severity. However, these conclusions are drawn from a small number of animals and studies. Further research is required to address the fundamental issue of biological sex differences in LPS-induced ALI. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Author

Page, Matthew J., McKenzie, Joanne E., Bossuyt, Patrick M., Boutron, Isabelle, Hoffmann, Tammy C., Mulrow, Cynthia D., Shamseer, Larissa, Tetzlaff, Jennifer M., Akl, Elie A., Brennan, Sue E., Chou, Roger, Glanville, Julie, Grimshaw, Jeremy M., Hróbjartsson, Asbjørn, Lalu, Manoj M., Li, Tianjing, Loder, Elizabeth W., Mayo-Wilson, Evan, McDonald, Steve, McGuinness, Luke A., Stewart, Lesley A., Thomas, James, Tricco, Andrea C., Welch, Vivian A., Whiting, Penny, and Moher, David

Published
2021
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46. What guidance exists to support patient partner compensation practices? A scoping review of available policies and guidelines.

Author

Fox, Grace, Fergusson, Dean A., Sadeknury, Ahmed, Nicholls, Stuart G., Smith, Maureen, Stacey, Dawn, and Lalu, Manoj M.

Subjects
HEALTH policy, MEETINGS, SOCIAL support, PATIENT participation, HEALTH services accessibility, MANUSCRIPTS, SYSTEMATIC reviews, MEDICAL protocols, SPOUSES, HEALTH insurance reimbursement, INTERPROFESSIONAL relations, RESEARCH funding, LITERATURE reviews, GREY literature
Abstract

Background: An integral aspect of patient engagement in research, also known as patient and public involvement, is appropriately recognising patient partners for their contributions through compensation (e.g., coauthorship, honoraria). Despite known benefits to compensating patient partners, our previous work suggested compensation is rarely reported and researchers perceive a lack of guidance on this issue. To address this gap, we identified and summarised available guidance and policy documents for patient partner compensation. Methods: We conducted this scoping review in accordance with methods suggested by the JBI. We searched the grey literature (Google, Google Scholar) in March 2022 and Overton (an international database of policy documents) in April 2022. We included articles, guidance or policy documents regarding the compensation of patient partners for their research contributions. Two reviewers independently extracted and synthesised document characteristics and recommendations. Results: We identified 65 guidance or policy documents. Most documents were published in Canada (57%, n = 37) or the United Kingdom (26%, n = 17). The most common recommended methods of nonfinancial compensation were offering training opportunities to patient partners (40%, n = 26) and facilitating patient partner attendance at conferences (38%, n = 25). The majority of guidance documents (95%) suggested financially compensating (i.e., offering something of monetary value) patient partners for their research contributions. Across guidance documents, the recommended monetary value of financial compensation was relatively consistent and associated with the role played by patient partners and/or specific engagement activities. For instance, the median monetary value for obtaining patient partner feedback (i.e., consultation) was $19/h (USD) (range of $12–$50/h). We identified several documents that guide the compensation of specific populations, including youth and Indigenous peoples. Conclusion: Multiple publicly available resources exist to guide researchers, patient partners and institutions in developing tailored patient partner compensation strategies. Our findings challenge the perception that a lack of guidance hinders patient partner financial compensation. Future efforts should prioritise the effective implementation of these compensation strategies to ensure that patient partners are appropriately recognised. Patient or Public Contributions: The patient partner coauthor informed protocol development, identified data items, and interpreted findings. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Predatory journals: no definition, no defence

Author

Grudniewicz, Agnes, Moher, David, Cobey, Kelly D., Bryson, Gregory L., Cukier, Samantha, Allen, Kristiann, Ardern, Clare, Balcom, Lesley, Barros, Tiago, Berger, Monica, Ciro, Jairo Buitrago, Cugusi, Lucia, Donaldson, Michael R., Egger, Matthias, Graham, Ian D., Hodgkinson, Matt, Khan, Karim M., Mabizela, Mahlubi, Manca, Andrea, Milzow, Katrin, Mouton, Johann, Muchenje, Marvelous, Olijhoek, Tom, Ommaya, Alexander, Patwardhan, Bhushan, Poff, Deborah, Proulx, Laurie, Rodger, Marc, Severin, Anna, Strinzel, Michaela, Sylos-Labini, Mauro, Tamblyn, Robyn, van Niekerk, Marthie, Wicherts, Jelte M., and Lalu, Manoj M.

Published
2019
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48. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians*

Author

McGinn, Ryan, Fergusson, Dean A., Stewart, Duncan J., Kristof, Arnold S., Barron, Carly C., Thebaud, Bernard, McIntyre, Lauralyn, Stacey, Dawn, Liepmann, Mark, Dodelet-Devillers, Aurore, Zhang, Haibo, Renlund, Richard, Lilley, Elliot, Downey, Gregory P., Brown, Earl G., Côté, Lucie, dos Santos, Claudia C., Fox-Robichaud, Alison E., Hussain, Sabah N.A., Laffey, John G., Liu, Mingyao, MacNeil, Jenna, Orlando, Holly, Qureshi, Salman T., Turner, Patricia V., Winston, Brent W., and Lalu, Manoj M.

Published
2021
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