626 results on '"Langley, Monica"'
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2. High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system
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Langley, Monica R., Yoon, Hyesook, Kim, Ha Neui, Choi, Chan-Il, Simon, Whitney, Kleppe, Laurel, Lanza, Ian R., LeBrasseur, Nathan K., Matveyenko, Aleksey, and Scarisbrick, Isobel A.
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- 2020
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3. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease
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Sarkar, Souvarish, Nguyen, Hai M., Malovic, Emir, Luo, Jie, Langley, Monica, Palanisamy, Bharathi N., Singh, Neeraj, Manne, Sireesha, Neal, Matthew, Gabrielle, Michelle, Abdalla, Ahmed, Anantharam, Poojya, Rokad, Dharmin, Panicker, Nikhil, Singh, Vikrant, Ay, Muhammet, Charli, Adhithiya, Harischandra, Dilshan, Jin, Lee-Way, Jin, Huajun, Rangaraju, Srikant, Anantharam, Vellareddy, Wulff, Heike, and Kanthasamy, Anumantha G.
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Thermo Fisher Scientific Inc. ,B cells -- Genetic aspects ,Health care industry ,Iowa State University - Abstract
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease progression. Here, we demonstrated that microglial Kv1.3, a voltage-gated potassium channel, was transcriptionally upregulated in response to aggregated [alpha]-synuclein ([alpha][Syn.sub.Agg]) stimulation in primary microglial cultures and animal models of PD, as well as in postmortem human PD brains. Patch-clamp electrophysiological studies confirmed that the observed Kv1.3 upregulation translated to increased Kv1.3 channel activity. The kinase Fyn, a risk factor for PD, modulated transcriptional upregulation and posttranslational modification of microglial Kv1.3. Multiple state-of-the-art analyses, including Duolink proximity ligation assay imaging, revealed that Fyn directly bound to Kv1.3 and posttranslationally modified its channel activity. Furthermore, we demonstrated the functional relevance of Kv1.3 in augmenting the neuroinflammatory response by using Kv1.3-KO primary microglia and the Kv1.3-specific small-molecule inhibitor PAP-1, thus highlighting the importance of Kv1.3 in neuroinflammation. Administration of PAP-1 significantly inhibited neurodegeneration and neuroinflammation in multiple animal models of PD. Collectively, our results imply that Fyn-dependent regulation of Kv1.3 channels plays an obligatory role in accentuating the neuroinflammatory response in PD and identify Kv1.3 as a potential therapeutic target for PD., Introduction Parkinson's disease (PD) is a complex neurodegenerative disorder that is characterized mainly by the slow and progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region [...]
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- 2020
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4. Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson's disease.
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Ay, Muhammet, Charli, Adhithiya, Langley, Monica, Ahyoung Jang, Padhi, Piyush, Huajun Jin, Anantharam, Vellareddy, Kalyanaraman, Balaraman, Kanthasamy, Arthi, and Kanthasamy, Anumantha G.
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PARKINSON'S disease ,CELL culture ,CELL death ,ANIMAL culture ,CELL communication ,MITOCHONDRIA ,PROTEIN kinases ,DOPAMINE - Abstract
Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson's disease (PD). Thus, identifying the key signaling mechanisms regulating mitochondrial biogenesis is crucial to developing new treatment strategies for PD. We previously reported that protein kinase D1 (PKD1) activation protects against neuronal cell death in PD models by regulating mitochondrial biogenesis. To further harness the translational drug discovery potential of targeting PKD1-mediated neuroprotective signaling, we synthesized mito-metformin (Mito-Met), a mitochondria-targeted analog derived from conjugating the anti-diabetic drug metformin with a triphenylphosphonium functional group, and then evaluated the preclinical efficacy of Mito-Met in cell culture and MitoPark animal models of PD. Mito-Met (100-300 nM) significantly activated PKD1 phosphorylation, as well as downstream Akt and AMPKa phosphorylation, more potently than metformin, in N27 dopaminergic neuronal cells. Furthermore, treatment with Mito-Met upregulated the mRNA and protein expression of mitochondrial transcription factor A (TFAM) implying that Mito-Met can promote mitochondrial biogenesis. Interestingly, Mito-Met significantly increased mitochondrial bioenergetics capacity in N27 dopaminergic cells. Mito-Met also reduced mitochondrial fragmentation induced by the Parkinsonian neurotoxicant MPP+ in N27 cells and protected against MPP+-induced TH-positive neurite loss in primary neurons. More importantly, Mito-Met treatment (10mg/kg, oral gavage for 8 week) significantly improved motor deficits and reduced striatal dopamine depletion in MitoPark mice. Taken together, our results demonstrate that Mito-Met possesses profound neuroprotective effects in both in vitro and in vivo models of PD, suggesting that pharmacological activation of PKD1 signaling could be a novel neuroprotective translational strategy in PD and other related neurocognitive diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson’s disease: Relevance to gene and environment interactions in metal neurotoxicity
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Langley, Monica R., Ghaisas, Shivani, Ay, Muhammet, Luo, Jie, Palanisamy, Bharathi N., Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, and Kanthasamy, Anumantha G.
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- 2018
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6. Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study
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Ghaisas, Shivani, Harischandra, Dilshan S., Palanisamy, Bharathi, Proctor, Alexandra, Jin, Huajun, Dutta, Somak, Sarkar, Souvarish, Langley, Monica, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Phillips, Gregory J., and Kanthasamy, Anumantha
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Manganese -- Environmental aspects -- Health aspects ,Nerves, Peripheral -- Health aspects -- Models ,Mitochondria -- Physiological aspects -- Health aspects ,Digestive system diseases -- Risk factors -- Models ,Environmental issues ,Health - Abstract
Background: Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) have yet to be assessed. Objective: We examined the effect of Mn on the ENS using both cell and animal models. Method: Rat enteric glial cells (EGCs) and mouse primary enteric cultures were exposed to increasing concentrations of Mn and cell viability and mitochondrial health were assessed using various morphological and functional assays. C57BL/6 mice were exposed daily to a sublethal dose of Mn (15 mg/kg/d) for 30 d. Gut peristalsis, enteric inflammation, gut microbiome profile, and fecal metabolite composition were assessed at the end of exposure. Results: EGC mitochondria were highly susceptible to Mn neurotoxicity, as evidenced by lower mitochondrial mass, adenosine triphosphate-linked respiration, and aconitase activity as well as higher mitochondrial superoxide, upon Mn exposure. Minor differences were seen in the mouse model: specifically, longer intestinal transit times and higher levels of colonic inflammation. Conclusion: Based on our findings from this study, Mn preferentially induced mitochondrial dysfunction in a rat EGC line and in vivo resulted in inflammation in the ENS. https://doi.org/10.1289/EHP7877, Introduction Manganese (Mn) is an essential trace metal for many enzymatic reactions, taking part in several metabolic as well as biological functions in the body (Bowman et al. 2011; Harischandra [...]
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- 2021
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7. The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation
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Choi, Chan-Il, Yoon, Hyesook, Drucker, Kristen L., Langley, Monica R., Kleppe, Laurel, and Scarisbrick, Isobel A.
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- 2018
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8. Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease
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Ghosh, Anamitra, Langley, Monica R., Harischandra, Dilshan S., Neal, Matthew L, Jin, Huajun, Anantharam, Vellareddy, Joseph, Joy, Brenza, Timothy, Narasimhan, Balaji, Kanthasamy, Arthi, Kalyanaraman, Balaraman, and Kanthasamy, Anumantha G.
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- 2016
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9. Critical Role of Astrocyte NAD1 Glycohydrolase in Myelin Injury and Regeneration.
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Langley, Monica R., Chan-Il Choi, Peclat, Thais R., Yong Guo, Simon, Whitney L., Hyesook Yoon, Kleppe, Laurel, Lucchinetti, Claudia F., Chini, Claudia C. S., Chini, Eduardo N., and Scarisbrick, Isobel A.
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MYELIN , *WESTERN diet , *MYELIN proteins , *SPINAL cord , *MYELIN oligodendrocyte glycoprotein , *NERVOUS system regeneration , *SPINAL cord injuries , *POLYNEUROPATHIES - Abstract
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinamide adenine dinucleotide (NAD1)-depleting enzyme in the CNS. Altered NAD1 metabolism is linked to both high fat consumption and multiple sclerosis (MS). Here, we identify increased CD38 expression in the male mouse spinal cord following chronic high fat consumption, after focal toxin [lysolecithin (LL)]-mediated demyelinating injury, and in reactive astrocytes within active MS lesions. We demonstrate that CD38 catalytically inactive mice are substantially protected from high fat-induced NAD1 depletion, oligodendrocyte loss, oxidative damage, and astrogliosis. A CD38 inhibitor, 78c, increased NAD1 and attenuated neuroinflammatory changes induced by saturated fat applied to astrocyte cultures. Conditioned media from saturated fat-exposed astrocytes applied to oligodendrocyte cultures impaired myelin protein production, suggesting astrocyte-driven indirect mechanisms of oligodendrogliopathy. In cerebellar organotypic slice cultures subject to LL-demyelination, saturated fat impaired signs of remyelination effects that were mitigated by concomitant 78c treatment. Significantly, oral 78c increased counts of oligodendrocytes and remyelinated axons after focal LL-induced spinal cord demyelination. Using a RiboTag approach, we identified a unique in vivo brain astrocyte translatome profile induced by 78c-mediated CD38 inhibition in mice, including decreased expression of proinflammatory astrocyte markers and increased growth factors. Our findings suggest that a high-fat diet impairs oligodendrocyte survival and differentiation through astrocyte-linked mechanisms mediated by the NAD1ase CD38 and highlights CD38 inhibitors as potential therapeutic candidates to improve myelin regeneration. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Editorial: Environmental effect on neuroinflammation and neurodegeneration, volume II.
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Sarkar, Souvarish, Rangaraju, Srikant, Espinosa-Garcia, Claudia, and Langley, Monica Renee
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NEUROINFLAMMATION ,NEURODEGENERATION ,MICROGLIA ,PESTICIDES - Published
- 2023
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11. Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain.
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Hyesook Yoon, Chan-Il Choi, Triplet, Erin M., Langley, Monica R., Kleppe, Laurel S., Ha Neui Kim, Simon, Whitney L., and Scarisbrick, Isobel A.
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THROMBIN receptors ,MYELIN sheath diseases ,BRAIN damage ,NEURONS ,NERVE fibers ,PROGENITOR cells - Abstract
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PARI), accelerates myelin development. Here we demonstrate that knocking out PAR 1 also promotes myelin regeneration. Outcomes in two unique models of myelin injury and repair, that is lysolecithin or cuprizone-mediated demyelination, showed that PARI knock-out in male mice improves replenishment of myelinating cells and remyelinated nerve fibers and slows early axon damage. Improvements in myelin regeneration in PARI knock-out mice occurred in tandem with a skewing of reactive astrocyte signatures toward a prorepair phenotype. In cell culture, the promyelinating effects ot PARI loss of function are consistent with possible direct effects on the myelinating potential of oligodendrocyte progenitor cells (OPCs), in addition to OPC-indirect effects involving enhanced astrocyte expression of promyelinating factors, such as BDNF. These findings highlight previously unrecognized roles of PARI in myelin regeneration, including integrated actions across the oligodendrocyte and astroglial compartments that are at least partially mechanistically linked to the powerful BDNF-TrkB neurotrophic signaling system. Altogether, findings suggest PARI may be a therapeutically tractable target for demyelinating disorders of the CNS. [ABSTRACT FROM AUTHOR]
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- 2020
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12. MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.
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Ghaisas, Shivani, Langley, Monica R., Palanisamy, Bharathi N., Dutta, Somak, Narayanaswamy, Kirthi, Plummer, Paul J., Sarkar, Souvarish, Ay, Muhammet, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, and Kanthasamy, Anumantha G.
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PARKINSON'S disease , *TRANSGENIC mice , *DOPAMINERGIC neurons , *DRUG efficacy , *FECES , *GUT microbiome , *LARGE intestine , *NEUROGLIA - Abstract
• MitoPark mice develop gut motility dysfunction weeks before motor deficits occur. • The MitoPark gut develops persistent, low-grade inflammation. • Metabolomic profile changes in fecal matter before weight-loss. • Temporal changes occur in the composition of the MitoPark gut microbiome. • MitoPark mouse model recapitulates key symptoms of Parkinsonian gut dysfunction. Gastrointestinal (GI) disturbances are one of the earliest symptoms affecting most patients with Parkinson's disease (PD). In many cases, these symptoms are observed years before motor impairments become apparent. Hence, the molecular and cellular underpinnings that contribute to this early GI dysfunction in PD have actively been explored using a relevant animal model. The MitoPark model is a chronic, progressive mouse model recapitulating several key pathophysiological aspects of PD. However, GI dysfunction and gut microbiome changes have not been categorized in this model. Herein, we show that decreased GI motility was one of the first non-motor symptoms to develop, evident as early as 8 weeks with significantly different transit times from 12 weeks onwards. These symptoms were observed well before motor symptoms developed, thereby paralleling PD progression in humans. At age 24 weeks, we observed increased colon transit time and reduced fecal water content, indicative of constipation. Intestinal inflammation was evidenced with increased expression of iNOS and TNFα in the small and large intestine. Specifically, iNOS was observed mainly in the enteric plexi, indicating enteric glial cell activation. A pronounced loss of tyrosine hydroxylase-positive neurons occurred at 24 weeks both in the mid-brain region as well as the gut, leading to a corresponding decrease in dopamine (DA) production. We also observed decreased DARPP-32 expression in the colon, validating the loss of DAergic neurons in the gut. However, the total number of enteric neurons did not significantly differ between the two groups. Metabolomic gas chromatography-mass spectrometry analysis of fecal samples showed increased sterol, glycerol, and tocopherol production in MitoPark mice compared to age-matched littermate controls at 20 weeks of age while 16 s microbiome sequencing showed a transient temporal increase in the genus Prevotella. Altogether, the data shed more light on the role of the gut dopaminergic system in maintaining intestinal health. Importantly, this model recapitulates the chronology and development of GI dysfunction along with other non-motor symptoms and can become an attractive translational animal model for pre-clinical assessment of the efficacy of new anti-Parkinsonian drugs that can alleviate GI dysfunction in PD. [ABSTRACT FROM AUTHOR]
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- 2019
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13. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes.
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Frederick, Natalie M, Shah, Parth V, Didonna, Alessandro, Langley, Monica R, Kanthasamy, Anumantha G, and Opal, Puneet
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- 2019
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14. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.
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Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A., and Woodruff, Trent M.
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INFLAMMASOMES ,NEURODEGENERATION ,DOPAMINERGIC neurons ,SYNUCLEINS ,PARKINSON'S disease ,OXIDATIVE stress - Abstract
Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson's disease. Systemic inflammasome inhibitor for Parkinson's disease: Brain accumulation of misfolded α-synuclein, progressive loss of dopaminergic neurons, and neuroinflammation are major hallmarks of Parkinson's disease (PD). Although neuroinflammation has been shown to contribute to the pathophysiology of the disease, the mechanisms mediating the activation of inflammatory signals remain unclear. Gordon and colleagues now show that, in mouse models of PD, α-synuclein aggregates promote inflammasome activation in brain microglia. Oral treatment with an inflammasome inhibitor improved motor performance and reduced neuroinflammation, neurodegeneration, and α-synuclein accumulation in mouse models of α-synuclein–mediated toxicity. The results suggest that systemic delivery of inflammasome inhibitors might have therapeutic effects in PD. Parkinson's disease (PD) is characterized by a profound loss of dopaminergic neurons in the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α-synuclein–rich protein aggregates in the form of Lewy bodies. However, the mechanisms linking α-synuclein pathology and dopaminergic neuronal death to chronic microglial neuroinflammation have not been completely elucidated. We show that activation of the microglial NLR family pyrin domain containing 3 (NLRP3) inflammasome is a common pathway triggered by both fibrillar α-synuclein and dopaminergic degeneration in the absence of α-synuclein aggregates. Cleaved caspase-1 and the inflammasome adaptor protein apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) were elevated in the substantia nigra of the brains of patients with PD and in multiple preclinical PD models. NLRP3 activation by fibrillar α-synuclein in mouse microglia resulted in a delayed but robust activation of the NLRP3 inflammasome leading to extracellular interleukin-1β and ASC release in the absence of pyroptosis. Nanomolar doses of a small-molecule NLRP3 inhibitor, MCC950, abolished fibrillar α-synuclein–mediated inflammasome activation in mouse microglial cells and extracellular ASC release. Furthermore, oral administration of MCC950 in multiple rodent PD models inhibited inflammasome activation and effectively mitigated motor deficits, nigrostriatal dopaminergic degeneration, and accumulation of α-synuclein aggregates. These findings suggest that microglial NLRP3 may be a sustained source of neuroinflammation that could drive progressive dopaminergic neuropathology and highlight NLRP3 as a potential target for disease-modifying treatments for PD. [ABSTRACT FROM AUTHOR]
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- 2018
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15. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.
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Langley, Monica, Ghosh, Anamitra, Charli, Adhithiya, Sarkar, Souvarish, Ay, Muhammet, Luo, Jie, Zielonka, Jacek, Brenza, Timothy, Bennett, Brian, Jin, Huajun, Ghaisas, Shivani, Schlichtmann, Benjamin, Kim, Dongsuk, Anantharam, Vellareddy, Kanthasamy, Arthi, Narasimhan, Balaji, Kalyanaraman, Balaraman, and Kanthasamy, Anumantha G.
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MITOCHONDRIAL pathology , *MICROGLIA , *OXIDATIVE stress , *PARKINSON'S disease , *DOPAMINERGIC neurons , *PREVENTION - Abstract
Aims: Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive motor deficits and degeneration of dopaminergic neurons. Caused by a number of genetic and environmental factors, mitochondrial dysfunction and oxidative stress play a role in neurodegeneration in PD. By selectively knocking out mitochondrial transcription factor A (TFAM) in dopaminergic neurons, the transgenic MitoPark mice recapitulate many signature features of the disease, including progressive motor deficits, neuronal loss, and protein inclusions. In the present study, we evaluated the neuroprotective efficacy of a novel mitochondrially targeted antioxidant, Mito-apocynin, in MitoPark mice and cell culture models of neuroinflammation and mitochondrial dysfunction. Results: Oral administration of Mito-apocynin (10 mg/kg, thrice a week) showed excellent central nervous system bioavailability and significantly improved locomotor activity and coordination in MitoPark mice. Importantly, Mito-apocynin also partially attenuated severe nigrostriatal degeneration in MitoPark mice. Mechanistic studies revealed that Mito-apo improves mitochondrial function and inhibits NOX2 activation, oxidative damage, and neuroinflammation. Innovation: The properties of Mito-apocynin identified in the MitoPark transgenic mouse model strongly support potential clinical applications for Mito-apocynin as a viable neuroprotective and anti-neuroinflammatory drug for treating PD when compared to conventional therapeutic approaches. Conclusion: Collectively, our data demonstrate, for the first time, that a novel orally active apocynin derivative improves behavioral, inflammatory, and neurodegenerative processes in a severe progressive dopaminergic neurodegenerative model of PD. Antioxid. Redox Signal. 27, 1048-1066. [ABSTRACT FROM AUTHOR]
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- 2017
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16. Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease.
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Qi Xu, Langley, Monica, Kanthasamy, Anumantha G., Reddy, Manju B., and Xu, Qi
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PARKINSON'S disease , *EXTRAPYRAMIDAL disorders , *NEURODEGENERATION , *EPIGALLOCATECHIN gallate , *NEUROTRANSMITTERS , *THERAPEUTIC use of antioxidants , *IRON metabolism , *DRUG therapy for Parkinson's disease , *ANIMAL behavior , *ANIMAL experimentation , *ANTIOXIDANTS , *BIOLOGICAL models , *BLOOD proteins , *BRAIN stem , *CARRIER proteins , *DOPAMINE , *FLAVONOIDS , *HERBAL medicine , *MICE , *MOTOR ability , *PEPTIDES , *PYRIDINE , *RESEARCH funding , *TEA , *PLANT extracts , *OXIDATIVE stress , *CARBOCYCLIC acids , *NEUROPROTECTIVE agents , *PHARMACODYNAMICS , *THERAPEUTICS ,THERAPEUTIC use of plant extracts - Abstract
Background: Parkinson disease (PD) is a neurodegenerative disorder that has been associated with many factors, including oxidative stress, inflammation, and iron accumulation. The antioxidant, anti-inflammatory, and iron-chelating properties of epigallocatechin gallate (EGCG), a major polyphenol in green tea, may offer protection against PD.Objective: We sought to determine the neurorescue effects of EGCG and the role of iron in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD.Methods: We evaluated the neurorescue effect of EGCG (25 mg/kg, 7 d, oral administration) against MPTP-induced (20 mg/kg, 3 d, intraperitoneal injection) neurodegeneration in C57 male black mice. Thirty mice weighing ∼25 g were divided into 3 groups: control, MPTP, and MPTP + EGCG. The neurorescue effect of EGCG was assessed with the use of motor behavior tests, neurotransmitter analysis, oxidative stress indicators, and iron-related protein expression.Results: Compared with the control group, MPTP treatment shortened the mice's latency to fall from the rotarod by 16% (P < 0.05), decreased the striatal dopamine concentration by 58% (P < 0.001) and dihydroxyphenylacetic acid by 35% (P < 0.05), and increased serum protein carbonyls by 71% (P = 0.07). However, EGCG rescued MPTP-induced neurotoxicity by increasing the rotational latency by 17% (P < 0.05) to a value similar to the control group. Striatal dopamine concentrations were 40% higher in the MPTP + EGCG group than in the MPTP group (P < 0.05), but the values were significantly lower than in the control group. Compared with the MPTP and control groups, mice in the MPTP + EGCG group had higher substantia nigra ferroportin expression (44% and 35%, respectively) (P < 0.05) but not hepcidin and divalent metal transporter 1 expression.Conclusion: Overall, our study demonstrated that EGCG regulated the iron-export protein ferroportin in substantia nigra, reduced oxidative stress, and exerted a neurorescue effect against MPTP-induced functional and neurochemical deficits in mice. [ABSTRACT FROM AUTHOR]
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- 2017
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17. Editorial: Environmental Effect on Neuroinflammation and Neurodegeneration.
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Langley, Monica Renee, Rangaraju, Srikant, Dey, Adwitia, and Sarkar, Souvarish
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NEUROINFLAMMATION ,NEURODEGENERATION ,ALZHEIMER'S disease ,DISEASE risk factors ,ETIOLOGY of diseases ,CELL culture - Abstract
Neuroinflammation, neurodegeneration, genetic, GWAS, gene-environment interactions A series of recent studies delved into the potential contribution of various environmental factors in regulating neuroinflammation and neurodegeneration in animal models and human populations. Keywords: neuroinflammation; neurodegeneration; genetic; GWAS; gene-environment interactions EN neuroinflammation neurodegeneration genetic GWAS gene-environment interactions 1 2 2 06/27/22 20220621 NES 220621 Introduction Neurodegenerative disorders like Parkinson's disease and Alzheimer's disease, among others, are characterized by the loss of a specific subset of neurons and glial activation. [Extracted from the article]
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- 2022
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18. Characterizing a mouse model for evaluation of countermeasures against hydrogen sulfide-induced neurotoxicity and neurological sequelae.
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Anantharam, Poojya, Whitley, Elizabeth M., Mahama, Belinda, Kim, Dong‐Suk, Imerman, Paula M., Shao, Dahai, Langley, Monica R., Kanthasamy, Arthi, and Rumbeiha, Wilson K.
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TOXICOLOGY of gases ,HYDROGEN sulfide ,NEUROTOXICOLOGY ,NEUROSCIENCES ,HISTOPATHOLOGY - Abstract
Hydrogen sulfide (H
2 S) is a highly neurotoxic gas. It is the second most common cause of gas-induced deaths. Beyond mortality, surviving victims of acute exposure may suffer long-term neurological sequelae. There is a need to develop countermeasures against H2 S poisoning. However, no translational animal model of H2 S-induced neurological sequelae exists. Here, we describe a novel mouse model of H2 S-induced neurotoxicity for translational research. In paradigm I, C57/BL6 mice were exposed to 765 ppm H2 S for 40 min on day 1, followed by 15-min daily exposures for periods ranging from 1 to 6 days. In paradigm II, mice were exposed once to 1000 ppm H2 S for 60 minutes. Mice were assessed for behavioral, neurochemical, biochemical, and histopathological changes. H2 S intoxication caused seizures, dyspnea, respiratory depression, knockdowns, and death. H2 S-exposed mice showed significant impairment in locomotor and coordinated motor movement activity compared with controls. Histopathology revealed neurodegenerative lesions in the collicular, thalamic, and cortical brain regions. H2 S significantly increased dopamine and serotonin concentration in several brain regions and caused time-dependent decreases in GABA and glutamate concentrations. Furthermore, H2 S significantly suppressed cytochrome c oxidase activity and caused significant loss in body weight. Overall, male mice were more sensitive than females. This novel translational mouse model of H2 S-induced neurotoxicity is reliable, reproducible, and recapitulates acute H2 S poisoning in humans. [ABSTRACT FROM AUTHOR]- Published
- 2017
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19. Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.
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Ay, Muhammet, Luo, Jie, Langley, Monica, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, and Kanthasamy, Anumantha G.
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QUERCETIN ,PARKINSON'S disease treatment ,NEURODEGENERATION ,MITOCHONDRIAL pathology ,DOPAMINERGIC mechanisms ,THERAPEUTICS - Abstract
Quercetin, one of the major flavonoids in plants, has been recently reported to have neuroprotective effects against neurodegenerative processes. However, since the molecular signaling mechanisms governing these effects are not well clarified, we evaluated quercetin's effect on the neuroprotective signaling events in dopaminergic neuronal models and further tested its efficacy in the MitoPark transgenic mouse model of Parkinson's disease ( PD). Western blot analysis revealed that quercetin significantly induced the activation of two major cell survival kinases, protein kinase D1 ( PKD1) and Akt in MN9D dopaminergic neuronal cells. Furthermore, pharmacological inhibition or si RNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling. Quercetin also enhanced cAMP response-element binding protein phosphorylation and expression of the cAMP response-element binding protein target gene brain-derived neurotrophic factor. Results from qRT- PCR, Western blot analysis, mt DNA content analysis, and MitoTracker assay experiments revealed that quercetin augmented mitochondrial biogenesis. Quercetin also increased mitochondrial bioenergetics capacity and protected MN9D cells against 6-hydroxydopamine-induced neurotoxicity. To further evaluate the neuroprotective efficacy of quercetin against the mitochondrial dysfunction underlying PD, we used the progressive dopaminergic neurodegenerative MitoPark transgenic mouse model of PD. Oral administration of quercetin significantly reversed behavioral deficits, striatal dopamine depletion, and TH neuronal cell loss in MitoPark mice. Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits. [ABSTRACT FROM AUTHOR]
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- 2017
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20. BP weighs dividend cut: estimate of spill's size is raised as Britain defends embattled oil giant
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Langley, Monica, Weisman, Jonathan, and MacDonald, Alistair
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BP PLC -- Public relations ,BP PLC -- Investigations ,BP PLC -- Finance ,BP PLC -- Investor relations ,Gulf of Mexico Oil Spill, 2010 -- Political aspects ,Gulf of Mexico Oil Spill, 2010 -- Economic aspects ,Gulf of Mexico Oil Spill, 2010 -- Investigations ,Oil spills ,Company public relations ,Company legal issue ,Company financing ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
In response to political pressure in the U.S. to fix the damage caused by the largest oil spill in that country's history, BP PLC is considering reducing or postponing its second-quarter dividend due to be announced July 27. Citing the oil company's economic value in Great Britain and the United States, the U.K. has taken steps to mediate a resolution between the U.S. government and BP.
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- 2010
21. SEC chief's big bet on Goldman
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Langley, Monica, Scannell, Kara, Pulliam, Susan, and Craig, Susanne
- Subjects
United States. Securities and Exchange Commission -- Investigations ,United States. Securities and Exchange Commission -- Conferences, meetings and seminars ,United States. Securities and Exchange Commission -- Officials and employees ,United States. Securities and Exchange Commission -- Cases ,The Goldman Sachs Group Inc. -- Investigations ,The Goldman Sachs Group Inc. -- Cases ,The Goldman Sachs Group Inc. -- Investments ,Banking industry -- Investments ,Banking industry -- Cases ,Banking industry -- Investigations ,Financial services industry -- Investigations ,Financial services industry -- Investments ,Administrative agencies -- Investigations ,Administrative agencies -- Officials and employees ,Administrative agencies -- Cases ,Administrative agencies -- Conferences, meetings and seminars ,Governmental investigations -- Analysis ,Governmental investigations -- Planning ,Investment banks -- Investigations ,Investment banks -- Investments ,Investment banks -- Officials and employees ,Investment banks -- Cases ,Mortgage-backed securities -- Investments ,Mortgage-backed securities -- Investigations ,Securities fraud -- Investigations ,Securities fraud -- Cases ,Wall Street -- Forecasts and trends ,Meetings -- Reports ,Public officers -- Conferences, meetings and seminars ,Public officers -- Beliefs, opinions and attitudes ,Public officers -- Powers and duties ,Banking industry ,Financial services industry ,Company legal issue ,Company investment ,Company business planning ,Market trend/market analysis ,News, opinion and commentary - Published
- 2010
22. GM solicits debtholders in its effort to revamp
- Author
-
Stoll, John D. and Langley, Monica
- Subjects
Motors Liquidation Co. -- Planning ,Motors Liquidation Co. -- Finance ,Motors Liquidation Co. -- Securities ,Motors Liquidation Co. -- Negotiation, mediation and arbitration ,Motors Liquidation Co. -- Reorganization and restructuring ,Transportation equipment industry ,Company restructuring/company reorganization ,Company organization ,Company business planning ,Company financing ,Company securities ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
It is speculated that, in an effort to avert bankruptcy, General Motors Corp. is negotiating with creditors the exchange of debt for equity. The offer gives debtholders an alternative to losses from unsecured loans, as creditors could potentially cash out at a later date at a more attractive stock price. GM has an estimated debt of $43.3 billion at an annual interest cost of about $2.9 billion.
- Published
- 2008
23. Google CEO hits the hustings for Obama
- Author
-
Langley, Monica and Vascellaro, Jessica E.
- Subjects
Google L.L.C. -- Political aspects ,Chief executive officers -- Endorsements -- Political aspects ,Information services industry -- Political aspects -- Endorsements ,Presidential candidates -- Endorsements -- Political aspects ,Information services -- Political aspects -- Endorsements ,Information services industry ,General interest ,News, opinion and commentary - Abstract
Byline: MONICA LANGLEY AND JESSICA E. VASCELLARO Google Inc. chief executive officer Eric Schmidt will hit the campaign trail this week on behalf of Democratic presidential candidate Barack Obama, signalling [...]
- Published
- 2008
24. Citigroup CEO Prince poised to resign
- Author
-
Sidel, Robin and Langley, Monica
- Subjects
Citigroup Inc. -- Officials and employees ,Financial services industry -- Officials and employees ,Chief executive officers -- Appointments, resignations and dismissals ,Financial services industry ,General interest ,News, opinion and commentary - Abstract
Byline: ROBIN SIDEL AND MONICA LANGLEY; WALL STREET JOURNAL STAFF Charles Prince, the beleaguered chief executive officer of Citigroup Inc., is planning to resign at a board meeting tomorrow, according [...]
- Published
- 2007
25. Citigroup likely to propose cuts of 15,000 jobs
- Author
-
Enrich, David, Mollenkamp, Carrick, and Langley, Monica
- Subjects
Citigroup Inc. -- Reorganization and restructuring ,Citigroup Inc. -- Human resource management ,Financial services industry -- Reorganization and restructuring ,Financial services industry -- Human resource management ,Financial services industry ,Company restructuring/company reorganization ,Company organization ,Company personnel management ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Citigroup Inc. of the United States is planning a restructuring that may include 15,000 job cuts with a loss of $1 billion. Charles Prince of the financial services group is orchestrating management changes.
- Published
- 2007
26. How Wagoner wins as Ghosn alliance talks fail: GM chief can now focus on his turnaround plan; Kerkorian weighs options
- Author
-
Langley, Monica and White, Joseph B.
- Subjects
Motors Liquidation Co. -- Officials and employees ,Motors Liquidation Co. -- Alliances and partnerships ,Motors Liquidation Co. -- Planning ,Nissan Motor Company Ltd. -- Officials and employees ,Nissan Motor Company Ltd. -- Alliances and partnerships ,Renault S.A. -- Officials and employees ,Renault S.A. -- Alliances and partnerships ,Automobile industry -- Officials and employees ,Automobile industry -- Alliances and partnerships ,Automobile industry -- Planning ,Automobile Industry ,Company business planning ,Company business management ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Although plans for an alliance between General Motors Corp., Renault S.A., and Nissan Motor Company Ltd. have failed, large automobile manufacturers will continue talking about such alliances. Rick Wagoner, CEO of General Motors, will now concentrate on returning the company to profitability.
- Published
- 2006
27. Kerkorian aims to boost GM stake in bid to add pressure on Wagoner
- Author
-
Stoll, John D. and Langley, Monica
- Subjects
Motors Liquidation Co. -- Securities ,Motors Liquidation Co. -- Officials and employees ,Motors Liquidation Co. -- Planning ,Transportation equipment industry -- Securities ,Transportation equipment industry -- Officials and employees ,Transportation equipment industry -- Planning ,Company securities ,Company business planning ,Company investment ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Billionaire Kirk Kerkorian plans to invest more heavily in General Motors, increasing both his ownership (to 12%) and his influence . Mr. Kerkorian is in favor of an alliance with Renault S.A., while CEO Rick Wagoner Jr. is opposed to such a partnership.
- Published
- 2006
28. GM, Nissan, Renault continue alliance talks
- Author
-
White, Joseph B. and Langley, Monica
- Subjects
Motors Liquidation Co. -- Management ,Nissan Motor Company Ltd. -- Management ,Renault S.A. -- Management ,Automobile industry -- Management ,Automobile Industry ,Company business management ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Negotiations between Chief Executive Rick Wagoner, General Motors Corp. of the United States and Chief Executive Carlos Ghosn, Regie Nationale des Usines Renault of France and Nissan Motor Co. of Japan occurred yesterday just outside of Paris at Renault headquarters. The automobile giants are considering a threeway alliance.
- Published
- 2006
29. AIG taps Citigroup veteran for chairman post
- Author
-
Pleven, Liam and Langley, Monica
- Subjects
American International Group Inc. -- Officials and employees ,Insurance industry -- Officials and employees ,Insurance industry ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Robert Willumstad, former president of Citigroup Inc., has been appointed chair of insurance company American International Group Inc. This appointment, following the previous appointment of CEO Martin Sullivan, marks a change in governance for AIG, with the top position split into two separate jobs.
- Published
- 2006
30. GM, Ford alliance talks mark auto-industry shift; aborted discussions reflect inroads by foreign firms, pressure from shareholders
- Author
-
Langley, Monica, Boudette, Neal E., and Mccracken, Jeffrey
- Subjects
Ford Motor Co. -- Alliances and partnerships ,Ford Motor Co. -- Reorganization and restructuring ,Motors Liquidation Co. -- Alliances and partnerships ,Motors Liquidation Co. -- Reorganization and restructuring ,Transportation equipment industry -- Alliances and partnerships ,Transportation equipment industry -- Reorganization and restructuring ,Company restructuring/company reorganization ,Company organization ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Although Ford Motor Co. and General Motors Corp. have abandoned talks of a partnership, such discussions show the current state of the automobile industry. The companies will instead focus on their own restructuring.
- Published
- 2006
31. Ghosn steps up push for an alliance with GM; meeting on possible tie-up is likely to be turning point in tussle over auto maker
- Author
-
White, Joseph B. and Langley, Monica
- Subjects
Motors Liquidation Co. -- Alliances and partnerships ,Nissan Motor Company Ltd. -- Officials and employees ,Nissan Motor Company Ltd. -- Alliances and partnerships ,Renault S.A. -- Officials and employees ,Renault S.A. -- Alliances and partnerships ,Automobile industry -- Officials and employees ,Automobile industry -- Alliances and partnerships ,Company business management ,Automobile Industry ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Carlos Ghosn, CEO of Renault and Nissan Motor Co., has intensified his efforts to establish a partnership with General Motors. Rick Wagoner, CEO of General Motors, is expressing a more cautious attitude towards the partnership. General Motors is the top automobile manufacturer in the United States.
- Published
- 2006
32. AIG expected to pay $1 billion-plus to settle probes
- Author
-
McDonald, Ian and Langley, Monica
- Subjects
United States. Securities and Exchange Commission -- Investigations ,American International Group Inc. -- Accounting and auditing ,American International Group Inc. -- Cases ,American International Group Inc. -- Officials and employees ,Insurance industry -- Accounting and auditing ,Insurance industry -- Cases ,Insurance industry -- Officials and employees ,Investor relations -- Cases ,Corporations -- Ethical aspects ,Corporations -- Cases ,Insurance industry ,Company legal issue ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
The possibility that insurance company, American International Group Inc., may be seeking to pay a $1 billion settlement to civil-fraud investigations being conducted by state and federal authorities is discussed. The insurer and its former chief executive, Maurice R. Greenberg, allegedly misled regulators and investors by using improper accounting practices and misrepresenting financial results.
- Published
- 2006
33. AIG is raising stakes in battle with Greenberg
- Author
-
Langley, Monica and Mac Donald, Ian
- Subjects
American International Group Inc. -- Cases ,Securities -- Cases ,Insurance industry -- Cases ,Insurance industry ,Company legal issue ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
American International Group Inc. is suing former executive Maurice R. 'Hank' Greenberg for control of approximately $20 billion worth of shares. The shares represent nearly 12 percent of the insurance company.
- Published
- 2005
34. Behind Citigroup departures: A culture shift by CEO Prince
- Author
-
Langley, Monica
- Subjects
Citigroup Inc. -- Management ,Citigroup Inc. -- Officials and employees ,Financial services industry -- Management ,Financial services industry -- Officials and employees ,Financial services industry ,Company business management ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Citigroup Inc. of the United States is seeing a management shake out with Chief Executive Officer Charles O. Prince. Mr. Prince has taken a longterm perspective concentrating on internal controls, improving the banking giant's reputation and keeping on top of regulatory relations. Citigroup Inc. is planning some divestments of life-insurance and asset-management units.
- Published
- 2005
35. CEO school: flung into top job, Sullivan of AIG learns on the fly
- Author
-
Langley, Monica
- Subjects
American International Group Inc. -- Officials and employees ,American International Group Inc. -- Management ,American International Group Inc. -- Investigations ,American International Group Inc. -- Accounting and auditing ,Insurance industry -- Officials and employees ,Insurance industry -- Management ,Insurance industry -- Investigations ,Insurance industry -- Accounting and auditing ,Management -- Analysis ,Insurance industry ,Company business management ,Company legal issue ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
The management style of Martin Sullivan, chief executive officer of American International Group Inc., is discussed and compared to that of his predecessor and mentor, the recently ousted Maurice Greenberg. Special attention is given to Sullivan's handling of both internal and external investigations into the accounting scandal that led to Greenberg's dismissal.
- Published
- 2005
36. Buffett didn't get deal details
- Author
-
Pulliman, Susan, McDonald, Ian, and Langley, Monica
- Subjects
United States. Securities and Exchange Commission -- Investigations ,American International Group Inc. -- Investigations ,Berkshire Hathaway Inc. -- Investigations ,Berkshire Hathaway Inc. -- Officials and employees ,Insurance industry -- Investigations ,Insurance industry -- Officials and employees ,Insurance industry ,Company legal issue ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Warren Buffett of Berkshire Hathaway Inc. has given evidence concerning a contentious deal with American International Group Inc. at the United States Securities and Exchange Commission in New York. Mr. Buffett said he asked the top executive of a Berkshire Hathaway Inc. insurance unit several times about the American International Group Inc. deal in question but did not receive details.
- Published
- 2005
37. Firm tied to AIG pay plan ousts board members; complex setup leaves Greenberg with big say in compensation at AIG
- Author
-
Langley, Monica
- Subjects
American International Group Inc. -- Officials and employees ,American International Group Inc. -- Compensation and benefits ,American International Group Inc. -- Accounting and auditing ,Associations, institutions, etc. -- Management ,Associations, institutions, etc. -- Officials and employees ,Insurance industry -- Officials and employees ,Insurance industry -- Compensation and benefits ,Insurance industry -- Accounting and auditing ,Corporate directors -- Appointments, resignations and dismissals ,Chief executive officers -- Management ,Chief executive officers -- Appointments, resignations and dismissals ,Executives -- Compensation and benefits ,Executives -- Management ,Insurance industry ,Company business management ,News, opinion and commentary - Published
- 2005
38. After a 37-year reign at AIG, chief's final tumultuous days; as directors take charge, Mr. Greenberg appeals to longtime loyalists
- Author
-
Langley, Monica
- Subjects
American International Group Inc. -- Officials and employees ,American International Group Inc. -- Reorganization and restructuring ,American International Group Inc. -- Accounting and auditing ,American International Group Inc. -- Investigations ,Insurance industry -- Officials and employees ,Insurance industry -- Reorganization and restructuring ,Insurance industry -- Accounting and auditing ,Insurance industry -- Investigations ,Chief executive officers -- Appointments, resignations and dismissals ,Chief executive officers -- Management ,Insurance industry ,Company business management ,Company restructuring/company reorganization ,Company legal issue ,Company organization ,News, opinion and commentary - Published
- 2005
39. Buffett is called for questioning in AIG inquiry; SEC requests interview as Greenberg decides to retire as chairman
- Author
-
Langley, Monica
- Subjects
United States. Securities and Exchange Commission -- Powers and duties ,American International Group Inc. -- Investigations ,American International Group Inc. -- Officials and employees ,American International Group Inc. -- Accounting and auditing ,American International Group Inc. -- Contracts ,Berkshire Hathaway Inc. -- Officials and employees ,Berkshire Hathaway Inc. -- Contracts ,Property and casualty insurance industry -- Officials and employees ,Property and casualty insurance industry -- Contracts ,Insurance industry -- Investigations ,Insurance industry -- Officials and employees ,Insurance industry -- Accounting and auditing ,Insurance industry -- Contracts ,Governmental investigations -- Management ,Chief executive officers -- Appointments, resignations and dismissals ,Billionaires -- Evidence ,Insurance industry ,Contract agreement ,Company business management ,Company legal issue ,News, opinion and commentary - Abstract
As part of its investigation into an insurance transaction between American International Group Inc. and Berkshire Hathaway Inc., the Securities and Exchange Commission has asked Berkshire Hathaway chairman Warren Buffett to appear to answer questions. AIG CEO Maurice Greenberg has meanwhile decided to step down.
- Published
- 2005
40. SEC subpoenas senior executives in probe at AIG; board, ex-CEO Greenberg movie closer to cutting ties; top manager forced out
- Author
-
Langley, Monica, Solomon, Deborah, Francis, Theo, and McDonald, Ian
- Subjects
United States. Securities and Exchange Commission -- Powers and duties ,American International Group Inc. -- Officials and employees ,American International Group Inc. -- Cases ,American International Group Inc. -- Accounting and auditing ,Insurance industry -- Officials and employees ,Insurance industry -- Cases ,Insurance industry -- Accounting and auditing ,Administrative agencies -- Powers and duties ,Executives -- Cases ,Chief executive officers -- Appointments, resignations and dismissals ,Subpoena ,Insurance industry ,Company legal issue ,News, opinion and commentary - Abstract
The Securities and Exchange Commission issued supoenas for several executives of troubled American International Group Inc., in its investigation of questionable deals by the company. CEO and founder M aurice Greenberg stepped down last week and the company is deciding whether or not to distance itself from him.
- Published
- 2005
41. AIG's mistakes over accounting may be in billions; as many as 30 transactions are scrutinized as some see systemic problem at insurer
- Author
-
Langley, Monica and McDonald, Ian
- Subjects
American International Group Inc. -- Accounting and auditing ,American International Group Inc. -- Investigations ,American International Group Inc. -- Officials and employees ,Insurance industry -- Accounting and auditing ,Insurance industry -- Investigations ,Insurance industry -- Officials and employees ,Chief executive officers -- Appointments, resignations and dismissals ,Accounting -- Technique ,Accounting -- Investigations ,Insurance industry ,Company legal issue ,News, opinion and commentary - Published
- 2005
42. Auditor's flag on AIG's books explains exit; Pricewaterhouse private warning on possible flaws in controls leads to finance chief's leave
- Author
-
Francis, Theo and Langley, Monica
- Subjects
United States. Securities and Exchange Commission -- Investigations ,American International Group Inc. -- Officials and employees ,American International Group Inc. -- Finance ,American International Group Inc. -- Investigations ,American International Group Inc. -- Contracts ,PricewaterhouseCoopers L.L.P. (New York, New York) -- Contracts ,Accounting firms -- Contracts ,Insurance industry -- Officials and employees ,Insurance industry -- Finance ,Insurance industry -- Investigations ,Insurance industry -- Contracts ,Insurance industry ,Contract agreement ,Company financing ,Company legal issue ,News, opinion and commentary - Published
- 2005
43. AIG considers cutting Greenberg ties; board's damage-control efforts may include ex-CEO's departure as nonexecutive chairman in May
- Author
-
Langley, Monica
- Subjects
United States. Securities and Exchange Commission -- Investigations ,American International Group Inc. -- Management ,American International Group Inc. -- Officials and employees ,American International Group Inc. -- Investigations ,Insurance industry -- Management ,Insurance industry -- Officials and employees ,Insurance industry -- Investigations ,Insurance industry ,Company business management ,Company legal issue ,News, opinion and commentary - Published
- 2005
44. How investigations of AIG led to retirement of longtime CEO
- Author
-
Langley, Monica and Francis, Theo
- Subjects
American International Group Inc. -- Officials and employees ,American International Group Inc. -- Investigations ,Insurance industry -- Officials and employees ,Insurance industry -- Investigations ,Insurance industry ,Company legal issue ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
Chief Executive Officer Maurice Greenberg of American International Group Inc. has resigned over mounting pressure from regulators over a deal with Berkshire Hathaway Inc. that could have been considered misleading to American International Group Inc. investors.
- Published
- 2005
45. Sullivan is expected to succeed Greenberg at AIG
- Author
-
Langley, Monica and Dugan, Ianthe Jeanne
- Subjects
American International Group Inc. -- Officials and employees ,American International Group Inc. -- Human resource management ,American International Group Inc. -- Investigations ,Insurance industry -- Officials and employees ,Insurance industry -- Human resource management ,Insurance industry -- Investigations ,Insurance industry ,Company personnel management ,Company legal issue ,News, opinion and commentary - Published
- 2005
46. Bush set to sign landmark bill on class actions; law aims to curb ability to 'shop' for state courts; a victory for the business lobby
- Author
-
Rogers, David and Langley, Monica
- Subjects
Tort reform -- Planning ,State courts -- Powers and duties ,Presidents -- Powers and duties ,Jurisdiction -- Laws, regulations and rules ,Federal courts -- Powers and duties ,Class actions (Civil procedure) -- Laws, regulations and rules ,Company business planning ,Government regulation ,News, opinion and commentary - Published
- 2005
47. Ground war: drivers deliver trouble to FedEx by seeking employee benefits
- Author
-
Langley, Monica
- Subjects
FedEx Ground -- Human resource management ,FedEx Ground -- Cases ,FedEx Ground -- Company sales and earnings ,FedEx Ground -- Investigations ,FedEx Corp. -- Cases ,FedEx Corp. -- Company sales and earnings ,Transport workers -- Cases ,Transport workers -- Labor relations ,Worker classification -- Cases ,Worker classification -- Analysis ,Courier services -- Human resource management ,Courier services -- Cases ,Courier services -- Company sales and earnings ,Courier services -- Investigations ,Contract labor -- Cases ,Contract labor -- Finance ,Contract labor -- Labor relations ,Company legal issue ,Company earnings/profit ,Company personnel management ,Company financing ,Banking, finance and accounting industries ,Business ,Business, international - Abstract
The practice at express delivery service FedEx and its subsidiary FedEx Ground of hiring contract workers as drivers of its trucks is discussed. A case brought by FedEx drivers against the company raises issues long confronted by U.S. firms that prefer to hire independent contractors rather than employees for whom they are required to provide benefits such as health care, paid leave, and pensions.
- Published
- 2005
48. Drivers deliver trouble to FedEx by seeking employee benefits; some 'contractors' contend company calls all shots; IRS weighs complaints
- Author
-
Langley, Monica
- Subjects
FedEx Corp. -- Contracts ,FedEx Corp. -- Laws, regulations and rules ,FedEx Corp. -- Cases ,FedEx Corp. -- Officials and employees ,Truck drivers -- Compensation and benefits ,Truck drivers -- Cases ,Truck drivers -- Contracts ,Courier services -- Contracts ,Courier services -- Laws, regulations and rules ,Courier services -- Cases ,Courier services -- Officials and employees ,Employment discrimination -- Cases ,Class actions (Civil procedure) ,Contract agreement ,Company legal issue ,Government regulation ,News, opinion and commentary - Published
- 2005
49. Opinions labeling deals 'fair' can be far from independent; banks that do them often are advisors on transactions and have fees at stake
- Author
-
Davis, Ann and Langley, Monica
- Subjects
JPMorgan Chase & Co. -- Ethical aspects ,JPMorgan Chase & Co. -- Cases ,JPMorgan Chase & Co. -- Mergers, acquisitions and divestments ,JPMorgan Chase & Co. -- Investor relations ,Bank One Corp. -- Mergers, acquisitions and divestments ,Bank One Corp. -- Valuation ,BankAmerica Corp. -- Ethical aspects ,BankAmerica Corp. -- Mergers, acquisitions and divestments ,BankAmerica Corp. -- Investor relations ,FleetBoston Financial Corp. -- Mergers, acquisitions and divestments ,FleetBoston Financial Corp. -- Valuation ,Best Lock Corp. -- Cases ,Best Lock Corp. -- Mergers, acquisitions and divestments ,Best Lock Corp. -- Valuation ,Piper Jaffray Cos. -- Mergers, acquisitions and divestments ,BSB Bancorporation Inc. -- Mergers, acquisitions and divestments ,BSB Bancorporation Inc. -- Investor relations ,BSB Bancorporation Inc. -- Valuation ,Crown American Realty Trust -- Valuation ,Crown American Realty Trust -- Contracts ,Wachovia Corp. (Winston-Salem, North Carolina) -- Contracts ,Real estate investment trusts -- Valuation ,Real estate investment trusts -- Contracts ,Fairness -- Economic aspects ,Securities industry -- Mergers, acquisitions and divestments ,Securities industry -- Investor relations ,Securities industry -- Valuation ,Hardware industry -- Cases ,Hardware industry -- Mergers, acquisitions and divestments ,Hardware industry -- Valuation ,Banking industry -- Ethical aspects ,Banking industry -- Cases ,Banking industry -- Mergers, acquisitions and divestments ,Banking industry -- Investor relations ,Banking industry -- Valuation ,Banking industry -- Contracts ,Securities industry ,Banking industry ,Contract agreement ,Company acquisition/merger ,Company legal issue ,News, opinion and commentary ,National Association of Securities Dealers Inc. -- Investigations - Abstract
The National Association of Securities Dealers is investigating whether deals that are supposed to be deemed fair adhere to ethical standards.
- Published
- 2004
50. Consultant leads secret double life as Internet sleuth; assuming identity of 'Patriot', Ms. MacNab helps undo several tax shelter scams
- Author
-
Langley, Monica
- Subjects
Tax shelters -- Investigations ,Fraud -- Investigations ,Consultants -- Management ,Consultants -- Investigations ,Company legal issue ,Company business management ,News, opinion and commentary - Published
- 2004
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