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Your search keyword '"Langston, Catherine E."' showing total 11 results
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11 results on '"Langston, Catherine E."'

1. Successful hemodialysis treatment of a Quarter Horse mare with silver maple leaf toxicity and acute kidney injury.

Author

Pinnell, Erin F., Her, Jiwoong, Gordon, Daniel, Kinsella, Hannah M., Langston, Catherine E., and Toribio, Ramiro E.

Subjects
RENAL replacement therapy, BLOOD urea nitrogen, ACUTE kidney failure, BLOOD transfusion, NEPHROTOXICOLOGY
Abstract

An adult American Quarter Horse mare presented for pigmenturia and lethargy of 12 hours' duration and was diagnosed with silver maple leaf toxicity. The mare had intravascular hemolysis and azotemia. The mare was treated with a transfusion of whole blood, fluids administered IV, antibiotics, oxygen insufflation, and supportive care. The azotemia persisted despite conventional medical management and hemodialysis was elected. After 2 intermittent hemodialysis treatments over 3 days, the azotemia almost resolved, clinical signs improved, and the mare was discharged. The blood urea nitrogen, creatinine, and electrolyte concentrations remained normal 6 months later after examination by the referring veterinarian. Hemodialysis treatment can be feasible in horses if equipment and expertise are available and should be considered as a treatment option if indicated. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Prevalence of aldosterone breakthrough in dogs receiving renin‐angiotensin system inhibitors for proteinuric chronic kidney disease.

Author

Ames, Marisa K., Vaden, Shelly L., Atkins, Clarke E., Palerme, Jean‐Sebastien, Langston, Catherine E., Grauer, Gregory F., Shropshire, Sarah, Bove, Christina, and Webb, Tracy

Subjects
RENIN-angiotensin system, CHRONIC kidney failure, DOGS, ANGIOTENSIN-receptor blockers, ACE inhibitors, ALDOSTERONE
Abstract

Background: The influence of aldosterone breakthrough (ABT) on proteinuria reduction during renin‐angiotensin system (RAS) inhibition for spontaneous proteinuric chronic kidney disease (CKDP) has not been determined in dogs. Objectives: Determine whether ABT occurs in dogs with CKDP and if it is associated with decreased efficacy in proteinuria reduction during RAS inhibitor treatment. Animals: Fifty‐six client‐owned dogs with CKDP and 31 healthy client‐owned dogs. Methods: Prospective, multicenter, open‐label clinical trial. Dogs were treated with an angiotensin‐converting enzyme inhibitor or angiotensin receptor blocker alone or in combination at the attending clinician's discretion and evaluated at 5 time points over 6 months. Healthy dogs were used to determine the urine aldosterone‐to‐creatinine ratio cutoff that defined ABT. The relationship of ABT (present at ≥50% of visits) and proteinuria outcome (≥50% reduction in urine protein‐to‐creatinine ratio from baseline at ≥50% of subsequent visits) was evaluated. Mixed effects logistic regression was used to evaluate the relationship between clinical variables and outcomes (either successful proteinuria reduction or ABT). Results: Thirty‐six percent (20/56) of dogs had successful proteinuria reduction. Between 34% and 59% of dogs had ABT, depending on the definition used. Aldosterone breakthrough was not associated with proteinuria outcome. Longer duration in the study was associated with greater likelihood of successful proteinuria reduction (P =.002; odds ratio, 1.6; 95% confidence interval [CI], 1.2‐2.2). Conclusions and Clinical Importance: Aldosterone breakthrough was common in dogs receiving RAS inhibitors for CKDp but was not associated with proteinuria outcome. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Contributors

Author

Adamantos, Sophie, Allen-Durrance, Ashley E., Armentano, Robert A., Aronson, Lillian Ruth, Arrowood, Amanda, Balakrishnan, Anusha, Balsa, Ingrid M., Barfield, Dominic, Barr, Ciara A., Barter, Linda S., Barthélemy, Anthony, Beer, Kari Santoro, Berent, Allyson, Birkbeck, Rachael, Boag, Amanda K., Boller, Elise Mittleman, Boller, Manuel, Boyd, Corrin, Boysen, Søren R., Brainard, Benjamin M., Brethel, Sara R., Buckley, Gareth J., Buriko, Yekaterina, Burton, Jenna H., Cenani, Alessia, Centola, Steven J., Chan, Daniel L., Chapman, Peter S., Chew, Dennis J., Clarke, Dana L., Claus, Melissa A., Cohn, Leah A., Cole, Stephen, Cooper, Edward S., Burkitt Creedon, Jamie M., Daly, Meredith L., Davis, Harold, Laforcade, Armelle de, De Rosa, Sage M., DeFrancesco, Teresa C., Dixon-Jimenez, Amy, Drobatz, Kenneth J., Duval, Justin, Eatroff, Adam E., Epstein, Steven E., Farrell, Kate S., Fischer, Christiana, Flaherty, Molly J., Fletcher, Daniel J., Francey, Thierry, Fudge, Mack, Brito Galvao, Joao Felipe de, Garzotto, Caroline K., Gelzer, Anna R.M., Gerken, Katherine K., Gianotti, Giacomo, Gibson, Erin A., Giunti, Massimo, Gommeren, Kris, Good, Jennifer M., Greensmith, Thomas D., Grubb, Tamara, Guillaumin, Julien, Hackett, Timothy B., Hagley, Simon P., Hansen, Bernie, Hart, Samantha, Harvey, Ralph C., Hayes, Galina, Hess, Rebecka S., Hoareau, Guillaume Laurent, Hoehne, Sabrina N., Holowaychuk, Marie K., Hopper, Kate, Hughes, Dez, Hume, Daniel Z., Humm, Karen, Jandrey, Karl E., Jimenez, Tania Perez, Johnson, Lynelle R., Johnston, Andrea N., Kaplan, Joanna L., Keir, Iain, Kerl, Marie E., Knipe, Marguerite F., Good, Kathryn, Koenig, Amie, Kopecny, Lucy, Kovak, Natalie, Kraus, Marc S., Langston, Catherine E., Larsen, Jennifer A., Li, Chai-Fei, Li, Ronald H.L., Debra Liu, Ta-Ying, Lynch, Alex, Lyons, Bridget M., MacDonald, Kristin A., Mandell, Deborah C., Martin, Linda G., Mathews, Karol, Mauro, Katie D., Mazzaferro, Elisa M., McBride, Duana, McClosky, Megan E., McMichael, Maureen A., Mehl, Margo, Mellema, Matthew S., Menard, Julie M., Miller, Carrie J., Miller, James B., Moeser, Adam, Monteiro, Bea, Murthy, Vishal D., Musulin, Sarah E., Odunayo, Adesola, Oldach, Maureen S., Osborne, Laura, Osekavage, Katie E., Oyama, Mark A., Palm, Carrie A., Pariaut, Romain, Pashmakova, Medora, Platt, Simon, Pouzot-Nevoret, Céline, Powell, Lisa Leigh, Pypendop, Bruno H., Quandt, Jane, Quimby, Jessica M., Rahilly, Louisa J., Ralph, Alan G., Rank, Kaitlyn, Rankin, Shelley C., Rebar, Alan H., Reineke, Erica L., Reminga, Christin L., Robben, Joris H., Robinson, Narda G., Rondeau, Mark P., Rosati, Tommaso, Rosenstein, Patricia G., Rozanski, Elizabeth, Rudloff, Elke, Schaefer, Jonathan, Schaer, Michael, Schoeffler, Gretchen L., Serrano, Sergi, Sharp, Claire R., Sharpe, Ashley N., Shropshire, Sarah B., Sigrist, Nadja E., Silverstein, Deborah C., Sleeper, Meg M., Slensky, Kimberly, Smarick, Sean D., Smart, Lisa, Soares-Dabalos, Florence, Steagall, Paulo V., Stern, Joshua A., Stewart, Randolph H., Sturges, Beverly K., Sykes, Jane E., Syring, Rebecca S., Tart, Kelly, Thawley, Vincent J., Goy-Thollot, Isabelle, Thomovsky, Elizabeth J., Todd, Jeffrey Michael, Tong, Carissa W., Troia, Roberta, Ueda, Yu, Varner, Kelley M., Vernau, Karen M., Villaverde, Cecilia, Visser, Lance C., Waddell, Lori S., Mahoney-Wages, Orla, Walker, Ashley L., Ward, Cynthia R., Ware, Wendy A., Wigglesworth, Samantha, Willard, Michael D., Winkler, Kevin, Wolf, Jake, Wright, Bonnie, Wright, Kathy N., and Green, Todd A.

Published
2023
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6. Pilot study of side effects and serum and urine concentrations of amoxicillin–clavulanic acid in azotemic and non-azotemic cats.

Author

Benson, Kellyi K, Quimby, Jessica M, Dowers, Kristy L, Sieberg, Liberty G, Daniels, Joshua B, Langston, Catherine E, Lunghofer, Paul J, and Gustafson, Daniel L

Abstract

Objectives: The aims of this study were to determine the side effect frequency and serum and urine drug concentrations of amoxicillin–clavulanic acid in cats with and without azotemic chronic kidney disease (azCKD). Methods: Owners whose cats had been prescribed amoxicillin–clavulanic acid completed a survey regarding the occurrence and type of side effects, and whether treatment was altered as a result. Cats were defined as azCKD (serum creatinine concentration >2.0 mg/dl, urine specific gravity [USG] <1.035 with a clinical diagnosis of chronic kidney disease) and without azCKD (serum creatinine concentration <2.0 mg/dl). Data were assessed with Fisher's exact test. Serum and urine samples were obtained from client-owned cats with azCKD (n = 6) and without azCKD (n = 6, serum creatinine concentration <1.8 mg/dl, USG >1.035) that were receiving amoxicillin–clavulanic acid. Amoxicillin and clavulanic acid were measured with liquid chromatography coupled to tandem mass spectrometry and compared between groups with a Mann–Whitney test. Correlation between serum creatinine and drug concentrations in urine and serum was determined using Spearman's rank test. Results: Sixty-one surveys were returned (11 azCKD cats and 50 without azCKD cats). No significant difference in the presence of side effects or type of side effects was seen between groups; however, significantly more azCKD cats had more than one side effect (P = 0.02). More owners of azCKD cats reported that an alteration in treatment plan was necessitated by side effects (55% vs 12%; P = 0.008). Urine amoxicillin was significantly lower in cats with azCKD (P = 0.01) and serum amoxicillin trended toward significance (P = 0.07). Serum amoxicillin concentration was positively correlated with serum creatinine (P = 0.02; r = 0.62) and urine amoxicillin concentration was negatively correlated with serum creatinine (P = 0.01; r = –0.65). Conclusions and relevance: The data suggest that cats with azCKD have altered pharmacokinetics of amoxicillin, which may contribute to an increased incidence of multiple side effects. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Intra‐arterial renal infusion of autologous mesenchymal stem cells for treatment of chronic kidney disease in cats: Phase I clinical trial.

Author

Thomson, Abigail L., Berent, Allyson C., Weisse, Chick, and Langston, Catherine E.

Subjects
CHRONIC kidney failure, CAT diseases, MESENCHYMAL stem cells, INTERVENTIONAL radiology, BLOOD urea nitrogen, CREATININE
Abstract

Background: There are no known treatments that halt or reverse chronic kidney disease (CKD) in cats. In rodent models, stem cell treatment has been associated with improvement in renal function parameters, especially when stem cells were delivered intra‐arterially to the kidney. To date, only IV and intrarenal stem cell infusions have been studied in cats with CKD with no clinically relevant improvement noted. Objective: To assess the safety and feasibility of intra‐arterial delivery of autologous mesenchymal stem cells (MSC) in stromal vascular fraction (SVF) to the kidney in cats with CKD. Animals: Five client‐owned domestic cats with International Renal Interest Society stage III CKD. Methods: Prospective cohort study (phase I clinical trial). Adipose tissue was harvested from study animals on day 0. On days 2 and 14, an infusion of MSC in SVF was administered into the renal artery via the femoral or carotid artery using fluoroscopic guidance. Serum creatinine and blood urea nitrogen concentration, plasma iohexol clearance, and quality of life assessments were monitored between days 0 and 90. Results: The procedure was performed successfully in all cats. No severe adverse events were observed in any cat during the study period. Conclusions and Clinical Importance: Intra‐arterial infusion of MSC into the renal artery in CKD cats was feasible and safe within a 3‐month postoperative period. Efficacy and long‐term safety have yet to be established. This procedure requires careful technique and training. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Contributors

Author

Abbott, Jonathan A., Adamantos, Sophie, Adin, Christopher A., Allen-Durrance, Ashley E., Armentano, Robert A., Aronson, Lillian R., Balakrishnan, Anusha, Beal, Matthew W., Berent, Allyson, Boag, Amanda K., Boller, Elise Mittleman, Boller, Manuel, Boothe, Dawn Merton, Borchers, Angela, Boysen, Søren R., Brainard, Benjamin M., Brown, Andrew J., Brown, Scott, Burkitt, Jamie M., Casal, Margret L., Caulfield, Ann M., Chan, Daniel L., Chapman, Peter S., Chastain, C.B., Chew, Dennis J., Clarke, Dana L., Claus, Melissa A., Cohn, Leah A., Cooper, Edward, Côté, Etienne, Crane, M. Bronwyn, Culp, William T.N., Daly, Meredith L., Davis, Emily, Davis, Harold, de Laforcade, Armelle, DeFrancesco, Teresa, Dixon-Jimenez, Amy, Donahue, Suzanne, Dowling, Patricia M., Drobatz, Kenneth J., Eatroff, Adam E., Edwards, Melissa, Eirmann, Laura, Epstein, Steven, Fletcher, Daniel J., Francey, Thierry, Fudge, Mack, Garzotto, Caroline K., Gaynor, Alison R., Giger, Urs, Giunti, Massimo, Goggs, Robert A.N., Goldstein, Richard E., Green, Todd A., Groman, Reid P., Guillaumin, Julien, Hackett, Tim B., Hackner, Susan G., Haldane, Sarah, Hallowell, Terry C., Harvey, Ralph C., Haskins, Steve C., Hayes, Galina, Hess, Rebecka S., Hoareau, Guillaume L., Hogan, Daniel F., Hollingsworth, Steven R., Holmberg, Bradford J., Holt, David, Hopper, Kate, Hughes, Dez, Hume, Daniel Z., Humm, Karen R., Jandrey, Karl E., Jasani, Shailen, Johnson, Lynelle R., Jutkowitz, L. Ari, Kanakubo, Kayo, Kerl, Marie E., King, Lesley G., Knipe, Marguerite F., Koenig, Amie, Labato, Mary Anna, Langston, Catherine E., Larsen, Jennifer A., Larson, Victoria S., LeCouteur, Richard A., Lee, Justine A., Lewis, Daniel Huw, Li, Ronald, Liu, Debra T., MacDonald, Kristin A., Machen, Maggie C., Madden, Valerie, Maglaras, Christina, Mandell, Deborah C., Mann, F.A. (Tony), Martin, Linda G., Massicotte, Christiane, Mathews, Karol A., Mazzaferro, Elisa M., McIntyre, Robin L., McMichael, Maureen, Mehl, Margo, Mellema, Matthew S., Michel, Kathryn E., Miller, Carrie J., Miller, James B., Moeser, Adam, Otto, Cynthia M., Oura, Trisha J., Oyama, Mark A., Palm, Carrie A., Papich, Mark G., Pariaut, Romain, Perkowski, Sandra, Pich, Michele, Platt, Simon R., Powell, Lisa Leigh, Prošek, Robert, Pypendop, Bruno H., Quandt, Jane, Rahilly, Louisa J., Ralph, Alan G., Rankin, Shelley C., Rebar, Alan H., Reineke, Erica L., Reiss, Adam J., Reynolds, Caryn, Riordan, Laura L., Robben, Joris H., Robinson, Narda G., Rondeau, Mark P., Rosenstein, Patricia G., Rousseau, Alexandre, Rozanski, Elizabeth A., Rudloff, Elke, Santoro-Beer, Kari, Sauvé, Valérie, Savino, Emily, Schaer, Michael, Serrano, Sergio, Sharp, Claire R., Shaw, Scott P., Sigrist, Nadja E., Silverstein, Deborah C., Sleeper, Meg, Smarick, Sean, Smart, Lisa, Sorrell-Raschi, Laurie, Steinberg, Sheldon A., Stewart, Randolph H., Sturges, Beverly K., Sykes, Jane E., Syring, Rebecca S., Todd, Jeffrey M., Trotman, Tara K., Vernau, Karen M., Villaverde, Cecilia, Vite, Charles H., Volk, Susan W., Waddell, Lori S., Wang, Andrea, Ward, Cynthia R., Ware, Wendy A., Wey, Aaron C., Willard, Michael D., Winkler, Kevin P., Wright, Annie Malouin, Wright, Bonnie, and Wright, Kathy N.

Published
2015
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