389 results on '"Leadlay, Peter F."'
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2. Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
3. Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition
4. Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
5. C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A
6. Methyltransferases of gentamicin biosynthesis
7. A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis
8. Giant Plasmid-Encoded Polyketide Synthases Produce the Macrolide Toxin of Mycobacterium ulcerans
9. Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase
10. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin
11. Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex
12. Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis
13. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
14. Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK
15. The Biosynthetic Gene Cluster for the Polyketide Immunosuppressant Rapamycin
16. Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
17. Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
18. STRUCTURAL BIOLOGY: Enzyme assembly line pictured
19. Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin
20. Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449
21. Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans
22. Active-site residue, domain and module swaps in modular polyketide synthases
23. The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry
24. Engineering broader specificity into an antibiotic-producing polyketide synthase
25. Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry
26. The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin
27. Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
28. Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage
29. Induction, purification and characterisation of acyl-ACP thioesterase from developing seeds of oil seed rape (Brassica napus)
30. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation
31. Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases
32. Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
33. Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea
34. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase
35. New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster
36. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea
37. A chain initiation factor common to both modular and aromatic polyketide synthases
38. Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones
39. Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
40. Cross‐Module Enoylreduction in the Azalomycin F Polyketide Synthase.
41. The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate‐forming enzyme family.
42. Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering
43. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
44. The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic.
45. Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation
46. An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics
47. Sarpeptins A and B, Lipopeptides Produced by sp. KO-7888 Overexpressing a Specific SARP Regulator.
48. Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase.
49. The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.
50. Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis
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