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135 results on '"Lebesque, J"'

3. MRI-guided needle localisation of suspicious breast lesions: results of a freehand technique

Author

van den Bosch, M A A J, Daniel, B L, Jeffrey, S S, Ikeda, D M, Veltman, J, Boetes, C, Kok, T, Obdeijn, I M, Manoliu, R, Blickman, J G, Barentsz, J O, Huisman, H J, Rizzo, S, Preda, L, Villa, G, Bazzi, L, Cassano, E, Bellomi, M, Dicken, V, Bornemann, L, Kuhnigk, J-M, Krass, S, Wormanns, D, Peitgen, O, Schmidt, G P, de Geus-Oei, L F, Pieters, G F F M, Bonenkamp, J J, Mudde, A H, Corstens, F H M, Oyen, W J G, Fütterer, J J, Th van Lin, E N J, Heijmink, S W T P J, van der Vight, L P, Visser, A G, Sonke, J-J, Remeijer, P, Betgen, A, Lebesque, J, Jaffray, D, Herk, M V, Schueller, G, Prokesch, R, Schueller-Weidekamm, C, Schima, W, Bent, C L, Sahdev, A, Wenaden, A, Sohaib, S A, Rockall, A, Reznek, R H, Hughes, J L, Wenaden, A E T, Shepherd, J H, Anderson, K E, Hewitt, M J, Wilkinson, N, Swift, S E, Weston, M J, and Spencer, J A

Subjects
Symposium, Article
Published
2005

12. Radiotherapy of tonsillar and base of the tongue carcinoma. Prediction of local control

Author

Mak-Kregar, S., Baris, G., Lebesque, J. V., Balm, A. J., Hart, A. A., Hilgers, F. J., and Other departments

Abstract

119 patients with squamous cell carcinoma of the tonsillar region (68) and the base of the tongue (51), who received external radiotherapy with curative intent between 1966 and 1984, are analysed with respect to overall treatment results, local tumour control and prognostic factors. Radiation doses were equivalent to 60-70 Gy in 6-7 weeks, with a mean fraction dose of 2.4 Gy on the cobalt 60 equipment and 2 Gy on the linear accelerator. Significant differences were found between both oropharyngeal subsites. Three-year overall survival was 57% in tonsillar carcinoma and 38% in base of the tongue (P = 0.006); disease-specific survival was 70% and 47%, respectively (P = 0.005); and local control rates were 82% and 61% (P = 0.02). Late damage to normal tissues, like persistent dysphagia and osteomyelitis, were seen in 11% of patients. Patients with large tumours in the tongue based developed significantly more complications (P = 0.04). T-stage and tumour subsite predicted local control independently before start of the treatment (P = 0.02 in both cases). A significant nonlinear correlation between Normalised Total Dose (using an alpha/beta ratio of 15 Gy) and local control rate was found (P = 0.006), the middle range having the worst prognosis. The size of radiation field and overall treatment time did not correlate with local control in either site. Response at the end of radiotherapy and 6 weeks later have additional prognostic value for local control, irrespective of the initial stage or subsite (P = 0.004 and

Published
1993

48. Modeling radiation pneumonitis of pulmonary stereotactic body radiotherapy: The impact of a local dose-effect relationship for lung perfusion loss.

Author

Selvaraj J, Lebesque J, Hope A, Guckenberger M, Werner-Wasik M, Peulen H, Giuliani M, Mantel F, Belderbos J, Grills I, and Sonke JJ

Subjects
Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Dose-Response Relationship, Radiation, Female, Humans, Incidence, Lung physiopathology, Lung radiation effects, Lung Neoplasms physiopathology, Lung Neoplasms radiotherapy, Male, Models, Biological, Perfusion, Radiation Pneumonitis physiopathology, Radiotherapy Dosage, Radiation Pneumonitis etiology, Radiosurgery adverse effects
Abstract

Purpose: To investigate if a local dose-effect (LDE) relationship for perfusion loss improves the NTCP model fit for SBRT induced radiation pneumonitis (RP) compared to conventional LDEs., Methods and Materials: Multi-institutional data of 1015 patients treated with SBRT were analyzed. Dose distributions were converted to NTD with α/β = 3 Gy. The Lyman-Kutcher-Burman NTCP model was fitted to the incidence grade ≥2 RP by maximum likelihood estimation with mean lung dose (MLD), equivalent uniform doses (EUD) using three LDE functions (power-law (EUD power ), logistic with 2 free parameters (EUD log-free ) and logistic with fixed parameters describing local perfusion loss (EUD Perfusion )) and volume above a threshold dose (V x ). Models were compared with the Akaike weights (Aw) derived from the Akaike information criteria (AIC)., Results: The median time to grade ≥2 RP was 4.2 months and plateaued after 17 months at 5.4%. A strong dose-effect relationship for RP incidence was observed. The EUD Perfusion based NTCP model had the lowest AIC. The Aw were 0.53, 0.19, 0.11, 0.11, 0.05 for the EUD Perfusion , V x , MLD, EUD log-free and EUD power LDEs respectively., Conclusion: A LDE for perfusion loss provided modest improvement in NTCP model fit for SBRT induced radiation pneumonitis., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2019
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49. Relating acute esophagitis to radiotherapy dose using FDG-PET in concurrent chemo-radiotherapy for locally advanced non-small cell lung cancer.

Author

Nijkamp J, Rossi M, Lebesque J, Belderbos J, van den Heuvel M, Kwint M, Uyterlinde W, Vogel W, and Sonke JJ

Subjects
Acute Disease, Adult, Aged, Carcinoma, Non-Small-Cell Lung diagnostic imaging, Dose-Response Relationship, Radiation, Female, Humans, Lung Neoplasms diagnostic imaging, Male, Middle Aged, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Carcinoma, Non-Small-Cell Lung therapy, Chemoradiotherapy adverse effects, Esophagitis etiology, Fluorodeoxyglucose F18, Lung Neoplasms therapy, Positron-Emission Tomography, Radiopharmaceuticals
Abstract

Purpose: To correlate radiotherapy (RT) dose to acute esophagitis (AE) by means of FDG-PET scans acquired after concurrent chemo-radiotherapy (cCRT) for locally advanced non-small-cell lung cancer (NSCLC)., Materials and Methods: Patients treated with 24 × 2.75 Gy were selected on presence of a post-RT PET (PET(post)) scan acquired within 3 months after cCRT. The value of PET(post) in relation to AE was evaluated by comparing the mean esophageal SUV of the highest 50% (mathematical left angle bracket SUV(50%) mathematical right angle bracket) between gr < 2 and gr ≥ 2AE. The local dose on the esophagus wall was correlated to the SUV and modeled using a power-law fit. The Lyman-Kutcher-Burman (LKB) model was used to predict gr ≥ 2AE. The local dose-response relation was used in the LKB model to calculate the EUD. Resulting prediction accuracy was compared to D(mean), V(35), V(55) and V(60)., Results: Eighty-two patients were included (gr < 2 = 25, gr ≥ 2=57). The mathematical left angle bracket SUV(50%) mathematical right angle bracket ≥ was significantly higher for gr ≥ 2AE (2.2 vs. 2.6, p < 0.01). The LKB parameters (95% CI) were n = 0.130 (0.120-0.141), m = 0.25 (0.13-0.85) and TD(50) = 50.4 Gy (37.5-55.4), which resulted in improved predictability of AE compared to other predictors., Conclusion: Esophageal uptake of FDG post-cCRT reflects AE severity. Predictability of grade ≥ 2AE was improved by using the local dose-SUV response model, with narrow confidence intervals for the optimized LKB parameters., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2013
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50. Re: Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer.

Author

Borst GR, Belderbos J, Burgers S, Sonke JJ, and Lebesque J

Subjects
Adult, Aged, Aged, 80 and over, Carboplatin administration & dosage, Cisplatin administration & dosage, Combined Modality Therapy, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Female, Humans, Male, Middle Aged, Radiotherapy Dosage, Treatment Outcome, Vinblastine administration & dosage, Vinblastine analogs & derivatives, Vinorelbine, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung radiotherapy, Dyspnea etiology, Dyspnea physiopathology, Lung radiation effects, Lung Neoplasms drug therapy, Lung Neoplasms radiotherapy
Published
2009
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