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266 results on '"Lee, Leonard Y."'

11. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Author

Newman, Jenna H., Chesson, C. Brent, Herzog, Nora L., Bommareddy, Praveen K., Aspromonte, Salvatore M., Pepe, Russell, Estupinian, Ricardo, Aboelatta, Mones M., Buddhadev, Stuti, Tarabichi, Saeed, Lee, Michael, Li, Shengguo, Medina, Daniel J., Giurini, Eileena F., Gupta, Kajal H., Guevara-Aleman, Gabriel, Rossi, Marco, Nowicki, Christina, Abed, Abdulkareem, Goldufsky, Josef W., Broucek, Joseph R., Redondo, Raquel E., Rotter, David, Jhawar, Sachin R., Wang, Shang-Jui, Kohlhapp, Frederick J., Kaufman, Howard L., Thomas, Paul G., Gupta, Vineet, Kuzel, Timothy M., Reiser, Jochen, Paras, Joyce, Kane, Michael P., Singer, Eric A., Malhotra, Jyoti, Denzin, Lisa K., Sant’Angelo, Derek B., Rabson, Arnold B., Lee, Leonard Y., Lasfar, Ahmed, Langenfeld, John, Schenkel, Jason M., Fidler, Mary Jo, Ruiz, Emily S., Marzo, Amanda L., Rudra, Jai S., Silk, Ann W., and Zloza, Andrew

Published
2020

30. Quality of Mitral Valve Surgery Does Not Differ by Hospital Volume in New Jersey

Author

Laraia, Kayla N., Sabatino, Marlena E., Volk, Lindsay, Dewan, Krish C., Yang, NaYoung K., Yoo, Jin, Dindigal, Ankitha H., Russo, Mark J., and Lee, Leonard Y.

Abstract

Background and Aim of the Study. To investigate if mitral valve (MV) surgery quality differs by hospital volume in New Jersey (NJ). Methods. Using the NJ State Inpatient Database, patients ≥18 years undergoing MV repair or replacement from 2016–2019 were identified. Centers were considered high-volume if they performed more than 50 mitral operations annually. Baseline characteristics and outcomes (in-hospital mortality, seven-day readmission, hospital length of stay (LOS), and postoperative complications) were evaluated for the population and by center volume. Subanalysis by center volume within each procedure was conducted. Results. Among 2,560 mitral operations, MV replacement (92.3% (n = 2,362)) was performed more often than repair. High- (4) and low-volume (15) centers performed 1,180 (46.1%) and 1,380 (53.9%) mitral surgeries, respectively. Charlson Comorbidity Indices did not differ by center volume, including in subgroup analyses. Low-volume centers had higher rates of Hispanic patients, low-income patients, and readmission rates. High-volume centers had more transfers, urgent/emergent admissions, higher rates of in-hospital mortality, and longer LOS. Postoperative complications did not differ by volume. The MV replacement cohort reflected many of the differences seen in the total population, in addition to seeing higher rates of heart failure at high-volume centers and stroke at low-volume centers. Within MV repairs, significantly more Hispanic patients presented to low-volume centers and high-volume centers had longer LOS. Multivariable analysis indicated that hospital volume was not correlated to in-hospital mortality for the total population and within each procedure. Conclusions. MV replacement is performed more frequently than repair. Hospital volume is not correlated with MV surgical quality, and more representative quality measures are needed.

Published
2023
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35. Use of Sodium Bicarbonate Purge Solution in Impella Devices for Heparin-Induced Thrombocytopenia.

Author

Al-Ayoubi, Adnan M., Bhavsar, Kinnari, Hobbs, Ryan A., Smith, Katharyn L., Lee, Leonard Y., Ikegami, Hirohisa, and Singhal, Arun K.

Subjects
WARFARIN, SODIUM bicarbonate, HYPERTENSION, PROTEINS, COVID-19, HEART assist devices, ANTICOAGULANTS, HYPERLIPIDEMIA, CASE studies, CARDIOGENIC shock, THROMBOCYTOPENIA, HEPARIN, HEART failure
Abstract

Heparin purge solution is recommended to be used in Impella devices to prevent biomaterial buildup and subsequent device dysfunction. The use of sodium bicarbonate purge solution in an Impella device is described in two patients with heparin-induced thrombocytopenia (HIT). The first case details a patient with severe mitral regurgitation and cardiogenic shock who had an Impella CP placed who developed HIT. Heparin purge solution was replaced by sodium bicarbonate purge solution in addition to systemic direct thrombin inhibitor (DTI) initiation. There was no significant change in Impella purge pressure or flow over the 13 days of Impella use. The second case describes a patient who developed an acute myocardial infarction and subsequent cardiogenic shock for which an Impella CP was placed who also developed HIT. Heparin purge solution was replaced by sodium bicarbonate purge solution. There was no significant change in purge pressure, flow, or motor current spikes over 11 days of use. In conclusion, we describe the successful use of a novel sodium bicarbonate purge solution utilized in patients with HIT for Impella management alone and in combination with systemic direct thrombin inhibitor therapy. This resulted in no protein deposition in the device gaps or device dysfunction. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Delayed Sternal Closure After Cardiac Surgery

Author

Saadat, Siavash, Schultheis, Molly, Romero, Joseph, Azzolini, Anthony, Dombrovskiy, Viktor, Odroniec, Karen, Scholz, Peter, Lemaire, Anthony, Batsides, George, and Lee, Leonard Y.

Published
2014

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