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Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear translocation might inhibit development of fibrosis following injury. We now demonstrate that levels of nuclear FUS are significantly increased in mouse models of kidney and liver fibrosis. To evaluate the direct role of FUS nuclear translocation in fibrosis, we used mice that carry a mutation in the FUS nuclear localization sequence (FUSR521G) and the cell-penetrating peptide CP-FUS-NLS that we previously showed inhibits FUS nuclear translocation in vitro. We provide evidence that FUSR521G mice or CP-FUS-NLS-treated mice showed reduced nuclear FUS and fibrosis following injury. Finally, differential gene expression analysis and immunohistochemistry of tissues from individuals with focal segmental glomerulosclerosis or nonalcoholic steatohepatitis revealed significant upregulation of FUS and/or collagen genes and FUS protein nuclear localization in diseased organs. These results demonstrate that injury-induced nuclear translocation of FUS contributes to fibrosis and highlight CP-FUS-NLS as a promising therapeutic option for organ fibrosis., Introduction Organ fibrosis is characterized by excessive deposition of extracellular matrix (ECM) components (mainly collagen) within an injured organ that leads to the disruption of normal tissue architecture and loss [...]

Let kk be a nonnegative integer. Let KK be a number field and OK{{\mathcal{O}}}_{K} be the ring of integers of KK. Let ℓ≥5\ell \ge 5 be a prime and vv be a prime ideal of OK{{\mathcal{O}}}_{K} over ℓ\ell . Let ff be a modular form of weight k+12k+\frac{1}{2} on Γ0{\Gamma }_{0}(4) such that its Fourier coefficients are in OK{{\mathcal{O}}}_{K}. In this article, we study sufficient conditions that if ff has the form f(z)≡∑n=1∞∑i=1taf(sin2)qsin2(modv)f\left(z)\equiv \mathop{\sum }\limits_{n=1}^{\infty }\mathop{\sum }\limits_{i=1}^{t}{a}_{f}\left({s}_{i}{n}^{2}){q}^{{s}_{i}{n}^{2}}\hspace{0.5em}\left({\rm{mod}}\hspace{0.33em}v) with square-free integers si{s}_{i}, then ff is congruent to a linear combination of iterated derivatives of a single theta function modulo vv.

Advancing neuromorphic computing technology requires the development of versatile synaptic devices. In this study, we fabricated a high-performance Al/LiNbO3/Pt memristive synapse and emulated various synaptic functions using its primary key operating mechanism, known as oxygen vacancy-mediated valence charge migration (VO-VCM). The voltage-controlled VO-VCM induced space-charge-limited conduction and self-rectifying asymmetric hysteresis behaviors. Moreover, the device exhibited voltage pulse-tunable multi-state memory characteristics because the degree of VO-VCM was dependent on the applied pulse parameters (e.g., polarity, amplitude, width, and interval). As a result, synaptic functions such as short-term memory, dynamic range-tunable long-term memory, and spike time-dependent synaptic plasticity were successfully demonstrated by modulating those pulse parameters. Additionally, simulation studies on hand-written image pattern recognition confirmed that the present device performed with high accuracy, reaching up to 95.2%. The findings suggest that the VO-VCM-based Al/LiNbO3/Pt memristive synapse holds significant promise as a brain-inspired neuromorphic device. [ABSTRACT FROM AUTHOR]

This article reviews the latest advancements in perovskite solar cell (PSC) components for innovative photovoltaic applications. Perovskite materials have emerged as promising candidates for next-generation solar cells due to their exceptional light-absorbing capabilities and facile fabrication processes. However, limitations in their stability, scalability, and efficiency have hindered their widespread adoption. This review systematically explores recent breakthroughs in PSC components, focusing on absorbed layer engineering, electron and hole transport layers, and interface materials. In particular, it discusses novel perovskite compositions, crystal structures, and manufacturing techniques that enhance stability and scalability. Additionally, the review evaluates strategies to improve charge carrier mobility, reduce recombination, and address environmental considerations. Emphasis is placed on scalable manufacturing methods suitable for large-scale integration into existing infrastructure. This comprehensive review thus provides researchers, engineers, and policymakers with the key information needed to motivate the further advancements required for the transformative integration of PSCs into global energy production. [ABSTRACT FROM AUTHOR]

Site selection and characterisation are key factors influencing the safe, stable disposal of spent nuclear fuel. Site selection can be based on geophysical surveys, and geophysical well logging is performed at the detailed survey stage. Typically, gamma – gamma density logging is conducted to continuously obtain in situ density information regarding the well depth. However, gamma – gamma density logging is often influenced by the geological characteristics of the site. The ratio of atomic number to atomic weight is required to convert the electron density obtained through density logging counts into bulk density. Because it is difficult to calculate these ratios for the entire depth, an equation based on water-filled limestone is typically used for conversion. Therefore, as the difference in the ratio of the atomic number and atomic weight increases relative to that of limestone, the difference between the converted bulk density and the actual bulk density increases. In this study, equations were derived for various mineral compositions and applied to the density logging results. Matrix density was analyzed using a pycnometer, and the ratio between the atomic number and weight was calculated according to X-ray fluorescence analysis results. This approach improved the accuracy of the density logging data and reduced density errors. The proposed method is expected to be particularly useful for estimating in situ density at high-level radioactive waste disposal sites without complex geological formations. [ABSTRACT FROM AUTHOR]

This study explores the application of fine-tuned large language models for predicting physicochemical properties, specifically focusing on Abraham model solute descriptors (E, S, A, B, V) and modified solvent parameters (e0, s0, a0, b0, v0). By leveraging ChemLLaMA, a specialized version of the LLaMA model for cheminformatics tasks, we developed the AbraLlama-Solvent and AbraLlama-Solute models using curated datasets of experimentally derived solute descriptors and solvent parameters. Our findings demonstrate that AbraLlama-Solvent and AbraLlama-Solute predict modified solvent parameters and solute descriptors with high accuracy, comparable to existing methods. The AbraLlama-Solvent model shows varying prediction accuracy across different solvents, influenced by their position within the chemical space, while the AbraLlama-Solute model consistently predicts solute descriptors with high accuracy. Both models are available as applications on Hugging Face, facilitating easy predictions from SMILES strings. This research highlights the potential of LLMs in chemistry applications, offering practical tools for solvent comparison and expanding the applicability of Abraham solvation equations to a broader range of organic solvents. [ABSTRACT FROM AUTHOR]

Let m and N be positive integers and k be a negative real number. Let χ be a multiplier system of weight k on Γ 0 (N). In this paper, we give an exact formula for the Fourier coefficients of the holomorphic part of a harmonic Maass–Jacobi form of weight k, index m, and multiplier system χ on Γ 0 (N). As an application, we investigate the number of ratios of the Fourier coefficients of the holomorphic parts of two harmonic Maass–Jacobi forms. Moreover, we obtain the equivalent conditions for the principal part of a harmonic Maass–Jacobi form to be the principal part of a weak Jacobi form with poles only at infinity. [ABSTRACT FROM AUTHOR]

Bismuth titanate (Bi4Ti3O12, BTO) thin films were deposited on a platinized silicon (Pt/Ti/SiO2/Si) substrate using a spin-coating method with varying thicknesses (138–528 nm). XRD results revealed that the growth temperature and film thickness were major factors that influenced the quality and morphology of the film surface. The thickness-dependent structural, morphological, and optical properties of BTO thin films were analyzed. The Bi/Ti ratio was quantitatively assessed through EDS analysis to obtain compositional data. The decreasing of the substrate clamping effect and the interfacial-layer effect caused the dielectric constant to increase the thickness. A series capacitor model was used to illustrate the relationship between dielectric behavior and thickness. The optimum value of the dielectric constant (4228 at 100 Hz) and dielectric loss (0.074) was observed for the PT/BTO/Pt interfacial layer with a film thickness of 528 nm. [ABSTRACT FROM AUTHOR]

In this study, two types of Si3N4 ball bearings for integrated-type EV reducers developed via different manufacturing processes were analyzed to study the microstructure of the balls and the defects that may occur during the manufacturing process. Three types of defects were confirmed that can reduce the fatigue life of Si3N4 ball bearings in operating environments. The microstructure was analyzed to identify the main additive components of each bearing, and pore defects with a size of less than 1 μm, and the types (particle defects or surface defects) and sizes of defects, were analyzed using LSCM, OM, and SEM. Hardness and fracture toughness, which are representative mechanical properties of ceramic materials, were evaluated. The results, evaluated using a Vickers indentation crack-based method, were statistically analyzed to confirm differences in hardness and fracture toughness between the two samples. [ABSTRACT FROM AUTHOR]

Developing the ecofriendly and high-fidelity electrocatalysts for the oxygen evolution reaction (OER) is essential to foster effective production of environmentally friendly hydrogen. Herein, we fabricated the highly efficient OER electrocatalysts of the activated carbon-decorated vanadium pentoxide (AC-V2O5) nanocomposites using a facile hydrothermal technique. The AC-V2O5 nanocomposites displayed an aggregated structure of the AC nano-sheet-anchored orthorhombic V2O5 nanorods. When performing the OER process in an alkaline electrolyte at 10 mA/cm2, AC-V2O5 exhibited the low overpotential (~230 mV), small Tafel slope (~54 mV/dec), and excellent stability. These substantial OER performances of AC-V2O5 could be ascribed to the synergistic effects from both the electrochemically active V2O5 nanorods and the highly conductive AC nanosheets. The results infer that the AC-V2O5 nanocomposites possess a substantial aptitude as a high-performance OER electrocatalyst for production of the future green energy source—hydrogen. [ABSTRACT FROM AUTHOR]