34 results on '"Leon Wang"'
Search Results
2. Polymeric nanocarriers co-encapsulating PET probes and protein therapeutics
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Chester Markwalter, Leon Wang, Ola Sharaf, Prashanth Padakanti, Mark Esposito, Brian Wilson, Eric Blankemeyer, Sean Carlin, Abass Alavi, and Robert K. Prud'homme
- Subjects
Medicine ,Medical technology ,R855-855.5 - Abstract
Nanocarriers encapsulating nucleic acids or protein therapeutics are important tools for modulating biodistribution and enhancing intracellular delivery of biologics. We have recently developed inverse Flash NanoPrecipitation (iFNP), demonstrating its effectiveness in encapsulating biologics at high loadings and encapsulation efficiency. Here, we present the biodistribution of two iFNP nanocarriers using 64Cu positron emission tomography imaging in a murine adenocarcinoma xenograft model characterized by elevated macrophage content. Two nanocarriers with similar sizes and surfaces were prepared. iFNP produces core-shell-corona nanocarriers where the hydrophobic shell layer in one case was poly(lactic acid) (PLA), and the other nanocarrier shell was poly(styrene) (PS). While the expectation was that the biodistribution and clearance of both nanocarriers would be similar, it was found that the clearance of the PS nanocarrier oc-curred in less than 3 hours while the PLA nanocarrier exhibited sustained circulation times. The mechanism of nanocarrier instability for the PS shell nanocarrier manifests as the development of a negative surface charge due to the exposure of the anionic nanocarrier inner core. The stable PLA-based formulation exhibited circulation times greater than 24 hours and enhanced accumu-lation in the lymphatics and the tumor relative to the unstable formulation. The novel mecha-nism of encapsulation by iFNP motivates the fundamental studies on nanoparticle biodistribu-tion reported here.
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- 2022
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3. Analyzing the impact of various factors on leaf surface temperature based on a new tree-scale canopy energy balance model
- Author
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Li, Ruibin, Zeng, Fanxing, Zhao, Yi, Wu, Yan, Niu, Jianlei, (Leon) Wang, Liangzhu, Gao, Naiping, Zhou, Haizhu, Shi, Xing, and Huang, Zishuo
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- 2023
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4. A real-time web tool for monitoring and mitigating indoor airborne COVID-19 transmission risks at city scale
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Katal, Ali, (Leon) Wang, Liangzhu, and Albettar, Maher
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- 2022
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5. Moderate-severe peripheral neuropathy in diabetes associated with an increased risk of dry eye disease.
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Tummanapalli, Shyam Sunder, Leiao Leon Wang, Dhanapalaratnam, Roshan, Poynten, Ann, Papas, Eric B., Krishnan, Arun Vishwanathan, and Markoulli, Maria
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- 2024
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6. Application of the EnKF method for real-time forecasting of smoke movement during tunnel fires
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Ji, Jie, Tong, Qi, (Leon) Wang, Liangzhu, Lin, Cheng-Chun, Zhang, Cong, Gao, Zihe, and Fang, Jun
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- 2018
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7. Froude-Stanton modeling of heat and mass transfer in large vertical spaces of high-rise buildings
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Qi, Dahai, (Leon) Wang, Liangzhu, and Zhao, Guanchao
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- 2017
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8. Multizone Modeling of Airborne SARS-CoV-2 Quanta Transmission and Infection Mitigation Strategies in Office, Hotel, Retail, and School Buildings
- Author
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Shujie Yan, Liangzhu (Leon) Wang, Michael J. Birnkrant, Zhiqiang (John) Zhai, and Shelly L. Miller
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multizone ,SARS-CoV-2 ,quanta ,airborne transmission ,Architecture ,Building and Construction ,Civil and Structural Engineering - Abstract
Airborne transmission of SARS-CoV-2 mostly occurs indoors, and effective mitigation strategies for specific building types are needed. Most guidance provided during the pandemic focused on general strategies that may not be applicable for all buildings. A systematic evaluation of infection risk mitigation strategies for different public and commercial buildings would facilitate their reopening process as well as post-pandemic operation. This study evaluates engineering mitigation strategies for five selected US Department of Energy prototype commercial buildings (i.e., Medium Office, Large Office, Small Hotel, Stand-Alone Retail, and Secondary School). The evaluation applied the multizone airflow and contaminant simulation software, CONTAM, with a newly developed CONTAM-quanta approach for infection risk assessment. The zone-to-zone quanta transmission and quanta fate were analyzed. The effectiveness of mechanical ventilation, and in-duct and in-room air treatment mitigation strategies were evaluated and compared. The efficacy of mitigation strategies was evaluated for full, 75%, 50% and 25% of design occupancy of these buildings under no-mask and mask-wearing conditions. Results suggested that for small spaces, in-duct air treatment would be insufficient for mitigating infection risks and additional in-room treatment devices would be needed. To avoid assessing mitigation strategies by simulating every building configuration, correlations of individual infection risk as a function of building mitigation parameters were developed upon extensive parametric studies.
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- 2022
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9. Impact of Chronic Kidney Disease on Corneal Neuroimmune Features in Type 2 Diabetes
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Kofi Asiedu, Maria Markoulli, Shyam Sunder Tummanapalli, Jeremy Chung Bo Chiang, Sultan Alotaibi, Leiao Leon Wang, Roshan Dhanapalaratnam, Natalie Kwai, Ann Poynten, and Arun V. Krishnan
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General Medicine ,diabetes ,chronic kidney disease ,corneal nerves ,dendritic cells ,neuroinflammation - Abstract
Aim: To determine the impact of chronic kidney disease on corneal nerve measures and dendritic cell counts in type 2 diabetes. Methods: In vivo corneal confocal microscopy images were used to estimate corneal nerve parameters and compared in people with type 2 diabetes with chronic kidney disease (T2DM-CKD) (n = 29) and those with type 2 diabetes without chronic kidney disease (T2DM-no CKD) (n = 29), along with 30 healthy controls. Corneal dendritic cell densities were compared between people with T2DM-CKD and those with T2DM-no CKD. The groups were matched for neuropathy status. Results: There was a significant difference in corneal nerve fiber density (p < 0.01) and corneal nerve fiber length (p = 0.04) between T2DM-CKD and T2DM-no CKD groups. The two diabetes groups had reduced corneal nerve parameters compared to healthy controls (all parameters: p < 0.01). Immature central dendritic cell density was significantly higher in the T2DM-CKD group compared to the T2DM-no CKD group ((7.0 (3.8–12.8) and 3.5 (1.4–13.4) cells/mm2, respectively, p < 0.05). Likewise, central mature dendritic cell density was significantly higher in the T2DM-CKD group compared to the T2DM-no CKD group (0.8 (0.4–2.2) and 0.4 (0.6–1.1) cells/mm2, respectively, p = 0.02). Additionally, total central dendritic cell density was increased in the T2DM-CKD group compared to T2DM-no CKD group (10.4 (4.3–16.1) and 3.9 (2.1–21.0) cells/mm2, respectively, p = 0.03). Conclusion: The study showed that central corneal dendritic cell density is increased in T2DM-CKD compared to T2DM-no CKD, with groups matched for peripheral neuropathy severity. This is accompanied by a loss of central corneal nerve fibers. The findings raise the possibility of additional local factors exacerbating central corneal nerve injury in people with diabetic chronic kidney disease.
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- 2022
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10. Resilient cooling strategies – A critical review and qualitative assessment
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Giacomo Chiesa, Agnese Salvati, Feryal Chtioui, Philipp Stern, Maria Kolokotroni, Chen Zhang, Hilde Breesch, Ramin Rahif, Behzad Sodagar, Hui Zhang, Dahai Qi, Abantika Sengupta, Ardeshir Mahdavi, Vincent Lemort, Helene Teufl, Saqib Javed, Abolfazl Hayati, Liangzhu Leon Wang, Shady Attia, Stephen Selkowitz, Taha Arghand, Emmanuel Bozonnet, Mathias Cehlin, Michele Zinzi, Ronnen Levinson, Ricardo Forgiarini Rupp, Guoqiang Zhang, Dragos-Ioan Bogatu, Sana Sayadi, Edward Arens, Jan Akander, Ongun Berk Kazanci, Zhengtao Ai, Per Heiselberg, Sadegh Forghani, Patrick Salagnac, Bjarne W. Olesen, Essam Elnagar, Nari Yoon, Universitat Politècnica de Catalunya. Departament de Tecnologia de l'Arquitectura, Universitat Politècnica de Catalunya. AIEM - Arquitectura, energia i medi ambient, Zhang, C., Kazanci, O. B., Levinson, R., Heiselberg, P., Olesen, B. W., Chiesa, G., Sodagar, B., Ai, Z., Selkowitz, S., Zinzi, M., Mahdavi, A., Teufl, H., Kolokotroni, M., Salvati, A., Bozonnet, E., Chtioui, F., Salagnac, P., Rahif, R., Attia, S., Lemort, V., Elnagar, E., Breesch, H., Sengupta, A., Wang, L. L., Qi, D., Stern, P., Yoon, N., Bogatu, D. -I., Rupp, R. F., Arghand, T., Javed, S., Akander, J., Hayati, A., Cehlin, M., Sayadi, S., Forghani, S., Zhang, H., Arens, E., Zhang, G., Institut de Recherche en Sciences et Techniques de la Ville - FR 2488 (IRSTV), Université de Nantes (UN)-École Centrale de Nantes (ECN)-EC. ARCHIT. NANTES-Université d'Angers (UA)-Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 (LaSIE), and Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)
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Passive cooling ,Computer science ,Arquitectura::Arquitectura sostenible [Àrees temàtiques de la UPC] ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,7. Clean energy ,[SPI]Engineering Sciences [physics] ,Building cooling ,Arquitectura i estalvi d'energia ,Power outage ,11. Sustainability ,Resilient Climate change ,SDG 13 - Climate Action ,0202 electrical engineering, electronic engineering, information engineering ,Water cooling ,Active cooling ,Climate change ,Critical review ,Heatwave ,Low-energy cooling ,Qualitative analysis ,Resilient ,uilding cooling ,ComputingMilieux_MISCELLANEOUS ,Architecture and energy conservation ,Energies::Gestió de l'energia::Estalvi energètic [Àrees temàtiques de la UPC] ,climate change ,building cooling ,resilient ,power outage ,020209 energy ,Heatwave Power outage ,Energy Engineering ,Effects of global warming ,Electrical and Electronic Engineering ,Resilience (network) ,0105 earth and related environmental sciences ,Civil and Structural Engineering ,Adaptive capacity ,Mechanical Engineering ,Buildings -- Cooling ,Edificis -- Refrigeració ,Building and Construction ,Reliability engineering ,Energiteknik ,13. Climate action ,K100 Architecture ,Envelope (motion) - Abstract
Copyright © 2021 The Author(s). The global effects of climate change will increase the frequency and intensity of extreme events such as heatwaves and power outages, which have consequences for buildings and their cooling systems. Buildings and their cooling systems should be designed and operated to be resilient under such events to protect occupants from potentially dangerous indoor thermal conditions. This study performed a critical review on the state-of-the-art of cooling strategies, with special attention to their performance under heatwaves and power outages. We proposed a definition of resilient cooling and described four criteria for resilience—absorptive capacity, adaptive capacity, restorative capacity, and recovery speed —and used them to qualitatively evaluate the resilience of each strategy. The literature review and qualitative analyses show that to attain resilient cooling, the four resilience criteria should be considered in the design phase of a building or during the planning of retrofits. The building and relevant cooling system characteristics should be considered simultaneously to withstand extreme events. A combination of strategies with different resilience capacities, such as a passive envelope strategy coupled with a low-energy space-cooling solution, may be needed to obtain resilient cooling. Finally, a further direction for a quantitative assessment approach has been pointed out. The research is supported by Det Energiteknologisk Udviklings- og Demonstrationsprogram (EUDP) under grant 64018-0578. It was also supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Building Technologies Office of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.
- Published
- 2021
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11. Evaluation and improvement of the thermoregulatory system for the two-node bioheat model
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Abdelaziz Laouadi, Liangzhu (Leon) Wang, Lili Ji, Michael A. Lacasse, and Chang Shu
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Mean squared error ,Computer science ,thermal comfort ,Mechanical Engineering ,Cold exposure ,Thermal comfort ,Experimental data ,Skin temperature ,Building and Construction ,heat stress ,thermoregulatory system ,Thermoregulatory system ,bioheat modeling ,Shivering ,medicine ,cold stress ,Node (circuits) ,Electrical and Electronic Engineering ,medicine.symptom ,Biological system ,two-node model ,Civil and Structural Engineering - Abstract
The two-node bioheat model is widely used in thermal comfort standards and design tools. In recent years, there have been many new experimental studies and thermoregulatory models developed under stressful heat or cold conditions, but those have not been tested under the two-node model structure. Furthermore, limited validation studies of the two-node model revealed significant discrepancies in the prediction of skin temperature. This study collects relevant thermoregulatory models (six for sweating, three for skin blood flow and shivering, and four for sweat evaporation efficiency) and devises a methodology to compare the accuracy of various model combinations against experimental data. An improved model is developed and validated under heat and cold exposure conditions. The RMSE method is used to compare the accuracy of various model combinations and to optimize the proposed thermoregulatory model constants. The results reveal that only several model combinations can be considered as accurate for the core and skin temperature predictions, amongst which are the proposed models at the first rank.
- Published
- 2021
12. Proceedings of the 5th International Conference on Building Energy and Environment
- Author
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Liangzhu Leon Wang, Hua Ge, Zhiqiang John Zhai, Dahai Qi, Mohamed Ouf, Chanjuan Sun, Dengjia Wang, Liangzhu Leon Wang, Hua Ge, Zhiqiang John Zhai, Dahai Qi, Mohamed Ouf, Chanjuan Sun, and Dengjia Wang
- Subjects
- Buildings—Environmental engineering, Fire prevention, Buildings—Protection, Sustainable architecture, Solar energy, Environmental engineering, Civil engineering, Renewable energy sources
- Abstract
This book is a compilation of selected papers from the 5th International Conference on Building Energy and Environment (COBEE2022), held in Montreal, Canada, in July 2022. The work focuses on the most recent technologies and knowledge of building energy and the environment, including health, energy, urban microclimate, smart cities, safety, etc. The contents make valuable contributions to academic researchers, engineers in the industry, and regulators of buildings. As well, readers encounter new ideas for achieving healthy, comfortable, energy-efficient, resilient, and safe buildings.
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- 2023
13. Computer modeling of multiscale fluid flow and heat and mass transfer in engineered spaces
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Chen, Qingyan (Yan), (John) Zhai, Zhiqiang, and (Leon) Wang, Liangzhu
- Published
- 2007
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14. Acknowledgement to Reviewers of Fluids in 2018
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Yoshiyuki Tagawa, Ali Bakhshandeh Rostami, Radwin Askari, Sergio Chiva, Caleb Brooks, Moon Son, Brandon L. Helfield, Jorge Peixinho, Thomas Gomez, Jiming Bao, Raghavendra Krishnamurthy, Luca Biferale, Karen Mulleners, Charlie Lin, Vincent Faucher, Sandra Rafael, Małgorzata Król, Albert Oliver, Pierre Thibault, Zhaoming He, Dragan Marinkovic, Julio Marti, Abbas Firoozabadi, Melanie Jimenez, Mercedes Fernández, Samane Zeyghami, Roman Chertovskih, Petros J. Ioannou, Valentina Domenici, Ramon Pamies, Claude Inserra, Jamal Naser, Karl W. Bandilla, Mark A. Stremler, Wei Tao Wu, Sayantan Ganguly, Mehdi Habibi, Yannis Dimakopoulos, Yancheng Zhang, Laurent Cordier, Holger Foysi, Sina Rezaei-Gomari, Lance Traub, Tuyen Quang Le, Thomas Baboolal, Albino Martins, Takashi Watanabe, Tannin Schmidt, Giancarlo Sorrentino, Valerio Pini, Ali Tafarojnoruz, Chengyu Li, Ans Punt, Shyy Woei Chang, John Methven, Konstantinos Verdelis, Stephen Hoath, D. Felipe Gaitan, Maria Alzira Pimenta Dinis, Mehrdad Massoudi, Arnold J. T. M. Mathijssen, Yasuyuki Maki, Hamid Arastoopour, Ali K. Oskouie, Peter D. Minev, Elna Heimdal Nilsson, Naum Gershenzon, Razvan Stefanescu, Patrick Richard, Vivek V. Ranade, John F. Mejia, Karsten Trulsen, Amin Doostmohammadi, Jung Il Choi, Mohammad Hashemi, Quoc Nguyen, Luis G. Baltazar, James S. Bus, Stefano Benni, David French, Ian Jacobi, Abraham N. Gissen, Chengcheng Tao, Ciro Apollonio, Marwan Fahs, Ismael Falcon Suarez, Traian Iliescu, Guillaume Roullet, Wei Lun Hsu, E. Eric Adams, Jose Alvarado, Ali Shafiei, Antonio Monzón, Alan J. Thorpe, Brian Helenbrook, Nicolas Espinoza, Takahiro Tsukahara, Dieter Braun, Tsevi Beatus, Jasmina Casals Terre, Tarak Nath Nandi, Marco Scapinello, Ahmad Malekpour, Georgios Martinopoulos, Mikhail A. Sheremet, David J. Collins, Pavel Kopel, William B. Zimmerman, Adnan Rajib, Ekaterina Ezhova, Alejandro D. Rey, Christian Nayeri, Cristian Marchioli, Antonio Perazzo, Alois Peter Schaffarczyk, Grazia Leonzio, Sunny Jung, Florent Malloggi, Franco Concli, David G. Dritschel, Fangxin Fang, Mostafa Safdari Shadloo, Pedro Dinis Gaspar, Michael Hargather, Chris Walcek, Dimitri Gidaspow, Lars Göran Westerberg, Diego Romano Perinelli, Guilhem Poy, Xuping Xie, Ken Kamrin, Daniela Malcangio, Ioannis Papantoniou, Ilias G. Papakonstantis, Mario Oertel, Thanh Toan Tran, Ioan Pop, Laurent Duchemin, Kelly M. Schultz, Javier Rodriguez-Rodriguez, Pejman Tahmasebi, Gergely Kristóf, Ke Xu, Greg Burgreen, Scott Mccue, Reza Barati, Ali Cemal Benim, Xuan Mu, Hamid Emami-Meybodi, John Bartzis, Zelin Xu, Carlos Borrego, Chadi Maalouf, Ulrike Müller, Hari B. Vuthaluru, Emil-Alexandru Brujan, Qingan Li, Kakkattukuzhy Isaac, Mahnoush Babaei, Juan Garrido-Jurado, Gualtiero Badin, Khashayar Khoshmanesh, Elsen Tjhung, Rita Carvalho, Robert Ettema, Xavier Carton, Shigeo Yoshida, Antal Jakli, Aleksey S. Telyakovskiy, Shohel Mahmud, Daniele Chiappini, Vít Průša, Alistair Revell, Thomas Engles, Evangelos Keramaris, Francesca Lionetto, Robin Singh, Evgeny Ryzhov, Wouter Zijl, Citsabehsan Devendran, Omar Basha, Rene Woszidlo, Joseph Tribbia, Amelia Carolina Sparavigna, Manfred Wagner, Michele Palermo, Umberto Morbiducci, Francesca Oliviero, Dima Bolmatov, Georgios Dimitrakopoulos, Javier Atencia, Víctor Vilarrasa, Chirag Trivedi, Raffaele Marino, J. C. Vassilicos, Hai Yao Deng, Petra Amparo López-Jiménez, Jorge Morillo, John Wanjiku, Gerardo Severino, Konstantin V. Koshel, Sahil Sandesh Gandhi, Ijung Kim, Philippe Sucosky, Joshua Bostwick, Robert A. Van Gorder, Davide Gardini, Tore Flåtten, Monirosadat Sadati, Enrico Ferrero, John J. Socha, Dmitri Kondrashov, Jinchen Ji, Julio Garcia, John Crawshaw, Wen Dar Guo, Mauro Scungio, Roberto Mauri, Alexander A. Schekochihin, Yaocihuatl Medina, Benjamin M. Friedrich, Gilles Bouchet, Cosimo Bianchini, Marek Stastna, Pradeep Sharma, Ashkan Vatani, David M. Dudzinski, Manicham Sivakumar, Juho Lintuvuori, Icíar González, Michael Nones, Seyyed Muhammad Salili, Andrew R. Teixeira, Geng Liu, Fardin Khalili, Ram Balachandar, Giorgio Besagni, Nivesh K. Mittal, Raf Theunissen, Anastasios J. Karabelas, Ramis Örlü, Markus Scholle, Adam Jirásek, Jens Olaf Delfs, Ricardo Vinuesa, Georgi Sutyrin, Stephen Wilson, Sébastien Poncet, Ardalan Javadi, Jean Lou Dorne, Yoshiaki Uchida, Bo Kong, Lauren E. Beckingham, Rossella Arrigo, Oxana E. Kurkina, Soo Kim Jeong, Francesco Meneguzzo, Kazumichi Kobayashi, Alex Skvortsov, Michalis Xenos, Davide Ferraro, Vitaliy Krivets, Mudde Rob, Eugene Benilov, Han Hu, Chandrashekhar S. Jog, Laura Miller, Omer San, Nikolai Brilliantov, Annalisa Dalmoro, Gaojin Li, Arthur E.P. Veldman, Iman Borazjani, Kongchang Wei, Luigi De Luca, Vladislav Zheligovsky, Kumbakonam R. Rajagopal, Raul Sanchez, Masaki Kubo, Rajib L. Goswamee, Zeynep Aytac, Nils T. Basse, Yuliang Xie, Saurin Patel, Mauro Malvé, Majid Mohammadian, Patrice Estelle, Bernd R. Noack, Christian Breitsamter, Layachi Hadji, Kim Boon Lua, Yongxing Wang, Ellahi Rahmat, Marco Evangelos Biancolini, Alberto Alberello, Andreas Gross, Xiangdong Li, Giuseppe Oliveto, Thomas Blacker, Samim Ali, Azar Eslam-Panah, Bo Cheng, Neil M. Ribe, Kaspar Vereide, Ryohji Ohba, Josep Maria Soler, Min Chan Kim, Albert Kwan, Astolfi Davide, Corina Drapaca, Ruth Baltus, Liqiang Ren, Anabela Maia, Gilad Arwatz, Paul Manneville, Marco Pellegrini, Vlassios Hrissanthou, Mohsen Soleimani-Mohseni, T. Juan García, Adriano Tiribocchi, Daniel Bonn, Michael S. Triantafyllou, Yan Zhang, Ali M. Hamed, Peiman Valipour, Mohsen Besharat, Lev A. Ostrovsky, Mauro Giudici, M. N. Islam, Sergey Suslov, Eric Climent, Dahai Qi, Dimitris Ipsakis, Vilhjálmur Nielsen, Leon Glicksman, Julio Martinell, Keith W. Moored, Dejan Brkić, Roman Mukin, Atle Jensen, Dimitris Drikakis, Fabien Anselmet, Vahid Dokhani, Soledad Le Clainche, Jozsef Rohacs, Yehuda Zeiri, D. J.E.M. Roekaerts, Daniel R. Einstein, Aashwin Mishra, Navid Kashaninejad, Yaoyi Guan, Erich Carr Everbach, Aliyu M. Aliyu, Alexander M. Balk, Hamidreza Shabgard, Alexander Doinikov, Jerome Charmet, Elizabeth H. Keating, Erico Luiz Rempel, Rui Sun, Hassan Dashtian, Lampros Vasiliades, Dmitry Kolomenskiy, Leon Wang, Hyeun Joong Yoon, V. L. Zimont, Shigeru Ikeo, Fernando Nardi, Odin Gramstad, Andrew Hazel, Stefano Discetti, C.D. Dritselis, Ignacio Pagonabarraga, Manfred Heuberger, Viatcheslav Bykov, Miroslav Stayanov, Mohammed Azaroual, Amirhossein Arzani, Abubakar Abbas Jibrin, Junru Wu, Alberto Meiss, Robert Stahelin, Mohammad Robiul Hossan, Walter Grondzik, Susan Kurien, Kyung Hwan Kwak, Peter Sunderland, Philippe Marmottant, and Dana Grecov
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Fluid Flow and Transfer Processes ,Medical education ,n/a ,Mechanical Engineering ,lcsh:QC310.15-319 ,Acknowledgement ,lcsh:Descriptive and experimental mechanics ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,lcsh:Thermodynamics ,Condensed Matter Physics ,Psychology ,lcsh:QC120-168.85 - Abstract
Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
- Published
- 2019
15. Ring currents modulate optoelectronic properties of aromatic chromophores at 25 T.
- Author
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Kudisch, Bryan, Maiuri, Margherita, Moretti, Luca, Oviedo, Maria B., Leon Wang, Oblinsky, Daniel G., Prud'homme, Robert K., Wong, Bryan M., McGill, Stephen A., and Scholes, Gregory D.
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MAGNETIC field effects ,TIME-dependent density functional theory ,MAGNETICS ,NUCLEAR magnetic resonance spectroscopy ,MAGNETIC fields - Abstract
The properties of organic molecules can be influenced by magnetic fields, and these magnetic field effects are diverse. They range from inducing nuclear Zeeman splitting for structural determination in NMR spectroscopy to polaron Zeeman splitting organic spintronics and organic magnetoresistance. A pervasive magnetic field effect on an aromatic molecule is the aromatic ring current, which can be thought of as an induction of a circular current of π-electrons upon the application of a magnetic field perpendicular to the π-system of the molecule. While in NMR spectroscopy the effects of ring currents on the chemical shifts of nearby protons are relatively well understood, and even predictable, the consequences of these modified electronic states on the spectroscopy of molecules has remained unknown. In this work, we find that photophysical properties of model phthalocyanine compounds and their aggregates display clear magnetic field dependences up to 25 T, with the aggregates showing more drastic magnetic field sensitivities depending on the intermolecular interactions with the amplification of ring currents in stacked aggregates. These observations are consistent with ring currents measured in NMR spectroscopy and simulated in time-dependent density functional theory calculations of magnetic field-dependent phthalocyanine monomer and dimer absorption spectra. We propose that ring currents in organic semiconductors, which commonly comprise aromatic moieties, may present new opportunities for the understanding and exploitation of combined optical, electronic, and magnetic properties. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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16. Multidisciplinary Social Networks Research : Second International Conference, MISNC 2015, Matsuyama, Japan, September 1-3, 2015. Proceedings
- Author
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Leon Wang, Shiro Uesugi, I-Hsien Ting, Koji Okuhara, Kai Wang, Leon Wang, Shiro Uesugi, I-Hsien Ting, Koji Okuhara, and Kai Wang
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- Data mining, Information storage and retrieval systems, Social sciences—Data processing, Electronic commerce
- Abstract
This book constitutes the refereed proceedings of the Second International Multidisciplinary Social Networks Conference, MISNC 2015, held in Matsuyama, Japan, in September 2015. The 49 full papers presented were carefully reviewed and selected from 125 submissions. The papers deal with the following topics: multidisciplinary research on social networks; ethical issues related to SNS; information technology and social networks mining.
- Published
- 2015
17. Airflow and Energy Simulations to Assess Energy Savings from Vestibules and Air Curtains.
- Author
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Goubran, Sherif, Liangzhu (Leon) Wang, and Dahai Qi
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- *
BUILDING design & construction , *ENERGY consumption of buildings , *AIR flow , *AIR curtains - Abstract
ANSI/ASHRAE/IES Standard 90.1 requires vestibules to be installed in buildings in climate zones 3 through 8 based on building energy simulations with a series of assumptions which can be avoided using a new method of airflow and energy simulations. Instead of vestibules, it is believed that air curtains can also reduce infiltration and the associated energy loss through building entrances. Therefore, this study proposes a method to estimate energy savings from vestibule and air-curtain doors for two U.S. Department of Energy reference buildings in 16 U.S. climate zone locations in terms of national weighted average energy savings and a sensitivity study of different contributing parameters. [ABSTRACT FROM AUTHOR]
- Published
- 2018
18. An adaptive time-stepping semi-Lagrangian method for incompressible flows.
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Mortezazadeh, Mohammad and (Leon) Wang, Liangzhu
- Subjects
- *
LAGRANGE equations , *ERROR functions , *INCOMPRESSIBLE flow , *ADVECTION - Abstract
The semi-Lagrangian method is widely applied to solving the advection term of the Navier–Stokes (N–S) equations whereas the role of time step is often unclear. This article proposed an adaptive time-stepping method, which first calculates local adaptive time step based on truncation error coefficient functions, and then to obtain global time step based on an averaging function for all grid points. The new method was tested for solving 1-D and 2-D advections with different initial time steps and grid resolutions, and the transient incompressible N–S equations. Better simulation accuracy can be achieved than the cases with constant time steps. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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19. Modeling Urban Microclimates of Extreme Weathers by Integrating City Fast Fluid Dynamics and City Building Energy Model.
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Liangzhu (Leon) Wang, Katal, Ali, and Dorostkar, Mohammad Mortezazadeh
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URBAN heat islands , *ENERGY consumption of buildings , *FLUID dynamics , *STRUCTURAL dynamics , *ATMOSPHERIC temperature , *HYGROTHERMOELASTICITY , *COMBINED sewer overflows - Abstract
Extreme weather events, such as unusually high or low temperatures, and severe winds pose a threat to people and properties in cities. Managing the risk caused by these events requires effective climate adaptation policies to strengthen urban resilience to climate-related stresses. Simulation tools are needed for this purpose. In this work, an integrated CityFFD and CityBEM platform is used to study two extreme weather events in Montreal, Canada: the snowstorm of the century, and the urban heat island (UHI) in a hot summer day. CityFFD simulates local urban microclimate of a city to find the most vulnerable areas at extreme weather events, which are then used for the calculation of building thermal loads and indoor air temperatures using the CityBEM. The results show that integrated framework can produce high-resolution microclimate and building behavior under extreme weather events. [ABSTRACT FROM AUTHOR]
- Published
- 2019
20. Dimensionless CFD Analysis of Reynolds Independence and Similarity in Urban and Built Environment Airflows.
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Liangzhu (Leon) Wang and Chang Shu
- Subjects
- *
BUILT environment , *INCOMPRESSIBLE flow , *SIMILARITY (Physics) , *FLUID flow , *EDDY viscosity , *AIR flow ,URBAN ecology (Sociology) - Abstract
In this study, a dimensionless CFD analysis for the isothermal incompressible fluid flow in buildings is conducted to illustrate the Reynolds number similarity among different scales and the Reynolds independent phenomenon for the same scaled setup. For the similarity in different scales, the geometry similarity is required, and the Reynolds number is conserved by the boundary condition configurations to achieve the dynamic similarity, and a good match of the dimensionless results between scales can verify the dimensionless analysis procedure. For the simulations in the same scale, the dimensionless governing equations is further simplified and revealed the role of turbulence viscosity in Reynold independent phenomenon. A series of CFD simulation are conducted to study the distribution and evolution of turbulence viscosity with its relationship to achieve Reynolds independence. This paper develops a new method of justifying the Reynolds independence with CFD simulations, and this dimensionless CFD analysis method can be an important procedure for airflow pattern scaled experiments design and problem simplifications in urban and building airflows. [ABSTRACT FROM AUTHOR]
- Published
- 2019
21. Modeling Smoke Movement in Shafts During High-Rise Fires by a Multizone Airflow and Energy Network Program.
- Author
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Dahai (Darren) Qi, Liangzhu (Leon) Wang, and Radu Zmeureanu
- Subjects
- *
ATTENUATION coefficients , *SMOKE , *TEMPERATURE distribution , *ENERGY conservation , *TALL buildings - Abstract
Multizone airflow network programs are increasingly used to study smoke movement during fires in buildings. Multizone programs often do not solve energy conservation equations, so temperatures ofrooms/zones need to be specified. The lack of energy models limits the capability of a multizone program for modeling building smoke movement, especially in shafts, where temperature distribution is often unknown. This paper introduces a multizone program with an added energy equation, CONTAM97R, with the focus of its application to simulations of smoke movement, especially in shafts of highrise buildings. First, CONTAM97R was validated by experimental data from a 1/3-scale building stairwell under fires, and verified by an analytical model of high-rise fires. The program was then used to model a 16-storey building with a fire located at the firstfloor. To model the building shaft by CONTAM97R, we proposed and compared two zoning methods, floor zoning strategy (FZS) and adaptive zoning strategy (AZS), when the shaft is with and without air infiltrations. It shows that the accuracy of FZS is inversely related to a dimensionless parameter, the temperature attenuation coefficient, a, but can be improved by increasing the number of zones dividing the shaft until the results do not depend on zone numbers. Compared to FZS, AZS obtains results ofsimilar level of accuracy but with fewer zones for the simulations. [ABSTRACT FROM AUTHOR]
- Published
- 2015
22. A Hand Calculation Method of Smoke Movement through A High-Rise Airtight Single Shaft.
- Author
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Dahai (Darren) Qi, Liangzhu (Leon) Wang, and Zmeureanu, Radu
- Subjects
- *
SMOKE control systems in buildings , *HEAT transfer , *TEMPERATURE effect , *COMPUTATIONAL fluid dynamics , *NUMERICAL analysis - Published
- 2014
23. Comparison of Simulation Programs for Airflow and Smoke Movement during High-Rise Fires.
- Author
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Liangzhu (Leon) Wang, Black, William Z., and Guanchao Zhao
- Subjects
- *
SMOKE control systems in buildings , *FIRE prevention , *COMPUTER simulation , *AIR flow , *SKYSCRAPERS , *STRUCTURAL analysis (Engineering) , *CONSTRUCTION - Abstract
Computer modeling of structural fires can play a significant role in simulating the development of a fire and the subsequent movement of smoke throughout the building. Computer programs have evolved to such an extent that they are able to predict where smoke will travel and to what extent it will contaminate various areas throughout the building such as fire escape stairwells and elevator shafts. Therefore, they can be employed to suggest modifications in the building construction, employment of building HVAC equipment, and use of pressurization fans in order to formulate a building life-safety plan that has a reasonable chance of reducing injuries due to smoke inhalation. In this work, the results provided by two computer programs that are capable of simulating smoke movement during building fires are compared for a simulated fire in a high-rise structure. Major differences in the formulation of the two programs are identified, and the differences in the predicted smoke movement results are explained. The temperature distribution throughout the building is shown to be a major factor in moving smoke within the building. Overall, there is reasonable comparison between the two computer predictions; however, large errors can result if the models employ unrealistic temperature distributions throughout the building structure. [ABSTRACT FROM AUTHOR]
- Published
- 2013
24. A 3.4 GHz to 4.3 GHz frequency-reconfigurable class E power amplifier with an integrated CMOS-MEMS LC balun.
- Author
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Leon Wang and Mukherjee, T.
- Published
- 2010
- Full Text
- View/download PDF
25. MEMS varactor enabled frequency-reconfigurable LNA and PA in the upper UHF band.
- Author
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Jajoo, A., Leon Wang, and Mukherjee, T.
- Published
- 2009
- Full Text
- View/download PDF
26. Design of Side Weirs in Subcritical Flow.
- Author
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Huagao Tan, Leon Wang, and Gilbreth, Ken
- Published
- 2001
- Full Text
- View/download PDF
27. Evaluating Approaches to Developing Building Archetype Models for Estimating Cooling Energy Consumption in Hot and Arid Climate.
- Author
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Moujahed, Majd, Danlin Hou, Liangzhu (Leon) Wang, and Hassan, Ibrahim
- Subjects
- *
ENERGY consumption , *ARCHETYPES , *COOLING loads (Mechanical engineering) , *SENSITIVITY analysis , *FACTORY design & construction - Abstract
District Cooling is an energy-efficient technology that can satisfy the cooling demands of regions with extremely hot climates such as the middle east. Designing and operating these plants requires accurate modeling of the existing cooling load created by the building stock connected to the central plant. During the design stage, building archetype models can be used for sizing district cooling load, whereas both the input and output uncertainties of these models have not been well addressed. This paper conducts a comparative analysis of two methodologies of building archetype development, develops an importance ranking for the input parameters of these models, and tries to quantify the uncertainty of the cooling energy output due to input value uncertainty. It develops a region-specific highrise residential archetype and compares it to the US DOE Prototype models. It also develops the parameter ranking using a global sensitivity analysis methodology. It is found that the most practical approach towards the development of building archetypes for a specific region is the development of region-specific models adapted to local practices rather than converting standard models for accuracy and computational cost considerations. It was also concluded that a set number of parameters are responsible for most of the model's output variability. Finally, this study demonstrated the usability of the building archetype models for the hot and arid climate. [ABSTRACT FROM AUTHOR]
- Published
- 2022
28. Comparing Two Simulation Approaches for Quantifying Urban Microclimate Impact on Building Energy Performance.
- Author
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Dongxue Zhan, Danlin Hou, Liangzhu (Leon) Wang, and Hassan, Ibrahim Galal
- Subjects
- *
BUILDING performance , *ENERGY consumption of buildings , *ATMOSPHERIC temperature , *WEATHER , *WIND speed - Abstract
Building energy modeling (BEM) involves many input parameters, including weather conditions, building geometry and properties, and building system and occupant information. Typical Meteorological Year (TMY) data are often used for the definition of weather conditions without considering urban microclimate variations. Compared to other inputs, the impacts of urban microclimate on BEM results are not adequately understood, and the literature also often presents inconsistent conclusions. In this paper, we conducted a sensitivity analysis (SA) to quantify the importance of urban microclimate and to identify the key parameters for the model output variations. Based on the Sensitivity Value Index (SVI), 13 BEM inputs were evaluated. It shows that the outdoor air temperature and wind speed play an essential role in building cooling energy usages in the hot and arid climate. Then, two approaches to estimating urban climate impacts on BEMs were compared in terms of outdoor air temperature, wind speed, and humidity in Lusail, Qatar by the 3D urban microclimate CFD model, City Fast Fluid Dynamics (CityFFD), and the simplified microclimate model, Urban Weather Generator (UWG). A comparative analysis of the simulation results to the local weather station measurements reveals the capabilities of the two approaches to estimating urban microclimate impacts on building energy performance. [ABSTRACT FROM AUTHOR]
- Published
- 2022
29. Development and Application of BIR-BEM: A Bayesian Inference R Platform for Building Energy Model Calibration.
- Author
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Danlin Hou, Hassan, Ibrahim Galal, and Liangzhu (Leon) Wang
- Subjects
- *
ENERGY consumption of buildings , *BAYESIAN field theory , *MARKOV chain Monte Carlo , *CALIBRATION , *ENERGY consumption , *COMMERCIAL buildings - Abstract
The building sector accounts for nearly 40% of global energy consumption and plays a critical role in societal energy security and sustainability. A building energy model (BEM) simulates complex building physics and provides insights into the performance of various energy-saving measures. The analysis based on BEMs has thus become an essential approach to slowing down the process of increasing building energy consumption. The reliability and accuracy of BEMs have a high impact on decision-making. However, how to calibrate a building energy model has remained a challenge. Existing calibrations are often deterministic without uncertainties quantified. In this study, a new automated multi-module calibration platform, BIRBEM (Bayesian Inference on R for Building Energy Model), is developed using an R programming language for calibrating building energy models. The sensitivity analysis module determines the calibration parameters, and the building energy model is replaced by the developed meta-model module for the Markov Chain Monte Carlo (MCMC) process to save computing time. An application of a high-rise residential building case in a hot and arid climate was demonstrated. The coefficient of variation with a root-mean-square error (CVRMSE) value of the monthly total cooling energy consumption is 13.95%, which satisfies the monthly calibration tolerance of 15% required by ASHRAE Guideline 14. [ABSTRACT FROM AUTHOR]
- Published
- 2022
30. Typical and extreme weather datasets for studying the resilience of buildings to climate change and heatwaves
- Author
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Anaïs Machard, Agnese Salvati, Mamak P. Tootkaboni, Abhishek Gaur, Jiwei Zou, Liangzhu Leon Wang, Fuad Baba, Hua Ge, Facundo Bre, Emmanuel Bozonnet, Vincenzo Corrado, Xuan Luo, Ronnen Levinson, Sang Hoon Lee, Tianzhen Hong, Marcello Salles Olinger, Rayner Maurício e Silva Machado, Emeli Lalesca Aparecida da Guarda, Rodolfo Kirch Veiga, Roberto Lamberts, Afshin Afshari, Delphine Ramon, Hoang Ngoc Dung Ngo, Abantika Sengupta, Hilde Breesch, Nicolas Heijmans, Jade Deltour, Xavier Kuborn, Sana Sayadi, Bin Qian, Chen Zhang, Ramin Rahif, Shady Attia, Philipp Stern, and Peter Holzer
- Subjects
Science - Abstract
Abstract We present unprecedented datasets of current and future projected weather files for building simulations in 15 major cities distributed across 10 climate zones worldwide. The datasets include ambient air temperature, relative humidity, atmospheric pressure, direct and diffuse solar irradiance, and wind speed at hourly resolution, which are essential climate elements needed to undertake building simulations. The datasets contain typical and extreme weather years in the EnergyPlus weather file (EPW) format and multiyear projections in comma-separated value (CSV) format for three periods: historical (2001–2020), future mid-term (2041–2060), and future long-term (2081–2100). The datasets were generated from projections of one regional climate model, which were bias-corrected using multiyear observational data for each city. The methodology used makes the datasets among the first to incorporate complex changes in the future climate for the frequency, duration, and magnitude of extreme temperatures. These datasets, created within the IEA EBC Annex 80 “Resilient Cooling for Buildings”, are ready to be used for different types of building adaptation and resilience studies to climate change and heatwaves.
- Published
- 2024
- Full Text
- View/download PDF
31. Use of Vertical Shafts as Routes of Smoke Extraction and Safe Egress During High-Rise Fires.
- Author
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Guanchao Zhao, Black, W. Z., and Liangzhu (Leon) Wang
- Subjects
- *
FIRE victims , *SMOKE , *COMPUTATIONAL fluid dynamics , *DISCHARGE coefficient , *GAS flow , *FIRE prevention - Abstract
Smoke inhalation is the leading cause of death during structural fires. In order to improve life safety during a fire, smoke must be managed and kept away from building occupants. In high-rise buildings, the problem of smoke movement is compounded by a strong stack effect that draws smoke into the vertical shafts within the building and contaminates the fire-escape stairwells as well as the elevator shafts. I f the smoke can be managed so that the stack effect can be used to advantage and egress routes can be maintained smoke free, then occupants will have a greater opportunity to avoid the effects of the smoke generated by the fie. This paper investigates a smoke control strategy that involves using the elevator shafts as a route ofsmoke extraction coupled with pressurizing the stairwells with sufficient fresh air to maintain smoke-free conditions in thefire escapes for the entire height of the building. The practicality and efficacy of this smoke management strategy is evaluated by employing a differential-network smoke management computer program that simulates the paths that smoke will take during a simulated fire. The computer program is verified by comparing its results with a computational fluid dynamics (CFD) software tool, Fire Dynamics Simulator, for a simple building geometry. Both programs compare well when a reasonable set of discharge coefficients is used to calculate the gas flows through various openings in the modeled building. The differential-network model quantifies the paths that the smoke will take and determines the smoke properties with a significant reduction of computational time when compared to the time required to provide the CFD simulations. Smoke generated by the fire will naturally tend to gravitate toward the elevator shafts, which exist at the lowest pressure within the building. Computer results show that large quantities ofsmoke can be directed away from occupants by controlling and exhausting the smoke through the top vent of the elevator shaft. If exhaust fans are used for smoke venting at the top of the elevator shafts and pressurization fans are used to maintain smoke-free conditions in the stairwells, then a prudent fire safety plan will result. The program output is used to quantify the amount of elevator exhaust and stainvell pressurization that is necessary to achieve safe conditions during the fire for various building geometries and fire conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2015
32. Nature-Based Solutions for Carbon Neutral Climate Resilient Buildings and Communities: A Review of Technical Evidence, Design Guidelines, and Policies
- Author
-
Zhe Xiao, Hua Ge, Michael A. Lacasse, Liangzhu (Leon) Wang, and Radu Zmeureanu
- Subjects
climate change ,nature-based solutions ,carbon neutral ,carbon sequestration ,resilient buildings and communities ,Building construction ,TH1-9745 - Abstract
The building sector is responsible for nearly 40% of the total global direct and indirect CO2 emissions. Urban green infrastructure, which includes features such as urban trees, vegetation, green roofs, and green facades, are examples of nature-based solutions often employed as municipal climate mitigation and adaptation strategies. This approach offers a range of cost-effective strategies for reducing municipal CO2 emissions and presents compelling public policy co-benefits such as improved urban livability and enhanced environmental conditions. For municipalities to confidently deploy these solutions at a scale necessary to achieve climate benefits, acquiring knowledge of quantifiable and demonstrated outcomes is an essential requirement. The objectives of this paper are to (1) provide a comprehensive analysis of the advantages and limitations of nature-based solutions (NBS) to address the challenge of reducing CO2 emissions; (2) evaluate existing design guidelines and policies as may be available across Canada, and that that support the of implementation of NBS in urban agglomerations; (3) identify knowledge gaps and research needs to address challenges to the implementation of NBS. In this review, suggestions and requirements as presented in these documents are examined while giving due consideration to the scientific evidence available in research papers. It was found that the adoption of NBS can contribute to carbon neutral communities through reduced building energy consumption and carbon sequestration. Supportive guidelines and policies have been developed, or are in development, to promote the implementation of NBS at the city scale, despite challenges in assessing, quantitatively, their impact due to uncertainties in data, methods, and scale. Nonetheless, existing research provides sufficient evidence to qualify the measures and suggestions outlined in the guidelines and policies described in this paper.
- Published
- 2023
- Full Text
- View/download PDF
33. Overheating Risk Analysis in Long-Term Care Homes—Development of Overheating Limit Criteria
- Author
-
Abdelaziz Laouadi, Lili Ji, Chang Shu, Liangzhu (Leon) Wang, and Michael A. Lacasse
- Subjects
overheating ,thermal comfort ,older people ,long-term care home ,nursing home ,building ,Building construction ,TH1-9745 - Abstract
Climate heat waves occurring in urban centers are a serious threat to public health and wellbeing. Historically, most heat-related mortalities have arisen from excessive overheating of building interiors housing older occupants. This paper developed an approach that combines the results from building simulation and bioheat models to generate health-based limit criteria for overheating in long-term care homes (LTCHs) by which the body dehydration and core temperature of older residents are capped during overheating events. The models of the LTCHs were created for buildings representative of old and current construction practices for selected Canadian locations. The models were calibrated using measurements of indoor temperature and humidity acquired from monitoring the building interiors and the use of published building energy use intensity data. A general procedure to identify overheating events and quantify their attributes in terms of duration, intensity, and severity was developed and applied to LTCHs to generate the limit criteria. Comparing the limit criteria from the proposed and comfort-based methods showed evident differences. The proposed method predicted the overheating risk consistent with the overall thermal comfort during overheating events in contrast to the comfort-based methods. The new limit criteria are intended to be used in any study to evaluate overheating risk in similar buildings.
- Published
- 2023
- Full Text
- View/download PDF
34. A real-time web tool for monitoring and mitigating indoor airborne COVID-19 transmission risks at city scale.
- Author
-
Albettar M, Leon Wang L, and Katal A
- Abstract
Airborne transmission of aerosols contributes to a large portion of the SARS-CoV-2 spread indoors. This study develops a real-time interactive web-based platform for the public to compare various strategies to curb indoor airborne transmission of COVID-19 in different archetype buildings at a city scale. Although many countries have started vaccination and a gradual re-opening, because of emerging new variants of the virus and the possibility of future pandemics, a lively updated tool for monitoring and mitigation of infection risk is essential. As a demonstration, we evaluated the impacts of six mitigation measures on the infection risks in various building types in a city. It shows that the same strategy could perform quite differently, depending on building types and properties. All strategies are shown to reduce the infection risk but wearing a mask and reducing exposure time are the most effective strategies in many buildings, with around 60% reduction. Doubling the minimum required outdoor air ventilation rate is not as effective as other strategies to reduce the risk. It also causes considerable penalties on energy consumption. Therefore, new building ventilation standards, control actions, and design criteria should be considered to mitigate the infection risk and save energy., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
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