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Aim: To investigate the efficacy of a combined intravitreal therapy with prior photodynamic therapy (PDT) in patients with wet age-related macular degeneration. Methods: Fifty-two patients (mean age: 72.7 years) with predominantly classic choroidal neovascularization received low-fluence PDT (42 J/cm2 for 72 s), followed 24 h later by a 0.4-ml core pars plana vitrectomy with intravitreal injection of dexamethasone (0.8 mg) and bevacizumab (1.25 mg). The best-corrected visual acuity (BCVA; 6 m Snellen), central macular thickness (optical coherence tomography), intraocular pressure and the need for retreatment were assessed. Results: BCVA changed significantly (vs. baseline) at 3 months (+0.11), 9 months (+0.19) and 14 months (+0.16). At the end of the follow-up period, BCVA had improved by >0.1 in the majority of the patients (72.9%), and the mean central retinal thickness had decreased by -44.3% (-211 μm). The retreatment rate was 25%. No increase in intraocular pressure or other adverse event was reported. Conclusions: The pharmacological effects of the drugs, the low-fluence PDT, and the physiological effects of the therapy may have contributed to the sustainability of the therapeutic benefits. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Retinal degenerative diseases are an extensive group of ocular diseases, leading to vision disorders and finally irreversible vision loss. They are an significant problem, because degenerative processes exist in common ocular disorders like glaucoma or age-related macular degeneration and many other less frequently occurring disorders. In this article, we present mechanisms leading to retinal degeneration like excitotoxicity, oxidative stress, inflammation and summarize the latest reports concerning neuroprotection in the treatment of retina degenerative diseases.