259 results on '"Leynaert B"'
Search Results
2. Occupation and adult onset of rhinitis in the general population
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Radon, K, Gerhardinger, U, Schulze, A, Zock, J-P, Norback, D, Toren, K, Jarvis, D, Held, L, Heinrich, J, Leynaert, B, Nowak, D, and Kogevinas, M
- Published
- 2008
3. The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels
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Olivieri, M., Heinrich, J., Schlünssen, V., Antó, J. M., Forsberg, B., Janson, C., Leynaert, B., Norback, D., Sigsgaard, T., Svanes, C., Tischer, C., Villani, S., Jarvis, D., and Verlato, G.
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- 2016
- Full Text
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4. The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin
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Newson, R. B., Jones, M., Forsberg, B., Janson, C., Bossios, A., Dahlen, S.-E., Toskala, E. M., Al-Kalemji, A., Kowalski, M. L., Rymarczyk, B., Salagean, E. M., van Drunen, C. M., Bachert, C., Wehrend, T., Krämer, U., Mota-Pinto, A., Burney, P., Leynaert, B., and Jarvis, D.
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- 2014
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- View/download PDF
5. Risk factors of new-onset asthma in adults: a population-based international cohort study
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Antó, J. M., Sunyer, J., Basagaña, X., Garcia-Esteban, R., Cerveri, I., de Marco, R., Heinrich, J., Janson, C., Jarvis, D., Kogevinas, M., Kuenzli, N., Leynaert, B., Svanes, C., Wjst, M., Gislason, T., and Burney, P.
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- 2010
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- View/download PDF
6. Risk factors of adverse reactions to food in German adults
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Soost, S., Leynaert, B., Almqvist, C., Edenharter, G., Zuberbier, T., and Worm, M.
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- 2009
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- View/download PDF
7. Geographical distribution of atopic rhinitis in the European Community Respiratory Health Survey I*
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Bousquet, P.-J., Leynaert, B., Neukirch, F., Sunyer, J., Janson, C. M., Anto, J., Jarvis, D., and Burney, P.
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- 2008
8. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper
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Bousquet, J., Fokkens, W., Burney, P., Durham, S. R., Bachert, C., Akdis, C. A., Canonica, G. W., Dahlen, S.-E., Zuberbier, T., Bieber, T., Bonini, S., Bousquet, P. J., Brozek, J. L., Cardell, L.-O., Crameri, R., Custovic, A., Demoly, P., van Wijk, R. G., Gjomarkaj, M., Holland, C., Howarth, P., Humbert, M., Johnston, S. L., Kauffmann, F., Kowalski, M. L., Lambrecht, B., Lehmann, S., Leynaert, B., Lodrup-Carlsen, K., Mullol, J., Niggemann, B., Nizankowska-Mogilnicka, E., Papadopoulos, N., Passalacqua, G., Schünemann, H. J., Simon, H.-U., Todo-Bom, A., Toskala, E., Valenta, R., Wickman, M., and Zock, J. P.
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- 2008
9. Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study
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Siroux, V., Boudier, A., Anto, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A., Gulsvik, A., Jarvis, D., de Marco, R., Marcon, A., Marques, E. A., Bugiani, M., Janson, C., Leynaert, B., and Pin, I.
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- 2008
10. The socio-economic burden of asthma is substantial in Europe
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Accordini, S., Corsico, A., Cerveri, I., Gislason, D., Gulsvik, A., Janson, C., Jarvis, D., Marcon, A., Pin, I., Vermeire, P., Almar, E., Bugiani, M., Cazzoletti, L., Duran-Tauleria, E., Jõgi, R., Marinoni, A., Martínez-Moratalla, J., Leynaert, B., and de Marco, R.
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- 2008
11. The association of asthma, atopy and lung function with hormone replacement therapy and surgical cessation of menstruation in a population-based sample of English women
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Jarvis, D. and Leynaert, B.
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- 2008
12. Impact of gender on asthma in childhood and adolescence: a GA2LEN review
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Almqvist, C., Worm, M., and Leynaert, B.
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- 2008
13. Time and age trends in smoking cessation in Europe
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Pesce, G, Marcon, A, Calciano, L, Perret, JL, Abramson, MJ, Bono, R, Bousquet, J, Fois, AG, Janson, C, Jarvis, D, Jogi, R, Leynaert, B, Nowak, D, Schlunssen, V, Urrutia-Landa, I, Verlato, G, Villani, S, Zuberbier, T, Minelli, C, Accordini, S, Boezen, M, Elger, B, Gleditsch, BA, Heijmans, B, Romieu, I, Thompson, J, Commission of the European Communities, Salvy-Córdoba, Nathalie, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University Hospital of Verona, Università degli studi di Verona = University of Verona (UNIVR), University of Melbourne, Monash University [Melbourne], Università degli studi di Torino = University of Turin (UNITO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Uppsala University Hospital, MRC Centre for Molecular Microbiology and Infection [Imperial College, London] (CMBI), Imperial College London, University of Tartu, Ludwig Maximilian University [Munich] (LMU), Aarhus University Hospital, Galdakao Hospital, Università degli Studi di Pavia = University of Pavia (UNIPV), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Verona (UNIVR), University of Turin, University of Sassari, Università degli Studi di Pavia, Groningen Research Institute for Asthma and COPD (GRIAC), and Life Course Epidemiology (LCE)
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Male ,Pulmonology ,IMPACT ,medicine.medical_treatment ,Maternal Health ,Tobacco Smoking / epidemiology ,Social Sciences ,RELAPSE ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Geographical Locations ,Habits ,INITIATION ,0302 clinical medicine ,Elderly ,Quality of life ,Pregnancy ,Smoking Habits ,Medicine and Health Sciences ,Medicine ,Psychology ,Public and Occupational Health ,030212 general & internal medicine ,Young adult ,PREDICTORS ,0303 health sciences ,Multidisciplinary ,Tobacco control ,food and beverages ,Obstetrics and Gynecology ,Public Health, Global Health, Social Medicine and Epidemiology ,Middle Aged ,3. Good health ,PREVALENCE ,Europe ,Multidisciplinary Sciences ,ALLERGIC RHINITIS ,Age trends, Ageing Lungs in European Cohorts (ALEC) study, Europe, smoking cessation, time trends ,Science & Technology - Other Topics ,Female ,Public Health ,Europe / epidemiology ,Research Article ,Adult ,medicine.medical_specialty ,Tobacco Control ,Smoking Cessation / statistics & numerical data ,Adolescent ,Substance-Related Disorders ,General Science & Technology ,Science ,Health Promotion ,Age trends ,03 medical and health sciences ,Young Adult ,Age Distribution ,Sex Factors ,Public Health, Tobacco Control, Tobacco Smoking, Smoking Cessation, Time Trends, Pregnancy ,Mental Health and Psychiatry ,MD Multidisciplinary ,Tobacco Smoking ,Humans ,Risk factor ,030304 developmental biology ,time trends ,Behavior ,Science & Technology ,business.industry ,Public health ,Biology and Life Sciences ,Smoking Related Disorders ,Retrospective cohort study ,ADULTS ,Ageing Lungs in European Cohorts (ALEC) study ,smoking cessation ,Young Adults ,Health Care ,Retrospective studies ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Health promotion ,Age Groups ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,People and Places ,Quality of Life ,Smoking cessation ,Women's Health ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,ASTHMA ,Population Groupings ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Demography - Abstract
BackgroundSmoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010.MethodsData on the smoking history of 50,228 lifetime smokers from 17 European countries were obtained from six large population-based studies included in the Ageing Lungs in European Cohorts (ALEC) consortium. Smoking cessation rates were assessed retrospectively, and age trends were estimated for three decades (1980-1989, 1990-1999, 2000-2010). The analyses were stratified by sex and region (North, East, South, West Europe).ResultsOverall, 21,735 subjects (43.3%) quit smoking over a total time-at-risk of 803,031 years. Cessation rates increased between 1980 and 2010 in young adults (16-40 years), especially females, from all the regions, and in older adults (41-60 years) from North Europe, while they were stable in older adults from East, South and West Europe. In the 2000s, the cessation rates for men and women combined were highest in North Europe (49.9 per 1,000/ year) compared to the other regions (range: 26.5-32.7 per 1,000/ year). A sharp peak in rates was observed for women around the age of 30, possibly as a consequence of pregnancy-related smoking cessation. In most regions, subjects who started smoking before the age of 16 were less likely to quit than those who started later.ConclusionsOur findings suggest an increasing awareness on the detrimental effects of smoking across Europe. However, East, South and West European countries are lagging behind North Europe, suggesting the need to intensify tobacco control strategies in these regions. Additional efforts should be made to keep young adolescents away from taking up smoking, as early initiation could make quitting more challenging during later life.
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- 2019
14. Eczema, atopy and allergen exposure in adults: a population-based study
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Harrop, J., Chinn, S., Verlato, G., Olivieri, M., Norbäck, D., Wjst, M., Janson, C., Zock, J.-P., Leynaert, B., Gislason, D., Ponzio, M., Villani, S., Carosso, A., Svanes, C., Heinrich, J., and Jarvis, D.
- Published
- 2007
15. Association of lung function decline with the heme oxygenase-1 gene promoter microsatellite polymorphism in a general population sample. Results from the European Community Respiratory Health Survey (ECRHS), France
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Guénégou, A, Leynaert, B, Bénessiano, J, Pin, I, Demoly, P, Neukirch, F, Boczkowski, J, and Aubier, M
- Published
- 2006
16. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project
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Bousquet, J., Anto, J. M., Bachert, C., Bousquet, P. J., Colombo, P., Crameri, R., Daëron, M., Fokkens, W., Leynaert, B., Lahoz, C., Maurer, M., Passalacqua, G., Valenta, R., van Hage, M., and Van Ree, R.
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- 2006
17. Serum carotenoids, vitamins A and E, and 8 year lung function decline in a general population
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Guénégou, A, Leynaert, B, Pin, I, Le Moël, G, Zureik, M, and Neukirch, F
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- 2006
18. Fruit and vegetable intakes and asthma in the E3N study
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Romieu, I, Varraso, R, Avenel, V, Leynaert, B, Kauffmann, F, and Clavel-Chapelon, F
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- 2006
19. Maternal atopy and changes in parity
- Author
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Sunyer, J., Antó, J. M., Plana, E., Janson, C., Jarvis, D., Kony, S., Omenaas, E. R., Svanes, C., Wjst, M., and Leynaert, B.
- Published
- 2005
20. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study
- Author
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Kony, S, Zureik, M, Driss, F, Neukirch, C, Leynaert, B, and Neukirch, F
- Published
- 2004
21. Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey
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Chinn, S, Jarvis, D, Burney, P, Luczynska, C, Ackermann-Liebrich, U, Antó, J M, Cerveri, I, de Marco, R, Gislason, T, Heinrich, J, Janson, C, Künzli, N, Leynaert, B, Neukirch, F, Schouten, J, Sunyer, J, Svanes, C, Vermeire, P, and Wjst, M
- Published
- 2004
22. An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages
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de Marco, R, Accordini, S, Cerveri, I, Corsico, A, Sunyer, J, Neukirch, F, Künzli, N, Leynaert, B, Janson, C, Gislason, T, Vermeire, P, Svanes, C, Anto, J M, and Burney, P
- Published
- 2004
23. Body Mass Index, Change in Body Silhouette, and Risk of Asthma in the E3N Cohort Study
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Romieu, I., Avenel, V., Leynaert, B., Kauffmann, F., and Clavel-Chapelon, F.
- Published
- 2003
24. Mould exposure in indoor environments: The French ANSES recommendations to reinforce measures for preventing mould growth and the impact on human health
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Keirsbulck, Marion, Aschan-Leygonie, Christina, Bayeux, Thomas, Bex, Valerie, Boulanger, Gabrielle, Bretagne, Stéphane, Caillaud, D., Colleville, A-C., Fourneau, C., Frealle, Emilie, Ginestet, Stéphane, Lecoq, Laetitia, Leynaert, B., Nadif, Rachel, F., Oswald, Reboux, Gabriel, Roussel, S., Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Service de parasitologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire Matériaux et Durabilité des constructions (LMDC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Environnement Ville Société (EVS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale des Travaux Publics de l'État (ENTPE)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Body, Salima, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
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[SHS] Humanities and Social Sciences ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2018
25. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II)
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Kogevinas, M, Zock, Jp, Jarvis, D, Kromhout, H, Lillienberg, L, Plana, E, Radon, K, Torén, K, Alliksoo, A, Benke, G, Blanc, Pd, Dahlman Hoglund, A, D’Errico, A, Héry, M, Kennedy, S, Kunzli, N, Leynaert, B, Mirabelli, Mc, Muniozguren, N, Norbäck, D, Olivieri, M, Payo, F, Villani, S, van Sprundel, M, Urrutia, I, Wieslander, G, Sunyer, J, Principal investigators, Antó J. M., senior scientific team: Australia, Belgium—p, Vermeire, Weyler, J., Van Sprundel, M., Nelen, V., Estonia—R Jogi, A. Soon, France—f, Neukirch, Leynaert, B., Liard, R., Pin, M. Zureik—I., Ferran Quentin, J., Germany—j, Heinrich, Wjst, M., Frye, C., Meyer, I., Iceland—t, Gislason, Italy—m, Bugiani, Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, Canzio, Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Verlato, G., Zanolin, E., Accordini, S., Poli, A., Lo Cascio, V., Ferrari, M., The Netherlands—J Schouten, Norway, Antó, Spain J. M., Sunyer, J., Kogevinas, M., Zock, J. P., Basagana, X., Jaen, A., Maldonado, F. Burgos—J., Pereira, A., Martinez Moratalla Rovira, J. L. Sanchez—J., Muniozguren, E. Almar—N., Payo, I. Urritia—F., Sweden—c, Janson, Boman, G., Norback, D., Toren, M. Gunnbjornsdottir—K., Lillienberg, L., Dahlman Höglund, A., Norrman, R. Sundberg—E., Soderberg, M., Franklin, K., Lundback, B., Forsberg, B., Nystrom, L., Switzerland—n, Künzli, Dibbert, B., Hazenkamp, M., Brutsche, M., Ackermann Liebrich, U., United Kingdom—P Burney, Chinn, S., Jarvis, D. Jarvis—D., Harrison, B., Jarvis, —d, Hall, R., Seaton, D., Usa—m, Osborne, Buist, S., Vollmer, W., and Johnson, L.
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OCCUPATIONAL EXPOSURE ,ASTHMA - Published
- 2007
26. Important research questions in allergy and related diseases: Nonallergic rhinitis: A GA2LEN paper
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Bousquet, J. Fokkens, W. Burney, P. Durham, S.R. Bachert, C. Akdis, C.A. Canonica, G.W. Dahlen, S.-E. Zuberbier, T. Bieber, T. Bonini, S. Bousquet, P.J. Brozek, J.L. Cardell, L.-O. Crameri, R. Custovic, A. Demoly, P. Van Wijk, R.G. Gjomarkaj, M. Holland, C. Howarth, P. Humbert, M. Johnston, S.L. Kauffmann, F. Kowalski, M.L. Lambrecht, B. Lehmann, S. Leynaert, B. Lodrup-Carlsen, K. Mullol, J. Niggemann, B. Nizankowska-Mogilnicka, E. Papadopoulos, N. Passalacqua, G. Schünemann, H.J. Simon, H.-U. Todo-Bom, A. Toskala, E. Valenta, R. Wickman, M. Zock, J.P.
- Abstract
Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis. © 2008 The Authors.
- Published
- 2008
27. Factors responsible for the differences between asymptomatic subjects and patients presenting an IgE Sensitization to allergens
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Bousquet, J, Anto, Jm, Bachert, C, Bousqet, Pj, Colombo, P, Crameri, R, Daeron, M, Fokkens, W, Leynaert, B, Lahoz, C, Maurer, M, Passalacqua, Giovanni, Valenta, R, VAN HAGE, M, and VAN REE, R.
- Published
- 2006
28. Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.
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Bertelsen, R. J., Rava, M., Carsin, A. E., Accordini, S., Benediktsdóttir, B., Dratva, J., Franklin, K. A., Heinrich, J., Holm, M., Janson, C., Johannessen, A., Jarvis, D. L., Jogi, R., Leynaert, B., Norback, D., Omenaas, E. R., Raherison, C., Sánchez‐Ramos, J. L., Schlünssen, V., and Sigsgaard, T.
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LABORATORY mice ,ANIMAL epigenetics ,GENETIC disorders in animals ,ALLERGY in animals ,ASTHMA - Abstract
Background Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans. Objective We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness ( BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever. Methods The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey ( ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk ratios ( aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions. Results Offspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [ BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11-22 years with information on parental disease activity both before and after birth. Conclusion & Clinical Relevance Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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29. The European Community Respiratory Health Survey II
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Jarvis, D, Knox, J, Burney, P, Chinn, S, Luczynska, C, Anto, Jm, Cerveri, I, DE MARCO, Roberto, Gislasson, T, Heinrich, J, Janson, C, Kuenzli, N, Leynaert, B, Neukirch, F, Schouten, J, Sunyer, J, Svanes, C, Vermeire, P, and Wjst, M.
- Published
- 2002
30. Does Living on a Farm during Childhood Protect againstAsthma, Allergic Rhinitis, and Atopy in Adulthood?
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Leynaert, B., Neukirch, C., Jarvis, D., Chinn, S., Burney, P., Popp, F. N. e. u. k. i. r. c. h. Participating Centers: Austria: W., Australia: M. Abramson, J. Kutin, Belgium: P. Vermeire, F. van Bastelaer, Bousquet, France: J., Knani, J., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Magnussen, Germany: H., Nowak, D., Wichmann, H. E., Heinrich, J., Papageorgiou, Greece: N., Avarlis, P., Gaga, M., Marossis, C., Iceland: T. Gislason, D. Gislason, Prichard, Ireland: the late J., Allwright, S., Macleod, D., Bugiani, Italy: M., Bucca, Caterina, Romano, Canzio, de Marco Lo Cascio, R., Campello, C., Marinoni, A., Cerveri, I., Casali, L., and The Netherlands: B. Rijcken, A. Kremer
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Allergic Rhinitis ,Atopy ,Asthma - Published
- 2001
31. Long-term outcomes in mild/moderate chronic obstructive pulmonary disease in the European community respiratory health survey.
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de Marco R, Accordini S, Antò JM, Gislason T, Heinrich J, Janson C, Jarvis D, Künzli N, Leynaert B, Marcon A, Sunyer J, Svanes C, Wjst M, and Burney P
- Abstract
RATIONALE: Little is known about the long-term outcomes of individuals with mild/moderate chronic obstructive pulmonary disease (COPD) according to spirometric criteria. OBJECTIVES: To test whether nonsmokers and asymptomatic subjects with a spirometric diagnosis of COPD have a steeper decrease in lung function and higher hospitalization rates than subjects without airway obstruction. METHODS: A total of 5,205 subjects without asthma (20-44 years of age) from the general population, with FEV(1) >or= 50% predicted at baseline, were followed for 9 years in the frame of an international cohort study. Percent decrease in FEV(1) (DeltaFEV(1)%) and the annual hospitalization rate for respiratory causes during the follow-up were assessed for each subject. MEASUREMENTS AND MAIN RESULTS: At baseline, 324 (6.2%) subjects had the prebronchodilator FEV(1)/FVC ratio less than the lower limit of normal (LLN-COPD), and 105 (2.0%) subjects had the same ratio less than 0.70 (modified GOLD-COPD). At follow-up, smokers with LLN-COPD (n = 205) had a greater mean DeltaFEV(1)% (1.7%; 95% confidence interval [CI], 0.8-2.7) and a higher hospitalization rate (rate ratio [RR], 2.52; 95% CI, 1.65-3.86) than normal subjects. Similarly, symptomatic subjects with LLN-COPD (n = 104) had DeltaFEV(1)% (2.0%; 95% CI, 0.8-3.3) and the hospitalization rate (RR, 4.18; 95% CI, 2.43-7.21) higher than the reference group. By contrast, nonsmokers and asymptomatic subjects with LLN-COPD had outcomes that were similar or even better than normal subjects. Among subjects with LLN-COPD, the association of symptoms with DeltaFEV(1)% varied according to smoking habits (P = 0.007); it was particularly strong in symptomatic smokers and disappeared in symptomatic nonsmokers. Similar results were found with the modified GOLD classification. CONCLUSIONS: In relatively young populations, COPD is associated with poor long-term outcomes in smokers and in symptomatic subjects only. [ABSTRACT FROM AUTHOR]
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- 2009
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32. Lung function impairment and metabolic syndrome: the critical role of abdominal obesity.
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Leone N, Courbon D, Thomas F, Bean K, Jégo B, Leynaert B, Guize L, and Zureik M
- Abstract
Rationale: Increased risk for cardiovascular morbidity and mortality has been related to both lung function impairment and metabolic syndrome. Data on the relationship between lung function and metabolic syndrome are sparse. Objectives: To investigate risk for lung function impairment according to metabolic syndrome traits. Methods: This cross-sectional population-based study included 121,965 men and women examined at the Paris Investigations Préventives et Cliniques Center between 1999 and 2006. The lower limit of normal was used to define lung function impairment (FEV(1) or FVC < lower limit of normal). Metabolic syndrome was assessed according to the American Heart Association/National Heart, Lung, and Blood Institute statement. Measurements and Main Results: We used a logistic regression model and principal component analysis to investigate the differential associations between lung function impairment and specific components of metabolic syndrome. Lung function impairment was associated with metabolic syndrome (prevalence = 15.0%) independently of age, sex, smoking status, alcohol consumption, educational level, body mass index, leisure-time physical activity, and cardiovascular disease history (odds ratio [OR] [95% confidence interval], 1.28 [1.20-1.37] and OR, 1.41 [1.31-1.51] for FEV(1) and FVC, respectively). Three factors were identified from factor analysis: 'lipids' (low high-density lipoprotein cholesterol, high triglycerides), 'glucose-blood pressure' (high fasting glycemia, high blood pressure), and 'abdominal obesity' (large waist circumference). All factors were inversely related to lung function, but abdominal obesity was the strongest predictor of lung function impairment (OR, 1.94 [1.80-2.09] and OR, 2.11 [1.95-2.29], for FEV(1) and FVC, respectively). Similar results were obtained for women and men. Conclusions: We found a positive independent relationship between lung function impairment and metabolic syndrome in both sexes, predominantly due to abdominal obesity. Further studies are required to clarify the underlying mechanisms. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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33. Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies.
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Dratva J, Gómez Real F, Schindler C, Ackermann-Liebrich U, Gerbase MW, Probst-Hensch NM, Svanes C, Omenaas ER, Neukirch F, Wjst M, Morabia A, Jarvis D, Leynaert B, Zemp E, Dratva, Julia, Gómez Real, Francisco, Schindler, Christian, Ackermann-Liebrich, Ursula, Gerbase, Margaret W, and Probst-Hensch, Nicole M
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- 2009
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34. Interaction between a heme oxygenase-1 gene promoter polymorphism and serum beta-carotene levels on 8-year lung function decline in a general population: the European Community Respiratory Health Survey (France)
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Guenegou A, Boczkowski J, Aubier M, Neukirch F, and Leynaert B
- Abstract
Oxidative stress is thought to play a major role in the pathogenesis of chronic obstructive pulmonary disease, characterized by impaired lung function. A large number (> or =33) of GT repeats (L-allele) in the gene of the powerful antioxidant enzyme heme oxygenase-1 has been associated with susceptibility to accelerated lung function decline. In contrast, beta-carotene may help to protect against accelerated decline. To determine whether high serum levels of beta-carotene might counterbalance the greater susceptibility of L-allele carriers, the authors analyzed the annual decline in forced expiratory volume in 1 second (FEV1) in a general population sample of 523 French subjects (20-44 years, 50% men) examined in 1992 and 2000 as part of the European Community Respiratory Health Survey. Analysis of covariance, adjusted for sex as well as baseline age, body mass index, smoking, and FEV1, showed that, among subjects with low beta-carotene levels, L-allele carriers experienced a steeper mean FEV1 decline than did noncarriers (mean = -58.8, 95% confidence interval: -73.2, -44.5 vs. mean = -34.7, 95% confidence interval: -38.9, -29.8 ml/year) (p = 0.009), whereas among subjects with high beta-carotene levels, the FEV1 decline was not different in L-allele carriers and noncarriers (two-sided p = 0.9). The results suggest that high levels of beta-carotene might counterbalance the effects on FEV1 decline of a genetically determined deficiency in antioxidant response. [ABSTRACT FROM AUTHOR]
- Published
- 2008
35. Impact of gender on asthma in childhood and adolescence: a GA2LEN review.
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Almqvist, C., Worm, M., and Leynaert, B.
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ASTHMA in children ,ALLERGY in children ,ASTHMATICS ,SEX differences (Biology) ,WHEEZE ,IMMUNE response - Abstract
A number of studies have shown gender differences in the prevalence of wheeze and asthma. The aim of this review was to examine published results on gender differences in childhood and adolescent asthma incidence and prevalence, define current concepts and to identify new research needs. A Medline search was performed with the search words (gender OR sex) AND (child OR childhood OR adolescence) AND (asthma). Articles that reported on abscence or prescence of gender differences in asthma were included and reviewed, and cross-references were checked. Boys are consistently reported to have more prevalent wheeze and asthma than girls. In adolescence, the pattern changes and onset of wheeze is more prevalent in females than males. Asthma, after childhood, is more severe in females than in males, and is underdiagnosed and undertreated in female adolescents. Possible explanations for this switch around puberty in the gender susceptibility to develop asthma include hormonal changes and gender-specific differences in environmental exposures. This aspect needs consideration of the doctors and allergists who diagnose and treat asthmatic individuals. In conclusion, sex hormones are likely to play an important role in the development and outcome of the allergic immune response and asthma in particular. By obtaining functional data from appropriate models, the exact underlying mechanisms can be unravelled. To examine the effect of gender-specific differences in environmental exposures and changes of asthma prevalence and severity in puberty, larger populations may need to be investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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36. Occupation and adult onset of rhinitis in the general population.
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K. Radon, Gerhardinger, U., Schulze, A., Zock, J. -P., Norback, D., Toren, K., Jarvis, D., Held, L., Heinrich, J., Leynaert, B., Nowak, D., and Kogevinas, M.
- Abstract
Objectives: Occupational exposures have been associated with an increased risk of new-onset rhinitis in apprentices. However, population-based prospective data are scarce and do not cover new onset of rhinitis later in life. The authors studied the association between occupational exposure and adult onset of rhinitis prospectively. Methods: The data of 4994 participants (age at follow-up 28-57 years) from 27 centres of the European Community Respiratory Health Survey II who were symptom-free at baseline were analysed. As outcome at follow-up self- reported (a) nasal allergies ("allergic rhinitis"( and (b( runny, blocked nose for 12 months a year ("perennial rhinitis"( were used. Occupational exposures at any time during follow-up were defined by job title. Results: The cumulative incidence of allergic rhinitis, perennial rhinitis and both conditions was 12%, 11% and 3%, respectively. Compared to office workers, male medical professionals were at increased risk of new onset of allergic rhinitis (OR 3.0; 95% Cl 1.4 to 6.4). Odds ratios were reduced in metal workers not involved in metal making or treating (0.3; 95% Cl 0.1 to 0.7). For perennial rhinitis ORs were significantly increased in cleaners (1.4; 95% Cl 1.0 to 2.1). Conclusions: Cleaners and medical professionals may be at increased risk for adult-onset rhinitis. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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37. Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study.
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Shaaban R, Zureik M, Soussan D, Antó JM, Heinrich J, Janson C, Künzli N, Sunyer J, Wjst M, Burney PG, Neukirch F, and Leynaert B
- Abstract
Rationale: Patients with allergic rhinitis have more frequent bronchial hyperresponsiveness (BHR) in cross-sectional studies. Objectives: To estimate the changes in BHR in nonasthmatic subjects with and without allergic rhinitis during a 9-year period. Methods: BHR onset was studied in 3,719 subjects without BHR at baseline, who participated in the follow-up of the European Community Respiratory Health Survey. Measurements and Main Results: BHR was defined as a >/=20% decrease in FEV(1) for a maximum dose of 1 mg of methacholine. Allergic rhinitis was defined as having a history of nasal allergy and positive specific IgE (>/=0.35 IU/ml) to pollen, cat, mites, or Cladosporium. The cumulative incidence of BHR was 9.7% in subjects with allergic rhinitis and 7.0% in subjects with atopy but no rhinitis, compared with 5.5% in subjects without allergic rhinitis and atopy (respective odds ratios [OR] and their 95% confidence intervals [95% CI] for BHR onset, 2.44 [1.73-3.45]; and 1.35 [0.86-2.11], after adjustment for potential confounders including sex, smoking, body mass index and FEV(1)). Subjects with rhinitis sensitized exclusively to cat or to mites were particularly at increased risk of developing BHR (ORs [95% CI], 7.90 [3.48-17.93] and 2.84 [1.36-5.93], respectively). Conversely, in subjects with BHR at baseline (n = 372), 35.3% of those with allergic rhinitis, compared with 51.8% of those without rhinitis had no more BHR at follow-up (OR [95% CI], 0.51 [0.33-0.78]). BHR 'remission' was more frequent in patients with rhinitis treated by nasal steroids than in those not treated (OR [95% CI], 0.33 [0.14-0.75]). Conclusions: Allergic rhinitis was associated with increased onset of BHR, and less chance for remission except in those treated for rhinitis. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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38. Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.
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de Marco R, Accordini S, Cerveri I, Corsico A, Antó JM, Künzli N, Janson C, Sunyer J, Jarvis D, Chinn S, Vermeire P, Svanes C, Ackermann-Liebrich U, Gislason T, Heinrich J, Leynaert B, Neukirch F, Schouten JP, Wjst M, and Burney P
- Abstract
RATIONALE: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. OBJECTIVES: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. METHODS: An international cohort of 5,002 subjects without asthma (ages 20-44 yr) with normal lung function (FEV(1)/FVC ratio >/= 70%) from 12 countries was followed from 1991-2002 in the frame of the European Community Respiratory Health Survey II. Incident cases of COPD were those who had an FEV(1)/FVC ratio less than 70% at the end of the follow-up, but did not report having had a doctor diagnose asthma during the follow-up. MAIN RESULTS: The incidence rate of COPD was 2.8 cases/1,000/yr (95% confidence interval [CI], 2.3-3.3). Chronic cough/phlegm was an independent and statistically significant predictor of COPD (incidence rate ratio [IRR], 1.85; 95% CI, 1.17-2.93) after adjusting for smoking habits and other potential confounders, whereas dyspnea was not associated with the disease (IRR = 0.98; 95% CI, 0.64-1.50). Subjects who reported chronic cough/phlegm both at baseline and at the follow-up had a nearly threefold-increased risk of developing COPD with respect to asymptomatic subjects (IRR = 2.88; 95% CI, 1.44-5.79). CONCLUSIONS: The incidence of COPD is substantial even in young adults. The presence of chronic cough/phlegm identifies a subgroup of subjects with a high risk of developing COPD, independently of smoking habits. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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39. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project.
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Bousquet, J., Anto, J. M., Bachert, C., Bousquet, P. J., Colombo, P., Crameri, R., Daëron, M., Fokkens, W., Leynaert, B., Lahoz, C., Maurer, M., Passalacqua, G., Valenta, R., van Hage, M., and Van Ree, R.
- Subjects
ALLERGENS ,IMMUNOGLOBULIN E ,ALLERGIES ,ALLERGIC rhinitis ,RHINITIS ,RESPIRATORY allergy ,ASTHMA - Abstract
The synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono- vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (Fc ℇRI) and other factors regulating the activation of Fc ℇRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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40. An increase in bronchial responsiveness is associated with continuing or restarting smoking.
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Chinn S, Jarvis D, Luczynska CM, Ackermann-Liebrich U, Antó JM, Cerveri I, de Marco R, Gislason T, Heinrich J, Janson C, Künzli N, Leynaert B, Neukirch F, Schouten JP, Sunyer J, Svanes C, Wjst M, and Burney PG
- Abstract
Rationale: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults.Objectives: To analyze change in bronchial responsiveness in an international longitudinal community study.Methods: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002.Measurements: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex.Main Results: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD[20] of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV[1]. No other risk factor for change in bronchial responsiveness was identified.Conclusions: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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41. Monitoring the quality-of-life in allergic disorders.
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Leynaert B, Soussan D, Leynaert, Bénédicte, and Soussan, David
- Published
- 2003
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42. Rhinitis is associated with increased systolic blood pressure in men: a population-based study.
- Author
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Kony S, Zureik M, Neukirch C, Leynaert B, Vervloet D, and Neukirch F
- Abstract
An association between impaired lower respiratory function and cardiovascular risk factors, such as hypertension, is often reported but it is unknown whether there is a relationship between upper airway disorders and cardiovascular risk factors, despite evidence that upper and lower respiratory tract disorders are closely linked. Our objective was to assess whether rhinitis is associated with arterial blood pressure and hypertension. In a population-based study of 330 adults aged 28-56 years, as part of the European Community Respiratory Health Survey, rhinitis was assessed by means of a questionnaire, and cardiovascular data were obtained using a questionnaire and by measuring blood pressure. Systolic blood pressure (SBP) was higher in men with rhinitis than in men without rhinitis (130.6 +/- 12.7 mm Hg versus 123.5 +/- 13.9 mm Hg; p = 0.002), and it was still the case after adjustment for cardiovascular and respiratory confounding factors. Hypertension was more frequent in men with rhinitis than in men without rhinitis, even after multivariate adjustment (odds ratio = 2.6, 95% confidence interval = [1.14-5.91]). The observation of SBP levels according to whether men have no rhinitis, seasonal rhinitis, or perennial rhinitis was compatible with a dose-response relationship (p for trend = 0.02). In conclusion, rhinitis is strongly associated with SBP and hypertension in men. Blood pressure should be regularly checked in men with rhinitis. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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43. Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey
- Author
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Bakke Per S, Omenaas Ernst R, Plana Estel, Eagan Tomas ML, Voll-Aanerud Marianne, Svanes Cecilie, Siroux Valerie, Pin Isabelle, Antó Josep M, and Leynaert Benedicte
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Respiratory symptoms are common in the general population, and their presence is related to Health-related quality of life (HRQoL). The objective was to describe the association of respiratory symptoms with HRQoL in subjects with and without asthma or COPD and to investigate the role of atopy, bronchial hyperresponsiveness (BHR), and lung function in HRQoL. Methods The European Community Respiratory Health Survey (ECRHS) I and II provided data on HRQoL, lung function, respiratory symptoms, asthma, atopy, and BHR from 6009 subjects. Generic HRQoL was assessed through the physical component summary (PCS) score and the mental component summary (MCS) score of the SF-36. Factor analyses and linear regressions adjusted for age, gender, smoking, occupation, BMI, comorbidity, and study centre were conducted. Results Having breathlessness at rest in ECRHS II was associated with mean score (95% CI) impairment in PCS of -8.05 (-11.18, -4.93). Impairment in MCS score in subjects waking up with chest tightness was -4.02 (-5.51, -2.52). The magnitude of HRQoL impairment associated with respiratory symptoms was similar for subjects with and without asthma/COPD. Adjustments for atopy, BHR, and lung function did not explain the association of respiratory symptoms and HRQoL in subjects without asthma and/or COPD. Conclusion Subjects with respiratory symptoms had poorer HRQoL; including subjects without a diagnosis of asthma or COPD. These findings suggest that respiratory symptoms in the absence of a medical diagnosis of asthma or COPD are by no means trivial, and that clarifying the nature and natural history of respiratory symptoms is a relevant challenge. Several community studies have estimated the prevalence of common respiratory symptoms like cough, dyspnoea, and wheeze in adults 123. Although the prevalence varies to a large degree between studies and geographical areas, respiratory symptoms are quite common. The prevalences of respiratory symptoms in the European Community Respiratory Health Study (ECRHS) varied from one percent to 35% 1. In fact, two studies have reported that more than half of the adult population suffers from one or more respiratory symptoms 45. Respiratory symptoms are important markers of the risk of having or developing disease. Respiratory symptoms have been shown to be predictors for lung function decline 678, asthma 910, and even all-cause mortality in a general population study 11. In patients with a known diagnosis of asthma or chronic obstructive pulmonary disease (COPD), respiratory symptoms are important determinants of reduced health related quality of life (HRQoL) 12131415. The prevalence of respiratory symptoms exceeds the combined prevalences of asthma and COPD, and both asthma and COPD are frequently undiagnosed diseases 161718. Thus, the high prevalence of respipratory symptoms may mirror undiagnosed and untreated disease. The common occurrence of respiratory symptoms calls for attention to how these symptoms affect health also in subjects with no diagnosis of obstructive airways disease. Impaired HRQoL in the presence of respiratory symptoms have been found in two population-based studies 619, but no study of respiratory sypmtoms and HRQoL have separate analyses for subjects with and without asthma and COPD, and no study provide information about extensive objective measurements of respiratory health. The ECRHS is a randomly sampled, multi-cultural, population based cohort study. The ECRHS included measurements of atopy, bronchial hyperresponsiveness (BHR), and lung function, and offers a unique opportunity to investigate how respiratory symptoms affect HRQoL among subjects both with and without obstructive lung disease. In the present paper we aimed to: 1) Describe the relationship between respiratory symptoms and HRQoL in an international adult general population and: 2) To assess whether this relationship varied with presence of asthma and/or COPD, or presence of objective functional markers like atopy and BHR.
- Published
- 2010
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44. ETB receptor polymorphism is associated with airway obstruction
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Aubier Michel, Boczkowski Jorge, Neukirch Françoise, Vuillaumier Sandrine, Leynaert Bénédicte, Piperaud Marie, Almolki Abdelhamid, Guénégou Armelle, Taillé Camille, Benessiano Joëlle, and Crestani Bruno
- Subjects
Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precursor of ET-1, and for ETA (EDNRA) and ETB (EDNRB), the two receptors for EDN1. In the present work, we hypothesised that molecular variation in these genes could be a major determinant of the degree of bronchial obstruction. The purpose of this study was to investigate whether the genetic polymorphisms of preproET-1, EDNRA and EDNRB genes were associated with the degree of airway obstruction, assessed by FEV1. Methods Polymorphisms of preproET-1, EDNRA and EDNRB were first studied in a population of adult asthmatic patients. Results were confirmed in a large population of adults from the general population from the ECRHS II study. Results In our population of adult asthmatic patients, the EDNRB-30G>A (Leu277Leu) polymorphism (GG genotype) is strongly associated with a low FEV1 and with a higher percentage of patients with FEV1 < 80% of predicted value. No relationship was found between pulmonary function and EDNRA-1363C>T (His323His) or preproET-1-595G>T (Lys198Asp) polymorphism. In the adult population from the ECRHS II, we found a similar association between GG genotype and a low FEV1 or a higher percentage of subjects with FEV1 < 80% predicted, especially in the subgroups of asthmatics subjects (OR = 4.31 (95%CI 1.03 – 18.04)) and smokers (OR = 7.42 (95%CI 1.69 – 32.6)). Conclusion the EDNRB-30G>A polymorphism could be a determinant of airway obstruction in humans with predisposing factors such as tobacco smoke exposure or asthma.
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- 2007
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45. Gas cooking and respiratory health in women.
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Leynaert, B, Liard, R, Bousquet, J, Mesbah, H, and Neukirch, F
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- 1996
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46. Dietary habits: a long-term effect of childhood farming lifestyle.
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Varraso, R., Oryszczyn, M. P., Leynaert, B., Boutron-Ruault, M. C., Clavel-Chapelon, F., Romieu, I., and Kauffmann, F.
- Published
- 2008
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47. Rhinitis and onset of asthma: a longitudinal population-based study.
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Shaaban R, Zureik M, Soussan D, Neukirch C, Heinrich J, Sunyer J, Wjst M, Cerveri I, Pin I, Bousquet J, Jarvis D, Burney PG, Neukirch F, and Leynaert B
- Published
- 2008
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48. Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II)
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Kogevinas M, Zock JP, Jarvis D, Kromhout H, Lillienberg L, Plana E, Radon K, Torén K, Alliksoo A, Benke G, Blanc PD, Dahlman-Hoglund A, D'Errico A, Héry M, Kennedy S, Kunzli N, Leynaert B, Mirabelli MC, Muniozguren N, and Norbäck D
- Published
- 2007
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49. Smoking cessation, lung function, and weight gain: a follow-up study.
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Chinn S, Jarvis D, Melotti R, Luczynska C, Ackermann-Liebrich U, Antó JM, Cerveri I, de Marco R, Gislason T, Heinrich J, Janson C, Künzli N, Leynaert B, Neukirch F, Schouten J, Sunyer J, Svanes C, Vermeire P, Wjst M, and Burney P
- Published
- 2005
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50. Quantitative assessments of indoor air pollution and respiratory health in a population-based sample of French dwellings
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Isabella Annesi-Maesano, Bénédicte Leynaert, Cécile Billionnet, Séverine Kirchner, Centre Scientifique et Technique du Bâtiment (CSTB), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Billionnet C, Gay E, Kirchner S, Leynaert B, and Annesi-Maesano I.
- Subjects
Adult ,Adolescent ,Cross-sectional study ,Threshold limit value ,voc ,Air pollution ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,Statistics, Nonparametric ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Indoor air quality ,rhinitis ,Environmental health ,Surveys and Questionnaires ,11. Sustainability ,Medicine ,Humans ,0105 earth and related environmental sciences ,General Environmental Science ,Asthma ,Aged ,Aged, 80 and over ,Air Pollutants ,Volatile Organic Compounds ,multipollution ,indoor air pollution ,business.industry ,Odds ratio ,Middle Aged ,asthma ,medicine.disease ,Confidence interval ,3. Good health ,Cross-Sectional Studies ,030228 respiratory system ,Quartile ,13. Climate action ,Environmental chemistry ,Air Pollution, Indoor ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,France ,business - Abstract
International audience; BACKGROUND: Various volatile organic compounds (VOCs) have been related to respiratory health effects, but have generally been assessed individually without taking into account the fact that such pollutants are highly correlated to one other. AIMS: We investigated the effects of exposure to various VOC, and considered their combined effect on adult asthma and rhinitis. METHOD: A national cross-sectional representative survey conducted by the Indoor Air Quality Observatory objectively assessed 20 VOCs in 490 main dwellings in France. A standardized questionnaire determined the prevalence of asthma and rhinitis among 1012 inhabitants of the dwellings (≥ 15 years). Marginal models for binary outcome were used to relate VOCs exposure to asthma and rhinitis, controlling for potential confounders. A global score representing the number of VOCs in each dwelling with an elevated concentration (using the 3(rd) quartile value of the distribution as a threshold value) was then derived as a measure of the combined effect of VOCs. Specific scores were built using a similar approach, grouping VOCs by family. RESULTS: Asthma (8.6%) was significantly associated with N-undecane and 1,2,4-trimethylbenzene and rhinitis (38.3%) with ethylbenzene, trichloroethylene, m/p- and o-xylene. The global VOC score was associated with a significant risk of asthma and rhinitis (odds ratio (OR) of 1.40 and 1.22, respectively, for 5 additional VOCs with high exposure level). Both specific scores for aromatic hydrocarbons and aliphatic hydrocarbons were associated with a significantly risk of asthma (OR=1.12; 95% confidence interval (CI): 1.01-1.24 and OR=1.41; 95% CI=1.03-1.93, respectively). The specific VOC score for halogenated hydrocarbons was associated with a significant risk of rhinitis (OR=1.28; 95% CI: 1.07-1.54). CONCLUSION: We have shown that high concentrations of VOCs in homes were associated with an increasing prevalence of asthma and rhinitis in adults.
- Published
- 2011
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