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In order to solve the problem of multi-AGV path planning in a packaging workshop, this paper proposes a multi-AGV path-planning method based on time windows. A grid method is selected to build a map model. A penalty function is added to the A* algorithm to reduce the number of invalid turns made by AGVs during transportation. The AGV priorities are set according to the differences in AGV transport states. At the same time, the raster time window method is used to describe the five types of conflict that may occur in the process of multi-AGV transport. Combined with the AGV priorities, a multi-AGV anti-collision strategy is provided to realize the conflict-free path planning of multiple AGVs. The algorithm's effectiveness was verified by simulation, and a reasonable quantity of AGVs was proposed based on AGV sensitivity analysis. The improved A* algorithm combined with the time window method can realize multi-AGV collision-free transportation and improve the efficiency and reliability of multi-AGV transportation. [ABSTRACT FROM AUTHOR]

More than 6 million small-incision lenticule extraction (SMILE) procedures have been performed worldwide since 2011. Therefore, its long-term safety and efficacy should be investigated. This study aimed to evaluate 10-year refractive outcomes, corneal stability, axial length, and wavefront aberrations in patients who underwent SMILE to correct myopia. Thirty two patients (32 eyes) who underwent SMILE-based myopic correction. Corrected distance visual acuity, uncorrected distance visual acuity, corneal stability, axial length, and wavefront aberrations were evaluated preoperatively and at 1 month and 1, 5, and 10 years postoperatively. At 10 years postoperatively, the safety and efficacy indices for the patients included in this study were 1.19 ± 0.21 and 1.04 ± 0.27, respectively. For 26 (81%) and 30 eyes (94%), correction to within ±0.50 D and ±1.00 D of the target was achieved, respectively. Over the 10-year follow-up duration, a mean −0.32 ± 0.56 D regression was observed (−0.03 ± 0.06 D/year). Relative to baseline, horizontal and vertical comas significantly increased, as did the incidence of higher-order aberrations (all P < 0.001), whereas axial length and corneal elevation remained stable during follow-up. These results indicate that the SMILE-based correction for myopia of up to -10 Dioptres is safe, effective, and stable, with relatively constant wavefront aberrations and corneal stability over time after treatment. [ABSTRACT FROM AUTHOR]

Biomedical patches offer significant potential for keratitis treatment. Building on advances in multifunctionality and biomimicry, an innovative, multifunctional hydrogel patch with high therapeutic efficacy, inspired by the native architecture and functions of the cornea, is introduced. By engineering a composite patch comprising recombinant human collagen (RHC) hydrogel, near‐field electrospinning (NFES) microfibers, and gold‐nanoparticle‐decorated tetragonal barium titanates (BTO@Au), structural mimicry, mechanical reinforcement, tissue‐specific adhesion, and bacterial inhibition are achieved. The RHC hydrogel recreates a three‐dimensional (3D) microenvironment that emulates the natural structure of the corneal tissue, demonstrating excellent tissue adhesion. Integrated within this hydrogel, the NFES microfibers, designed to emulate the orthogonal arrangement of native corneal stroma, not only reinforce the mechanical strength of the RHC hydrogel but also act as scaffolds to guide the aligned growth of human keratocytes. A unique aspect of this advanced patch is the incorporation of BTO@Au nanoparticles, which generate reactive oxygen species for effective bacterial eradication when subjected to ultrasound stimulation. Through in vivo studies on rat models with infected corneal wounds, this hydrogel patch exhibits superior therapeutic efficacy compared to the current treatment. It is posited that these cornea‐inspired ultrasound‐responsive adhesive hydrogel patches represent a significant scientific advancement with high potential for clinical applications. [ABSTRACT FROM AUTHOR]

In order to explore the positive impact of the joint distribution model on the reduction in logistics costs in small-scale logistics enterprises, considering the demand on enterprises for simultaneous pick-up and delivery, as well as the cost of carbon emissions, this study considers the vehicle routing problem of simultaneous pick-up and delivery under a joint distribution model. First of all, an independent distribution model and a joint distribution model including fixed transportation, variable transportation, time penalty, and carbon emissions costs are established; second, by adding the self-adaption cross-mutation probability and the destruction and repair mechanism in the large-scale neighborhood search algorithm, the genetic algorithm is improved to adapt to the solution of the model in this paper, and the effectiveness of the improved algorithm is verified and analyzed. It is found that the improved genetic algorithm is more advantageous than the original algorithm for solving the problems of both models designed in this paper. Finally, the improved genetic algorithm is used to solve the two models, and the results are compared and analyzed. It is found that the joint distribution model can reduce the total cost by 6.61% and the carbon emissions cost by 5.73%. Additionally, the impact of the carbon trading mechanism on the simultaneous pick-up and delivery vehicle routing problem under the joint distribution model is further explored. The results of this study prove that enterprises can effectively reduce costs, improve profits, reduce carbon emissions, and promote the sustainable development of logistics enterprises under the condition of joint distribution. [ABSTRACT FROM AUTHOR]