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Highlights Ni3Fe oxide, with an average size of 3.5 ± 1.5 nm, was successfully deposited onto polyaniline (PANI) support through a solvothermal strategy followed by calcination. The catalyst–support interaction between Ni3Fe oxide and PANI can enhance the Ni-O covalency via the interfacial Ni-N bond. Ni3Fe oxide/PANI-assembled Zn-air batteries achieve superior cycling life for over 400 h at 10 mA cm−2 and a low charge potential of around 1.95 V.

Regenerative fuel cells can operate alternately as an electrolyzer and as a fuel cell, frequently involving water as a reactant or product. Modifying the electrode surface to manipulate water can prevent electrode flooding and enhance the electrode's mass transfer efficiency by facilitating better contact with gaseous reactants. However, conventional electrodes face difficulties in allowing water droplets to penetrate in a single direction leaving electrodes. In this work to address this issue, a wettability gradient electrode is designed and fabricated for efficient water manipulation in regenerative fuel cells. The findings demonstrate that the water removal strategy in the electrolyzer mode yields the highest ammonia yield and Faradaic efficiency of 3.39 × 10-10 mol s-1 cm-2 and 0.49 %, respectively. Furthermore, in the fuel cell mode, the discharging process sustains for approximately 20.5 h, which is six times longer than the conventional strategy. The ability to sustain the discharging process for extended periods is particularly advantageous in regenerative fuel cells, as it enables the cells to operate for longer periods without the need for regeneration.

Abstract A comprehensive understanding of the transient characteristics in solid oxide cells (SOCs) is crucial for advancing SOC technology in renewable energy storage and conversion. However, general formulas describing the relationship between SOC transients and multiple parameters remain elusive. Through comprehensive numerical analysis, we find that the thermal and gaseous response times of SOCs upon rapid electrical variations are on the order of two characteristic times (τ h and τ m), respectively. The gaseous response time is approximately 1τ m, and the thermal response time aligns with roughly 2τ h. These characteristic times represent the overall heat and mass transfer rates within the cell, and their mathematical relationships with various SOC design and operating parameters are revealed. Validation of τ h and τ m is achieved through comparison with an in-house experiment and existing literature data, achieving the same order of magnitude for a wide range of electrochemical cells, showcasing their potential use for characterizing transient behaviors in a wide range of electrochemical cells. Moreover, two examples are presented to demonstrate how these characteristic times can streamline SOC design and control without the need for complex numerical simulations, thus offering valuable insights and tools for enhancing the efficiency and durability of electrochemical cells.

Abstract The safety performance and structural stiffness of a rim, which is the main load-bearing structure of the loader during operation, influence the overall performance, stability, and braking capabilities of the machine. In the industry, researchers are currently pursuing lightweight and high-strength rims as a primary objective. A low weight not only enhances machinery fuel efficiency but also aligns with societal demands for sustainable development, energy conservation, and emission reduction. In this article, multiobjective optimization analysis on rims composed of three different materials is performed, and the relationships between various optimization parameters and target parameters are established using the results of response surface construction. Multiobjective genetic algorithms are utilized to derive various optimization plans, which are subsequently evaluated through static analysis, fatigue analysis, and weight loss analysis. The final optimization plan is determined based on the calculation results while considering production costs. Field tests are conducted on the optimized rims under various working conditions to verify the test results, evaluate the reliability of the finite element analysis results, and confirm the safety of the optimized rim.

Abstract Background This work conducted quantitative and qualitative analyses on the heavy metals in 32 surface sediment samples collected from eight sampling sites across four seasons in the Yutan reservoir, a typical mountainous hilly riverine reservoir in Southwest China. Results Nine heavy metals were identified: (Cr, Cd, Pb, Cu, Zn, Hg, As, Ni, and Co). The concentrations varied within the ranges of 23.16 ~ 34.62, 0.53 ~ 1.09, 31.88 ~ 59.04, 51.94 ~ 85.84, 106.76 ~ 227.69, 0.08 ~ 0.15, 12.57 ~ 25.60, 12.06 ~ 27.64 and 11.04 ~ 14.56 mg/kg, respectively, following a decreased concentration order of Zn > Cu > Pb > Cr > Ni > As > Co > Cd > Hg. Except for Cd, which accumulated in winter, and Hg, which reduced in spring. The concentration of heavy metals showed no significant seasonal variation and generally had higher contents at the river mouth and lower concentrations in open water areas and branches. The geoaccumulation index (I geo) assessment also indicated that the reservoir was uncontaminated by Cr and Ni (I geo

Intervertebral disc degeneration (IDD) is the cause of low back pain (LBP), and recent research has suggested that inflammatory cytokines play a significant role in this process. Maslinic acid (MA), a natural compound found in olive plants (Olea europaea), has anti-inflammatory properties, but its potential for treating IDD is unclear. The current study aims to investigate the effects of MA on TNFα-induced IDD in vitro and in other in vivo models. Our findings suggest that MA ameliorates the imbalance of the extracellular matrix (ECM) and mitigates senescence by upregulating aggrecan and collagen II levels as well as downregulating MMP and ADAMTS levels in nucleus pulposus cells (NPCs). It can also impede the progression of IDD in rats. We further find that MA significantly affects the PI3K/AKT and NF-κB pathways in TNFα-induced NPCs determined by RNA-seq and experimental verification, while the AKT agonist Sc-79 eliminates these signaling cascades. Furthermore, molecular docking simulation shows that MA directly binds to PI3K. Dysfunction of the PI3K/AKT pathway and ECM metabolism has also been confirmed in clinical specimens of degenerated nucleus pulposus. This study demonstrates that MA may hold promise as a therapeutic agent for alleviating ECM metabolism disorders and senescence to treat IDD.

Serious bubble clogging in flow-field channels will hinder the water supply to the electrode of proton exchange membrane water electrolyzer (PEMWE), deteriorating the cell performance. In order to address this issue, the dual-layer flow field design has been proposed in our previous study. In this study, the VOF (volume of fluid) method is utilized to investigate the effects of different degassing layer and base heights on the bubble behavior in channel and determine the time for the bubbles to detach from the electrode surface. However, it is very time-consuming to get the optimal combination of base layer and degassing layer heights due to the large number of potential cases, which needs to be calculated through computation-intensive physical model. Therefore, machine learning methods are adopted to accelerate the optimization. A data-driven surrogate model based on deep neural network (DNN) is developed and successfully trained using data obtained by the physical VOF method. Based on the highly efficient surrogate, genetic algorithm (GA) is further utilized to determine the optimal heights of base layer and degassing layer. Finally, the reliability of the optimization was validated by bubble visualization in channel and electrochemical characterization in PEMWE through experiments.

Haptic communications is recognized as a promising enabler of extensive services by enabling real-time haptic control and feedback in remote environments, e.g., teleoperation and autonomous driving. Considering the strict transmission requirements on reliability and latency, Device-to-Device (D2D) communications is introduced to assist haptic communications. In particular, the teleoperators with poor channel quality are assisted by auxiliaries, and each auxiliary and its corresponding teleoperator constitute a D2D pair. However, the haptic interaction and the scarcity of radio resources pose severe challenges to the resource allocation, especially facing the sporadic packet arrivals. First, the contention-based access scheme is applied to achieve low-latency transmission, where the resource scheduling latency is omitted and users can directly access available resources. In this context, we derive the reliability index of D2D pairs under the contention-based access scheme, i.e., closed-loop packet error probability. Then, the reliability performance is guaranteed by bidirectional power control, which aims to minimize the sum packet error probability of all D2D pairs. Potential game theory is introduced to solve the problem with low complexity. Accordingly, a distributed power control algorithm based on synchronous log-linear learning is proposed to converge to the optimal Nash Equilibrium. Experimental results demonstrate the superiority of the proposed learning algorithm.

Abstract Background Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery. Methods Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software. Results A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P

Abstract Understandings of the three-dimensional social behaviors of freely moving large-size mammals are valuable for both agriculture and life science, yet challenging due to occlusions in close interactions. Although existing animal pose estimation methods captured keypoint trajectories, they ignored deformable surfaces which contained geometric information essential for social interaction prediction and for dealing with the occlusions. In this study, we develop a Multi-Animal Mesh Model Alignment (MAMMAL) system based on an articulated surface mesh model. Our self-designed MAMMAL algorithms automatically enable us to align multi-view images into our mesh model and to capture 3D surface motions of multiple animals, which display better performance upon severe occlusions compared to traditional triangulation and allow complex social analysis. By utilizing MAMMAL, we are able to quantitatively analyze the locomotion, postures, animal-scene interactions, social interactions, as well as detailed tail motions of pigs. Furthermore, experiments on mouse and Beagle dogs demonstrate the generalizability of MAMMAL across different environments and mammal species.

Abstract Background Unstable femoral neck fractures have a high likelihood of causing severe disruption to the blood supply. This study aimed to assess the therapeutic effect of surgical hip dislocation using a medial support plate combined with cannulated screw fixation for the treatment of unstable femoral neck fractures in young and middle-aged adults. Methods We retrospectively analyzed the medical records of 68 young adults who underwent internal fixation of unstable femoral neck fractures. The observation group included 32 patients who had received medial support plate and cannulated screw fixation by the surgical hip dislocation method and 36 patients who had undergone anti-rotation screw composite compression system fixation comprised the comparison group. The amount of intraoperative bleeding, surgery duration, fracture recovery time and complications were recorded. The degree of femoral neck shortening and Garden index were assessed using the Zlowodzki method. Additionally, hip functionality was evaluated using the Harris score at 3 and 6 months and at the last follow-up. Results All 68 patients in both groups were followed up for 12–42 months (mean, 22.4 months). The postoperative incision was well-aligned and no inflation was observed. The intraoperative blood loss and surgery duration in the comparison group were longer than those in the observation. Additionally, the observation group had a significantly shorter fracture recovery time and a higher Garden index than the comparison at 6 months postoperatively; however, there was no significant statistical discrepancy between the two groups at the remaining time points. The observation group had higher Harris scores than the comparison at 3 and 6 months postoperatively. Conclusion Surgical hip dislocation applied to the medial support plate combined with cannulated screw fixation has clinical application value in restoring the stability of femoral neck fractures while facilitating the maintenance of blood flow to the femoral head and neck.

Abstract Nowadays, the development of diagnosis and treatment technology is constantly changing the pedigree and classification of nervous system diseases. Analyzing changes in earlier disease pedigrees can help us understand the changes involved in disease diagnosis from a macro perspective, as well as predict changes in later disease pedigrees and the direction of diagnosis and treatment. The inpatients of the neurology department from January 2012 to December 2020 in Hunan Children's Hospital were retrospectively analyzed. There were 36,777 patients enrolled in this study. The next analysis was based on factors like age, gender, length of stay (LoS), number of patients per month and per year (MNoP and ANoP, respectively), and average daily hospital cost (ADHE). To evaluate the characteristics of neurological diseases, we applied a series of statistical tools such as numerical characteristics, boxplots, density charts, one-way ANOVA, Kruskal–Wallis tests, time-series plots, and seasonally adjusted indices. The statistical analysis of neurological diseases led to the following conclusions: First, children having neurological illnesses are most likely to develop them between the ages of 4 and 8 years. Benign intracranial hypertension was the youngest mean age of onset among the various neurologic diseases, and most patients with bacterial intracranial infection were young children. Some diseases have a similar mean age of onset, such as seizures (gastroenteritis/diarrhea) and febrile convulsions. Second, women made up most patients with autoimmune diseases of the central nervous system. Treatment options for inherited metabolic encephalopathy and epilepsy are similar, but they differ significantly for viral intracranial infection. Some neurologic diseases were found to have seasonal variations; for example, infectious diseases of the central nervous system were shown to occur more commonly in the warm season, whereas, autoimmune diseases primarily appeared in the autumn and winter months. Additionally, the number of patients admitted to hospitals with intracranial infections and encephalopathy has dramatically dropped recently, but the number of patients with autoimmune diseases of the central nervous system and hereditary metabolic encephalopathy has been rising year over year. Finally, we discovered apparent polycentric distributions in various illnesses’ density distributions. The study offered an epidemiological basis for common nervous system diseases, including evidence from age of onset, number of cases, and so on. The pedigree of nervous system diseases has significantly changed. The proportion of patients with neuroimmune diseases and genetic metabolic diseases is rising while the number of patients with infection-related diseases and uncertain diagnoses is decreasing. The existence of a disease multimodal model suggests that there is still a lack of understanding of many diseases' diagnosis and treatment, which needs to be improved further because accurate diagnosis aids in the formulation of individualized treatment plans and the allocation of medical resources; additionally, there is still a lack of effective treatment for most genetic diseases. The seasonal characteristics of nervous system diseases suggest the need for the improvement of sanitation, living conditions, and awareness of daily health care.

Red resources are an important part of China’s red culture, condensing red genes such as firm ideals and lofty revolutionary spirit, and have rich values of education. This paper combines red resources and Internet technology to design an intelligent parenting system for architecture majors and uses questionnaires to analyze the changes in students’ cognition of red resources and ideological quality level after the application of the parenting system. At the same time, we construct an evaluation index system for the implementation quality of the intelligent parenting system and obtain evaluation results by constructing an affiliation matrix between the indexes. Then analyze the correlation between the level of ideological quality and the quality of implementation of the parenting system. After the parenting system is applied, the mean value of each dimension of students’ ideological quality is distributed between 3.52 and 4.65 points, as evidenced by the application practice results. It has also been found that the average assessment score of the overall implementation quality of the intelligent parenting system for architecture majors based on red resources in colleges and universities is 3.94 points. The level of ideological quality and the implementation quality of the parenting system have a strong correlation. This paper lays the foundation for achieving the all-around integration of red resources and human education for architectural students and provides a reference basis for improving their ideological quality.

Circular RNAs (circRNAs) regulate Jumonji domain-containing protein-3 (JMJD3) by sponging with microRNAs (miRNAs). This study aimed to investigate the role of icariin on specific circRNA/miRNA/JMJD3 axis in osteogenic differentiation of MC3T3-E1 cells. CircRNA sequencing was performed on the MC3T3-E1 cells induced by osteogenic differentiation medium for 1 d (negative control (NC) group) and 14 d (osteogenesis group). And mmu_circ_0000349 was verified using Sanger sequencing, ribonuclease R degradation, and actinomycin D assay. The function of mmu_circ_0000349 was validated by detecting the expressions of osteogenic differentiation markers, alkaline phosphatase (ALP), and runt-related transcription (RUNX2), via real-time quantitative PCR (qPCR) and Western blotting or ALP and alizarin red staining assay. Dual luciferase reporter gene assay confirmed the relationship between mmu_circ_0000349 and mmu-miR-138-5p (or mmu-miR-138-5p and JMJD3). Meanwhile, the JMJD3 binding to mmu_circ_0000349 was screened using an RNA pull-down assay. qPCR and Western blotting confirmed the effect of icariin on the mmu_circ_0000349/mmu-miR-138-5p/JMJD3 axis and osteogenic differentiation. As MC3T3-E1 osteogenic differentiation progressed, the JMJD3 expression level increased. A total of 361 circRNAs exhibited differences between the NC and osteogenesis groups. After validation, mmu_circ_0000349 was further analyzed as it exhibited the largest expression. And mmu_circ_0000349 was identified as a stable circular structure. Overexpression of mmu_circ_0000349 increased the expression levels of ALP and RUNX2, enhanced ALP activity, and increased the number of mineralized nodules; contrarily, inhibition of mmu_circ_0000349 exerted opposite effects. The data also confirmed that mmu_circ_0000349 regulated JMJD3 by sponging with mmu-miR-138-5p. With the increase in icariin concentration and time for treatment, the expression levels of mmu_circ_0000349, JMJD3, ALP, and RUNX2 also increased, whereas that of mmu-miR-138-5p decreased. In conclusion, Icariin promoted osteogenic differentiation by regulating the mmu_circ_0000349/mmu-miR-138-5p/JMJD3 pathway. Therefore, this provides a theoretical basis for the treatment of diseases related to osteogenic differentiation.

Summary: Solar-driven thermochemical conversion of H2O and CO2 into sustainable fuels, based on redox cycle, provides a promising path for alternative energy, as it employs the solar energy as high-temperature heat supply and adopts H2O and CO2 as initial feedstock. This review describes the sustainable fuels production system, including a series of physical and chemical processes for converting solar energy into chemical energy in the form of sustainable fuels. Detailed working principles, redox materials, and key devices are reviewed and discussed to provide systematic and in-depth understanding of thermochemical fuels production with the aid of concentrated solar power technology. In addition, limiting factors affecting the solar-to-fuel efficiency are analyzed; meanwhile, the improvement technologies (heat recovery concepts and designs) are summarized. This study therefore sets a pathway for future research works based on the current status and demand for further development of such technologies on a commercial scale.

Lately, utilizing a novel electrically rechargeable liquid fuel (e-fuel), a fuel cell has been designed and fabricated, which is demonstrated to achieve a much better performance than alcoholic liquid fuel cells do. However, its current performance, which thus hampers its wide application, demands further improvement to meet up with industrial requirement. Therefore, to attain a better performance for this system, an in-depth understanding of the complex physical and chemical processes within this fuel cell is essential. To this end, in this work, a two-dimensional transient model has been developed to gain an extensive knowledge of a passive e-fuel cell and analyze the major factors limiting its performance. The effects of various structural parameters and operating conditions are studied to identify the underlying performance-limiting factors, where deficient mass transport is found to be one of the major causes. The increment of anode porosity and thickness are found to be effective methods of improving the cell performance. This study therefore provides insights on achieving further performance advancement of the fuel cell in the future.

The green production of ammonia, in an electrochemical flow cell under ambient conditions, is a promising way to replace the energy-intensive Haber-Bosch process. In the operation of this flow cell with an alkaline electrolyte, water is produced at the anode but also required as an essential reactant at the cathode for nitrogen reduction. Hence, water from the anode is expected to diffuse through the membrane to the cathode to compensate for the water needed for nitrogen reduction. Excessive water permeation, however, tends to increase the possibility of water flooding, which would not only create a large barrier for nitrogen delivery and availability, but also lead to severe hydrogen evolution as side reaction, and thus significantly lower the ammonia production rate and Faradaic efficiency. In this work, the water flooding phenomenon in flow cells for ammonia production via electrocatalytic nitrogen reduction is verified via the visualization approach and the electrochemical cell performance. In addition, the effects of the nitrogen flow rate, applied current density, and membrane thickness on the water crossover flux and ammonia production rate are comprehensively studied. The underlying mechanism of water transport through the membrane, including diffusion and electro-osmotic drag, is precisely examined and specified to provide more insight on water flooding behavior in the flow cell.

Rechargeable Zn-air batteries are considered the next-generation energy storage devices for renewable energy due to their high energy density, high safety, low cost, and eco-friendliness. However, rechargeable Zn-air batteries are still far from practical applications for existing many issues, including low energy efficiency, inferior cycling stability, poor depth of discharge, etc. Therefore, understanding the relationship between issues of each component and performance is requested to construct practical rechargeable Zn-air batteries. Herein, we provide an in-depth discussion about the challenge of engineering future rechargeable Zn-air batteries. First, the performance evaluation index and the configuration of rechargeable Zn-air batteries are first introduced. Then we introduce the issues of each component in rechargeable Zn-air batteries and the corresponding solution based on recently reported works. Simultaneously, the impact of each component on performance is discussed. Finally, some personal perspectives, including key component design, performance evaluation index, test conditions, etc., on future development, are presented. This review may afford a direction for the future development of rechargeable Zn-air batteries and inspires more research work under industrial testing conditions.

Photonic topological crystalline insulators (PTCIs) with helical edge states provide an alternative way to achieve robust electromagnetic wave transport and processing. However, most existing PTCIs only involve a single topological bandgap, and generally support a pair of gapped helical edge states, restricting the scope of applications in various fields such as multiband waveguides, filters, and communication systems. Here, we design dual-band PTCIs, in which multiple helical edge modes appear within two distinct bulk gaps, for transverse electric (TE) and transverse magnetic (TM) modes, respectively, by introducing the topology optimization method into the photonic crystals with glide symmetry. For PTCIs with TE modes, the mismatched frequency ranges of edge modes hosted by two orthometric boundaries offer an opportunity to realize a photonic demultiplexer. For PTCIs with TM modes, we show the enhanced second harmonic (SH) generation through the coupling of multiband edge modes by matching the frequency ranges of edge modes within the first and second bandgaps to fundamental and SH waves, respectively. This work provides a new way for designing multiband PTCIs with helical edge states, having promising potentials in developing multiband topological photonic devices for both linear and nonlinear applications.

Spermatogenic dysfunction is one of the major secondary complications of diabetes; however, the underlying mechanisms remain ill-defined, and there is no available drug or strategy for the radical treatment of diabetic spermatogenic dysfunction. Therefore, the objective of this study is to investigate the protective effects of nicotinamide mononucleotide (NMN) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic mice. The results show that oral administration of NMN significantly increases the body and testis weight and the number of sperms. Moreover, the abnormal sperm count and the rate of sperm malformation are significantly decreased compared with the saline-treated diabetic mice. Histological analysis reveals that NMN treatment significantly increases the area and diameter of seminiferous tubules, accompanied by an increased number of spermatogenic cells and sperms. Immunohistochemistry and qRT-PCR results show that NMN increases Bcl-2 expression and decreases Bax expression in the testis. NMN also increases the protein expression of Vimentin and the mRNA expressions of WT1 and GATA4. In addition, qRT-PCR, western blot analysis and immunohistochemistry results also show that NMN increases the expressions of glycolysis-related rate-limiting enzymes including HK2, PKM2, and LDHA. In summary, this study demonstrates the protective effects of NMN on the testis in an STZ-induced diabetic mice model. NMN exerts its protective effects via reducing spermatogenic cell apoptosis by regulating glycolysis of Sertoli cells in diabetic mice. This study provides an experimental basis for the future clinical application of NMN in diabetes-induced spermatogenic dysfunction.

Gaoyu Chen,1 Mohamed Oubibi,1,2 Anni Liang,1 Yueliang Zhou1,2 1College of Teacher Education, College of Education and Human Development, Zhejiang Normal University, Jinhua, People’s Republic of China; 2Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, People’s Republic of ChinaCorrespondence: Mohamed Oubibi, Email liby478@nenu.edu.cnIntroduction: Educational anxiety is a true portrayal of Chinese parents. As an endogenous problem in the development of modern education system, the pressure of students’ entrance examination continues to rise.Methods: Based on the empirical survey data of education in 3298 families, this study uses the analysis method of multiple linear regressions to analyze the influencing factors of parental education anxiety and finds that educational anxiety has become a common social emotion.Results: After the regression analysis of the four-layer model was established, it was found that different school segments, school priorities, and student achievements had a significant impact on parents’ educational anxiety, and factors such as annual family income, educational satisfaction and family parenting style had a significant impact on parental educational anxiety. It is worth noting that the gap in parental expectations has a significant positive effect on educational anxiety, and the greater the expectation gap, the higher the educational anxiety of parents.Discussion: Therefore, it is suggested that governments at all levels should conscientiously implement the task of “reducing burdens” and rationally allocate high-quality educational resources; parents and teachers should start from the needs of children to establish a scientific concept of education and the concept of becoming a talent; the whole society should put forward reasonable educational expectations in education, and be good at adjusting expectations on time so that education can return to a rational natural growth state and eliminate parents’ educational anxiety.Keywords: parental expectation gap, educational anxiety, educational expectations, Chinese students

Clinical mastitis (CM) is one of the most common diseases of dairy cows globally, has a complex aetiology and recurs easily. Staphylococcus aureus is a frequently isolated pathogen responsible for bovine mastitis and remains difficult to eradicate.

In the global context, male participation in early childhood education is notably low, with only 3% of the workforce in mainland China comprising male professionals. This study delves into the intrinsic motivation of male kindergarten teachers, employing the framework of self-determination theory. Qualitative research, comprising face-to-face interviews with seven Chinese kindergarten teachers, aims to uncover the factors influencing their intrinsic motivation at work. By understanding their perspectives on intrinsic motivation, this research offers valuable insights to professionals in the field of early childhood education.

BackgroundLimited data are available about superior rectal artery (SRA) preservation in laparoscopic resection for sigmoid colon cancer (SCC). This study aimed to evaluate the short-term and long-term efficacies of SRA preservation in laparoscopic radical resection for SCC.MethodsWe retrospectively analyzed 207 patients with SCC who underwent laparoscopic radical resection for SCC from January 2017 to June 2021. A total of 84 patients received lymph node clearance around the inferior mesenteric artery (IMA) root (D3 lymph node dissection) with preservation of SRA (SRA preservation group), and 123 patients received high ligation of the IMA (control group). The clinicopathological data of the two groups were compared, and Kaplan–Meier method was performed to estimate patient survival.ResultsCompared with the control group, the operation time of the SRA preservation group was longer (p

Abstract Lithium‐ion batteries (LIBs) are regarded to be the most promising electrochemical energy storage device for portable electronics as well as electrical vehicles. However, due to their limited‐service life, tons of spent LIBs are expected to be produced in the recent years. Suitable recycling technology is therefore becoming more and more important as improper treatment of spent LIBs, especially the aged organic electrolyte, can cause severe environmental pollution and threats to human health. The organic solvents and high concentration of lithium salts in aged electrolytes are always sensitive toward water and air, which would easily hydrolyze and decompose into toxic fluorine‐containing compounds, leading to severe fluorine pollution of the surrounding environment. Hence, recycling aged electrolytes from spent LIBs is an efficient way to avoid this potential risk to the environment. However, several issues inhibit the realization of electrolyte recycling, including the volatile, inflammable, and toxic nature of the electrolytes, the difficulty to extract electrolytes from the electrodes and separators, and various electrolyte compositions inside LIBs from different applications and companies. Herein, the current progress in recycling methods for aged electrolytes from spent LIBs is summarized and perspectives on future development of electrolyte recycling are presented.

Chinese students studying abroad have been increasing rapidly in the past decades and become a significant financial contribution to receiving countries. Accordingly, understanding their enrollment choice is essential to facilitate college marketing and admission strategies. Though the decision process is believed to be different from domestic students, empirical analysis of Chinese students' enrollment choices is still lacking. This paper fills the void by examining the influential factors of Chinese students' enrollment choice with novel student-level data. We find that in addition to factors domestic students typically consider, such as financial aid and academic quality, Chinese students particularly emphasize college ranking, reputation, and location in their decision process. Furthermore, unlike domestic students who usually prefer colleges with proximity to home, Chinese students' location preference is linked to job prosperity. We also find that the impact of the factors varies for students from different regions of China, which can be attributable to uneven economic development within the country.

The study explored how the quality of Internet access influenced students' online learning experiences during the pandemic-imposed large-scale adoption of online education. Drawing upon digital inequality research, we analyzed data collected from 894 higher education international students in China. We found that both access devices and Internet stability exerted significant impacts on international students' satisfaction with and performance of synchronous online learning (SOL). The path model further revealed that the underlying mechanisms through which the two dimensions of access inequality affected learning outcomes were different. While the effects of access devices on learning satisfaction and course performance were only mediated by adaptability to online pedagogy, Internet stability affected the two outcome variables via both interaction and adaptability. The study highlights the implications of these findings in the context of online education.

The Question-Answer-Relationship (QAR) strategy has been suggested to improve EFL students' reading comprehension. Nonetheless, disappointing outcomes when using the QAR instruction were noted. The current study seeks to: (1) add the Review (R) component to the instruction; and (2) assess the effectiveness of the developed Question-Answer-Response-Review (QARR) instruction to improve reading comprehension among Thai EFL university students. Instructional concepts such as common question types (Yathip & Chanyoo, 2022), the Question-Answer-Relationship strategy (Raphael & Au, 2005), the experiential learning approach (Kolb, 2014), and the reading instruction principle (Raphael, Highfield, & Au, 2006) were synthesized to create the instruction. The developed curriculum was implemented with 58 Thai EFL students. Data were examined using frequency, mean, standard deviation, and F-test. As for the findings, the experts' high degree of agreement (M = 0.96) demonstrated the efficiency of the developed instruction. One-way repeated measures revealed that the posttest (M = 21.74, SD = 4.12, d = 0.89) and delayed posttest (M = 22.19, SD = 4.23, d = 0.95) were substantially higher than the pretest mean scores (M = 16.86, SD = 5.59, p <0.001) with a large effect size ([eta squared] = 0.209). Participants' satisfaction surveys strongly agreed with the created instruction (M = 4.36, SD = 0.63), consistent with interview data.

BackgroundWith respect to knee arthroscopy, assessing the amount of hidden blood loss is of great importance to avoid potential complications such as fever, anemia, difficulty in wound healing and wound infection. The current study aims to investigate the hidden blood loss and its factors in patients who underwent minimally invasive knee arthroscopy.MethodsConsecutive patients with knee joint injury, who underwent arthroscopic minimally invasive treatment, were enrolled from January 2019 to November 2020 and were retrospectively studied. Demographic information on these patients, such as medical history and biochemical parameters, was collected. The hidden blood loss was calculated. Multivariate linear regression analysis was used to confirm independent factors associated with hidden blood loss.ResultsFinally, a total of 100 patients aged 44.78 ± 13.67 (range 17–66) years were reviewed, and it was found that a substantial amount of [387.02 ± 252.56 (range 18.89–1130.06) ml] hidden blood loss occurred after minimally invasive knee arthroscopy. Univariate analysis showed that this hidden blood loss was negatively correlated with age, gender, postoperative hemoglobin, and postoperative hematocrit (all P

Many children living in linguistically diverse low- and middle-income countries learn to read and write in multiple languages. Recent research provides implications for effective reading instruction with multilingual learners (e.g., Hall et al. in New Dir Child Adolesc Dev 166:145-189, 2019). However, there is limited empirical evidence on effective instructional practices for multilingual early grade learners who are at-risk of reading failure. The goal of our research was to examine the effect of a structured literacy intervention on literacy skills for a cohort of first grade children at-risk of reading failure as they learned to read in Kiswahili and English. Data were drawn from a larger longitudinal randomized control trial of the Primary Math and Reading Initiative in four counties in Kenya (Kiambu, Nakuru, Nairobi, and Kisumu, with 165 at-risk children identified (71 control; 94 treatment). Children in the treatment condition received daily structured instruction in letter knowledge, phonological awareness, decoding, word reading, and reading comprehension in Kiswahili and English. Children in the control condition continued with the business-as-usual approach, typically whole word instruction. Path analysis was used to examine the intervention effect of the PRIMR program through second grade. The path models further explored the within- and cross-language relationships of variables that predict oral reading fluency over time. Our analyses revealed that children in the treatment condition exhibited significantly higher growth in letter-sound knowledge for both Kiswahili and English. While growth was also observed for non-word fluency in Kiswahili and English for both treatment and control groups, there were no significant findings for this skill that can be attributed to the PRIMR intervention. Our analysis revealed that cross-linguistic elements of English reading skills contribute to oral reading fluency skills in Kiswahili. We discuss implications for aspects of structured literacy instruction essential for multilingual learners at-risk of reading failure.

This large-scale survey study examined how teachers select and integrate global and culturally diverse children's and young adult literature for their classrooms. Results from the survey captured self-reports of the selection process, suggesting if and how teachers were selecting and integrating this literature and reflecting possible influence from children's and young adult literature courses taken in teacher preparation programs. Taking general children's and young adult literature courses, and specific courses on diverse literature and global literature was found to be related to teachers' responses to questions centered on selecting, evaluating, and integrating global and culturally diverse literature. These courses may be pivotal to increase the needed integration of global and culturally diverse children's and young adult literature into secondary and elementary classroom instruction.

This qualitative descriptive study examined the process of purpose development of nine (seven females, two males; M[subscript age] = 20.2, age range 18-21 years) college students who completed interviews in fall 2017 and spring 2019 at a private university. Across the two time points, participants engaged in an iterative process that led them to refine (i.e., narrow or specify) or redefine (i.e., change or adapt) their purpose or ultimate aims. Participants used the time between interviews to restructure their purpose in a way that integrated their experiences until they believed their purpose was best aligned with their skills, values, and interests. More specifically, consensual qualitative research analysis revealed seven themes that suggested ways in which participants acted to refine and/or redefine their purposes: (1) clarifying definition of purpose; (2) engaging known strengths or skills; (3) exploring new activities or experiences; (4) identifying a beyond-the-self intention that aligned with their purpose; (5) discerning the fit between their passions and interests with their circumstance or plans; (6) determining whether their strengths and skills aligned well with their purpose; and (7) integrating their passions into their beyond-the-self intention. A supplemental theme was added that outlines researchers' observations about the features of participants' purpose.

Recently, alternate reality games (ARGs) have been applied in museum learning to encourage learners' active engagement through playful problem-solving activities. However, most learners have insufficient prior knowledge and metacognitive skills to complete the learning tasks in such games. To support learning with ARGs, there is a need to provide proper feedback so that the learners are capable of self-regulated learning and solving the problems encountered during the learning process. Considering the influences of individual differences, this research developed a chatbot as a learning partner in ARG-based learning to support students' learning with adaptive feedback in a museum. A quasi-experimental study was conducted to evaluate the effectiveness with and without the proposed approach. The results showed that the AI-based chatbot approach could significantly improve learners' metacognition awareness, emotional engagement and behavioural engagement. Besides, it is helpful to facilitate students' double-loop learning.

Abstract Radioresistance continues to be the leading cause of recurrence and metastasis in nasopharyngeal cancer. Long noncoding RNAs are emerging as regulators of DNA damage and radioresistance. LINC-PINT was originally identified as a tumor suppressor in various cancers. In this study, LINC-PINT was significantly downregulated in nasopharyngeal cancer tissues than in rhinitis tissues, and low LINC-PINT expressions showed poorer prognosis in patients who received radiotherapy. We further identified a functional role of LINC-PINT in inhibiting the malignant phenotypes and sensitizing cancer cells to irradiation in vitro and in vivo. Mechanistically, LINC-PINT was responsive to DNA damage, inhibiting DNA damage repair through ATM/ATR-Chk1/Chk2 signaling pathways. Moreover, LINC-PINT increased radiosensitivity by interacting with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and negatively regulated the expression and recruitment of DNA-PKcs. Therefore, these findings collectively support the possibility that LINC-PINT serves as an attractive target to overcome radioresistance in NPC.

Background: The current position of robotic surgery in the field of minimally invasive surgery remains ambiguous. We evaluated long-term trends of robotic general surgery and the future direction of its development. Methods: Data on robotic cancer surgeries between 2005 and 2014 were retrospectively collected by volunteer institutions in the Republic of Korea. Spearman's correlation and logistic regression analyses were used to compare robotic and laparoscopic surgery trends in general surgery. Results: The odds that robotic surgery was performed instead of laparoscopic surgery significantly decreased in the fields of colorectal, stomach, and hepato-biliary-pancreatic surgery (odds ratio [OR]: 0.95, 95% confidence interval [CI]: 0.93–0.97; OR: 0.90, 95% CI: 0.88–0.92; and OR: 0.71, 95% CI: 0.65–0.78, respectively), except for thyroid surgery (OR: 1.28, 95% CI: 1.25–1.30). Of the total numbers of each procedure, proportions of robotic intersphincteric resections, abdominoperineal resections, and pylorus-preserving surgery performed significantly increased (r = 0.98, P

In the presence of multiple sources, the performance of direction-of-arrival (DOA) estimation based on beam power maximization is susceptible to the energy leaking from the interference beams to the target beam, especially in the case that the signal of interest (SOI) is quite weak. To address this issue, a robust wideband DOA estimation method is proposed in this paper. Unlike those conventional high-resolution methods which mitigate the influence of energy leakage by reducing beamwidths and sidelobe levels, the proposed method achieves this by directly reconstructing the element-space data to approach the received hydrophone data of the single-source scenario containing only the SOI. Element-space data reconstruction (ESDR) for the SOI is achieved by removing the element-space waveforms of all the interference signals from the received hydrophone data. Moreover, an iterative algorithm is developed to adaptively extract the element-space waveform of each interference signal, without requiring the prior information of the array amplitude response coefficients and hydrophone coordinates of a distorted towed array. Simulation results show that the proposed method outperforms its counterparts in terms of estimation accuracy for a multi-source scenario. Meanwhile, the DOA estimation performance of the proposed method in a multi-source environment is close to that obtained by the beam power maximization method in the single-source scenario, even if the signal-to-interference ratio (SIR) is as low as −25 dB. At-sea experimental results prove that, even though the number of signal sources is as many as seven and the SOI is contaminated by real ocean ambient noise, the proposed method still achieves a better DOA estimation performance compared to existing state-of-the-art methods.

BackgroundMitochondrial diseases are clinically heterogeneous, can occur at any age, and can manifest with a wide range of clinical symptoms. They can involve any organ or tissue, characteristically involve multiple systems, typically affecting organs that are highly dependent on aerobic metabolism, and making a definitive molecular diagnosis of a mitochondrial disorder is challenging.MethodsClinical data of the proband and his family members were gathered in a retrospective study. Whole-exome sequencing and full-length sequencing of the mitochondrial genome that were performed on peripheral blood, urine, and oral mucosa cells were applied for genetic analysis.ResultsIn this study, we reported a childhood-onset mitochondrial phenotype in a 13-year-old patient. Analysis of the next-generation sequencing data of the nuclear genome and the full-length sequencing of the mitochondrial genome revealed the rare m.10000G>A variant in MT-TG that was present at variable heteroplasmy levels across tissue types: 32.7% in the blood, 56.15% in urinary epithelial cells, and 27.3% in oral mucosa cells. No variant was found in the peripheral blood of his mother and sister. No pathogenic mutation of nDNA was found.ConclusionOur results added evidence that the de novo m.10000G>A variation in the highly conserved sequence of MT-TG appears to suggest a childhood-onset mitochondrial phenotype in the 13-year-old patient, thus broadening the genotypic interpretation of mitochondrial DNA-related diseases.

We present a neural hand reconstruction method for monocular 3D hand pose and shape estimation in this paper. Instead of directly representing hand with 3D data, a novel UV position map is introduced to represent hand pose and shape with 2D data, which maps 3D hand surface points to 2D image space. Furthermore, an encoder-decoder neural network is proposed to infer such UV position map from only single image. To train such network with the lack of ground truth training pairs, we propose a novel MANOReg module which employs MANO model as shape prior to constrain high-dimensional space of UV position map. Both quantitative and qualitative experiments demonstrate the effectiveness of our UV position map representation and MANOReg module.

[Introduction] In order to increase the capacity of a 220 kV transmission line, conventional conductor and various heat-resistant conductors are selected to make comprehensive comparison. [Method] This article calculated the maximum operating temperature and power loss, compared effects of mechanical load and wire sag variation on tower foundation, analyzed difficulty of construction and maintenance, and calculated investment and annual cost. [Result] The results show that all selected conductors can meet the need of increasing capacity and maximum operating temperature; towers and foundations need rebuilding if using conventional conductor; mechanical load and wire sag of heat-resistant conductors meet the design conditions of original transmission line; conventional conductor and Aluminum Conductor Multi-strand Carbon Fiber Core (ACMCC Conductor) have lower annual costs and more convenience for maintenance. [Conclusion] Our work shows that ACMCC Conductor has excellent comprehensive performance and is suitable for enhancing transmission capability of transmission lines in operation without rebuilding, especially in urban or suburban areas where it is difficult to build new towers.

River-riparian interfaces (RRIs) of urban rivers are where river ecosystems interact with the riparian soil ecosystems. However, with the intensification of urbanization, the construction of various revetments changes the energy exchange process between the river and the RRI, affects the soil properties, and then affects the soil bacterial community composition and structure. In this study, natural (NR), permeable (PR), and impervious revetments (IR) of the same river section were selected. The composition and abundance of soil bacterial communities were detected by PCR amplification technology. The Alpha diversity, Beta diversity, community composition, and environmental factor correlations of bacterial communities were analyzed. The results showed: (1) The dominant bacterial genera of NR, IR, and PR were similar, mainly Anaerolineae, Vicinamibacterales, Ardenticatenales, and Rokubacteriales. There were 504 bacterial genera with the same NR, IR, and PR, accounting for NR, IR, and PR bacterial genera 69.52%, 69.33%, and 62.22% of the total, respectively. (2) Due to the material and energy exchange between soil water and river water and the buffering effect of permeable revetment on frequent river water level changes, the bacterial community richness, community diversity, and lineage diversity of PR are higher than those of NR and IR. (3) SOM, pH, oxygen, and soil nutrients are critical environmental factors that affect the composition and abundance of soil bacterial communities at RRI. The research results provide a theoretical basis for further exploring the impact of urban river revetment on the service function of soil ecosystems at RRI.

This paper selects the theory of "carbon source, carbon sink and carbon neutralization" witch has high applicability in the "dual-carbon" target theory, to clarify the construction of low-carbon community open space under the "dual-carbon" target. Discuss the realization of low-carbon community open space under this theory, and build the target layer and secondary indicator layer of low-carbon open space construction management indicators based on this theory. Fifty representative indicators related to the open space in low-carbon communities are selected from the eight widely used evaluation index systems in the world. According to the implementation path of the "double carbon" goal of the open space in low-carbon communities, these indicators are divided into six categories: "energy utilization", "resource utilization", "transportation", "carbon pool", "carbon absorption" and "low-carbon community management and culture”. Take the six categories as framework, combined with current condition and research status in China, the relevant indicators of "carbon absorption" are supplemented, and a low-carbon community open space management index system including three first-class indicators, six secondary indicators and twenty-eight tertiary indicators is constructed.