Search

Purposes Origin software was adopted to study the mechanism and final effects of rainwater erosion prevention of Earthen Sites with bare soil and herbs in Western Wall of Jinyang Ancient City. Methods The data analysis method of field artificial simulation rainfall experiment through the software of Origin was used to compare the effects of the underlying surface layer on the runoff and sediment producing processes on the slope surface at different times. Findings Pre-runoff interception Q0 of Fresh Herbs was negatively correlated with runoff starting time T0. And Q0 was in descending order of Dry Herbs, Fresh Herbs, and Bare Soil. Sediment producing coefficient Csy and sediment producing intensity Isy of Fresh Herbs were positively correlated with rainfall intensity Irf. Runoff coefficients Cro and Csy were in descending order of Bare Soil, Dry Herbs, and Fresh Herbs. By forming a mud surface, exposed earthen sites were less affected by rainwater infiltration, making them suitable for arid climate zones. By strengthening anti-erosion, herbal earthen sites reduced soil surface erosion, making them suitable for semi-arid and semi-humid climate areas. Conclusions Origin analysis confirms that herbal plants have a significant effect on improving the anti-erosion of earthen sites. The phenomenon of herbs covering is beneficial to the protection of local earthen sites in Shanxi. However, when extreme sustained heavy rainfall occurs between September and October, further research is needed to determine whether herbal plants are suitable or not for covering earthen sites.

Nonlinear photonics has unveiled new avenues for applications in metrology, spectroscopy, and optical communications. Recently, there has been a surge of interest in integrated platforms, attributed to their fundamental benefits, including compatibility with complementary metal-oxide semiconductor (CMOS) processes, reduced power consumption, compactness, and cost-effectiveness. This paper provides a comprehensive review of the key nonlinear effects and material properties utilized in integrated platforms. It discusses the applications and significant achievements in supercontinuum generation, a key nonlinear phenomenon. Additionally, the evolution of chip-based optical frequency combs is reviewed, highlighting recent pivotal works across four main categories. The paper also examines the recent advances in on-chip switching, computing, signal processing, microwave generation, and quantum applications. Finally, it provides perspectives on the development and challenges of nonlinear photonics in integrated platforms, offering insights into future directions for this rapidly evolving field.

Abstract Aiming at the reasonable width of the narrow coal pillar of a fully mechanized caving face and the safety support of roadway, taking the coal pillar in the section between 110503 and 110505 face of the Yushuling Coal mine as the research background, a model of the hard basic roof fracture structure of fully mechanized caving face is established through theoretical analysis, and the roadway with narrow coal pillar is analyzed mechanically. Combined with the geological conditions of the working face, it is concluded that the low‐stress area is less than 3.29 m. When the internal stress field of the low‐stress environment is considered in the roadway layout, the influence of mining and the essential roof hardness should be considered. The reasonable size of the narrow coal pillar is 3 ~ 6 m, thinking that the load borne by the coal pillar is less than the ultimate strength of the coal pillar. The limit equilibrium theory calculates that the reasonable width of a coal pillar is at least 4 m. The stress and displacement of coal pillars with different widths of 3, 4, 5 and 6 m are analyzed by numerical simulation, and the 4 m narrow coal pillars are simulated and verified. Field industrial tests show that coal pillar and roadway surrounding rock deformation are small under asymmetric surrounding rock control. The research results have been successfully applied to engineering practice and can provide a reference for the research method of narrow coal pillar width under a hard basic roof.

Intratumoral Tregs are key mediators of cancer immunotherapy resistance, including anti-programmed cell death (ligand) 1 [anti-PD-(L)1] immune checkpoint blockade (ICB). The mechanisms driving Treg infiltration into the tumor microenvironment (TME) and the consequence on [CD8.sup.+] T cell exhaustion remain elusive. Here, we report that heat shock protein gp96 (also known as GRP94) was indispensable for Treg tumor infiltration, primarily through the roles of gp96 in chaperoning integrins. Among various gp96-dependent integrins, we found that only LFA-1 ([alpha]L integrin), and not [alpha]V, CD103 ([alpha]E), or [beta]7 integrin, was required for Treg tumor homing. Loss of Treg infiltration into the TME by genetic deletion of gp96/LFA-1 potently induced rejection of tumors in multiple ICB-resistant murine cancer models in a [CD8.sup.+] T cell-dependent manner, without loss of self-tolerance. Moreover, gp96 deletion impeded Treg activation primarily by suppressing IL-2/STAT5 signaling, which also contributed to tumor regression. By competing for intratumoral IL-2, Tregs prevented the activation of [CD8.sup.+] tumor-infiltrating lymphocytes, drove thymocyte selection-associated high mobility group box protein (TOX) induction, and induced bona fide [CD8.sup.+] T cell exhaustion. By contrast, Treg ablation led to striking [CD8.sup.+] T cell activation without TOX induction, demonstrating clear uncoupling of the 2 processes. Our study reveals that the gp96/LFA-1 axis plays a fundamental role in Treg biology and suggests that Treg-specific gp96/LFA-1 targeting represents a valuable strategy for cancer immunotherapy without inflicting autoinflammatory conditions., Introduction Regulatory T cells (Tregs) are characterized by high expression of IL-2 receptor a chain (CD25) and the transcription factor Foxp3, and their function in suppressing the effector immune response [...]