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432 results on '"Liu Jiani"'

1. The role of Shunaoxin pills in the treatment of chronic cerebral hypoperfusion and its main pharmacodynamic components

Author

Zhang Jin, Chang Nianwei, Liu Jiani, Liu Wenjuan, and Bai Gang

Subjects
shunaoxin pills, active ingredients discovery, ca2+, ligustilide, senkyunolide i, chronic cerebral hypoperfusion, Medicine
Abstract

Chronic cerebral hypoperfusion (CCH) is a frequent ischemic cerebrovascular disease that induces brain dysfunction. Shunaoxin pills (SNX) are traditional Chinese medicines (TCM), frequently used for the treatment of CCH. The purpose of this study was to develop an activity-based screening system to identify the active ingredients of SNX. We developed a model of CCH and revealed that SNX induces cerebrovascular dilatation and protects against CCH-induced nerve cell injury in rats. Using the transcriptome analysis, we found that Ca2+-related signaling pathways play a major role in the effect of SNX against CCH. We developed an activity-based screening system based on the ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry coupled with a dual-luciferase reporter calcium assay to identify the active components of SNX. As a result, SNX dilates cerebral blood vessels, increasing cerebral blood flow by modulating calcium-related signaling pathways and regulating calcium homeostasis. Two calcium antagonists, ligustilide and senkyunolide I, were identified as active ingredients in SNX. In conclusion, we developed a rapid screening method suitable for the discovery of active natural products in TCM by integrating genomics and target pathway-oriented spectroscopic analysis.

Published
2022
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2. Cross-species transmission of Cryptosporidium in wild rodents from the southern region of Zhejiang Province of China and its possible impact on public health

Author

Jiang Yanyan, Jiang Aiying, Ren Guangxu, Wang Long, Xin Xianming, Yuan Zhongying, Liu Jiani, Li Zhen, Sun Yanbin, Zhou Shanshan, Lu Gang, Huang Huicong, and Zhao Wei

Subjects
cryptosporidium, molecular detection, wild rodents, zoonotic, public health, china, Infectious and parasitic diseases, RC109-216
Abstract

Wild rodents serve as reservoirs for Cryptosporidium and are overpopulated globally. However, genetic data regarding Cryptosporidium in these animals from China are limited. Here, we have determined the prevalence and genetic characteristics of Cryptosporidium among 370 wild rodents captured from three distinct locations in the southern region of Zhejiang Province, China. Fresh feces were collected from the rectum of each rodent, and DNA was extracted from them. The rodent species was identified by PCR amplifying the vertebrate cytochrome b gene. Cryptosporidium was detected by PCR amplification and amplicon sequencing the small subunit of ribosomal RNA gene. Positive samples of C. viatorum and C. parvum were further subtyped by analyzing the 60-kDa glycoprotein gene. A positive Cryptosporidium result was found in 7% (26/370) of samples, involving five rodent species: Apodemus agrarius (36), Niviventer niviventer (75), Rattus losea (18), R. norvegicus (155), and R. tanezumi (86). Their respective Cryptosporidium positive rates were 8.3%, 5.3%, 11.1%, 7.1%, and 7.0%. Sequence analysis confirmed the presence of three Cryptosporidium species: C. parvum (4), C. viatorum (1), and C. muris (1), and two genotypes: Cryptosporidium rat genotype IV (16) and C. mortiferum-like (4). Additionally, two subtypes of C. parvum (IIdA15G1 and IIpA19) and one subtype of C. viatorum (XVdA3) were detected. These results demonstrate that various wild rodent species in Zhejiang were concurrently infected with rodent-adapted and zoonotic species/genotypes of Cryptosporidium, indicating that these rodents can play a role in maintaining and dispersing this parasite into the environment and other hosts, including humans.

Published
2024
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9. Research on the Emotional Expression and Innovation of Digital Technology under Visual Communication——Taking the fight 'epidemic' image as an example

Author

Liu Jiani

Subjects
Environmental sciences, GE1-350
Abstract

The unexpected outbreak of the Covid-19 in 2020 has shifted the focus of the media worldwide to the comprehensive, tridimensional and truthful coverage of the catastrophe to the audience. Through the shooting of the Wuhan epidemic as an example, the article analyzes the photographic works in the epidemic, and discusses the innovation of images under the visual communication of digital technology, so that the fight “epidemic” images have become historical witnesses and development tracks.

Published
2021
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10. Step up to Masters: Supporting the Academic Skills Transition for Taught Postgraduate Students

Author

Liu, Jiani and Pullinger, Daniel John

Abstract

The article in question introduces research conducted by the Learning Development Team at the University of Leeds on the academic literacy skills development needs and expectations of taught postgraduate students, and the subsequent creation of an innovative new online resource, Step Up to Masters. As well as focusing on key topics highlighted by the research, the resource encourages students to reflect on their individual development priorities and to select the most relevant support options for their successful transition to taught postgraduate (PGT) study. The rationale behind this reflect and select approach has been informed by a synthesis of (a) the outcomes of key studies on the diverse needs and challenges faced by PGT students when making the transition to Masters study, and (b) the team's own research findings on PGT students' academic development priorities and preferences. Step Up to Masters received the Digital Award for Information Literacy 2020, and was central to the online PGT induction programme initiated at Leeds for 2020/21 in response to the coronavirus pandemic.

Published
2021

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