Author: "López Cancio, Elena" / Language: english - Searchworks@Jio Institute Digital Library Search Results

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194 results on '"López Cancio, Elena"'

1. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment

Author: Dehghan, Abbas, Heath, Adam S., Morrison, Alanna C., Reiner, Alex P., Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M., Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P., Tregouet, David A., Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W., Leebeek, Frank W.G., Rosendaal, Frits R., Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A., Bressler, Jan, Huffman, Jennifer E., Rotter, Jerome I., Yao, Jie, Wilson, James F., Bis, Joshua C., Hahn, Julie M., Desch, Karl C., Wiggins, Kerri L., Díez-Ahijado, Laia, Raffield, Laura M., Bielak, Lawrence F., Yanek, Lisa R., Kleber, Marcus E., Sabater-Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P., Liu, Melissa, Brown, Michael R., Jhun, Min-A, Chen, Ming-Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L., Peyser, Patricia A., Elliot, Paul, de Vries, Paul S., Wei, Peng, Wild, Philipp S., Morange, Pierre E., van der Harst, Pim, Yang, Qiong, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M., Cox, Simon R., Trompet, Stella, Felix, Stephan B., Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Alvarez-Sabin, Jose, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomas, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria del Mar, and Fernández-Cadenas, Israel
Published: 2024
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2. Stent Retriever as Distal Filter for Endovascular Management of Acute Atherosclerosis-Related Carotid Occlusions: Preliminary Findings with a Novel Technique.

Author: Maestro, Víctor, Murias, Eduardo, Campo, Davinia Larrosa, Rodríguez Castro, José, Puig, Josep, Chaviano, Juan, López-Cancio, Elena, Calleja, Sergio, and Vega, Pedro
Subjects: ISCHEMIC stroke, ENDOVASCULAR surgery, CEREBRAL infarction, CAROTID artery, ARTERIAL occlusions
Abstract: Objectives: This study focuses on a novel endovascular technique for treating acute ischemic stroke caused by carotid artery occlusion (CAO) related to extracranial atherosclerosis, a condition typically associated with poor outcomes due to extensive brain infarction and high hemorrhagic risk. While stent retriever thrombectomy is effective for large-vessel occlusions, managing atherosclerosis-related CAO presents challenges. Methods: This retrospective analysis involved a cohort of 18 consecutive patients treated at our center using a new approach that employs a balloon guide catheter (BGC) to access the common carotid artery. Stent retrievers are used as distal filters, and angioplasty is performed through the stent pusher. The technique aims to reduce procedural time and prevent distal embolisms, which are common complications in traditional methods. Results: The results indicate that this approach improves intervention times, increases first-pass success rates, and decreases distal embolism occurrences compared to conventional techniques. It also effectively overcomes obstacles like the management of antiplatelet therapy and lengthy procedures. Conclusions: These preliminary findings demonstrate that using stent retrievers as filters with BGCs, without the need for aspiration catheters, may offer a safer and faster treatment option for atherosclerosis-related CAO. However, further research is required to confirm these findings and potentially establish this technique as the standard in clinical practice. [ABSTRACT FROM AUTHOR]
Published: 2025
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3. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author: García-Tornel, Álvaro, Flores, Alan, Terceño, Mikel, Cardona, Pedro, Amaro, Sergi, Gomis, Meritxell, Zaragoza, Josep, Krupinski, Jerzy, Gómez-Choco, Manuel, Mas, Natalia, Cocho, Dolores, Catena, Esther, Purroy, Francesc, Deck, Matias, Rubiera, Marta, Pagola, Jorge, Rodriguez-Luna, David, Juega, Jesús, Rodríguez-Villatoro, Noelia, Molina, Carlos A., Soro, Cristina, Jimenez, Xavier, Salvat-Plana, Mercè, Dávalos, Antoni, Jovin, Tudor G, Abilleira, Sonia, Pérez de la Ossa, Natalia, Ribó, Marc, Sanjuan, Estela, Santana, Katherine, Maisterra, Olga, Santamarina, Estevo, Muchada, Marian, Boned, Sandra, Franco, Antonio Palasi, Gadea, Marta Olivé, Deck, Matías, Requena, Manuel, Sala, Victoria, Muñoz, Lucía, Millán, Mónica, López-Cancio, Elena, Dorado, Laura, Hernández-Pérez, María, Ciurans, Jordi, Samaniego, Daniela, Canento, Tamara, Martin, Lorena, Planas, Anna, Broto, Joaquin, Sorrentino, Agustín, Paré, Martí, Zhu, Nuole, Garrido, Alicia, Grau, Laia, Crespo, Ane Miren, Presas, Silvia, Almendrote, Miriam, Ramos, Alba, Lucente, Giuseppe, Ispierto, Lourdes, Lozano, Manuel, Becerra, Juan Luis, Jiménez, Marta, Rolán, Dolores Vilas, Guanyabens, Nicolas, Sanchez-Ojanguren, Josep, Martínez-Piñeiro, Alicia, Forcén, Sara, Gea, Mireia, Álvarez, Marta, Ramos, Anna, Lizarbe, Manuel Domínguez, Guerra, Rubio, Bragado, Irene, Arbex, Andrea, Rodríguez, Luis, Bustamante, Alejandro, Portela, Pere Cardona, García, Helena Quesada, Rodríguez, Blanca Lara, Cayuela, Nuria, Miró, Julia, Marzal, Clara, Paipa, Andrés, Campoy, Sergio, Núñez, Ana, Arroyo, Pablo, Besora, Sarah, Adell, Vanessa, Campdelacreu, Jaume, Martí, Montse Alemany, González, Belén, Vila, Laura Bau, Crespo, Marta Fiter, Berbel, Anna, Urbaneja, Ma. Cristina Villaescusa, Guillen, Núria, Vidal, Nuria, Santamaria, Patricia Valentina Vérez, Navarro, Diego Herrero, Simó, Marta, Falip, Mercedes, Matas, Elisabeth, Ochoa, Neus Mongay, Gifreu, Ariadna, Muñoz, Albert, Romero, Lucía, Portell, Eduard, Perez, Guillermo Hernández, Esteve, F. Ruiz, Teixidor, Silvia, Talavera, Augusto Salazar, Gómez, Roser, Nuin, Xabier Urra, Vargas, Martha, Chamorro, Ángel, Llull, Laura, Renú, Arturo, Rudilosso, Salvatore, del Valle, Raquel Sánchez, Ariño, Helena, Solà, Nuria, la Puma, Delón, Gil, Francisco, Gómez, Juan Bernardo, Matos, Nuria, Falgàs, Neus, Borrego, Sergi, Sánchez, Almudena, Balasa, Mircea, Montejo, Carmen, Guasp, Mar, Reyes, David, Cervilla, Pablo Sánchez, Contador, Jose Miguel, Monge, Victor Augusto Vera, Ramos, Oscar, Rodríguez, Alejandro, Campello, Ana Rodríguez, Ballester, Gemma Romeral, Trujillano, Mireia Llop, Steinhauer, Eva Giralt, Godia, Elisa Cuadrado, Santiago, Angel Javier Ois, Conde, Jordi Jimenez, Fábregas, Joan Martí, Guisado, Daniel, Prats, Luís, Camps, Pol, Delgado, Raquel, Domeño, Alejandro Martínez, Marín, Rebeca, Cànovas, David, Estela, Jordi, Ros, Marta, Aranceta, Sonsoles, Espinosa, Jordi, Rubio, Marta, Lafuente, Cristina, Barrachina, Oriol, Anguita, Alicia, Reverter, Anna, García, Carmen, Sansa, Gemma, Hervas, Mariona, Crosas, Monica, Delgado, Tania, Folch, Dra Sonia Huertas, Gamito, Gemma Muñoz, Alvarez, Josep Trenado, Subirana, Teresa, Molina, Jessica, Besora, Sarah, Romero, Laura Comes, Valls, Gemma Guardia, Jover, Miriam, Sotova, Javier Joaquín, García Sánchez, Sonia Mª, Valenzuela, Sebastian, Mengual, Juan José, Font, M. Àngels, Gómez Ruiz, Mª Isabel, Zubizarreta, Irati, González, Susana Fernández, Gubieras, Laura, Cobos, Carmen E., Romo, Luis Mena, Caballol, Nuria, Cano, Luis, Leal, Joaquín Serena, Blas, Yolanda Silva, Trigo, Irene Bragado, Viturro, Saima Bashir, Albiñana, Laura Pardo, Garrido, Montserrat Reina, Cazcarra, Carla Marco, Uscamaita, Karol Enrique, Márquez, Fabian, Coll, Cristina, Villlas, Mar Irida Lloret, Vila, Berta Solano, Perna, Berta Alemany, Domínguezl, Daniel López, de Lera, Mercedes, Foraster, Anna Cots, Monge, Victor Augusto Vera, Bojaryn, Urszula, Benabdelhak, Ikram, Capdevila, Gerard Mauri, Montesinos, Jordi Sanahuja, Vázquez, Daniel, Hervás, José Vicente, González, Cristina, Quílez, Alejandro, Pascual, Mikel Vicente, Ruiz, María, Riba, Yolanda, Villar, M. Pilar Gil, García, Cristina, Roig, Xavier Ustrell, Mora, Mònica Baldrich, Guinjoan, Anna Pellisé, Borras, Judit, Martínez, Alba Mañé, Marés, Rafael, Viñas i Gaya, Jaume, Seró, Laia, Rodríguez, Paula, Castilho, Gislaine, Ortega, Angela Monterde, Reverté, Silvia, Baiges, Joan Josep, Ozaeta, Gisela Martín, Escalante, Sonia, Belloch, Patricia Esteve, Payo, Iago, Salvado, Júlia Saura, Soler Insa, Josep M, Vilamala, Ester Tio, Navarro, Josep Abos, Tabuenca, Héctor Cruz, Sánchez, Tamara Canento, Ros, Marta, Matos, Nuria, Roldán, Elisabet, Rubiol, Elsa Puiggrós, Franquet, Elisabet, Fuentes, Lidia, Donaire, Javier, Martí, Elena, Giménez, Laura, Vázquez, Junior Gil, Ambrós, Eloisa Nieto Clara Gris, Rodríguez, Puri, Oletta, José Félix, Mellado, Pilar Pons, Gómez, Bárbara, Raileau, Vergilin, Pardina, Oscar, Mercadal, Jordi, López-Diéguez, María, Pérez, Pilar, Gabarró, Lourdes, Orriols, María, Molina, José Carlos, Canet, Joan Josep, Roca, Mireia, Álvaro, Muriel, Boneu, Francesc, Giménez, Georgina, Albà, Jaume, Gibert, Francesc, Garcia, Jéssica, Barragan, Patricia, Jurado, Gustavo, Pascual_Medicina Interna, Vanesa, Ortega, Josep Sabaté, Solano, Joan Amaurys Martínez, Fernández, Víctor, Torres, Mónica, Alvaredo, Ana Belén Montero, Parejo, Laura Redondo, Aragonés, Josep Maria, Bullón, Anna, Loste, Cora, González, Paula, Bejarano, Neker, Sanchez, Francisco, Lucchetti, Gianni, Pla, Xavier, Gimeno, Dr Javier, Reynaga, Esteban, Barcons, Montse, Celedón, Gabriel, Ortiz, Juan, Anastasovski, Dr Goran, Mascaró, Dr Oscar, de los Ríos, Dr Javier Diez, Feliu, Meritxell, Ribera, Anna, Ruiz, Cristhian, Corominas, Gerard, Nunes, Dra Daniella, Roca, Claudia, Latorre, Nadina, Yataco, Lizbeth, Cruz, Maricelys, Blanco, Nerea, Castejón, Santiago, Sunyer, Claustre Pont, Garcia, Jordi Espinosa, Martin, Rodrigo Paz, de Luis Sanchez, Albert, Vivas, Dolores Espinosa, Molina, Juan Valencia, Palome, Planels, Chaume, Laia Tomas, Vilella, Ares Villagrasa, Bustamante, Marco, Boltes, Anunciación, Rodríguez, Fernando, Arrieta, Itziar, Molist, Jordi Ciurans, Andreu, Barnés, Soler, Ernest Palomeras, Buscà, Nicolau Guanyabens, López, Manuel Daza, Farreres, Jordi Bigas, Ruiz, Virginia Casado, Batiste, Desiree Muriana, Sanz Cartagena, Mª Pilar, de Vega, Eulalia Cabot, Real, Josep Bassa, Roman, Hector Pelaez, Socolich, César, Alonso Camp, Josep Mª, Orgaz, Antonio Tomás Cano, Fossas Felip, Mª Pilar, Morón, Nicolás, Bacca, Sandra, Molina, Mauricio, Casarramona, Francesc, Elias, Lorena, Bukaei, Muhammad Zidane, Gutierrez, Jose Antonio Martos, Escuin, Judith Lopez, Olaizola, Cristina, Vargas, Yolexis López, Oyonarte, Juan Jiménez, Soultana, Rashida, Golpe, Eduardo Sanjurjo, Salvador, Esther, Vila, Guillem, Serrano, Marcos, Claverol, Matilde Nuria López, Lamolla, Marian, Amate, Miquel, Rodriguez, Adriana, Romero, Ruth, del Carpio, Montgomery, Hernandez, Ana Isabel, Martín, Julián, Rosas, M Carmen, Nogueroles, Antonio, Encarnación, Sorilandy, Robles, Augusto, Herrera, Jose Antonio, Gavilán, Roger, Mameghani, Toghrol, Araujo, Gastón, Morales, M.Angeles Garrido, Segui, Enric Ramon Albert, Climent, Eva Fernandez, Pujol, Francesc Paris, Seira, Mireia Judit Garrofé, Pía, Lucía Gómez, Nuñez, Fernando Salleres, Peñalver, Cristina Aguar, Lopes, Cristina Vaz, Tasa, Elisenda Ribera, Vilchez, Carmen Repullo, Zambrana, Modesto Sánchez, Ribas, Beatriu Suescun, Panés, Inés Vilà, Planavila, Montserrat Vila, Lorenzo, Alicia Vaqueiro, Guixes, Meritxell Sabartés, Medina, Jorge, Sambrano, David, Zamarreño, Javi, Pirela, Carmen, Vélez, Paola, Cajamarca, Luis, Pérez, Honey, Martínez, Yarles, Gonçalves, Jesus Alexander, Regordosa, Carles, Mormeneo, Claudia, Griu, Laura, Colina, Maria Francia, Farik, Enric, Duch, Dolors Carrión, Badenas, Carles, Bernal, Oscar, Agramunt, Núria, Morales, Shyrlei, Reynoso, Victoria, Guerrero, Miguel, Cid, Primitivo Romera, Folqué, Mònica, Pedroza, Claudia, Hachem, Adnan, Martínez, Íñigo Soteras, García, Xavier Verdera, Amorós, Mercè López, Subirós, Xavier Costa, Benet, Marta Cufí, Van Eendenburg, Cecile, Osuna, Teresa, Santos, Dra Gina, Pallisera, Dra Mireia, Oliva, Dr Lluís Gonzalo, Sanchez, Dra Gemma, Basurto, Dr Xavier, Vivoda, Dr Ludgi, Van der Kleyn, Dr Richard, Robles, Dra Laura, Barranco, Ana Cabanelas, Almendros, Mª Cruz, Oliveras, Marc Pérez, Álvarez, Amelia Fernández, Rybyeva, Maria, Viñas, Antoni, Barcons, Maria, Tavera, Joaquim Danès Alberto, Burbano, Pablo, López, Cintie, Cruz, David, Bisbe, Paula, Fernández, Nora, Palacio, Juan Carlos, Fraiz, Eduardo, Aguiló, Oriol, Amorodjo, Rollmy, Velázquez, John, Sánchez, Elena, Español, Jaume, Perez de Celis, Judit, Coll, Anna, Díaz, Glòria, Vergés i Sala, Margarida, Casas Capdevila, Mª Ángels, Ferrini, Yosmairy Yoselin, Gorriz, Aitor, Navarro, Diego-Javier Cucurell, Velásquez, Dulce, Pla Soler, Jaume, González, Josep, Higuera, Julian David, Cuellar, Lina, Miniello, Liza Margarita, Pujol, Lluis, Cracan, Sorin, Vives, Mora, Angela, M, Lopez, Lopez, Molist, Montse Gorchs, Anna, Delofeu, Muñoz, Silvia Solà, Yolanda, Ferreres, Pujalte, Carol, Marín, Elisabeth Téllez, Casas, Yolanda Font, Luque, Sara Hernández, Sendra, Joaquim Mejias, Valero, Francesca Mellado, Escala, Campos, De Lacanal, Galup, Diaz, Lopez, Paramio, Castillo, Estopà, Català, Moreda, Español, Majo, Calafell, Almeida, Carballo, Naval, Castro, Elena, M, Ruiz, Cregut, Lluis, Pere, Font, Deulofeu, Sanjuan, Fabregat, Pere, Joan, Gorchs, Fontquerni, Bellés, Forés, Antoni, Joan, Herrera, Gomez, Carlos, Juan, Prades, Hijazo, Torvisco, Itzaina, Rovira, Marti, Gonzalez, Obiols, Cavero, Olive, Gil, Querol, Soledad, M, Rodriguez, Rico, Sambernardo, Rios, Molina, Ropero, Ramon, Jose, Valero, Sanchez, Arevalo, Santos, Jose, Maria, Garcia, Soto, Angeles, Maria, Escribano, Tebar, Garcia, Torres, José, Pedro, Carrion, Verdes, Isabel, M, Lopez, Verge, Jose, Juan, Canela, Lopez, Angeles, M, Guarque, Lucas, Alvarez, Morales, Arnulfo, Jorge, Fornieles, Morell, Gomez, Subirats, Teresa, Maria, Masa, Miquel, Torello, Lopez, Val, Mercedes, Maria, Reyes, Palmero, Manuel, Juan, Forne, Rodriguez, Turiel, Ruana, Gonzalez, Sanchez, Gornals, Sebastia, Rico, Abrio, Falip, Albert Gual, Oliveros, Aznar, Perotti, Brugues, Molinero, Calvet, Franco, Catells, Medina, Corrales, Miro, Daroca, Marquez, Duran, Pradas, Feliu, Casanova, Figueras, Tortajada, Garcia, Gallego, Grajera, del Mar, Azahara, Arroyo, Las, de Jesus, Dulcenombre, Sanz, Laserreta, Vidal, Llambrich, Corral, Monllao, de la Cruz, Morales, Blanco, Moreno, Orgaz, Orejuela, Suazo, Piñana, Minguillon, Pons, Gómez, Rodríguez, Carlos, José, Pereira, Rodriguez, Porcel, Anna, Sedo, Villar, Sevil, Lopez, Sierra, Romero, Torres, Calveres, Anna, Trepat, Arnella, Ventura, Gil, Acera, Teresa, M, Vico, Biesot, Galea, Castro, Maria, Rosa, Chafer, Escorcia, Antonio, Juan, Moreda, Español, Faure, Gil, Luque, Hernandez, Delgado, Jimenez, Gay, Mallafre, Angel, M., Sanzo, Olivares, Fondevila, Pubill, Fort, Sabate, Agámez, Segovia, Carlos, Antonio, Longaretti, Turata, Hernandez, Valle, Guixens, Trayner, Valor, Aguilar, Alvarez, Aguirre, Naval, Alastrue, Baquero, Alferez, Marne, Alonso, Orozco, Aloy, Colino, Alvarez, Peñuela, Alvarez, Cirilo, Ameller, Vanessa, Maria, Guerrero, Andujar, Remedios, Estefania, Sillero, Auladell, Sorbet, Azcarate, Genesca, Basany, Barduena, Benavent, Tudela, Benito, Pardo, Blanch, Pla, Boluda, Gonzalez, Bonilla, Serramalera, Bru, Andreu, Burnat, Calvo-Rayo, Caballero, Casellas, Calvo, Mombiela, Camps, Bresme, Cano, Fernandez, Carcelen, Solà, Caro, Matavacas, Casasas, Bolado, Castanedo, Cortina, Cerdeña, Jane, Abella, Borrego, Laia Collado, Orri, Colom, Vilanova, Comellas, Sole, Conillera, Torres, Cots, Estepa, Cuchi, de Sostoa Graell, Marc, del Rio Lopez, Laura, Compte, Delgado, Bueno, Diaz, Maneiro, Diaz, Lucia, Andrea, Palau, Domenech, Carme, M., Carasso, Duran, Javier, Pablo, Marquez, Duran, Abidi, El, Martin, Escoda, Casanovas, Esteve, Perez, Fernandez, Quintero, Ferre, Escobar, Flores, Abad, Fontcuberta, del Valle, Fortes, del Valle, Fortes, Luisa, Mª, Quesada, Franco, Maria, Sara, Romero, Franco, Teresa, Maria, Francisco, Gallego, Gala, Gamiz, Castañeda, Garcia, Rodriguez, Garcia, Gemma, Casajuana, Arroyo, Gomez, Girbau, Gomez, Fernandez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Lopez, Gonzalez, Obeso, Gual, Blanco, Guerrero, Roca, Guillemas, Eudaldo, Guillermo, Hernandez, Sebastia, Covas, Homar, Alvarez, Hostench, Royo, Huerta, Barcelo, Ibañez, Cruz, Izquiero, Etxetxikia, Jaione Urdangarin, Gimenez, Juárez, Alami, Khlifi, Gasco, Laparra, Moreales, Lara, Arroyo, Las, de Jesus, Dulcenombre, Medina, Lasaosa, Lourdes, Maria, Cava, Lazaro, Berrar, Leon, Maturana, López, Ramirez, Lopez, Romero, López, Marco, Lorente, Martin, Lorenzo, Casals, Lozano, Nicola, Lujan, Diaz, Madrid, Antonio, Jose, Morales, Maria Teresa Peris, Clemente, Marti, Castaño, Martinez, Natanael, David, Gamez, Martinez, Gonzalez, Martinez, Quesada, Martinez, de la Cabeza, Maria, Fusté, Marzà, Lasheras, Melendo, Mestre, Miralles, Pastalle, Montserrat Puig, Vidal, Montserrate, Mellado, Mora, Ponce, Morales, Fornieles, Morell, Cabre, Morera, Vivet, Morera, Souza, Mundi, Quiles, Muñoz, Rosa, Navea, Iglesias, Neira, Asuncion, M, Manrique, Nuñez, Pilar, Mª, Martinez, Obiols, Reig, Pallares, Torres, Partegas, Berengueras, Pascual, Gamez, Perez, Oset, Perez, Restrepo, Perez, Alejandra, Maria, Yeste, Planas, Mangado, Planells, Minguillon, Pons, Carbonell, Puertas, Blanco, Quinteiro, Benavente, Rebollar, Fernandez, Recasens, Gomez, Reyes, del Carmen, Maria, Pou, Roca, Ferrer, Rodriguez, Franco, Rodriguez, Fuertes, Rodriguez, Muñoz, Rodriguez, Navarro, Rodriguez, Iniesta, Roig, Gracia, Romero, Brunet, Rovira, de Eugenio, Rovira, Baena, Rubio, Llorens, Ruiz, Llamazares, Sala, Alaez, San Juan, Segura, Sanchez, Soldevilla, Santasusana, Salmeron, Sanz, Perez, Segura, Balcells, Serra, Dumitras, Sorina, Montoya, Teixidor, Vicente, Tena, Salinas, Tierno, Ines, Ester, Testa, Toledo, Figueras, Tomàs, Ruperez, Tomas, Garcia-Penche, Torrano, Esparza, Torres, Blanco, Vazquez, De la Paz, Vazquez, Gil, Vazquez, Gonzalez, Vazquez, Meler, Vidal, Cots, Vilalta, Jimenez, Vilches, Jose, Maria, Fernandez, Visser, Gavin, Viu, Vives, Vives, Jimenez, Carmona, Jose, Francisco, Vilches, Galobardes, Gomez, Gonzalez, Manzanera, Jodar, Cortes, Marimon, Orive, Marrodan, Bosch, Martin, Jose, Maria, Lopez, Martorell, Roca, Millares, Jesus, M, Guri, Miralles, Hernandez, Muliterno, Oliva, Muñoz, Pujol, Pons, Conde, Postius, Arruñada, Prieto, Antonio, Jose, Mathé, Quintana, Mata, Rosell, Alvarez, Aguirre, Alvarez, Alvarin, Flores, Arrufat, Pago, Bañuelos, Andreu, Burnat, Vilar, Campo, Hidalgo, Cardus, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Estopà, Català, Garces, Clave, Sanroma, Comes, Sequi, Descalzo, Ricol, Errando, Campillo, Escudero, del Mar, Maria, Alvarez, Fernandez, Gomez, Fernandez, Perez, Fernandez, Espinosa, Franch, Graells, Freixes, Plaza, Garcia, Gallego, Garcia-Marron, Simancas, Hernandez, Covas, Homar, Royo, Huerta, Armas, Jaraba, Ramos, Jimenez, Canela, Lopez, Angeles, M, Lopez, Lopez, Oganissian, Lopez, Romero, Madrona, Rosa, M, Millan, Martinez, Morón, Martínez, Encinas, Merchan, Fornieles, Morell, Jimenez, Moreno, Rico, Muñoz, Rodriguez, Navarro, Ibañez, Nogales, Maria, Rita, Viera, Novillo, Torrabadella, Parella, Alba, Mari, Villar, Pera, Montserrat, Carla, Carbonell, Puertas, Miralles, Rabella, Trilles, Ramis, Ortiz, Ribera, Fuertes, Rodriguez, Gonzalez, Sanchez, Perez, Sastre, Perez, Segura, Borrega, Soro, Garcia, Soto, Angeles, Maria, Fores, Tapia, Bernad, Tellez, Alvarez, Trenado, Moreda, Español, Martin, Felix, Perez, Herrero, Manzanera, Jodar, Fuster, Lanau, Gomariz, Lopez, Orive, Marrodan, Bosch, Martin, Jose, Maria, Guri, Miralles, Oliva, Muñoz, Lozano, Pardo, Pujol, Pons, Altimiras, Quintana, Lopez, Ventosa, Damian, Almodovar, Colino, Alvarez, Monterroso, Alvarez, Comas, Arambudo, Garzon, Boullon, Capella, Burgos, Garcia, Campuzano, Del Mar, Maria, Olivas, Capdevila, Fernandez, Carcelen, Solà, Caro, Marti, Carre, Isabel, Clara, Bacaicoa, Carretero, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Calderon, Cazorla, Osuna, Chacon, Planas, Cortes, Olio, Cortit, Estany, Delhomme, Carasso, Duran, Javier, Pablo, Campillo, Escudero, del Mar, Maria, Martinez, Fructuos, Lopez, Garcia, Luis, Pascual, Plaza, Garcia, Vallve, Genis Amill, Arroyo, Gomez, Girbau, Gomez, Muñoz, Gonzalez, Ventura, Hernaez, Covas, Homar, Gimenez, Lavernia, Rojo, Martin, Medina, Martínez, Millan, Martinez, Barrera, Mayol, Pi, Mercader, Dalmau, Merino, Campodarbe, Miguel, Pastalle, Montserrat Puig, de la Cruz, Morales, Fornieles, Morell, Sanchez, Moreno, Javier, Francisco, Reig, Pallares, Torrabadella, Parella, Alba, Mari, Barrameda, Penela, Ajenjo, Prieto, Benavente, Rebollar, Pareja, Rodriguez, Piñar, Rodríguez, Javier, Francisco, Tello, Rodriguez, Pereda, Romero, Saborido, Sainz, Martin, Santacana, Martinez, Santos, Chavez, Sierra, Testa, Toledo, Figueras, Tomàs, Garcia, Torres, José, Pedro, Torres, Turbau, Domenech, Vicente, Esteo, Villena, Pertegaz, Vives, Gonzalez, Baena, Pont, Bagaria, Sanchez, Beltran, Alarcon, Bonet, Ballescà, Borch, Clanchet, Buhils, Garcia, Closa, Carril, Colomina, Sanchez, Cristina Fernandez, Toledo, Edurne Judith Fernandez, Rodriguez, Espases, Resa, Espert, Xavier, F, Sol, Fernández, Lugo, Gonzalez, Llesera, Gracia, Lendinez, Herrada, Liesa, Juliench, Alicia, Sandra, Ortega, Lopez, Yuste, Lopez, Villanueva, Lozano, Soto, Lucia Sola, Castellano, Madrid, Cano, Megias, Jesus, Daniel, Ponce, Montasell, Sospedra, Montesinos, Martinez, Moya, Herrera, Muñoz, Isabel, M, Fernandez, Ocaña, Jose, Maria, Bernal, Palau, Sole, Perez, Carbonell, Ramon, Lop, Ribas, López, Rubio, Lopez, Rueda, Castaño, Sabat, Lara, Sabata, Ramírez, Salmerón, Gornals, Sebastia, Creus, Serra, Dalmau, Serrano, Mainero, Sumasi, Gabriel, Gonzalo, Masa, Torello, Primo, Valencia, Muñoz, Ana Maria Viñuales, Roig, Josep, and Hidalgo, Verònica
Published: 2023
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4. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author: Acosta, Boris Raul, Aegidius, Karen, Albiker, Christian, Alegiani, Anna, Almendrote, Miriam, Alonso, Angelika, Althaus, Katharina, Amarenco, Pierre, Amiri, Hemasse, Anders, Bettina, Aniculaesei, Adriana, Appleton, Jason, Arenillas, Juan, Back, Christina, Bähr, Christian, Bardutzky, Jürgen, Baronnet-Chauvet, Flore, Bathe-Peters, Rouven, Bayer-Karpinska, Anna, Becerra, Juan L., Beck, Christoph, Belchí Guillamon, Olga, Benoit, Amandine, Berhoune, Nadia, Bindila, Daniela, Birchenall, Julia, Blanc-Lasserre, Karine, Blanco Gonzales, Miguel, Bobinger, Tobias, Bodechtel, Ulf, Bodiguel, Eric, Bojaryn, Urszula, Bonnet, Louise, Bouamra, Benjamin, Bourgeois, Paul, Boutitie, Florent, Breuer, Lorenz, Breynaert, Ludovic, Broughton, David, Brouns, Raf, Brugirard, Sébastian, Bruneel, Bart, Buggle, Florian, Cakmak, Serkan, Calleja, Ana, Calvet, David, Carrera, David, Chen, Hsin-Chieh, Cheng, Bastian, Cheripelli, Bharath, Cho, Tae-Hee, Choe, Chi-un, Choy, Lillian, Christensen, Hanne, Ciatipis, Mareva, Cloud, Geoffrey, Cogez, Julien, Cortijo, Elisa, Crozier, Sophie, Damgaard, Dorte, Dani, Krishna, De Coene, Beatrijs, De Hollander, Isabel, De Keyser, Jacques, De Klippel, Nina, De Maeseneire, Charlotte, De Smedt, Ann, del Mar Castellanos Rodrigo, Maria, Deltour, Sandrine, Demeestere, Jelle, Derex, Laurent, Desfontaines, Philippe, Dittrich, Ralf, Dixit, Anand, Dobbels, Laurens, Domigo, Valérie, Dorado, Laura, Druart, Charlotte, Dupont, Kristina Hougaard, Dusart, Anne, Dziewas, Rainer, Ebinger, Martin, Ebner, Matthias, Edjali-Goujon, Myriam, Eisele, Philipp, El Tawil, Salwa, Elhfnawy, Ahmed, Endres, Matthias, Etexberria, Ana, Evans, Nicholas, Fandler, Simon, Fazekas, Franz, Felix, Sandra, Fiebach, Jochen B., Fiehler, Jens, Filipov, Alexandra, Filipski, Katharina, Fleischmann, Robert, Foerch, Christian, Ford, Ian, Gaenslen, Alexandra, Galinovic, Ivana, Gancedo, Elena Meseguer, Ganeshan, Ramanan, García Esperón, Carlos, Garrido, Alicia, Gattringer, Thomas, Geraghty, Olivia, Geran, Rohat, Gerloff, Christian, Gerner, Stefan, Godon-Hardy, Sylvie, Göhler, Jos, Golsari, Amir, Gomis, Meritxell, Gorriz, David, Gramse, Verena, Grau, Laia, Griebe, Martin, Guerrero, Cristina, Guerzoglu, Damla, Guettier, Sophie, Guiraud, Vincent, Gumbinger, Christoph, Gunreben, Ignaz, Haertig, Florian, Hametner, Christian, Hanseeuw, Bernard, Hansen, Andreas, Hansen, Jakob, Harbo, Thomas, Harloff, Andreas, Harmel, Peter, Häusler, Karl Georg, Heinen, Florian, Held, Valentin, Hellwig, Simon, Hemelsoet, Dimitri, Hennerici, Michael, Herm, Juliane, Hermans, Sylvia, Hernández, María, Hervas Vicente, Jose, Hjort, Niels, Hobeanu, Cristina, Hobohm, Carsten, Höfner, Elmar, Hohenbichler, Katharina, Hommel, Marc, Hoppe, Julia, Hornberger, Eva, Hoyer, Carolin, Huang, Xuya, Ipsen, Nils, Isern, Irina, Ispierto, Lourdes, Iversen, Helle, Jeppesen, Lise, Jimenez, Marta, Jungehülsing, Jan, Jüttler, Eric, Kalladka, Dheeraj, Kallmünzer, Bernd, Kar, Arindam, Kellert, Lars, Kemmling, André, Kessler, Tobias, Khan, Usman, Klein, Matthias, Kleinschnitz, Christoph, Klockziem, Matti, Knops, Michael, Koehler, Luzie, Koehrmann, Martin, Kohlfürst, Heinz, Kollmar, Rainer, Kraft, Peter, Krause, Thomas, Kristensen, Bo, Kröber, Jan M., Kurka, Natalia, Ladoux, Alexandre, Laloux, Patrice, Lamy, Catherine, Landrault, Emmanuelle, Lauer, Arne, Lebely, Claire, Leempoel, Jonathan, Lees, Kennedy, Leger, Anne, Legrand, Laurence, Lemmens, Robin, Li, Lin, Löbbe, Anna-Mareike, London, Frederic, Lopez-cancio, Elena, Lorenz, Matthias, Louw, Stephen, Lovelock, Caroline, Lozano Sánchez, Manuel, Lucente, Giuseppe, Lückl, Janos, Luna, Alain, Macha, Kosmas, Machet, Alexandre, Mackenrodt, Daniel, Madzar, Dominik, Majoie, Charles, Männer, Anika, Maqueda, Vicky, Marstrand, Jacob, Martinez, Alicia, Marzina, Annika, Mechthouff, Laura, Meden, Per, Meersman, Guy, Meier, Julia, Mellerio, Charles, Menn, Oliver, Meyer, Nadja, Michalski, Dominik, Michels, Peter, Michelsen, Lene, Millán Torne, Monica, Minnerup, Jens, Modrau, Boris, Moeller, Sebastian, Møller, Anette, Morel, Nathalie, Moreton, Fiona, Morin, Ludovic, Moulin, Thierry, Moynihan, Barry, Mueller, Anne K., Muir, Keith W., Mulero, Patricia, Mundiyanapurath, Sibu, Mutzenbach, Johannes, Nagel, Simon, Naggara, Oliver, Nallasivan, Arumugam, Navalpotro, Irene, Nave, Alexander H., Nederkoorn, Paul, Neeb, Lars, Neugebauer, Hermann, Neumann-Haefelin, Tobias, Nighoghossian, Norbert, Oberndorfer, Stefan, Opherk, Christian, Oppel, Lorenz, Oppenheim, Catherine, Orthgieß, Johannes, Ostergaard, Leif, Paindeville, Perrine, Palomeras, Ernest, Panitz, Verena, Patel, Bhavni, Peeters, Andre, Peeters, Dirk, Pellisé, Anna, Pelz, Johann, Pereira, Anthony, Pérez de la Ossa, Natalia, Perry, Richard, Petraza, Salvador, Peysson, Stéphane, Pfeilschifter, Waltraud, Pichler, Alexander, Pierskalla, Alexandra, Pledl, Hans-Werner, Poli, Sven, Pomrehn, Katrin, Poulsen, Marika, Prats, Luis, Presas, Silvia, Prohaska, Elisabeth, Puetz, Volker, Puig, Josep, Puig Alcántara, Josep, Purrucker, Jan, Quenardelle, Veronique, Ramachandran, Sankaranarayanan, Raphaelle, Soulliard, Raposo, Nicolas, Reiff, Tilman, Remmers, Michel, Renou, Pauline, Ribitsch, Martin, Richter, Hardy, Ringleb, Peter, Ritter, Martin, Ritzenthaler, Thomas, Rodier, Gilles, Rodriguez-Regent, Christine, Rodríguez-Yáñez, Manuel, Roennefarth, Maria, Roffe, Christine, Rosenbaum, Sverre, Rosso, Charlotte, Röther, Joachim, Rozanski, Michal, Ruiz de Morales, Noelia, Russo, Francesca, Rutgers, Matthieu, Sagnier, Sharmilla, Samson, Yves, Sánchez, Josep, Sauer, Tamara, Schäfer, Jan H., Schieber, Simon, Schill, Josef, Schlak, Dennis, Schlemm, Ludwig, Schmidt, Sein, Schonewille, Wouter, Schröder, Julian, Schulz, Andreas, Schurig, Johannes, Schwarting, Sönke, Schwarz, Alexander, Schwarzbach, Christopher, Seidel, Matthias, Seiler, Alexander, Sembill, Jochen, Serena Leal, Joaquin, Shetty, Ashit, Sibon, Igor, Simonsen, Claus Z., Singer, Oliver, Sivagnanaratham, Aravinth, Smets, Ide, Smith, Craig, Soors, Peter, Sprigg, Nikola, Spruegel, Maximilian, Stark, David, Steinert, Susanne, Stösser, Sebastian, Stuermlinger, Markus, Swinnen, Bart, Tamazyan, Ruben, Tembl, Jose, Terceno Izaga, Mikel, Thijs, Vincent, Thomalla, Götz, Touze, Emmanuel, Truelsen, Thomas, Turc, Guillaume, Turine, Gaetane, Tütüncü, Serdar, Tyrell, Pippa, Ustrell, Xavier, Vadot, Wilfried, Vallet, Anne-Evelyne, Vallet, Pauline, van den Berg, Lucie, van den Berg, Sophie, van Eendenburg, Cecile, Van Hooff, Robbert-Jan, van Sloten, Isabelle, Vanacker, Peter, Vancaester, Evelien, Vanderdonckt, Patrick, Vandermeeren, Yves, Vanhee, Frederik, Veltkamp, Roland, Vestergaard, Karsten, Viguier, Alain, Vilas, Dolores, Villringer, Kersten, Voget, Dieke, von Schrader, Jörg, von Weitzel, Paul, Warburton, Elisabeth, Weber, Claudia, Weber, Jörg, Wegscheider, Karl, Wegscheider, Mirko, Weimar, Christian, Weinstich, Karin, Weise, Christopher, Weise, Gesa, Willems, Chris, Winder, Klemens, Wittayer, Matthias, Wolf, Marc, Wolf, Martin, Wolff, Valerie, Wollboldt, Christian, Wollenweber, Frank, Wouters, Anke, Yalo, Bertrand, Yger, Marion, Younan, Nadia, Yperzeele, Laetita, Zegarac, Vesna, Zeiner, Pia, Ziemann, Ulf, Zonneveld, Thomas, Zuber, Mathieu, Akutsu, Tsugio, Aoki, Junya, Arakawa, Shuji, Doijiri, Ryosuke, Egashira, Yusuke, Enomoto, Yukiko, Fukuda-Doi, Mayumi, Furui, Eisuke, Furuta, Konosuke, Gotoh, Seiji, Hamasaki, Toshimitsu, Hasegawa, Yasuhiro, Hirano, Teryuki, Homma, Kazunari, Ichijyo, Masahiko, Ide, Toshihiro, Igarashi, Shuichi, Iguchi, Yasuyuki, Ihara, Masafumi, Ikenouchi, Hajime, Inoue, Manabu, Inoue, Tsuyoshi, Itabashi, Ryo, Ito, Yasuhiro, Iwama, Toru, Kamiyama, Kenji, Kamiyoshi, Shoko, Kanai, Haruka, Kanematsu, Yasuhisa, Kanzawa, Takao, Kimura, Kazumi, Kitayama, Jiro, Kitazono, Takanari, Koga, Masatoshi, Kondo, Rei, Kudo, Kohsuke, Kusumi, Masayoshi, Kuwahara, Ken, Matsumoto, Shoji, Matsuoka, Hideki, Mihara, Ban, Minematsu, Kazuo, Miura, Ken, Miwa, Kaori, Morita, Naomi, Mouri, Wataru, Murata, Kayo, Nagakane, Yoshinari, Nakase, Taizen, Ohara, Hiromi, Ohara, Nobuyuki, Ohnishi, Hideyuki, Ohta, Hajime, Ohtaki, Masafumi, Ohtani, Ryo, Ohtsuki, Toshiho, Ohyama, Hideo, Okada, Takashi, Okada, Yasushi, Osaki, Masato, Sakai, Nobuyuki, Sanbongi, Yoshiki, Sasaki, Naoshi, Sasaki, Makoto, Sato, Shoichiro, Seki, Kenta, Shimizu, Wataru, Shiokawa, Yoshiaki, Sozu, Takashi, Suzuki, Junichiro, Suzuki, Rieko, Takagi, Yasushi, Takizawa, Shunya, Tanahashi, Norio, Tanaka, Eijiro, Tanaka, Ryota, Tateishi, Yohei, Terada, Tomoaki, Terasaki, Tadashi, Todo, Kenichi, Tokunaga, Azusa, Toyoda, Kazunori, Tsujino, Akira, Ueda, Toshihiro, Uesaka, Yoshikazu, Uotani, Mihoko, Urabe, Takao, Watanabe, Masao, Yagita, Yoshiki, Yakushiji, Yusuke, Yamamoto, Haruko, Yasui, Keizo, Yonehara, Toshiro, Yoshimura, Sohei, Yoshimura, Shinichi, Aarnio, K., Alemseged, F., Anderson, C., Ang, T., Archer, M.L., Attia, J., Bailey, P., Balabanski, A., Barber, A., Barber, P.A., Bernhardt, J., Bivard, A., Blacker, D., Bladin, C.F., Brodtmann, A., Cadilhac, D., Campbell, B.C.V., Carey, L., Celestino, S., Chan, L., Chang, W.H., ChangI, A., Chen, C.H., Chen, C.-I., Chen, H.F., Chen, T.C., Chen, W.H., Chen, Y.Y., Cheng, C.A., Cheong, E., Chiou, Y.W., Choi, P.M., Chu, H.J., Chuang, C.S., Chung, T.C., Churilov, L., Clissold, B., Connelly, A., Coote, S., Coulton, B., Cowley, E., Cranefield, J., Curtze, S., D'Este, C., Davis, S.M., Day, S., Desmond, P.M., Dewey, H.M., Ding, C., Donnan, G.A., Drew, R., Eirola, S., Field, D., Frost, T., Garcia-Esperon, C., George, K., Gerraty, R., Grimley, R., Guo, Y.C., Hankey, G., Harvey, J., Ho, S.C., Hogan, K., Howells, D., Hsiao, P.M., Hsu, C.H., Hsu, C.T., Hsu, C.-S., Hsu, J.P., Hsu, Y.D., Hsu, Y.T., Hu, C.J., Huang, C.C., Huang, H.Y., Huang, M.Y., Huang, S.C., Huang, W.S., Jackson, D., Jeng, J.S., Jiang, S.K., Kaauwai, L., Kasari, O., King, J., Kleinig, T.J., Koivu, M., Kolbe, J., Krause, M., Kuan, C.W., Kung, W.L., Kyndt, C., Lau, C.L., Lee, A., Lee, C.Y., Lee, J.T., Lee, Y., Lee, Y.C., Levi, C., Levi, C.R., Lien, L.M., Lim, J.C., Lin, C.C., Lin, C.H., Lin, C.M., Lin, D., Liu, C.H., Liu, J., Lo, Y.C., Loh, P.S., Low, E., Lu, C.H., Lu, C.J., Lu, M.K., Ly, J., Ma, H., Macaulay, L., Macdonnell, R., Mackey, E., Macleod, M., Mahadevan, J., Maxwell, V., McCoy, R., McDonald, A., McModie, S., Meretoja, A., Mishra, S., Mitchell, P.J., Miteff, F., Moore, A., Muller, C., Ng, F., Ng, F.C., Ng, J-L., O'Brian, W., O'Collins, V., Oxley, T.J., Parsons, M.W., Patel, S., Peng, G.S., Pesavento, L., Phan, T., Rodrigues, E., Ross, Z., Sabet, A., Sallaberger, M., Salvaris, P., Shah, D., Sharma, G., Sibolt, G., Simpson, M., Singhal, S., Snow, B., Spratt, N., Stark, R., Sturm, J., Sun, M.C., Sun, Y., Sung, P.S., Sung, Y.F., Suzuki, M., Tan, M., Tang, S.C., Tatlisumak, T., Thijs, V., Tiainen, M., Tsai, C.H., Tsai, C.K., Tsai, C.L., Tsai, H.T., Tsai, L.K., Tseng, C.H., Tseng, L.T., Tsoleridis, J., Tu, H., Tu, H.T-H., Vallat, W., Virta, J., Wang, W.C., Wang, Y.T., Waters, M., Weir, L., Wijeratne, T., Williams, C., Wilson, W., Wong, A.A., Wong, K., Wu, T.Y., Wu, Y.H., Yan, B., Yang, F.C., Yang, Y.W., Yassi, N., Yeh, H.L., Yeh, J.H., Yeh, S.J., Yen, C.H., Young, D., Ysai, C.L., Zhang, W.W., Zhao, H., Zhao, L., Althaus-Knaurer, Katharina, Bendszus, Martin, Berrouschot, Jörg, Bluhmki, Erich, Bovi, Paolo, Chatellier, Gilles, Cove, Lynda, Davis, Stephen, Dixit, A., Donnan, Geoffrey, Ehrenkrona, Christina, Eschenfelder, Christoph, Fatar, Marc, Francisco Arenillas, Juan, Gruber, Franz, Hacke, Werner, Kala, Lalit, Kapeller, Peter, Kaste, Markku, Kessler, Christof, Köhrmann, Martin, Laage, Rico, Lees, Kennedy R., Leys, Didier, Luna Rodriguez, Alain, Mas, Jean-Louis, Mikulik, Robert, Molina, Carlos, Muddegowda, Girish, Muir, Keith, Niederkorn, Kurt, Nuñez, Xavier, Schellinger, Peter, Schwab, Stefan, Serena, Joaquin, Sobesky, Jan, Steiner, Thorsten, Svenson, Ann-Sofie, Toni, Danilo, von Kummer, Rüdiger, Wahlgren, Nils, Wardlaw, Joanna, Betensky, Rebecca A., Boulouis, Gregoire, Carandang, Raphael A., Copen, William A., Cougo, Pedro, Cutting, Shawna, Drake, Kendra, Ford, Andria L., Hallenbeck, John, Harris, Gordon J., Hoesch, Robert, Hsia, Amie, Kase, Carlos, Latour, Lawrence, Lev, Michael H., Muzikansky, Alona, Nagaraja, Nandakumar, Schwamm, Lee H., Searls, Eric, Song, Shlee S., Starkman, Sidney, Warach, Steven, Wu, Ona, Yoo, Albert J., Zand, Ramin, Ma, Henry, Schwamm, Lee H, Bladin, Christopher F, Campbell, Bruce C V, Churilov, Leonid, Fiebach, Jochen B, Kleinig, Timothy J, Latour, Lawrence L, Levi, Christopher R, Molina, Carlos A, Muir, Keith W, Parsons, Mark W, Pedraza, Salvador, Schellinger, Peter D, Simonsen, Claus Z, Song, Shlee S, Hsu, Chung Y, Yassi, Nawaf, Donnan, Geoffrey A, and Davis, Stephen M
Published: 2020
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5. Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice

Author: Millán, Mònica, Ramos-Pachón, Anna, Dorado, Laura, Bustamante, Alejandro, Hernández-Pérez, María, Rodríguez-Esparragoza, Luís, Gomis, Meritxell, Remollo, Sebastia, Castaño, Carlos, Werner, Mariano, Wenger, Denisse, Rubio, Sara, Domínguez-Lizarbe, Manuel, Terceño, Mikel, Paipa, Andrés Julián, Rodríguez-Vázquez, Alejandro, Boned, Sandra, Camps-Renom, Pol, Cánovas, David, Giralt, Eva, López-Cancio, Elena, Dávalos, Antoni, Ros-Roig, Josep, and Pérez de la Ossa, Natalia
Published: 2022
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6. The Barcelona-Asymptomatic Intracranial Atherosclerosis study: Subclinical intracranial atherosclerosis as predictor of long-term vascular events

Author: Planas-Ballvé, Anna, Crespo, Ane Miren, Aguilar, Lorena Martín, Hernández-Pérez, María, Canento, Tamara, Dorado, Laura, Alzamora, María T., Torán, Pere, Pera, Guillem, Muñoz-Ortiz, Laura, Arenillas, Juan F., Castañón, María, Dávalos, Antoni, Millán, Mónica, and López-Cancio, Elena
Published: 2019
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7. Mediterranean Diet Prior to Ischemic Stroke and Potential Circulating Mediators of Favorable Outcomes.

Author: Castañón-Apilánez, María, García-Cabo, Carmen, Martin-Martin, Cristina, Prieto, Belén, Cernuda-Morollón, Eva, Rodríguez-González, Pablo, Pineda-Cevallos, Daniela, Benavente, Lorena, Calleja, Sergio, and López-Cancio, Elena
Abstract: Background/Objectives. A Mediterranean diet (MD) has been associated with neuroprotective effects. We aimed to assess the MD's association with stroke prognosis and the potential mediators involved. Methods. Seventy patients with acute anterior circulation ischemic stroke were included. Dietary patterns were evaluated using the MEDAS scale, a food-frequency questionnaire, and a 24 h recall. Circulating biomarkers including insulin resistance (HOMA index), adipokines (resistin, adiponectin, leptin), choline pathway metabolites (TMAO, betaine, choline), and endothelial progenitor cells (EPCs) were measured. Early neurological improvement (ENI) at 24 h, final infarct volume, and functional outcome at 3 months were assessed. Results. Adherence to MD and olive oil consumption were associated with a lower prevalence of diabetes and atherothrombotic stroke, and with lower levels of fasting glycemia, hemoglobinA1C, insulin resistance, and TMAO levels. Monounsaturated fatty acids and oleic acid consumption correlated with lower resistin levels, while olive oil consumption was significantly associated with EPC mobilization. Multivariate analysis showed that higher MD adherence was independently associated with ENI and good functional prognosis at 3 months. EPC mobilization, lower HOMA levels, and lower resistin levels were associated with ENI, a smaller infarct volume, and good functional outcome. Conclusions. MD was associated with better prognosis after ischemic stroke, potentially mediated by lower insulin resistance, increased EPC mobilization, and lower resistin levels, among other factors. [ABSTRACT FROM AUTHOR]
Published: 2024
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8. Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial

Author: Ribó, M., Sanjuan, E., Rubiera, M., Pagola, J., Flores, A., Muchada, M., Meler, P., Huerga, E., Gelabert, S., Coscojuela, P., Tomasello, A., Rodriguez, D., Santamarina, E., Maisterra, O., Boned, S., Seró, L., Rovira, A., Molina, C., Millán, M., Muñoz, L., de la Ossa, N. Pérez, Gomis, M., Dorado, L., López-Cancio, E., Palomeras, E., Munuera, J., García Bermejo, P., Remollo, S., Castaño, C., García-Sort, R., Cuadras, P., Puyalto, P., Hernández-Pérez, M., Jiménez, M., Martínez-Piñeiro, A., Lucente, G., Dávalos, A., Chamorro, A., Urra, X., Obach, V., Cervera, A., Amaro, S., Llull, L., Codas, J., Balasa, M., Navarro, J., Ariño, H., Aceituno, A., Rudilosso, S., Renu, A., Macho, J.M., San Roman, L., Blasco, J., López, A., Macías, N., Cardona, P., Quesada, H., Rubio, F., Cano, L., Lara, B., de Miquel, M.A., Aja, L., Jovin, T.G., Serena, J., San Román, L., Cobo, E., Albers, G., Lees, K., Arenillas, J., Roberts, R., Goyal, M., Demchuk, A.M., Minhas, P, Al-Ajlan, F, Salluzzi, M, Zimmel, L, Patel, S, Eesa, M, von Kummer, R., Martí-Fàbregas, J., Jankowitz, B., Salvat-Plana, M., Hernandez-Pérez, M., Dávalos, Antoni, Cobo, Erik, Molina, Carlos A, Chamorro, Angel, de Miquel, M Angeles, Román, Luis San, Serena, Joaquín, López-Cancio, Elena, Ribó, Marc, Millán, Mónica, Urra, Xabier, Cardona, Pere, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucía, Rubiera, Marta, Gomis, Meritxell, Renú, Arturo, Lara, Blanca, Martí-Fàbregas, Joan, Jankowitz, Brian, Cerdà, Neus, and Jovin, Tudor G
Published: 2017
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9. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome

Author: Heitsch, Laura, Ibanez, Laura, Carrera, Caty, Binkley, Michael M., Strbian, Daniel, Tatlisumak, Turgut, Bustamante, Alejandro, Ribó, Marc, Molina, Carlos, Dávalos, Antoni, López-Cancio, Elena, Muñoz-Narbona, Lucia, Soriano-Tárraga, Carol, Giralt-Steinhauer, Eva, Obach, Victor, Slowik, Agnieszka, Pera, Joanna, Lapicka-Bodzioch, Katarzyna, Derbisz, Justyna, Sobrino, Tomás, Castillo, José, Campos, Francisco, Rodríguez-Castro, Emilio, Arias-Rivas, Susana, Segura, Tomas, Serrano-Heras, Gemma, Vives-Bauza, Cristófol, Díaz-Navarro, Rosa, Tur, Silva, Jimenez, Carmen, Martí-Fàbregas, Joan, Delgado-Mederos, Raquel, Arenillas, Juan, Krupinski, Jerzy, Cullell, Natalia, Torres-Aguila, Nuria P., Muiño, Elena, Cárcel-Márquez, Jara, Moniche, Francisco, Cabezas, Juan A., Ford, Andria L., Dhar, Rajat, Roquer, Jaume, Khatri, Pooja, Jiménez-Conde, Jordi, Fernandez-Cadenas, Israel, Montaner, Joan, Rosand, Jonathan, Cruchaga, Carlos, and Lee, Jin-Moo
Published: 2021
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10. Reported Prestroke Physical Activity Is Associated with Vascular Endothelial Growth Factor Expression and Good Outcomes after Stroke

Author: López-Cancio, Elena, Ricciardi, Ana Clara, Sobrino, Tomás, Cortés, Jordi, de la Ossa, Natalia Pérez, Millán, Mónica, Hernández-Pérez, María, Gomis, Meritxell, Dorado, Laura, Muñoz-Narbona, Lucía, Campos, Francisco, Arenillas, Juan F., and Dávalos, Antoni
Published: 2017
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11. Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis

Author: Wabnitz, Ashley M., Derdeyn, Colin P., Fiorella, David J., Lynn, Michael J., Cotsonis, George A., Liebeskind, David S., Waters, Michael F., Lutsep, Helmi, López-Cancio, Elena, Turan, Tanya N., Montgomery, Jean, Janis, L. Scott, Lane, Bethany, and Chimowitz, Marc I.
Published: 2018
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12. Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

Author: Carrera, Caty, Cullell, Natalia, Torres-Águila, Nuria, Muiño, Elena, Bustamante, Alejandro, Dávalos, Antonio, López-Cancio, Elena, Ribó, Marc, Molina, Carlos A., Giralt-Steinhauer, Eva, Soriano-Tárraga, Carolina, Mola-Caminal, Marina, Jiménez-Conde, Jordi, Roquer, Jaume, Vives-Bauza, Cristófol, Navarro, Rosa Díaz, Obach, Victor, Arenillas, Juan Francisco, Segura, Tomás, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Freijo, Marimar, Cabezas, Juan Antonio, Tatlisumak, Turgut, Heitsch, Laura, Ibañez, Laura, Cruchaga, Carlos, Lee, Jin-Moo, Strbian, Daniel, Montaner, Joan, and Fernández-Cadenas, Israel
Published: 2019
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13. Neuroprotection Afforded by an Enriched Mediterranean-like Diet Is Modified by Exercise in a Rat Male Model of Cerebral Ischemia.

Author: Romaus-Sanjurjo, Daniel, Castañón-Apilánez, María, López-Arias, Esteban, Custodia, Antía, Martin-Martín, Cristina, Ouro, Alberto, López-Cancio, Elena, and Sobrino, Tomás
Subjects: CEREBRAL ischemia, MEDITERRANEAN diet, MALE models, REDUCING diets, ISCHEMIC stroke, DIET, TREADMILL exercise
Abstract: Ischemic stroke is an important cause of mortality and disability worldwide. Given that current treatments do not allow a remarkably better outcome in patients after stroke, it is mandatory to seek new approaches to preventing stroke and/or complementing the current treatments or ameliorating the ischemic insult. Multiple preclinical and clinical studies highlighted the potential beneficial roles of exercise and a Mediterranean diet following a stroke. Here, we investigated the effects of a pre-stroke Mediterranean-like diet supplemented with hydroxytyrosol and with/without physical exercise on male rats undergoing transient middle cerebral artery occlusion (tMCAO). We also assessed a potential synergistic effect with physical exercise. Our findings indicated that the diet reduced infarct and edema volumes, modulated acute immune response by altering cytokine and chemokine levels, decreased oxidative stress, and improved acute functional recovery post-ischemic injury. Interestingly, while physical exercise alone improved certain outcomes compared to control animals, it did not enhance, and in some aspects even impaired, the positive effects of the Mediterranean-like diet in the short term. Overall, these data provide the first preclinical evidence that a preemptive enriched Mediterranean diet modulates cytokines/chemokines levels downwards which eventually has an important role during the acute phase following ischemic damage, likely mediating neuroprotection. [ABSTRACT FROM AUTHOR]
Published: 2024
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14. Metabolic Syndrome Predicts Refractoriness to Intravenous Thrombolysis in Acute Ischemic Stroke

Author: Dorado, Laura, Arenillas, Juan F, López-Cancio, Elena, Hernández-Pérez, María, Pérez de la Ossa, Natalia, Gomis, Meritxell, Millán, Mònica, Granada, María Luisa, Galán, Amparo, Palomeras, Ernest, and Dávalos, Antoni
Published: 2015
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15. Thalamic diffusion differences related to cognitive function in white matter lesions

Author: Fernández-Andújar, Marina, Soriano-Raya, Juan José, Miralbell, Júlia, López-Cancio, Elena, Cáceres, Cynthia, Bargalló, Núria, Barrios, Maite, Arenillas, Juan Francisco, Toran, Pere, Alzamora, Maite, Clemente, Imma, Dávalos, Antoni, and Mataró, Maria
Published: 2014
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16. PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

Author: Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Natàlia, Torres-Aguila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Angel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernandez-Guillamon, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Martí-Fàbregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Victor, Ribó, Marc, Molina, Carlos A., Alvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibanez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kristiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, and Jiménez-Conde, Jordi
Published: 2019
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17. Hemorrhagic Risk of Emergent Endovascular Treatment Plus Stenting in Patients with Acute Ischemic Stroke

Author: Dorado, Laura, Castaño, Carlos, Millán, Mònica, Aleu, Aitziber, de la Ossa, Natàlia Pérez, Gomis, Meritxell, López-Cancio, Elena, Vivas, Elio, Rodriguez-Campello, Ana, Castellanos, Mar, and Dávalos, Antoni
Published: 2013
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18. Asymptomatic cervicocerebral atherosclerosis, intracranial vascular resistance and cognition: The AsIA-Neuropsychology Study

Author: López-Olóriz, Jorge, López-Cancio, Elena, Arenillas, Juan F., Hernández, María, Jiménez, Marta, Dorado, Laura, Barrios, Maite, Soriano-Raya, Juan José, Miralbell, Júlia, Cáceres, Cynthia, Forés, Rosa, Pera, Guillem, Dávalos, Antoni, and Mataró, Maria
Published: 2013
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19. Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study

Author: Bustamante, Alejandro, López-Cancio, Elena, Pich, Sara, Penalba, Anna, Giralt, Dolors, García-Berrocoso, Teresa, Ferrer-Costa, Carles, Gasull, Teresa, Hernández-Pérez, María, Millan, Mónica, Rubiera, Marta, Cardona, Pedro, Cano, Luis, Quesada, Helena, Terceño, Mikel, Silva, Yolanda, Castellanos, Mar, Garces, Moisés, Reverté, Silvia, Ustrell, Xavier, Marés, Rafael, Baiges, Joan Josep, Serena, Joaquín, Rubio, Francisco, Salas, Eduardo, Dávalos, Antoni, and Montaner, Joan
Published: 2017
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20. Outcomes After Direct Thrombectomy or Combined Intravenous and Endovascular Treatment Are Not Different

Author: Abilleira, Sònia, Ribera, Aida, Cardona, Pedro, Rubiera, Marta, López-Cancio, Elena, Amaro, Sergi, Rodríguez-Campello, Ana, Camps-Renom, Pol, Cánovas, David, de Miquel, Maria Angels, Tomasello, Alejandro, Remollo, Sebastian, López-Rueda, Antonio, Vivas, Elio, Perendreu, Joan, Gallofré, Miquel, Martí-Fàbregas, J., Delgado-Mederos, R., Martínez-Domeño, A., Marín, R., Roquer, J., Ois, Á., Jiménez-Conde, J., Guimaraens, L., Chamorro, Á., Obach, V., Urra, X., Macho, J.M., Blasco, J., San Roman, L., Martínez-Yélamos, A., Quesada, H., Lara, B, Cayuela, N., Aja, L., Mora, P., Molina, C., Ribó, M., Pagola, J., Rodríguez-Luna, D., Muchada, M., Coscojuela, P., Dávalos, A., Millán, M., Pérez de la Ossa, N., Gomis, M., Dorado, L., Castaño, C., Garcia, M.C., Estela, J., Krupinski, J., Huertas-Folch, S., Nicolás-Herrerias, M.C., Gómez-Choco, M., García, S., Martínez, R., Sanahuja, J., Purroy, F., Serena, J., Castellanos, M., Silva, Y., Marés, R., Pellisé, A., Ustrell, X., Baiges, J.J., Garcés, M., Saura, J., Soler-Insa, J.M., Aragonés, J.M., Cocho, D., and Palomeras, E.
Published: 2017
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21. Intracranial Carotid Artery Calcification Relates to Recanalization and Clinical Outcome After Mechanical Thrombectomy

Author: Hernández-Pérez, María, Bos, Daniel, Dorado, Laura, Pellikaan, Karlijn, Vernooij, Meike W., López-Cancio, Elena, Pérez de la Ossa, Natalia, Gomis, Meritxell, Castaño, Carlos, Munuera, Josep, Puig, Josep, Millán, Mònica, and Dávalos, Antoni
Published: 2017
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22. Endovascular treatment improves cognition after stroke: A secondary analysis of REVASCAT trial

Author: López-Cancio, Elena, Jovin, Tudor G., Cobo, Erik, Cerdá, Neus, Jiménez, Marta, Gomis, Meritxell, Hernández-Pérez, María, Cáceres, Cynthia, Cardona, Pere, Lara, Blanca, Renú, Arturo, Llull, Laura, Boned, Sandra, Muchada, Marian, and Dávalos, Antoni
Published: 2017
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23. Phone and Video-Based Modalities of Central Blinded Adjudication of Modified Rankin Scores in an Endovascular Stroke Trial

Author: López-Cancio, Elena, Salvat, Mercè, Cerdà, Neus, Jiménez, Marta, Codas, Javier, Llull, Laura, Boned, Sandra, Cano, Luis M., Lara, Blanca, Molina, Carlos, Cobo, Erik, Dávalos, Antoni, Jovin, Tudor G., and Serena, Joaquín
Published: 2015
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24. Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

Author: Jovin, Tudor G., Chamorro, Angel, Cobo, Erik, de Miquel, María A., Molina, Carlos A., Rovira, Alex, Román, Luis San, Serena, Joaquín, Abilleira, Sonia, Ribó, Marc, Millán, Mònica, Urra, Xabier, Cardona, Pere, López-Cancio, Elena, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucía, Dorado, Laura, Quesada, Helena, Rubiera, Marta, Hernandez-Pérez, María, Goyal, Mayank, Demchuk, Andrew M., von Kummer, Rüdiger, Gallofré, Miquel, and Dávalos, Antoni
Published: 2015
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25. Intracranial atherosclerotic plaque enhancement and long‐term risk of future strokes: A prospective, longitudinal study.

Author: Gómez‐Vicente, Beatriz, Hernández‐Pérez, María, Martínez‐Velasco, Elena, Rodríguez‐Velasco, Margarita, Munuera, Josep, Rubiera, Marta, Vert, Carla, Dorado, Laura, de Lera, Mercedes, Calleja, Ana Isabel, Cortijo, Elisa, Agulla, Jesús, López‐Cancio, Elena, and Arenillas, Juan Francisco
Subjects: STROKE, ATHEROSCLEROTIC plaque, TRANSIENT ischemic attack, RECEIVER operating characteristic curves, ASYMPTOMATIC patients
Abstract: Background and Purpose: The prognostic significance of postcontrast enhancement of intracranial atheromatous plaque is uncertain. Prospective, long‐term follow‐up studies in Caucasians, using a multicenter design, are lacking. We aimed to evaluate whether this radiological sign predicts long‐term new stroke in symptomatic and asymptomatic intracranial atherosclerotic disease (ICAD) patients. Methods: This was a prospective, observational, longitudinal, multicenter study. We included a symptomatic and an asymptomatic cohort of ICAD patients that underwent 3T MRI including high‐resolution sequences focused on the atheromatous plaque. We evaluated grade of stenosis, plaque characteristics, and gadolinium enhancement ratio (postcontrast plaque signal/postcontrast corpus callosum signal). The occurrence of new events was evaluated at 3, 6, 9, and 12 months and annually thereafter. The association between plaque characteristics and new stroke was studied using Cox multiple regression survival analysis and Kaplan‐Meier curves. Results: Forty‐eight symptomatic and 13 asymptomatic patients were included. During 56.3 ± 16.9 months, 11 patients (18%) suffered a new event (seven ischemic, two hemorrhagic, and two transient ischemic attacks). A receiver operating characteristic curve identified an enhancement ratio of >1.77 to predict a new event. In a multivariable Cox regression, postcontrast enhancement ratio >1.77 (hazard ratio [HR]= 3.632; 95% confidence interval [CI], 1.082‐12.101) and cerebral microbleeds (HR = 5.244; 95% CI, 1.476‐18.629) were independent predictors of future strokes. Patients with a plaque enhancement ratio >1.77 had a lower survival free of events (p <.05). Conclusions: High intracranial postcontrast enhancement is a long‐term predictor of new stroke in ICAD patients. Further studies are needed to elucidate whether postcontrast enhancement reflects inflammatory activity of intracranial atheromatous plaque. [ABSTRACT FROM AUTHOR]
Published: 2023
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26. Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke

Author: Almekhlafi, Mohammed, Goyal, Mayank, Dippel, Diederik, Majoie, Charles, Campbell, Bruce, Muir, Keith, Demchuk, Andrew, Bracard, Serge, Guillemin, Francis, Jovin, Tudor, Mitchell, Peter, White, Philip, Hill, Michael, Brown, Scott, Saver, Jeffrey, Berkhemer, Olvert, Fransen, Puck, Beumer, Debbie, Van Den Berg, Lucie, Lingsma, Hester, Yoo, Albert, Schonewille, Wouter, Vos, Jan, Nederkoorn, Paul, Wermer, Marieke, Van Walderveen, Marianne, Staals, Julie, Hofmeijer, Jeannette, Van Oostayen, Jacques, Lycklama À Nijeholt, Geert, Boiten, Jelis, Brouwer, Patrick, Emmer, Bart, De Bruijn, Sebastiaan, Van Dijk, Lukas, Kappelle, L, Lo, Rob, Van Dijk, Ewoud, de Vries, Joost, De Kort, Paul, Van Rooij, Willem, Van Den Berg, Jan, Van Hasselt, Boudewijn, Aerden, Leo, Dallinga, René, Visser, Marieke, Bot, Joseph, Vroomen, Patrick, Eshghi, Omid, Schreuder, Tobien, Heijboer, Roel, Keizer, Koos, Tielbeek, Alexander, Den Hertog, Heleen, Gerrits, Dick, Van Den Berg-Vos, Renske, Karas, Giorgos, Steyerberg, Ewout, Flach, H, Marquering, Henk, Sprengers, Marieke, Jenniskens, Sjoerd, Beenen, Ludo, Van Den Berg, René, Koudstaal, Peter, Van Zwam, Wim, Roos, Yvo, van der Lugt, Aad, Van Oostenbrugge, Robert, Menon, Bijoy, Eesa, Muneer, Rempel, Jeremy, Thornton, John, Roy, Daniel, Willinsky, Robert, Sapkota, Biggya, Dowlatshahi, Dar, Frei, Donald, Kamal, Noreen, Montanera, Walter, Poppe, Alexandre, Ryckborst, Karla, Silver, Frank, Shuaib, Ashfaq, Tampieri, Donatella, Williams, David, Bang, Oh, Baxter, Blaise, Burns, Paul, Choe, Hana, Heo, Ji-Hoe, Holmstedt, Christine, Jankowitz, Brian, KELLY, Michael, Linares, Guillermo, Mandzia, Jennifer, Shankar, Jai, Sohn, Sung-Il, Swartz, Richard, Coutts, Shelagh, Smith, Eric, Morrish, William, Weill, Alain, Subramaniam, Suresh, Mitha, Alim, Wong, John, Lowerison, Mark, Sajobi, Tolulope, Bonafe, Alain, Diener, Hans, Levy, Elad, Pereira, Vitor, Albers, Gregory, Cognard, Christophe, Cohen, David, Hacke, Werner, Jansen, Olav, Mattle, Heinrich, Nogueira, Raul, Siddiqui, Adnan, Yavagal, Dileep, Devlin, Thomas, Lopes, Demetrius, Reddy, Vivek, du Mesnil de Rochemont, Richard, Singer, Oliver, Jahan, Reza, Kleinig, Timothy, Dewey, Helen, Churilov, Leonid, Yassi, Nawaf, Yan, Bernard, Dowling, Richard, Parsons, Mark, Oxley, Thomas, Wu, Teddy, Brooks, Mark, Simpson, Marion, Miteff, Ferdinand, Levi, Christopher, Krause, Martin, Harrington, Timothy, Faulder, Kenneth, Steinfort, Brendan, Priglinger, Miriam, Ang, Timothy, Scroop, Rebecca, Barber, Philip, McGuinness, Ben, Wijeratne, Tissa, Phan, Thanh, Chong, Winston, Chandra, Ronil, Bladin, Christopher, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Ma, Henry, Desmond, Patricia, Donnan, Geoffrey, Davis, Stephen, Chamorro, Angel, Cobo, Erik, De Miquel, María, Molina, Carlos, Rovira, Alex, San Román, Luis, Serena, Joaquín, Abilleira, Sonia, Ribó, Marc, Millán, Mònica, Urra, Xabier, Cardona, Pere, López-Cancio, Elena, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucía, Dorado, Laura, Quesada, Helena, Rubiera, Marta, Hernandez-Pérez, María, von Kummer, Rüdiger, Gallofré, Miquel, Dávalos, Antoni, Ford, Gary, Messow, Claudia-Martina, Ford, Ian, Murray, Alicia, Clifton, Andrew, Brown, Martin, Madigan, Jeremy, Lenthall, Rob, Robertson, Fergus, Dixit, Anand, Cloud, Geoffrey, Wardlaw, Joanna, Freeman, Janet, Ducrocq, Xavier, Mas, Jean, Soudant, Marc, Oppenheim, Catherine, Moulin, Thierry, University of Calgary, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Radiology and Nuclear Medicine [Amsterdam], VU University Medical Center [Amsterdam], University of Melbourne, University of Glasgow, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), The Royal Melbourne Hospital, Newcastle University [Newcastle], Altair Development, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), and University of California-University of California
Subjects: [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known. OBJECTIVE To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). DATA SOURCES PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020.
Published: 2021
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27. Impairment of functional integration of the default mode network correlates with cognitive outcome at three months after stroke

Author: Dacosta-Aguayo, Rosalia, Graña, Manuel, Iturria-Medina, Yasser, Fernández-Andújar, Marina, López-Cancio, Elena, Cáceres, Cynthia, Bargalló, Núria, Barrios, Maite, Clemente, Immaculada, Toran, Pera, Forés, Rosa, Dávalos, Antoni, Auer, Tibor, and Mataró, Maria
Published: 2015
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28. Remote Thalamic Microstructural Abnormalities Related to Cognitive Function in Ischemic Stroke Patients

Author: Fernández-Andújar, Marina, Doornink, Fleur, Dacosta-Aguayo, Rosalía, Soriano-Raya, Juan José, Miralbell, Júlia, Bargalló, Núria, López-Cancio, Elena, de la Ossa, Natalia Pérez, Gomis, Meritxell, Millán, Mònica, Barrios, Maite, Cáceres, Cynthia, Pera, Guillem, Forés, Rosa, Clemente, Imma, Dávalos, Antoni, and Mataró, Maria
Published: 2014
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29. Diffusion Tensor Imaging, Intracranial Vascular Resistance and Cognition in Middle-Aged Asymptomatic Subjects

Author: López-Olóriz, Jorge, López-Cancio, Elena, Arenillas, Juan F., Hernández, María, Dorado, Laura, Dacosta-Aguayo, Rosalía, Barrios, Maite, Soriano-Raya, Juan José, Miralbell, Júlia, Bargalló, Núria, Cáceres, Cynthia, Torán, Pere, Alzamora, Maite, Dávalos, Antonio, and Mataró, Maria
Published: 2014
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30. Infarct Patterns, Collaterals and Likely Causative Mechanisms of Stroke in Symptomatic Intracranial Atherosclerosis

Author: López-Cancio, Elena, Gisele Matheus, Maria, Romano, Jose G., Liebeskind, David S., Prabhakaran, Shyam, Turan, Tanya N., Cotsonis, George A., Lynn, Michael J., Rumboldt, Zoran, and Chimowitz, Marc I.
Published: 2014
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31. Natural History of Acute Stroke due to Occlusion of the Middle Cerebral Artery and Intracranial Internal Carotid Artery

Author: Hernández-Pérez, María, Pérez de la Ossa, Natalia, Aleu, Aitziber, Millán, Mònica, Gomis, Meritxell, Dorado, Laura, López-Cancio, Elena, Jovin, Tudor, and Dávalos, Antoni
Published: 2014
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32. Tract-Specific Fractional Anisotropy Predicts Cognitive Outcome in a Community Sample of Middle-Aged Participants with White Matter Lesions

Author: Soriano-Raya, Juan José, Miralbell, Júlia, López-Cancio, Elena, Bargalló, Núria, Arenillas, Juan Francisco, Barrios, Maite, Cáceres, Cynthia, Toran, Pere, Alzamora, Maite, Dávalos, Antoni, and Mataró, Maria
Published: 2014
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33. Outcomes of a Contemporary Cohort of 536 Consecutive Patients With Acute Ischemic Stroke Treated With Endovascular Therapy

Author: Abilleira, Sònia, Cardona, Pere, Ribó, Marc, Millán, Mònica, Obach, Víctor, Roquer, Jaume, Cánovas, David, Martí-Fàbregas, Joan, Rubio, Francisco, Álvarez-Sabín, José, Dávalos, Antoni, Chamorro, Ángel, de Miquel, Maria Angeles, Tomasello, Alejandro, Castaño, Carlos, Macho, Juan M., Ribera, Aida, Gallofré, Miquel, Sanahuja, Jordi, Purroy, Francisco, Serena, Joaquín, Castellanos, Mar, Silva, Yolanda, van Eendenburg, Cecile, Pellisé, Anna, Ustrell, Xavier, Marés, Rafael, Baiges, Juanjo, Garcés, Moisés, Saura, Júlia, Soler Insa, Josep Maria, Aragonés, Josep Maria, Otermín, Pilar, Cocho, Dolores, Palomeras, Ernest, Pérez de la Ossa, Natalia, Gomis, Meritxell, López-Cancio, Elena, Dorado, Laura, Aleu, Aitzíber, García-Bermejo, Pablo, Rubiera, Marta, Santamarina, Esteban, Pagola, Jorge, Molina, Carlos, Coscojuela, Pilar, Quesada, Helena, Cano, Lluis, Aja, Lucia, Mora, Paloma, Cervera, Álvaro, Amaro, Sergio, Urra, Xabier, Blasco-Andaluz, Jordi, San Roman, Luis, Delgado-Mederos, Raquel, Dinia, Lavinia, Carrera-Giraldo, David, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivas, Elio, del Carmen Garcia, Maria, Estela, Jordi, Perendreu, Joan, Krupinski, Jerzy, Huertas-Folch, Sonia, Nicolás-Herrerias, M. Carme, Gómez-Choco, Manuel, García, Sonia, and Martínez, Raul
Published: 2014
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34. Design and Validation of a Prehospital Stroke Scale to Predict Large Arterial Occlusion: The Rapid Arterial Occlusion Evaluation Scale

Author: Pérez de la Ossa, Natalia, Carrera, David, Gorchs, Montse, Querol, Marisol, Millán, Mònica, Gomis, Meritxell, Dorado, Laura, López-Cancio, Elena, Hernández-Pérez, María, Chicharro, Vicente, Escalada, Xavier, Jiménez, Xavier, and Dávalos, Antoni
Published: 2014
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35. Cognitive Patterns in Relation to Biomarkers of Cerebrovascular Disease and Vascular Risk Factors

Author: Miralbell, Júlia, López-Cancio, Elena, López-Oloriz, Jorge, Arenillas, Juan Francisco, Barrios, Maite, Soriano-Raya, Juan José, Galán, Amparo, Cáceres, Cynthia, Alzamora, Maite, Pera, Guillem, Toran, Pere, Dávalos, Antoni, and Mataró, Maria
Published: 2013
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36. Serum Prealbumin Levels on Admission as a Prognostic Marker in Stroke Patients Treated with Mechanical Thrombectomy.

Author: López, Begoña, Castañón-Apilánez, Maria, Molina-Gil, Javier, Fernández-Gordón Sánchez, Santiago, González, Gemma, Reguera Acuña, Antía, Jimenez, Jose Maria, Larrosa Campo, Davinia, Delgado, Montserrat González, Benavente-Fernández, Lorena, Rico-Santos, Maria, García-Cabo, Carmen, Calleja Puerta, Sergio, and López-Cancio, Elena
Published: 2022
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37. Biological Signatures of Asymptomatic Extra- and Intracranial Atherosclerosis: The Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) Study

Author: López-Cancio, Elena, Galán, Amparo, Dorado, Laura, Jiménez, Marta, Hernández, María, Millán, Mónica, Reverté, Silvia, Suñol, Anna, Barallat, Jaume, Massuet, Anna, Alzamora, Maria Teresa, Dávalos, Antonio, and Arenillas, Juan Francisco
Published: 2012
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38. The Metabolic Syndrome Is Associated With a Higher Resistance to Intravenous Thrombolysis for Acute Ischemic Stroke in Women Than in Men

Author: Arenillas, Juan F., Sandoval, Patricio, de la Ossa, Natalia Pérez, Millán, Mónica, Guerrero, Cristina, Escudero, Domingo, Dorado, Laura, López-Cancio, Elena, Castillo, José, and Dávalos, Antoni
Published: 2009
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39. Structural brain changes and cognition in relation to markers of vascular dysfunction

Author: Miralbell, Julia, Soriano, Juan José, Spulber, Gabriela, López-Cancio, Elena, Arenillas, Juan Francisco, Bargalló, Núria, Galán, Amparo, Barrios, Maria Teresa, Cáceres, Cynthia, Alzamora, Maria Teresa, Pera, Guillem, Kivipelto, Miia, Wahlund, Lars-Olof, Dávalos, Antoni, and Mataró, Maria
Published: 2012
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40. A Genome-Wide Meta-Analysis

Author: Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)
Subjects: Allele, Genome-wide association study, Ischemic stroke, Genetic loci, cardiovascular diseases, Genetic variant
Abstract: [Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome., [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date., [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9)., [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci., Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.
Published: 2019

41. The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design

Author: Pera Guillem, Alzamora Maite, Galán Amparo, Mataró María, Massuet Anna, Suñol Anna, Reverté Silvia, Millán Mónica, Dorado Laura, López-Cancio Elena, Torán Pere, Dávalos Antoni, and Arenillas Juan F
Subjects: Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. Methods/Design Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. Discussion The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.
Published: 2011
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42. Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.

Author: Carrera, Caty, Cárcel-Márquez, Jara, Cullell, Natalia, Torres-Águila, Nuria, Muiño, Elena, Castillo, José, Sobrino, Tomás, Campos, Francisco, Rodríguez-Castro, Emilio, Llucià-Carol, Laia, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Bustamante, Alejandro, Ribó, Marc, Álvarez-Sabín, José, Jiménez-Conde, Jordi, Roquer, Jaume, Giralt-Steinhauer, Eva, and Soriano-Tárraga, Carolina
Subjects: SINGLE nucleotide polymorphisms, STROKE, GENOME-wide association studies, GENETIC variation, ISCHEMIC stroke, STROKE patients, BLOOD-brain barrier, GENETIC regulation
Abstract: Haemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. Our objective was to identify single nucleotide variations associated with a risk of parenchymal haematoma following thrombolytic therapy in patients with acute ischaemic stroke. A fixed-effect genome-wide meta-analysis was performed combining two-stage genome-wide association studies (n = 1904). The discovery stage (three cohorts) comprised 1324 ischaemic stroke individuals, 5.4% of whom had a parenchymal haematoma. Genetic variants yielding a P-value < 0.05 1 × 10-5 were analysed in the validation stage (six cohorts), formed by 580 ischaemic stroke patients with 12.1% haemorrhagic events. All participants received recombinant tissue-plasminogen activator; cases were parenchymal haematoma type 1 or 2 as defined by the European Cooperative Acute Stroke Study (ECASS) criteria. Genome-wide significant findings (P < 5 × 10-8) were characterized by in silico functional annotation, gene expression, and DNA regulatory elements. We analysed 7 989 272 single nucleotide polymorphisms and identified a genome-wide association locus on chromosome 20 in the discovery cohort; functional annotation indicated that the ZBTB46 gene was driving the association for chromosome 20. The top single nucleotide polymorphism was rs76484331 in the ZBTB46 gene [P = 2.49 × 10-8; odds ratio (OR): 11.21; 95% confidence interval (CI): 4.82-26.55]. In the replication cohort (n = 580), the rs76484331 polymorphism was associated with parenchymal haematoma (P = 0.01), and the overall association after meta-analysis increased (P = 1.61 × 10-8; OR: 5.84; 95% CI: 3.16-10.76). ZBTB46 codes the zinc finger and BTB domain-containing protein 46 that acts as a transcription factor. In silico studies indicated that ZBTB46 is expressed in brain tissue by neurons and endothelial cells. Moreover, rs76484331 interacts with the promoter sites located at 20q13. In conclusion, we identified single nucleotide variants in the ZBTB46 gene associated with a higher risk of parenchymal haematoma following recombinant tissue-plasminogen activator treatment. [ABSTRACT FROM AUTHOR]
Published: 2021
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43. Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke.

Author: Talavera, Blanca, Gómez-Vicente, Beatriz, Martínez-Galdámez, Mario, López-Cancio, Elena, García-Cabo, Carmen, Castellanos, Mar, Roel, Alexia, Tejada-Meza, Herbert, Marta-Moreno, Javier, Pérez-Lázaro, Cristina, Pilar Navarro-Pérez, María, Bravo-Anguiano, Yolanda, Bártulos-Iglesias, Mónica, Tejada-García, Javier, Rodrigo-Stevens, Gabriela, Martínez-Zabaleta, Maite, de la Riva, Patricia, José Timiraos-Fernández, Juan, del Mar Freijo, María, and Luna, Alain
Published: 2021
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44. Impact of Mediterranean Diet prior to Stroke on the Prognosis of Patients Undergoing Endovascular Treatment.

Author: García-Cabo, Carmen, Castañón-Apilánez, Maria, Benavente-Fernández, Lorena, Jimenez, Jose Maria, Arenillas, Juan, Castellanos, Mar, Rodrigo-Stevens, Gabriela, Tejada-Meza, Herbert, Pérez, Cristina, Martínez-Zabaleta, Maite, Rodriguez-Castro, Emilio, Sánchez, Joaquín, Julian-Villaverde, Francisco, Pinedo, Ana, Palacio, Enrique, and López-Cancio, Elena
Subjects: MEDITERRANEAN diet, ENDOVASCULAR surgery, STROKE patients, CEREBRAL infarction, STROKE, ISCHEMIC stroke, PATIENT compliance, OLIVE oil
Abstract: Introduction: Mediterranean diet (MeDiet) has been associated with lower risk of stroke. Additionally, animal models suggested that some components of MeDiet are associated with better outcomes after ischemic stroke (IS). We aimed to evaluate the association between global adherence to the MeDiet and the consumption of particular components of the MeDiet with stroke outcomes. Material and Methods: Multicenter observational study of consecutive IS patients treated with endovascular therapy. Inclusion criteria were large anterior circulation vessel occlusion and pre-stroke modified Rankin scale (mRS) <2. Adherence to MeDiet prior to stroke was evaluated using MEDAS 14-item scale. We evaluated the total score and also individual components of the scale. Clinical, radiological, and prognostic variables were collected. Good functional prognosis was considered as mRS ≤2 and complete recanalization as thrombolysis in cerebral infarction 3. Results: From January 1 to October 30, 2018, 239 patients were included (mean age 71 years, 48% women, median baseline NIHSS 16). Median MEDAS scale was 8 points (7–10). Patients with a higher adherence to MeDiet had significantly lower total and LDL-cholesterol levels. Total adherence score was not associated with stroke outcomes. In multivariate analyses, consumption of olive oil as the principal source of fat was independently associated with good functional outcome at 3 months, OR 3.2 (1.1–10.1) and daily consumption of wine was independently associated with complete recanalization, OR 2.0 (1.1–3.8). Conclusions: Our study suggests that some components of MeDiet, such as olive oil and wine consumption, are related to better prognosis after stroke. More studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
Published: 2021
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45. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke.

Author: Ramos-Pachón, Anna, López-Cancio, Elena, Bustamante, Alejandro, Pérez de la Ossa, Natàlia, Millán, Mònica, Hernández-Pérez, Maria, Garcia-Berrocoso, Teresa, Cardona, Pere, Rubiera, Marta, Serena, Joaquín, Ustrell, Xavier, Garcés, Moisés, Terceño, Mikel, Dávalos, Antoni, and Montaner, Joan
Published: 2021
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46. Blood Biomarker Panels for the Early Prediction of Stroke-Associated Complications.

Author: Faura, Júlia, Bustamante, Alejandro, Reverté, Silvia, García-Berrocoso, Teresa, Castellanos, Mar, Lara-Rodríguez, Blanca, Zaragoza, Josep, Ventura, Oriol, Hernández-Pérez, María, van Eendenburg, Cecile, Cardona, Pere, López-Cancio, Elena, Cánovas, David, Serena, Joaquín, Rubiera, Marta, Dávalos, Antoni, Montaner, Joan, and Millán, Mónica
Published: 2021
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47. Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance.

Author: Lamonja-Vicente, Noemí, Dacosta-Aguayo, Rosalia, López-Olóriz, Jorge, Prades-Senovilla, Laia, Roig-Coll, Francesca, Castells-Sánchez, Alba, Soriano-Raya, Juan José, Clemente, Inmaculada, Miralbell, Júlia, Barrios, Maite, López-Cancio, Elena, Cáceres, Cynthia, Arenillas, Juan Francisco, Millán, Mónica, Torán, Pere, Pera, Guillem, Fores, Rosa, Alzamora, Maria Teresa, Mataró, Maria, and Via, Marc
Subjects: BRAIN-derived neurotrophic factor, COGNITIVE aging, C-reactive protein, APOLIPOPROTEIN E, COGNITION, SEX distribution, APOLIPOPROTEINS, GENOTYPES, LONGITUDINAL method
Abstract: Apolipoprotein E (APOE) has an important role in the multiple trajectories of cognitive aging. However, environmental variables and other genes mediate the impact of APOE on cognition. Our main objective was to analyze the effect of APOE genotype on cognition and its interactions and relationships with sex, age, lipid profile, C-reactive protein, and Brain-derived neurotrophic factor (BDNF) genotype in a sample of 648 healthy participants over 50 years of age with a comprehensive neuropsychological assessment. Our results showed that APOE ε2 carriers performed better in the Verbal Memory (p = .002) and Fluency Domains (p = .001). When we studied the effect of sex, we observed that the beneficial effect of APOE ε2 on the normalized values of these cognitive domains occurred only in females (β = 0.735; 95% confidence interval, 0.396-1.074; p = 3.167·10-5 and β = 0.568; 95% confidence interval, 0.276-0.861; p = 1.853·10-4, respectively). Similarly, the sex-specific effects of APOE ε2 were further observed on lipidic and inflammation biomarkers. In the whole sample, APOE ε2 carriers showed significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein. These differences were found only among females. Furthermore, total cholesterol and low-density lipoprotein cholesterol mediated the protective effect of APOE ε2 on cognition in the whole sample and total cholesterol in females, providing candidate physiological mechanisms for the observed genetic effects. Our results show that the neuroprotective role of APOE ε2 in cognition varies with sex and that the lipidic profile partially mediates this protection. Age-related cognitive and functional decline is a continuous biological process with different cognitive trajectories (1). Complex interactions between heritability, environmental influence, and cognitive functions in aging have been highlighted (2). In particular, genetic differences explain around 15%-25% of the variance in life expectancy (3). Therefore, the identification of susceptibility genes and their biological effects on cognitive aging is required to establish interindividual differences in this process and promote early personalized interventions to delay cognitive decline and minimize the financial burden of aging in the health care system. [ABSTRACT FROM AUTHOR]
Published: 2021
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48. Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment.

Author: Crespo-Cuevas, Ane Miren, López-Cancio, Elena, Cáceres, Cynthia, González, Anna, Ispierto, Lourdes, Hernández-Pérez, María, Mataró, María, Planas, Anna, Canento, Tamara, Martín, Lorena, Arenillas, Juan Francisco, Alvarez, Ramiro, and Vilas, Dolores
Subjects: *COGNITION disorders, *ULTRASONIC imaging, *SUBSTANTIA nigra, *COGNITIVE testing, *EDUCATIONAL attainment, *LONGITUDINAL method
Abstract: Background: Non-invasive biomarkers of cognitive impairment are needed. We aim to evaluate transcranial sonographic markers as predictors of cognitive impairment in a prospective cohort.Objective: To study the changes in the third ventricle diameter and the SN echogenicity between the baseline and the control visit, as well as its association with cognitive performance and the diagnosis of cognitive impairment in a prospective cohort.Methods: From the longitudinal population-based Asymptomatic Intracranial Atherosclerosis Study, we selected those subjects that received a complete transcranial sonography (TCS) and extensive cognitive testing, both at baseline and follow-up. We evaluated third ventricle (IIIv) width, echogenicity of substantia nigra (SN), and temporal changes of these parameters.Results: We included 289 participants with a median follow-up time of 7.16 years. Those subjects who developed cognitive decline (n = 23, 7.96%) had a larger IIIv at baseline than those who did not (0.54±0.14 cm versus 0.41±0.15 cm; p = 0.001). A cut-off point of 0.465 cm for the IIIv width was identified as an independent predictor of long-term cognitive impairment after adjustment for age, gender, educational level, and vascular risk score. Change in IIIv diameter after follow-up was not associated with diagnosis of cognitive impairment. The area of SN and the presence of hyperechogenicity of the SN remained stable over time and was not associated with the diagnosis of cognitive impairment.Conclusion: IIIv width assessed by TCS emerged as an independent predictor of long-term cognitive impairment. [ABSTRACT FROM AUTHOR]
Published: 2020
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49. Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis.

Author: Wabnitz, Ashley M., Derdeyn, Colin P., Fiorella, David J., Lynn, Michael J., Cotsonis, George A., Liebeskind, David S., Waters, Michael F., Lutsep, Helmi, López-Cancio, Elena, Turan, Tanya N., Montgomery, Jean, Janis, L. Scott, Lane, Bethany, Chimowitz, Marc I., and SAMMPRIS Investigators
Published: 2019
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50. Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis.

Author: Kaesmacher, Johannes, Mordasini, Pasquale, Arnold, Marcel, López-cancio, Elena, Cerdá, Neus, Boeckh-Behrens, Tobias, Kleine, Justus F., Goyal, Mayank, Hill, Michael D., Pereira, Vitor Mendes, Saver, Jeffrey L., Gralla, Jan, and Fischer, Urs
Subjects: CEREBRAL ischemia, CONFIDENCE intervals, DISEASE complications, META-analysis, REPERFUSION, STROKE, THROMBOSIS, TISSUE plasminogen activator, VEIN surgery, SYSTEMATIC reviews, EFFECT sizes (Statistics), TREATMENT effectiveness, ODDS ratio
Abstract: Background Whether pretreatment with intravenous thrombolysis prior to mechanical thrombectomy (IVT+MTE) adds additional benefit over direct mechanical thrombectomy (dMTE) in patients with large vessel occlusions (LVO) is a matter of debate. Methods This study-level meta-analysis was presented in accord with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pooled effect sizes were calculated using the inverse variance heterogeneity model and displayed as summary Odds Ratio (s0R) and corresponding 95% confidence interval (95% Cl). Sensitivity analysis was performed by distinguishing between studies including dMTE patients eligible for IVT (IVT-E) or ineligible for IVT (IVT-IN). Primary outcome measures were functional independence (modified Rankin Scale ≤2) and mortality at day 90, successful reperfusion, and symptomatic intracerebral hemorrhage. Results Twenty studies, incorporating 5279 patients, were included. There was no evidence that rates of successful reperfusion differed in dMTE and IVT+MTE patients (sOR 0.93, 95% Cl 0.68 to 1.28). In studies including IVT-IN dMTE patients, patients undergoing dMTE tended to have lower rates of functional independence and had higher odds for a fatal outcome as compared with IVT+MTE patients (sOR 0.78, 95% Cl 0.61 to 1.01 and sOR 1.45, 95% CI 1.22 to 1.73). However, no such treatment group effect was found when analyses were confined to cohorts with a lower risk of selection bias (including IVT-E dMTE patients). Conclusion The quality of evidence regarding the relative merits of IVT+MTE versus dMTE is low. When considering studies with lower selection bias, the data suggest that dMTE may offer comparable safety and efficacy as compared with IVT+MTE. The conduct of randomized-controlled clinical trials seems justified. [ABSTRACT FROM AUTHOR]
Published: 2019
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